TAS2R16 - Gi2

GPCR CLASS (FAMILY)

Class T2 (Taste 2)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.8 Å

REFERENCE

PUBLICATION DATE

April 2, 2025

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

salicin - Agonist pubchem gtoplig

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Polar TM6 S 218 6x27 G.S6 Y 321 G.S6.02
Hydrophobic TM6 R 222 6x31 G.H5 L 349 G.H5.20
Hydrophobic TM5 Q 206 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 Q 206 5x68 G.H5 I 345 G.H5.16
Hydrophobic TM7 S 279 7x56 G.H5 G 353 G.H5.24
Van-der-waals TM7 S 279 7x56 G.H5 G 353 G.H5.24
Hydrophobic TM6 C 215 6x24 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 C 215 6x24 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM3 V 107 3x54 G.H5 C 352 G.H5.23
Hydrophobic TM6 T 224 6x33 G.H5 F 355 G.H5.26
Van-der-waals H8 P 281 8x48 G.H5 D 351 G.H5.22
Hydrophobic TM3 V 107 3x54 G.H5 N 348 G.H5.19
Hydrophobic TM2 V 45 2x39 G.H5 C 352 G.H5.23
Van-der-waals TM2 V 45 2x39 G.H5 D 351 G.H5.22
Ionic TM3 K 106 3x53 G.H5 D 351 G.H5.22
Polar TM3 K 106 3x53 G.H5 D 351 G.H5.22
Hydrophobic TM3 K 106 3x53 G.H5 D 351 G.H5.22
Ionic TM4 R 124 4x40 G.HN E 28 G.HN.52
Polar TM4 R 124 4x40 G.HN E 28 G.HN.52
Hydrophobic TM4 R 124 4x40 G.HN E 28 G.HN.52
Van-der-waals TM4 R 124 4x40 G.HN E 28 G.HN.52
Hydrophobic TM6 S 218 6x27 G.H5 K 346 G.H5.17
Hydrophobic TM6 A 225 6x34 G.H5 L 354 G.H5.25
Van-der-waals TM6 A 225 6x34 G.H5 L 354 G.H5.25
Polar TM3 K 106 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 K 106 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 K 106 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM6 A 221 6x30 G.H5 F 355 G.H5.26
Van-der-waals TM6 A 221 6x30 G.H5 F 355 G.H5.26
Polar TM6 N 216 6x25 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 L 229 6x38 G.H5 L 354 G.H5.25
Hydrophobic ICL2 S 109 - G.H5 T 341 G.H5.12
Hydrophobic TM6 P 217 6x26 G.h4s6 D 316 G.h4s6.09
Van-der-waals TM6 P 217 6x26 G.h4s6 D 316 G.h4s6.09
Hydrophobic TM3 V 107 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 107 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM3 F 102 3x49 G.H5 C 352 G.H5.23
Hydrophobic TM6 S 228 6x37 G.H5 L 354 G.H5.25
Polar TM6 S 218 6x27 G.H5 D 342 G.H5.13
Hydrophobic TM6 S 218 6x27 G.H5 D 342 G.H5.13
Van-der-waals TM6 S 218 6x27 G.H5 D 342 G.H5.13
Polar TM6 S 218 6x27 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 S 218 6x27 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 S 218 6x27 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 A 221 6x30 G.H5 L 349 G.H5.20
Hydrophobic TM6 P 217 6x26 G.h4s6 K 318 G.h4s6.11
Van-der-waals TM6 P 217 6x26 G.h4s6 K 318 G.h4s6.11
Hydrophobic TM6 A 225 6x34 G.H5 L 349 G.H5.20
Van-der-waals TM6 A 225 6x34 G.H5 L 349 G.H5.20
Polar TM3 Y 103 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 Y 103 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 Y 103 3x50 G.H5 C 352 G.H5.23
Ionic TM6 K 220 6x29 G.h4s6 D 316 G.h4s6.09
Polar TM6 K 220 6x29 G.h4s6 D 316 G.h4s6.09
Hydrophobic TM6 K 220 6x29 G.h4s6 D 316 G.h4s6.09
Van-der-waals TM6 K 220 6x29 G.h4s6 D 316 G.h4s6.09
Aromatic ICL2 W 120 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 W 120 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 W 120 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 C 215 6x24 G.S6 Y 321 G.S6.02
Van-der-waals TM6 C 215 6x24 G.S6 Y 321 G.S6.02
Ionic TM6 R 222 6x31 G.H5 D 342 G.H5.13
Polar TM6 R 222 6x31 G.H5 D 342 G.H5.13
Van-der-waals TM6 R 222 6x31 G.H5 D 342 G.H5.13
Hydrophobic TM4 R 124 4x40 G.HN R 24 G.HN.48
Hydrophobic ICL2 S 109 - G.H5 I 345 G.H5.16
Polar TM6 P 217 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 P 217 6x26 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 P 217 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM3 K 106 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 K 106 3x53 G.H5 C 352 G.H5.23
Hydrophobic TM3 V 107 3x54 G.H5 L 354 G.H5.25
Hydrophobic TM6 A 221 6x30 G.H5 K 346 G.H5.17
Hydrophobic TM3 Y 103 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 Y 103 3x50 G.H5 L 354 G.H5.25