GPR55 - G13

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

G12/13

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8ZX4

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

Nov. 13, 2024

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

LPI - Agonist

PHYSIOLOGICAL LIGANDS

N-palmitoylethanolamine, lysophosphatidylinositol, anandamide, 2-arachidonoylglycerolphosphoinositol, 2-arachidonoylglycerol



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 S 130 34x54 G.H5 I 219 G.H5.15
Van-der-waals ICL2 S 130 34x54 G.H5 I 219 G.H5.15
Polar ICL3 Q 220 - G.h4s6 Q 190 G.h4s6.11
Hydrophobic ICL3 Q 220 - G.h4s6 Q 190 G.h4s6.11
Van-der-waals ICL3 Q 220 - G.h4s6 Q 190 G.h4s6.11
Polar ICL1 D 55 - G.H5 Q 226 G.H5.22
Hydrophobic ICL1 D 55 - G.H5 Q 226 G.H5.22
Van-der-waals ICL1 D 55 - G.H5 Q 226 G.H5.22
Polar ICL3 Q 216 - G.H4 E 181 G.H4.13
Polar ICL3 Q 220 - G.H5 Q 230 G.H5.26
Van-der-waals ICL3 Q 220 - G.H5 Q 230 G.H5.26
Hydrophobic TM3 R 119 3x50 G.H5 L 229 G.H5.25
Van-der-waals TM3 R 119 3x50 G.H5 L 229 G.H5.25
Polar ICL3 T 215 - G.S6 L 195 G.S6.01
Van-der-waals ICL3 T 215 - G.S6 L 195 G.S6.01
Hydrophobic ICL2 L 127 34x51 G.H5 K 216 G.H5.12
Hydrophobic ICL3 T 215 - G.S6 Y 196 G.S6.02
Van-der-waals ICL3 T 215 - G.S6 Y 196 G.S6.02
Hydrophobic TM5 L 208 5x65 G.H5 L 224 G.H5.20
Van-der-waals TM5 L 208 5x65 G.H5 L 224 G.H5.20
Hydrophobic TM3 D 118 3x49 G.H5 L 227 G.H5.23
Van-der-waals TM3 D 118 3x49 G.H5 L 227 G.H5.23
Ionic ICL3 D 217 - G.h4s6 R 187 G.h4s6.08
Polar ICL3 D 217 - G.h4s6 R 187 G.h4s6.08
Hydrophobic ICL3 D 217 - G.h4s6 R 187 G.h4s6.08
Van-der-waals ICL3 D 217 - G.h4s6 R 187 G.h4s6.08
Hydrophobic TM3 I 123 3x54 G.H5 L 220 G.H5.16
Van-der-waals TM3 I 123 3x54 G.H5 L 220 G.H5.16
Hydrophobic ICL2 V 129 34x53 G.H5 N 223 G.H5.19
Hydrophobic TM3 R 119 3x50 G.H5 L 227 G.H5.23
Hydrophobic ICL2 L 127 34x51 G.S3 V 79 G.S3.01
Hydrophobic ICL2 R 133 34x57 G.H5 L 227 G.H5.23
Hydrophobic ICL2 P 126 34x50 G.H5 K 216 G.H5.12
Van-der-waals ICL2 P 126 34x50 G.H5 K 216 G.H5.12
Polar C-term V 291 - G.H5 Q 230 G.H5.26
Hydrophobic C-term V 291 - G.H5 Q 230 G.H5.26
Van-der-waals C-term V 291 - G.H5 Q 230 G.H5.26
Hydrophobic TM1 F 45 1x57 G.H5 M 228 G.H5.24
Van-der-waals TM1 F 45 1x57 G.H5 M 228 G.H5.24
Polar TM2 T 59 2x39 G.H5 Q 226 G.H5.22
Van-der-waals TM2 T 59 2x39 G.H5 Q 226 G.H5.22
Hydrophobic ICL3 T 215 - G.h4s6 P 194 G.h4s6.20
Hydrophobic TM3 I 123 3x54 G.H5 L 224 G.H5.20
Van-der-waals TM3 I 123 3x54 G.H5 L 224 G.H5.20
Hydrophobic TM6 I 228 6x37 G.H5 L 229 G.H5.25
Ionic TM5 H 214 5x71 G.H5 D 217 G.H5.13
Polar TM5 H 214 5x71 G.H5 D 217 G.H5.13
Hydrophobic TM5 H 214 5x71 G.H5 D 217 G.H5.13
Van-der-waals TM5 H 214 5x71 G.H5 D 217 G.H5.13
Hydrophobic ICL3 D 217 - G.h4s6 P 194 G.h4s6.20
Polar TM6 S 227 6x36 G.H5 L 229 G.H5.25
Van-der-waals TM6 S 227 6x36 G.H5 L 229 G.H5.25
Hydrophobic ICL2 L 127 34x51 G.H5 I 219 G.H5.15
Van-der-waals ICL2 L 127 34x51 G.H5 I 219 G.H5.15
Hydrophobic C-term I 292 - G.H5 Q 230 G.H5.26
