MAS1 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

May 20, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

AR234958 - Agonist pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Polar ICL2 P 137 34x50 G.H5 N 354 G.H5.19
Van-der-waals ICL2 P 137 34x50 G.H5 N 354 G.H5.19
Polar TM3 S 133 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM3 S 133 3x53 G.H5 N 354 G.H5.19
Van-der-waals TM3 S 133 3x53 G.H5 N 354 G.H5.19
Polar ICL2 R 141 34x54 G.H5 N 354 G.H5.19
Van-der-waals ICL2 R 141 34x54 G.H5 N 354 G.H5.19
Polar TM3 S 133 3x53 G.H5 C 358 G.H5.23
Hydrophobic TM3 S 133 3x53 G.H5 C 358 G.H5.23
Van-der-waals TM3 S 133 3x53 G.H5 C 358 G.H5.23
Hydrophobic ICL2 R 141 34x54 G.H5 M 353 G.H5.18
Van-der-waals ICL2 R 141 34x54 G.H5 M 353 G.H5.18
Hydrophobic TM2 F 66 2x39 G.H5 C 358 G.H5.23
Van-der-waals TM2 F 66 2x39 G.H5 C 358 G.H5.23
Hydrophobic TM6 I 230 6x37 G.H5 L 360 G.H5.25
Hydrophobic ICL2 P 137 34x50 G.H5 I 351 G.H5.16
Van-der-waals ICL2 P 137 34x50 G.H5 I 351 G.H5.16
Ionic ICL2 R 141 34x54 G.H5 D 357 G.H5.22
Polar ICL2 R 141 34x54 G.H5 D 357 G.H5.22
Van-der-waals ICL2 R 141 34x54 G.H5 D 357 G.H5.22
Hydrophobic ICL2 Y 140 34x53 G.H5 N 354 G.H5.19
Hydrophobic ICL2 P 137 34x50 G.H5 T 347 G.H5.12
Hydrophobic ICL2 I 138 34x51 G.S1 H 34 G.S1.02
Van-der-waals ICL2 I 138 34x51 G.S1 H 34 G.S1.02
Hydrophobic TM5 L 210 5x59 G.H5 L 360 G.H5.25
Polar ICL2 R 141 34x54 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 141 34x54 G.hns1 R 31 G.hns1.02
Polar ICL2 C 142 34x55 G.S1 H 34 G.S1.02
Hydrophobic ICL2 C 142 34x55 G.S1 H 34 G.S1.02
Van-der-waals ICL2 C 142 34x55 G.S1 H 34 G.S1.02
Polar TM2 N 64 2x37 G.H5 D 357 G.H5.22
Hydrophobic TM2 N 64 2x37 G.H5 D 357 G.H5.22
Hydrophobic TM5 I 214 5x63 G.H5 L 355 G.H5.20
Hydrophobic TM6 L 226 6x33 G.H5 F 361 G.H5.26
Hydrophobic TM6 L 226 6x33 G.H5 L 360 G.H5.25
Van-der-waals TM6 L 226 6x33 G.H5 L 360 G.H5.25
Hydrophobic TM6 V 229 6x36 G.H5 L 360 G.H5.25
Polar ICL2 R 144 34x57 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 144 34x57 G.hns1 R 31 G.hns1.02
Hydrophobic TM3 V 134 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 V 134 3x54 G.H5 L 355 G.H5.20
Hydrophobic TM5 I 214 5x63 G.H5 L 360 G.H5.25
Hydrophobic ICL2 R 141 34x54 G.H5 I 350 G.H5.15
Polar TM3 R 130 3x50 G.H5 C 358 G.H5.23
Hydrophobic TM3 R 130 3x50 G.H5 C 358 G.H5.23
Van-der-waals TM3 R 130 3x50 G.H5 C 358 G.H5.23
Hydrophobic ICL2 I 138 34x51 G.H5 I 350 G.H5.15
Van-der-waals ICL2 I 138 34x51 G.H5 I 350 G.H5.15
Hydrophobic ICL2 C 142 34x55 G.hns1 A 32 G.hns1.03
Hydrophobic TM3 R 130 3x50 G.H5 L 360 G.H5.25
Hydrophobic ICL3 T 218 - G.H5 I 351 G.H5.16
Polar ICL2 C 142 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 C 142 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic TM5 L 210 5x59 G.H5 L 355 G.H5.20
Hydrophobic ICL2 H 143 34x56 G.hns1 A 32 G.hns1.03
Hydrophobic ICL2 P 137 34x50 G.H5 I 350 G.H5.15
Van-der-waals ICL2 P 137 34x50 G.H5 I 350 G.H5.15