OPN1MW - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

Dec. 24, 2025

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

all-trans-retinal - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic TM3 R 151 3x50 G.H5 L 349 G.H5.25
Van-der-waals TM3 R 151 3x50 G.H5 L 349 G.H5.25
Hydrophobic TM5 I 246 5x65 G.H5 I 340 G.H5.16
Hydrophobic TM5 V 249 5x68 G.H5 D 337 G.H5.13
Van-der-waals TM5 V 249 5x68 G.H5 D 337 G.H5.13
Hydrophobic TM5 A 245 5x64 G.H5 I 340 G.H5.16
Hydrophobic TM3 V 155 3x54 G.H5 C 347 G.H5.23
Van-der-waals TM3 V 155 3x54 G.H5 C 347 G.H5.23
Hydrophobic ICL2 R 163 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 163 - G.hns1 R 31 G.hns1.02
Hydrophobic TM6 V 266 6x33 G.H5 L 344 G.H5.20
Hydrophobic TM6 A 262 6x29 G.H5 L 341 G.H5.17
Hydrophobic TM3 V 154 3x53 G.H5 C 347 G.H5.23
Van-der-waals TM3 V 154 3x53 G.H5 C 347 G.H5.23
Polar TM3 R 151 3x50 G.H5 C 347 G.H5.23
Hydrophobic TM3 R 151 3x50 G.H5 C 347 G.H5.23
Hydrophobic TM6 A 262 6x29 G.H5 F 350 G.H5.26
Hydrophobic TM5 Q 253 5x72 G.H5 D 337 G.H5.13
Polar TM6 T 259 6x26 G.H5 D 337 G.H5.13
Van-der-waals TM6 T 259 6x26 G.H5 D 337 G.H5.13
Polar TM5 Q 253 5x72 G.H5 N 333 G.H5.09
Hydrophobic TM5 I 246 5x65 G.H5 L 344 G.H5.20
Van-der-waals TM5 I 246 5x65 G.H5 L 344 G.H5.20
Hydrophobic TM6 T 259 6x26 G.H5 L 341 G.H5.17
Polar H8 R 327 8x48 G.H5 F 350 G.H5.26
Aromatic H8 R 327 8x48 G.H5 F 350 G.H5.26
Hydrophobic H8 R 327 8x48 G.H5 F 350 G.H5.26
Hydrophobic TM6 M 269 6x36 G.H5 L 349 G.H5.25
Hydrophobic TM5 V 249 5x68 G.H5 I 340 G.H5.16
Hydrophobic TM6 M 273 6x40 G.H5 L 349 G.H5.25
Hydrophobic H8 N 326 8x47 G.H5 G 348 G.H5.24
Polar TM5 Q 252 5x71 G.H5 N 333 G.H5.09
Hydrophobic TM5 V 249 5x68 G.H5 T 336 G.H5.12
Polar ICL2 N 161 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 N 161 - G.hns1 R 31 G.hns1.02
Hydrophobic TM6 A 262 6x29 G.H5 L 344 G.H5.20
Ionic TM3 K 157 3x56 G.H5 D 343 G.H5.19
Polar TM3 K 157 3x56 G.H5 D 343 G.H5.19
Van-der-waals TM3 K 157 3x56 G.H5 D 343 G.H5.19
Hydrophobic TM6 E 265 6x32 G.H5 F 350 G.H5.26
Van-der-waals TM6 E 265 6x32 G.H5 F 350 G.H5.26