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RECEPTOR
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STRUCTURE
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SIGNAL PROTEIN
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AUXILIARY PROTEIN
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STRUCTURE LIGAND
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ENDOGENOUS LIGAND
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SODIUM ION SITE
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REFERENCE
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ANNOTATED
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UniProt
|
IUPHAR | Receptor family | Cl. | Species | Method |
PDB
|
Refined structure |
Resolution | Preferred chain |
State |
Degree active (%) |
% of Seq | Family | Subtype | Note | % of Seq | Fusion | Antibodies | Name | Type | Function | Name | Type | D2x50 S3x39 |
Sodium in structure |
Authors | Reference | PDB Date | ||
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 2I35 | - | 3.8 | A | Inactive | 22 | 94 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | - | - | 2006-10-17 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 1HZX | - | 2.8 | A | Inactive | 22 | 98 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | - | 10.1021/BI0155091 | 2001-07-04 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 1F88 | 1F88_refined | 2.8 | A | Inactive | 22 | 97 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | - | 10.1126/SCIENCE.289.5480.739 | 2000-08-04 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 1L9H | - | 2.6 | A | Inactive | 22 | 98 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | - | 10.1073/PNAS.082666399 | 2002-05-15 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 2RH1 | - | 2.4 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
Carazolol
|
small-molecule | Inverse agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | - | 10.1126/SCIENCE.1150577 | 2007-10-30 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 1U19 | 1U19_refined | 2.2 | A | Inactive | 22 | 100 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | - | 10.1016/J.JMB.2004.07.044 | 2004-10-12 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 2HPY | - | 2.8 | B | Inactive | 22 | 100 | - | - | - | - | - | - |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | - | 10.1073/PNAS.0601765103 | 2006-08-22 | Yes | |
OPSD | Rhodopsin | Opsins | A | Japanese flying squid | X-ray | 2ZIY | - | 3.7 | A | Inactive | 17 | 83 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | - | 10.1074/JBC.C800040200 | 2008-05-06 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 3C9M | - | 3.4 | A | Inactive | 22 | 94 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | - | 10.1107/S0907444908017162 | 2008-08-05 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 1GZM | 1GZM_refined | 2.7 | A | Inactive | 22 | 94 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | - | 10.1016/J.JMB.2004.08.090 | 2003-11-20 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 2PED | - | 3.0 | B | Inactive | 22 | 100 | - | - | - | - | - | - |
Retinal (9-cis)
|
small-molecule | Inverse agonist | - | - | No | No | - | 10.1529/BIOPHYSJ.107.108225 | 2007-10-30 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 2I37 | 2I37_refined | 4.2 | A | Inactive | 22 | 91 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | 10.1073/PNAS.0608022103 | 2006-10-17 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 2I36 | - | 4.1 | A | Inactive | 22 | 94 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | - | 2006-10-17 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 2J4Y | - | 3.4 | B | Inactive | 22 | 94 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | - | 10.1016/J.JMB.2007.03.007 | 2007-09-25 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 2G87 | 2G87_refined | 2.6 | A | Inactive | 22 | 100 | - | - | - | - | - | - |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | - | 10.1002/ANIE.200600595 | 2006-09-02 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 2R4R | 2R4R_refined | 3.4 | A | Inactive | 1 | 52 | - | - | - | - | - | Antibody | - | - | - | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | - | 10.1038/NATURE06325 | 2007-11-06 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 3C9L | 3C9L_refined | 2.7 | A | Inactive | 22 | 94 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | - | - | 2008-08-05 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 2R4S | 2R4S_refined | 3.4 | A | Inactive | 1 | 52 | - | - | - | - | - | Antibody | - | - | - | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | - | - | 2007-11-06 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 2Y02 | 2Y02_refined | 2.6 | B | Inactive | 0 | 62 | - | - | - | - | - | - |
