ADGRL2 - G13

GPCR CLASS (FAMILY)

Class B2 (Adhesion)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

G12/13

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9E51

RESOLUTION

2.9 Å

REFERENCE

10.1073/PNAS.2508436122

PUBLICATION DATE

Nov. 12, 2025

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) -

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 H 1019 5x64 G.H5 L 224 G.H5.20
Van-der-waals TM5 H 1019 5x64 G.H5 L 224 G.H5.20
Hydrophobic TM5 M 1016 5x61 G.H5 L 227 G.H5.23
Hydrophobic TM3 L 935 3x54 G.H5 L 227 G.H5.23
Van-der-waals TM3 L 935 3x54 G.H5 L 227 G.H5.23
Polar TM3 V 940 3x59 G.H5 K 216 G.H5.12
Hydrophobic TM3 L 939 3x58 G.H5 L 227 G.H5.23
Hydrophobic TM5 H 1019 5x64 G.H5 L 220 G.H5.16
Van-der-waals TM5 H 1019 5x64 G.H5 L 220 G.H5.16
Hydrophobic ICL3 L 1023 - G.H5 H 221 G.H5.17
Polar TM6 S 1035 6x37 G.H5 Q 230 G.H5.26
Van-der-waals TM6 S 1035 6x37 G.H5 Q 230 G.H5.26
Hydrophobic TM2 R 879 2x46 G.H5 L 227 G.H5.23
Hydrophobic ICL3 K 1024 - G.h4s6 Q 191 G.h4s6.12
Hydrophobic ICL2 V 942 - G.H5 K 216 G.H5.12
Van-der-waals ICL2 V 942 - G.H5 K 216 G.H5.12
Hydrophobic ICL2 F 943 - G.H5 V 215 G.H5.11
Hydrophobic TM5 T 1012 5x57 G.H5 L 227 G.H5.23
Hydrophobic TM6 L 1038 6x40 G.H5 L 229 G.H5.25
Hydrophobic TM5 M 1016 5x61 G.H5 M 228 G.H5.24
Hydrophobic ICL3 T 1022 - G.H5 H 221 G.H5.17
Hydrophobic ICL3 L 1023 - G.H5 K 225 G.H5.21
Hydrophobic TM3 L 939 3x58 G.H5 L 224 G.H5.20
Hydrophobic ICL2 F 943 - G.H5 I 219 G.H5.15
Hydrophobic TM3 L 939 3x58 G.H5 L 220 G.H5.16
Van-der-waals TM3 L 939 3x58 G.H5 L 220 G.H5.16
Hydrophobic ICL2 F 943 - G.H5 K 216 G.H5.12
Van-der-waals ICL2 F 943 - G.H5 K 216 G.H5.12
Hydrophobic ICL2 S 945 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 E 946 - G.HN T 28 G.HN.52
Van-der-waals ICL2 E 946 - G.HN T 28 G.HN.52
Aromatic ICL2 F 943 - G.H5 F 212 G.H5.08
Hydrophobic ICL2 F 943 - G.H5 F 212 G.H5.08
Van-der-waals ICL2 F 943 - G.H5 F 212 G.H5.08
Hydrophobic ICL2 V 942 - G.H5 L 220 G.H5.16
Hydrophobic TM6 A 1042 6x44 G.H5 L 229 G.H5.25
Hydrophobic ICL2 F 943 - G.S3 V 79 G.S3.01
Polar TM3 M 938 3x57 G.H5 N 223 G.H5.19
Hydrophobic TM3 M 938 3x57 G.H5 N 223 G.H5.19
Van-der-waals TM3 M 938 3x57 G.H5 N 223 G.H5.19
Hydrophobic ICL2 E 946 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 E 946 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 W 1036 6x38 G.H5 M 228 G.H5.24
Ionic TM5 H 1019 5x64 G.H5 D 217 G.H5.13
Polar TM5 H 1019 5x64 G.H5 D 217 G.H5.13
Polar TM5 H 1019 5x64 G.H5 H 221 G.H5.17
Aromatic TM5 H 1019 5x64 G.H5 H 221 G.H5.17
Hydrophobic TM5 H 1019 5x64 G.H5 H 221 G.H5.17
Van-der-waals H8 Q 1088 8x47 G.H5 L 229 G.H5.25
Hydrophobic TM3 L 939 3x58 G.H5 N 223 G.H5.19
Hydrophobic ICL2 V 942 - G.H5 I 219 G.H5.15
Van-der-waals ICL2 V 942 - G.H5 I 219 G.H5.15
Ionic ICL2 E 944 - G.hns1 K 31 G.hns1.02
Polar ICL2 E 944 - G.hns1 K 31 G.hns1.02
Hydrophobic TM3 M 938 3x57 G.H5 L 227 G.H5.23
Van-der-waals TM3 M 938 3x57 G.H5 L 227 G.H5.23
Polar ICL2 E 944 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 E 944 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 E 944 - G.hns1 R 32 G.hns1.03
Hydrophobic TM5 M 1016 5x61 G.H5 L 224 G.H5.20