P2RY8 - G13

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

B

G PROTEIN (FAMILY)

G12/13

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9ECJ

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

Nov. 5, 2025

3D VIEW

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LIGAND INTERACTIONS

54 interactions (Click to see)

LIGANDS

S-geranylgeranyl-L-glutathione - Agonist pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 128 - G.H5 K 353 G.H5.12
Van-der-waals ICL2 P 128 - G.H5 K 353 G.H5.12
Hydrophobic TM5 L 220 5x65 G.H5 L 357 G.H5.16
Hydrophobic TM2 S 58 2x39 G.H5 M 365 G.H5.24
Polar TM3 L 126 3x55 G.H5 K 353 G.H5.12
Hydrophobic TM6 L 238 6x37 G.H5 L 366 G.H5.25
Van-der-waals TM6 L 238 6x37 G.H5 L 366 G.H5.25
Polar H8 S 297 8x47 G.H5 M 365 G.H5.24
Hydrophobic H8 S 297 8x47 G.H5 M 365 G.H5.24
Van-der-waals H8 S 297 8x47 G.H5 M 365 G.H5.24
Polar TM6 Q 231 6x30 G.H5 H 358 G.H5.17
Hydrophobic TM6 Q 231 6x30 G.H5 H 358 G.H5.17
Van-der-waals TM6 Q 231 6x30 G.H5 H 358 G.H5.17
Hydrophobic ICL2 P 128 - G.H5 I 356 G.H5.15
Van-der-waals ICL2 P 128 - G.H5 I 356 G.H5.15
Hydrophobic TM3 R 121 3x50 G.H5 L 366 G.H5.25
Hydrophobic TM6 A 235 6x34 G.H5 L 361 G.H5.20
Hydrophobic ICL3 E 225 - G.H5 D 354 G.H5.13
Van-der-waals ICL3 E 225 - G.H5 D 354 G.H5.13
Polar TM6 R 234 6x33 G.H5 Q 367 G.H5.26
Hydrophobic TM6 R 234 6x33 G.H5 Q 367 G.H5.26
Van-der-waals TM6 R 234 6x33 G.H5 Q 367 G.H5.26
Polar TM3 R 121 3x50 G.H5 L 364 G.H5.23
Hydrophobic TM3 R 121 3x50 G.H5 L 364 G.H5.23
Van-der-waals TM3 R 121 3x50 G.H5 L 364 G.H5.23
Polar TM6 Q 231 6x30 G.H5 Q 367 G.H5.26
Hydrophobic TM6 Q 231 6x30 G.H5 Q 367 G.H5.26
Van-der-waals TM6 Q 231 6x30 G.H5 Q 367 G.H5.26
Polar TM6 A 235 6x34 G.H5 L 366 G.H5.25
Hydrophobic TM6 A 235 6x34 G.H5 L 366 G.H5.25
Van-der-waals TM6 A 235 6x34 G.H5 L 366 G.H5.25
Hydrophobic TM2 M 62 2x43 G.H5 M 365 G.H5.24
Van-der-waals TM2 M 62 2x43 G.H5 M 365 G.H5.24
Hydrophobic TM5 K 219 5x64 G.H5 L 357 G.H5.16
Polar ICL3 H 227 - G.h4s6 K 330 G.h4s6.19
Hydrophobic ICL3 H 227 - G.h4s6 K 330 G.h4s6.19
Van-der-waals ICL3 H 227 - G.h4s6 K 330 G.h4s6.19
Polar H8 S 297 8x47 G.H5 L 366 G.H5.25
Hydrophobic TM2 V 59 2x40 G.H5 M 365 G.H5.24
Van-der-waals TM2 V 59 2x40 G.H5 M 365 G.H5.24
Polar ICL2 K 132 - G.S1 L 48 G.S1.01
Hydrophobic TM3 V 125 3x54 G.H5 L 361 G.H5.20
Van-der-waals TM3 V 125 3x54 G.H5 L 361 G.H5.20
Hydrophobic ICL2 P 128 - G.H5 L 357 G.H5.16
Hydrophobic TM6 A 239 6x38 G.H5 L 366 G.H5.25
Ionic ICL3 E 225 - G.H5 H 358 G.H5.17
Hydrophobic TM3 G 124 3x53 G.H5 L 364 G.H5.23