Van-der-waals C-term I 292 - G.H5 Q 230 G.H5.26
Hydrophobic TM3 I 123 3x54 G.H5 L 229 G.H5.25
Hydrophobic ICL2 P 126 34x50 G.H5 I 219 G.H5.15
Van-der-waals ICL3 Q 220 - G.H5 H 221 G.H5.17
Ionic ICL3 D 217 - G.H4 R 184 G.H4.16
Polar ICL3 D 217 - G.H4 R 184 G.H4.16
Hydrophobic ICL3 D 217 - G.H4 R 184 G.H4.16
Van-der-waals ICL3 D 217 - G.H4 R 184 G.H4.16
Polar TM6 C 224 6x33 G.H5 Q 230 G.H5.26
Hydrophobic TM6 C 224 6x33 G.H5 Q 230 G.H5.26
Van-der-waals TM6 C 224 6x33 G.H5 Q 230 G.H5.26
Van-der-waals ICL2 R 133 34x57 G.H5 Q 226 G.H5.22
Hydrophobic TM3 I 123 3x54 G.H5 L 227 G.H5.23
Hydrophobic C-term I 292 - G.H5 M 228 G.H5.24
Van-der-waals C-term I 292 - G.H5 M 228 G.H5.24
Polar TM2 Y 56 2x36 G.H5 K 225 G.H5.21
Polar ICL3 Q 216 - G.H4 R 184 G.H4.16
Hydrophobic ICL3 Q 216 - G.H4 R 184 G.H4.16
Hydrophobic ICL2 L 127 34x51 G.H5 F 212 G.H5.08
Van-der-waals ICL2 L 127 34x51 G.H5 F 212 G.H5.08
Hydrophobic ICL2 P 126 34x50 G.H5 L 220 G.H5.16
Hydrophobic TM2 Y 56 2x36 G.H5 M 228 G.H5.24
Van-der-waals TM2 Y 56 2x36 G.H5 M 228 G.H5.24
Hydrophobic TM5 R 211 5x68 G.H5 L 220 G.H5.16
Hydrophobic TM5 H 214 5x71 G.H5 R 213 G.H5.09
Polar ICL3 D 217 - G.S6 L 195 G.S6.01
Van-der-waals ICL3 D 217 - G.S6 L 195 G.S6.01
Polar ICL2 P 126 34x50 G.H5 N 223 G.H5.19
Van-der-waals ICL2 P 126 34x50 G.H5 N 223 G.H5.19
Ionic TM5 R 211 5x68 G.H5 D 217 G.H5.13
Polar TM5 R 211 5x68 G.H5 D 217 G.H5.13
Hydrophobic TM5 R 211 5x68 G.H5 D 217 G.H5.13
Van-der-waals TM5 R 211 5x68 G.H5 D 217 G.H5.13
Polar TM3 A 122 3x53 G.H5 N 223 G.H5.19
Hydrophobic TM3 A 122 3x53 G.H5 N 223 G.H5.19
Van-der-waals TM3 A 122 3x53 G.H5 N 223 G.H5.19
Hydrophobic TM2 T 59 2x39 G.H5 M 228 G.H5.24
Van-der-waals TM2 T 59 2x39 G.H5 M 228 G.H5.24
Hydrophobic ICL3 Q 220 - G.h4s6 Q 191 G.h4s6.12
Hydrophobic TM1 F 48 1x60 G.H5 M 228 G.H5.24
Hydrophobic ICL2 S 130 34x54 G.H5 N 223 G.H5.19
Hydrophobic TM6 C 224 6x33 G.H5 L 229 G.H5.25
Van-der-waals TM6 C 224 6x33 G.H5 L 229 G.H5.25
Van-der-waals TM2 S 60 2x40 G.H5 M 228 G.H5.24
Polar TM6 Q 221 6x30 G.H5 H 221 G.H5.17
Hydrophobic TM6 Q 221 6x30 G.H5 H 221 G.H5.17
Polar ICL2 H 131 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 H 131 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 H 131 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 A 122 3x53 G.H5 L 227 G.H5.23
Van-der-waals TM3 A 122 3x53 G.H5 L 227 G.H5.23
Polar TM2 T 59 2x39 G.H5 L 227 G.H5.23
Hydrophobic TM2 T 59 2x39 G.H5 L 227 G.H5.23
Hydrophobic TM5 H 214 5x71 G.S6 Y 196 G.S6.02
Polar TM6 Q 221 6x30 G.H5 Q 230 G.H5.26
Van-der-waals TM6 Q 221 6x30 G.H5 Q 230 G.H5.26
Polar C-term K 293 - G.H5 Q 230 G.H5.26
Hydrophobic C-term K 293 - G.H5 Q 230 G.H5.26
Polar ICL2 H 131 34x55 G.hns1 K 31 G.hns1.02
Hydrophobic ICL2 H 131 34x55 G.hns1 K 31 G.hns1.02
Van-der-waals ICL2 H 131 34x55 G.hns1 K 31 G.hns1.02
Hydrophobic TM6 Q 221 6x30 G.H5 L 224 G.H5.20
Van-der-waals TM6 Q 221 6x30 G.H5 L 224 G.H5.20
Hydrophobic TM6 A 223 6x32 G.H5 Q 230 G.H5.26