M5 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.8 Å

REFERENCE

PUBLICATION DATE

Oct. 8, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

iperoxo - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

acetylcholine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Polar H8 N 499 8x47 G.H5 E 390 G.H5.26
Hydrophobic TM5 Q 231 5x76 G.H5 V 346 G.H5.13
Polar ICL2 R 142 - G.H5 Y 391 G.H5.26
Van-der-waals ICL2 R 142 - G.H5 Y 391 G.H5.26
Hydrophobic H8 N 499 8x47 G.H5 E 390 G.H5.26
Van-der-waals H8 N 499 8x47 G.H5 E 390 G.H5.26
Polar TM5 L 230 5x75 G.H5 R 342 G.H5.09
Hydrophobic ICL2 P 135 - G.H5 K 380 G.H5.26
Van-der-waals ICL2 P 135 - G.H5 K 380 G.H5.26
Hydrophobic ICL2 A 140 - G.S1 R 39 G.S1.01
Hydrophobic ICL2 L 136 - G.S1 L 41 G.S1.03
Polar ICL2 R 139 - G.S1 T 40 G.S1.02
Hydrophobic TM5 R 223 5x68 G.H5 L 384 G.H5.26
Van-der-waals TM5 R 223 5x68 G.H5 L 384 G.H5.26
Hydrophobic ICL2 P 135 - G.H5 I 383 G.H5.26
Van-der-waals ICL2 P 135 - G.H5 I 383 G.H5.26
Hydrophobic TM3 I 132 3x54 G.H5 L 384 G.H5.26
Van-der-waals TM3 I 132 3x54 G.H5 L 384 G.H5.26
Hydrophobic ICL2 R 139 - G.S1 L 41 G.S1.03
Hydrophobic TM6 L 444 6x37 G.H5 L 393 G.H5.26
Polar TM5 Q 231 5x76 G.H5 R 342 G.H5.09
Hydrophobic TM5 Q 231 5x76 G.H5 R 342 G.H5.09
Hydrophobic TM3 I 132 3x54 G.H5 L 388 G.H5.26
Van-der-waals TM3 I 132 3x54 G.H5 L 388 G.H5.26
Polar TM6 T 443 6x36 G.H5 N 392 G.H5.26
Van-der-waals TM6 T 443 6x36 G.H5 N 392 G.H5.26
Hydrophobic TM7 C 498 7x56 G.H5 Y 391 G.H5.26
Hydrophobic TM3 I 132 3x54 G.H5 Y 391 G.H5.26
Van-der-waals TM3 I 132 3x54 G.H5 Y 391 G.H5.26
Hydrophobic TM6 T 443 6x36 G.H5 L 393 G.H5.26
Hydrophobic TM5 Q 231 5x76 G.H5 I 358 G.H5.25
Hydrophobic TM5 L 227 5x72 G.H5 Y 360 G.H5.26
Van-der-waals TM5 L 227 5x72 G.H5 Y 360 G.H5.26
Hydrophobic TM5 Q 231 5x76 G.H5 P 361 G.H5.26
Van-der-waals TM5 Q 231 5x76 G.H5 I 358 G.H5.25
Hydrophobic ICL2 L 136 - G.H5 K 380 G.H5.26
Polar TM3 S 131 3x53 G.H5 N 387 G.H5.26
Hydrophobic TM3 S 131 3x53 G.H5 N 387 G.H5.26
Van-der-waals TM3 S 131 3x53 G.H5 N 387 G.H5.26
Polar TM5 Q 231 5x76 G.H5 C 359 G.H5.26
Van-der-waals TM5 Q 231 5x76 G.H5 C 359 G.H5.26
Polar TM7 C 498 7x56 G.H5 N 392 G.H5.26
Hydrophobic ICL2 P 135 - G.H5 L 384 G.H5.26
Hydrophobic TM7 C 498 7x56 G.H5 N 392 G.H5.26
Ionic TM5 R 223 5x68 G.H5 D 381 G.H5.26
Polar TM5 R 223 5x68 G.H5 D 381 G.H5.26
Hydrophobic TM5 R 223 5x68 G.H5 D 381 G.H5.26
Van-der-waals TM5 R 223 5x68 G.H5 D 381 G.H5.26
Hydrophobic TM5 L 230 5x75 G.H5 H 362 G.H5.26
Hydrophobic ICL2 R 139 - G.H5 I 383 G.H5.26
Polar TM3 S 131 3x53 G.H5 Y 391 G.H5.26
Hydrophobic TM3 S 131 3x53 G.H5 Y 391 G.H5.26
Van-der-waals TM3 S 131 3x53 G.H5 Y 391 G.H5.26
Hydrophobic ICL2 L 136 - G.H5 F 376 G.H5.26
Van-der-waals ICL2 L 136 - G.H5 F 376 G.H5.26
Hydrophobic TM5 T 220 5x65 G.H5 L 388 G.H5.26
Van-der-waals TM5 T 220 5x65 G.H5 L 388 G.H5.26
Van-der-waals TM7 C 498 7x56 G.H5 N 392 G.H5.26
Hydrophobic TM5 L 227 5x72 G.H5 I 358 G.H5.25
Polar ICL2 R 139 - G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 R 139 - G.hns1 R 38 G.hns1.03
Hydrophobic TM5 L 230 5x75 G.H5 P 361 G.H5.26
Van-der-waals TM5 L 230 5x75 G.H5 P 361 G.H5.26
Hydrophobic TM5 L 230 5x75 G.H5 Y 360 G.H5.26
Polar TM6 A 440 6x33 G.H5 L 393 G.H5.26
Hydrophobic TM6 A 440 6x33 G.H5 L 393 G.H5.26
Van-der-waals TM6 A 440 6x33 G.H5 L 393 G.H5.26
Polar TM3 D 127 3x49 G.H5 Y 391 G.H5.26
Hydrophobic TM5 R 223 5x68 G.H5 Q 385 G.H5.26
Hydrophobic TM3 I 132 3x54 G.H5 L 393 G.H5.26
Hydrophobic ICL2 L 136 - G.H5 I 383 G.H5.26
Van-der-waals ICL2 L 136 - G.H5 I 383 G.H5.26
Van-der-waals TM5 L 227 5x72 G.H5 I 358 G.H5.25
Hydrophobic TM6 K 439 6x32 G.H5 L 393 G.H5.26
Van-der-waals TM6 K 439 6x32 G.H5 L 393 G.H5.26
Hydrophobic TM5 R 223 5x68 G.H5 L 388 G.H5.26
Van-der-waals TM5 R 223 5x68 G.H5 L 388 G.H5.26
Hydrophobic TM5 T 220 5x65 G.H5 V 394 G.H5.26
Hydrophobic ICL2 L 136 - G.H2 V 217 G.H2.08
Hydrophobic TM5 I 216 5x61 G.H5 L 393 G.H5.26
Hydrophobic ICL2 L 136 - G.H5 C 379 G.H5.26
Polar TM3 R 128 3x50 G.H5 Y 391 G.H5.26
Aromatic TM3 R 128 3x50 G.H5 Y 391 G.H5.26
Hydrophobic TM3 R 128 3x50 G.H5 Y 391 G.H5.26
Van-der-waals TM3 R 128 3x50 G.H5 Y 391 G.H5.26