MRGPRD - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

Dec. 11, 2024

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

2-[[1-[2-(4-chlorophenyl)-2-methylpropanoyl]piperidin-4-yl]amino]-5,6,7,8-tetrahydro-3H-quinazolin-4-one - Agonist pubchem

PHYSIOLOGICAL LIGANDS

β-alanine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM3 R 123 3x50 G.H5 Y 243 G.H5.23
Van-der-waals TM3 R 123 3x50 G.H5 Y 243 G.H5.23
Hydrophobic ICL3 P 216 - G.H5 V 246 G.H5.26
Polar ICL2 R 137 34x57 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 137 34x57 G.hns1 R 31 G.hns1.02
Polar TM6 R 218 6x32 G.H5 N 244 G.H5.24
Hydrophobic TM6 R 218 6x32 G.H5 N 244 G.H5.24
Van-der-waals TM6 R 218 6x32 G.H5 N 244 G.H5.24
Hydrophobic TM3 V 127 3x54 G.H5 L 236 G.H5.16
Van-der-waals TM3 V 127 3x54 G.H5 L 236 G.H5.16
Hydrophobic TM6 L 219 6x33 G.H5 L 240 G.H5.20
Van-der-waals TM6 L 219 6x33 G.H5 L 240 G.H5.20
Polar ICL2 P 130 34x50 G.H5 N 239 G.H5.19
Van-der-waals ICL2 P 130 34x50 G.H5 N 239 G.H5.19
Polar TM3 Q 122 3x49 G.H5 Y 243 G.H5.23
Hydrophobic TM3 Q 122 3x49 G.H5 Y 243 G.H5.23
Van-der-waals TM3 Q 122 3x49 G.H5 Y 243 G.H5.23
Hydrophobic TM5 S 208 5x66 G.H5 L 236 G.H5.16
Hydrophobic ICL3 W 212 - G.H5 Q 237 G.H5.17
Van-der-waals ICL3 W 212 - G.H5 Q 237 G.H5.17
Hydrophobic ICL2 I 131 34x51 G.H5 I 235 G.H5.15
Van-der-waals ICL2 I 131 34x51 G.H5 I 235 G.H5.15
Hydrophobic TM3 V 127 3x54 G.H5 L 240 G.H5.20
Van-der-waals TM3 V 127 3x54 G.H5 L 240 G.H5.20
Polar ICL2 H 136 34x56 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 H 136 34x56 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 H 136 34x56 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 R 218 6x32 G.H5 L 245 G.H5.25
Hydrophobic ICL3 W 212 - G.H5 V 246 G.H5.26
Hydrophobic ICL2 C 135 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 W 212 - G.H5 L 236 G.H5.16
Hydrophobic TM5 V 205 5x63 G.H5 L 240 G.H5.20
Hydrophobic C-term V 279 - G.H5 N 244 G.H5.24
Hydrophobic ICL2 C 135 34x55 G.S1 L 34 G.S1.02
Van-der-waals ICL2 C 135 34x55 G.S1 L 34 G.S1.02
Hydrophobic TM6 L 219 6x33 G.H5 V 246 G.H5.26
Polar ICL2 C 135 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 P 130 34x50 G.H5 I 235 G.H5.15
Van-der-waals ICL2 P 130 34x50 G.H5 I 235 G.H5.15
Hydrophobic ICL3 W 212 - G.H5 L 240 G.H5.20
Aromatic TM2 F 61 2x39 G.H5 Y 243 G.H5.23
Hydrophobic TM2 F 61 2x39 G.H5 Y 243 G.H5.23
Van-der-waals TM2 F 61 2x39 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 P 130 34x50 G.H5 L 236 G.H5.16
Hydrophobic ICL2 F 133 34x53 G.H5 N 239 G.H5.19
Hydrophobic ICL2 I 131 34x51 G.H5 F 228 G.H5.08
Van-der-waals ICL2 I 131 34x51 G.H5 F 228 G.H5.08
Hydrophobic ICL2 K 134 34x54 G.H5 M 238 G.H5.18
Van-der-waals ICL2 K 134 34x54 G.H5 M 238 G.H5.18
Polar ICL2 K 134 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 I 131 34x51 G.S3 V 79 G.S3.01
Polar TM3 S 126 3x53 G.H5 N 239 G.H5.19
Hydrophobic TM3 S 126 3x53 G.H5 N 239 G.H5.19
Van-der-waals TM3 S 126 3x53 G.H5 N 239 G.H5.19
Hydrophobic ICL2 K 134 34x54 G.H5 I 235 G.H5.15
Hydrophobic ICL2 I 131 34x51 G.H5 K 232 G.H5.12
Van-der-waals ICL2 I 131 34x51 G.H5 K 232 G.H5.12
Hydrophobic TM3 S 126 3x53 G.H5 Y 243 G.H5.23
Hydrophobic TM6 L 219 6x33 G.H5 L 245 G.H5.25
Van-der-waals TM6 L 219 6x33 G.H5 L 245 G.H5.25
Polar ICL3 W 212 - G.H5 D 233 G.H5.13
Hydrophobic TM6 V 222 6x36 G.H5 L 245 G.H5.25