Polar ICL2 P 128 - G.H5 N 360 G.H5.19
Hydrophobic H8 E 299 8x49 G.H5 K 362 G.H5.21
Hydrophobic H8 E 299 8x49 G.H5 M 365 G.H5.24
Hydrophobic ICL1 M 52 - G.H5 M 365 G.H5.24
Van-der-waals ICL1 M 52 - G.H5 M 365 G.H5.24
Polar ICL3 H 227 - G.h4s6 Q 329 G.h4s6.13
Hydrophobic ICL3 H 227 - G.h4s6 Q 329 G.h4s6.13
Van-der-waals ICL3 H 227 - G.h4s6 Q 329 G.h4s6.13
Hydrophobic ICL2 L 129 - G.S3 F 218 G.S3.03
Hydrophobic ICL2 R 133 - G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 R 133 - G.hns1 R 47 G.hns1.03
Polar TM2 S 58 2x39 G.H5 Q 363 G.H5.22
Hydrophobic TM2 S 58 2x39 G.H5 Q 363 G.H5.22
Van-der-waals TM2 S 58 2x39 G.H5 Q 363 G.H5.22
Hydrophobic TM3 V 125 3x54 G.H5 L 357 G.H5.16
Van-der-waals TM3 V 125 3x54 G.H5 L 357 G.H5.16
Hydrophobic TM3 V 125 3x54 G.H5 L 364 G.H5.23
Polar ICL3 H 227 - G.h4s6 P 331 G.h4s6.20
Hydrophobic ICL3 H 227 - G.h4s6 P 331 G.h4s6.20
Polar TM4 R 136 4x38 G.HN T 43 G.HN.52
Hydrophobic TM4 R 136 4x38 G.HN T 43 G.HN.52
Hydrophobic ICL2 S 130 - G.S3 V 216 G.S3.01
Polar ICL3 E 225 - G.S6 Y 333 G.S6.02
Hydrophobic ICL3 E 225 - G.S6 Y 333 G.S6.02
Van-der-waals ICL3 E 225 - G.S6 Y 333 G.S6.02
Hydrophobic ICL2 R 135 - G.H5 N 360 G.H5.19
Van-der-waals ICL2 R 135 - G.H5 N 360 G.H5.19
Hydrophobic TM4 R 136 4x38 G.hns1 K 46 G.hns1.02
Van-der-waals TM4 R 136 4x38 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 L 129 - G.H5 I 356 G.H5.15
Hydrophobic TM5 L 220 5x65 G.H5 L 361 G.H5.20
Hydrophobic TM6 G 228 6x27 G.H5 H 358 G.H5.17
Van-der-waals TM6 G 228 6x27 G.H5 H 358 G.H5.17
Hydrophobic ICL2 L 129 - G.H5 K 353 G.H5.12
Polar TM6 R 232 6x31 G.H5 H 358 G.H5.17
Hydrophobic TM6 R 232 6x31 G.H5 H 358 G.H5.17
Van-der-waals TM6 R 232 6x31 G.H5 H 358 G.H5.17
Hydrophobic TM3 E 120 3x49 G.H5 L 364 G.H5.23
Van-der-waals TM3 E 120 3x49 G.H5 L 364 G.H5.23
Hydrophobic ICL2 L 129 - G.S3 V 216 G.S3.01
Van-der-waals ICL2 L 129 - G.S3 V 216 G.S3.01
Hydrophobic TM2 S 58 2x39 G.H5 L 364 G.H5.23
Hydrophobic ICL2 L 129 - G.S1 V 49 G.S1.02
Hydrophobic ICL2 K 132 - G.hns1 R 47 G.hns1.03
Hydrophobic ICL3 E 225 - G.h4s6 P 331 G.h4s6.20
Van-der-waals ICL3 E 225 - G.h4s6 P 331 G.h4s6.20
Polar TM3 G 124 3x53 G.H5 N 360 G.H5.19
Hydrophobic TM3 G 124 3x53 G.H5 N 360 G.H5.19
Van-der-waals TM3 G 124 3x53 G.H5 N 360 G.H5.19
Polar TM3 R 121 3x50 G.H5 M 365 G.H5.24
Van-der-waals TM3 R 121 3x50 G.H5 M 365 G.H5.24
Hydrophobic ICL2 L 129 - G.H5 V 352 G.H5.11
Van-der-waals ICL2 L 129 - G.H5 V 352 G.H5.11
Hydrophobic ICL2 L 129 - G.H5 F 349 G.H5.08
Van-der-waals ICL2 L 129 - G.H5 F 349 G.H5.08