OR52E8 - Gs

GPCR CLASS (FAMILY)

Class O1 (Olfactory/extra-nasal 1)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

June 17, 2026

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

(3R)-3-Hydroxy-3-methylhexanoic acid - Agonist pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Polar TM3 D 123 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 123 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 123 3x49 G.H5 Y 391 G.H5.23
Polar TM3 A 127 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 127 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 127 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 I 128 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 128 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL3 L 230 - G.H5 L 388 G.H5.20
Van-der-waals ICL3 L 230 - G.H5 L 388 G.H5.20
Polar TM6 T 242 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 242 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 242 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM2 M 61 2x39 G.H5 Y 391 G.H5.23
Polar H8 K 299 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 K 299 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 299 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 T 298 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM3 A 127 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 127 3x53 G.H5 Y 391 G.H5.23
Polar TM3 C 129 3x55 G.H5 R 380 G.H5.12
Van-der-waals TM3 C 129 3x55 G.H5 R 380 G.H5.12
Hydrophobic ICL2 P 131 - G.H5 H 387 G.H5.19
Hydrophobic TM3 I 128 3x54 G.H5 H 387 G.H5.19
Van-der-waals TM3 I 128 3x54 G.H5 H 387 G.H5.19
Hydrophobic ICL3 A 235 - G.H5 L 394 G.H5.26
Van-der-waals ICL3 A 235 - G.H5 L 394 G.H5.26
Hydrophobic TM3 I 128 3x54 G.H5 Y 391 G.H5.23
Polar TM6 A 239 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 239 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 239 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 242 6x36 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 131 - G.H5 R 380 G.H5.12
Polar ICL2 Y 134 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 Y 134 - G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 124 3x50 G.H5 L 393 G.H5.25
Van-der-waals ICL3 A 235 - G.H5 L 393 G.H5.25
Hydrophobic TM6 K 238 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 238 6x32 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 132 - G.S3 V 217 G.S3.01
Aromatic ICL2 Y 134 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 134 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 Y 134 - G.H5 H 387 G.H5.19
Hydrophobic TM6 K 238 6x32 G.H5 L 393 G.H5.25
Polar ICL3 S 232 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 S 232 - G.H5 R 385 G.H5.17
Hydrophobic TM2 M 61 2x39 G.H5 Q 390 G.H5.22
Van-der-waals TM2 M 61 2x39 G.H5 Q 390 G.H5.22
Polar TM3 I 128 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 128 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 128 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 128 3x54 G.H5 L 393 G.H5.25
Hydrophobic TM5 V 227 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 V 227 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM5 I 223 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 223 5x61 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 131 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 131 - G.H5 I 383 G.H5.15
Polar ICL2 T 135 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 T 135 - G.hns1 R 38 G.hns1.02
Hydrophobic TM6 K 238 6x32 G.H5 L 394 G.H5.26
Hydrophobic ICL2 P 131 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 131 - G.H5 Q 384 G.H5.16
Hydrophobic TM3 R 124 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 124 3x50 G.H5 Y 391 G.H5.23