oxoglutarate receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9M1U

RESOLUTION

2.6 Å

REFERENCE

10.1038/S44318-026-00823-Y

PUBLICATION DATE

June 17, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

23 interactions (Click to see)

LIGANDS

succinic acid - Agonist pubchem gtoplig chembl_ligand drugbank drug_central pubchem drugbank drugbank

PHYSIOLOGICAL LIGANDS

α-ketoglutaric acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 131 3x50 G.H5 L 393 G.H5.25
Van-der-waals TM3 R 131 3x50 G.H5 L 393 G.H5.25
Hydrophobic TM6 K 236 6x30 G.H5 L 384 G.H5.16
Hydrophobic TM3 I 135 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 135 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 M 139 - G.S3 V 217 G.S3.01
Polar TM6 S 233 6x27 G.H5 Q 385 G.H5.17
Hydrophobic TM6 L 246 6x40 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 135 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 I 135 3x54 G.H5 L 393 G.H5.25
Hydrophobic ICL2 M 139 - G.H5 C 379 G.H5.11
Hydrophobic TM3 I 135 3x54 G.H5 L 384 G.H5.16
Van-der-waals TM3 I 135 3x54 G.H5 L 384 G.H5.16
Hydrophobic TM3 F 130 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 F 130 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM6 S 233 6x27 G.h4s6 I 358 G.h4s6.20
Van-der-waals TM6 S 233 6x27 G.h4s6 I 358 G.h4s6.20
Hydrophobic TM6 L 235 6x29 G.h4s6 G 355 G.h4s6.11
Van-der-waals TM6 L 235 6x29 G.h4s6 G 355 G.h4s6.11
Polar TM3 R 131 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 M 139 - G.H5 I 383 G.H5.15
Hydrophobic ICL3 Q 230 - G.h4s6 I 358 G.h4s6.20
Van-der-waals ICL3 Q 230 - G.h4s6 I 358 G.h4s6.20
Hydrophobic TM6 L 235 6x29 G.H5 V 394 G.H5.26
Van-der-waals TM6 L 235 6x29 G.H5 V 394 G.H5.26
Hydrophobic ICL3 Q 230 - G.S6 Y 360 G.S6.02
Hydrophobic ICL2 H 145 - G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 142 - G.hns1 R 39 G.hns1.03
Hydrophobic ICL3 L 229 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 L 229 - G.H5 D 381 G.H5.13
Ionic TM6 K 236 6x30 G.H5 D 381 G.H5.13
Polar TM6 K 236 6x30 G.H5 D 381 G.H5.13
Van-der-waals TM6 K 236 6x30 G.H5 D 381 G.H5.13
Hydrophobic ICL2 M 139 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 M 139 - G.H5 F 376 G.H5.08
Hydrophobic TM3 F 127 3x46 G.H5 Y 391 G.H5.23
Van-der-waals TM3 F 127 3x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 S 68 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM6 A 239 6x33 G.H5 V 394 G.H5.26
Van-der-waals TM6 A 239 6x33 G.H5 V 394 G.H5.26
Hydrophobic TM2 M 72 2x43 G.H5 N 392 G.H5.24
Van-der-waals TM2 M 72 2x43 G.H5 N 392 G.H5.24
Polar TM3 V 134 3x53 G.H5 N 387 G.H5.19
Hydrophobic TM3 V 134 3x53 G.H5 N 387 G.H5.19
Van-der-waals TM3 V 134 3x53 G.H5 N 387 G.H5.19
Hydrophobic ICL2 M 139 - G.S3 F 219 G.S3.03
Polar ICL2 H 145 - G.H5 N 387 G.H5.19
Hydrophobic ICL2 H 145 - G.H5 N 387 G.H5.19
Hydrophobic TM6 A 239 6x33 G.H5 L 388 G.H5.20
Hydrophobic TM3 F 127 3x46 G.H5 N 392 G.H5.24
Hydrophobic ICL2 P 138 - G.H5 L 384 G.H5.16
Polar ICL2 I 144 - G.H5 Y 391 G.H5.23
Hydrophobic TM6 T 243 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 243 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL3 Q 230 - G.H5 D 381 G.H5.13
Polar TM7 Y 302 7x53 G.H5 N 392 G.H5.24
Van-der-waals TM7 Y 302 7x53 G.H5 N 392 G.H5.24
Hydrophobic TM3 V 134 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 V 134 3x53 G.H5 Y 391 G.H5.23
Hydrophobic H8 S 306 8x47 G.H5 N 392 G.H5.24
Polar H8 D 307 8x48 G.H5 V 394 G.H5.26
Hydrophobic H8 D 307 8x48 G.H5 V 394 G.H5.26
Van-der-waals H8 D 307 8x48 G.H5 V 394 G.H5.26
Polar TM3 R 131 3x50 G.H5 N 392 G.H5.24
Van-der-waals TM3 R 131 3x50 G.H5 N 392 G.H5.24
Hydrophobic ICL3 L 229 - G.S6 Y 360 G.S6.02
Hydrophobic ICL2 F 142 - G.hns1 R 38 G.hns1.02
Ionic H8 D 307 8x48 G.H5 R 389 G.H5.21
Polar TM2 S 68 2x39 G.H5 E 390 G.H5.22
Hydrophobic TM2 S 68 2x39 G.H5 E 390 G.H5.22
Van-der-waals TM2 S 68 2x39 G.H5 E 390 G.H5.22
Hydrophobic TM5 I 221 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 235 6x29 G.H5 Q 385 G.H5.17
Hydrophobic ICL2 M 139 - G.H5 K 380 G.H5.12
Van-der-waals ICL2 M 139 - G.H5 K 380 G.H5.12
Hydrophobic TM5 L 225 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 138 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 138 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 M 139 - G.S1 L 41 G.S1.02
Van-der-waals ICL2 M 139 - G.S1 L 41 G.S1.02
Polar ICL2 H 145 - G.hns1 R 38 G.hns1.02
Aromatic ICL2 H 145 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 H 145 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 H 145 - G.hns1 R 38 G.hns1.02
Hydrophobic TM5 L 225 5x65 G.H5 L 384 G.H5.16
Hydrophobic TM6 A 239 6x33 G.H5 L 393 G.H5.25
Hydrophobic H8 S 306 8x47 G.H5 V 394 G.H5.26
Hydrophobic TM6 C 234 6x28 G.h4s6 G 355 G.h4s6.11
Hydrophobic TM6 L 242 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 242 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM6 K 238 6x32 G.H5 V 394 G.H5.26
Hydrophobic TM4 K 146 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 K 146 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM2 K 66 2x37 G.H5 E 390 G.H5.22
Ionic ICL2 H 145 - G.H5 E 390 G.H5.22
Polar ICL2 H 145 - G.H5 E 390 G.H5.22
Hydrophobic ICL2 H 145 - G.H5 E 390 G.H5.22
Van-der-waals ICL2 H 145 - G.H5 E 390 G.H5.22