CysLT2 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9UAM

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

March 18, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

16 interactions (Click to see)

LIGANDS

LTC4 - Agonist pubchem gtoplig chembl_ligand drugbank

PHYSIOLOGICAL LIGANDS

LTC4, LTE4, LTD4



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic H8 G 309 8x47 G.H5 N 244 G.H5.24
Van-der-waals H8 G 309 8x47 G.H5 N 244 G.H5.24
Hydrophobic TM6 T 248 6x37 G.H5 L 245 G.H5.25
Hydrophobic ICL2 F 144 - G.H5 C 231 G.H5.11
Hydrophobic TM3 A 139 3x53 G.H5 Y 243 G.H5.23
Van-der-waals TM3 A 139 3x53 G.H5 Y 243 G.H5.23
Hydrophobic TM3 R 136 3x50 G.H5 L 245 G.H5.25
Hydrophobic TM6 H 242 6x31 G.H5 Q 237 G.H5.17
Hydrophobic TM3 M 140 3x54 G.H5 L 245 G.H5.25
Van-der-waals TM3 M 140 3x54 G.H5 L 245 G.H5.25
Hydrophobic TM6 L 238 6x27 G.h4s6 G 207 G.h4s6.11
Van-der-waals TM6 L 238 6x27 G.h4s6 G 207 G.h4s6.11
Hydrophobic H8 E 310 8x48 G.H5 V 246 G.H5.26
Van-der-waals H8 E 310 8x48 G.H5 V 246 G.H5.26
Polar H8 N 311 8x49 G.H5 N 244 G.H5.24
Hydrophobic H8 N 311 8x49 G.H5 N 244 G.H5.24
Hydrophobic ICL2 L 146 - G.hns1 R 32 G.hns1.03
Polar TM6 S 241 6x30 G.H5 V 246 G.H5.26
Hydrophobic TM6 S 241 6x30 G.H5 V 246 G.H5.26
Van-der-waals TM6 S 241 6x30 G.H5 V 246 G.H5.26
Hydrophobic ICL2 F 144 - G.S3 V 79 G.S3.01
Hydrophobic TM6 A 245 6x34 G.H5 L 240 G.H5.20
Hydrophobic TM6 I 249 6x38 G.H5 L 245 G.H5.25
Van-der-waals TM6 I 249 6x38 G.H5 L 245 G.H5.25
Hydrophobic ICL2 F 144 - G.H5 I 235 G.H5.15
Van-der-waals ICL2 F 144 - G.H5 I 235 G.H5.15
Polar TM6 A 245 6x34 G.H5 V 246 G.H5.26
Hydrophobic TM6 A 245 6x34 G.H5 V 246 G.H5.26
Van-der-waals TM6 A 245 6x34 G.H5 V 246 G.H5.26
Hydrophobic ICL2 F 144 - G.H5 K 232 G.H5.12
Van-der-waals ICL2 F 144 - G.H5 K 232 G.H5.12
Hydrophobic ICL2 F 144 - G.S1 L 34 G.S1.02
Polar ICL2 V 149 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 V 149 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 V 149 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 P 143 - G.H5 I 235 G.H5.15
Polar TM3 A 139 3x53 G.H5 N 239 G.H5.19
Van-der-waals TM3 A 139 3x53 G.H5 N 239 G.H5.19
Hydrophobic ICL2 P 143 - G.H5 K 232 G.H5.12
Hydrophobic TM2 M 77 2x43 G.H5 N 244 G.H5.24
Van-der-waals TM2 M 77 2x43 G.H5 N 244 G.H5.24
Hydrophobic TM3 M 140 3x54 G.H5 L 240 G.H5.20
Van-der-waals TM3 M 140 3x54 G.H5 L 240 G.H5.20
Hydrophobic TM3 V 135 3x49 G.H5 Y 243 G.H5.23
Hydrophobic TM6 K 244 6x33 G.H5 V 246 G.H5.26
Van-der-waals TM6 K 244 6x33 G.H5 V 246 G.H5.26
Hydrophobic TM6 L 238 6x27 G.h4s6 I 210 G.h4s6.20
Polar H8 F 312 8x50 G.H5 N 244 G.H5.24
Hydrophobic H8 F 312 8x50 G.H5 N 244 G.H5.24
Van-der-waals H8 F 312 8x50 G.H5 N 244 G.H5.24
Hydrophobic TM3 M 140 3x54 G.H5 L 236 G.H5.16
Aromatic ICL2 F 144 - G.H5 F 228 G.H5.08
Hydrophobic ICL2 F 144 - G.H5 F 228 G.H5.08
Van-der-waals ICL2 F 144 - G.H5 F 228 G.H5.08
Polar TM3 R 136 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM3 R 136 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM5 L 228 5x65 G.H5 L 240 G.H5.20
Hydrophobic TM2 V 73 2x39 G.H5 Y 243 G.H5.23