CARMOTEROL
|
small-molecule | Agonist | - | - | No | No | - | - | 2011-01-12 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 2Y04 | 2Y04_refined | 3.1 | B | Inactive | 0 | 62 | - | - | - | - | - | - |
levosalbutamol
|
small-molecule | Agonist (partial) | - | - | No | No | - | - | 2011-01-12 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 3PDS | 3PDS_refined | 3.5 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
FAUC50
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | - | 10.1038/NATURE09665 | 2011-01-12 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 3RFM | 3RFM_refined | 3.6 | A | Inactive | 1 | 71 | - | - | - | - | - | - |
caffeine
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | - | - | 2011-09-07 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 3UZC | 3UZC_refined | 3.3 | A | Inactive | 1 | 71 | - | - | - | - | - | - |
CHEMBL2024114
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Congreve M, Andrews SP, Doré AS, Hollenstein K, Hurrell E, Langmead CJ, Mason JS, Ng IW, Tehan B, Zhukov A, Weir M, Marshall FH. | 10.1021/jm201376w | 2012-03-21 | Yes | |
OPRM | μ | Opioid | A | Mouse | X-ray | 4DKL | 4DKL_refined | 2.8 | A | Inactive | 4 | 71 | - | - | - | - | T4-Lysozyme | - |
Methyl 4-[[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]amino]-4-oxobutanoate
|
small-molecule | Antagonist | - | - | No | No | Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, Granier S | 10.1038/NATURE10954 | 2012-03-21 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 4AMI | 4AMI_refined | 3.2 | A | Inactive | 0 | 58 | - | - | - | - | - | - |
Bucindolol
|
small-molecule | Agonist | - | - | No | No | Warne T, Edwards PC, Leslie AG, Tate CG | 10.1016/J.STR.2012.03.014 | 2012-05-23 | Yes | |
5HT1B | 5-HT1B | 5-Hydroxytryptamine | A | Human | X-ray | 4IAR | 4IAR_refined | 2.7 | A | Inactive | 15 | 70 | - | - | - | - | BRIL | - |
ergotamine
|
small-molecule | Agonist | 5-hydroxytryptamine, 5-HT-moduline, tryptamine | small-molecule | No | No | Wang C, Jiang Y, Ma J, Wu H, Wacker D, Katritch V, Han GW, Liu W, Huang XP, Vardy E, McCorvy JD, Gao X, Zhou XE, Melcher K, Zhang C, Bai F, Yang H, Yang L, Jiang H, Roth BL, Cherezov V, Stevens RC, Xu HE | 10.1126/SCIENCE.1232807 | 2013-03-13 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 4BEZ | 4BEZ_refined | 3.3 | A | Active | 98 | 94 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Singhal A, Ostermaier MK, Vishnivetskiy SA, Panneels V, Homan KT, Tesmer JJ, Veprintsev D, Deupi X, Gurevich VV, Schertler GF, Standfuss J | 10.1038/EMBOR.2013.44 | 2013-04-24 | Yes | |
5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | Human | X-ray | 4NC3 | 4NC3_refined | 2.8 | A | Intermediate | 44 | 60 | - | - | - | - | BRIL | - |
ergotamine
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Liu W, Wacker D, Gati C, Han GW, James D, Wang D, Nelson G, Weierstall U, Katritch V, Barty A, Zatsepin NA, Li D, Messerschmidt M, Boutet S, Williams GJ, Koglin JE, Seibert MM, Wang C, Shah ST, Basu S, Fromme R, Kupitz C, Rendek KN, Grotjohann I, Fromme P, Kirian RA, Beyerlein KR, White TA, Chapman HN, Caffrey M, Spence JC, Stevens RC, Cherezov V | 10.1126/SCIENCE.1244142 | 2013-12-18 | Yes | |
OPRD | δ | Opioid | A | Human | X-ray | 4N6H | 4N6H_refined | 1.8 | A | Inactive | 4 | 81 | - | - | - | - | BRIL | - |
naltrindole
|
small-molecule | Antagonist | dynorphin A-(1-8), [Met]enkephalin, endomorphin-1, dynorphin A, [Leu]enkephalin, β-endorphin, dynorphin A-(1-13), dynorphin B, α-neoendorphin | peptide | No | Yes | Fenalti G, Giguere PM, Katritch V, Huang XP, Thompson AA, Cherezov V, Roth BL, Stevens RC | 10.1038/NATURE12944 | 2013-12-25 | Yes | |
P2Y12 | P2Y12 | P2Y | A | Human | X-ray | 4NTJ | 4NTJ_refined | 2.6 | A | Intermediate | 44 | 78 | - | - | - | - | BRIL | - |
AZD1283
|
small-molecule | Antagonist | ADP, ATP | small-molecule | No | No | Zhang K, Zhang J, Gao ZG, Zhang D, Zhu L, Han GW, Moss SM, Paoletta S, Kiselev E, Lu W, Fenalti G, Zhang W, Muller CE, Yang H, Jiang H, Cherezov V, Katritch V, Jacobson KA, Stevens RC, Wu B, Zhao Q | 10.1038/NATURE13083 | 2014-03-26 | Yes | |
ACM3 | M3 | Acetylcholine (muscarinic) | A | Rat | X-ray | 4U14 | 4U14_refined | 3.6 | A | Inactive | 2 | 47 | - | - | - | - | T4-Lysozyme | - |
tiotropium
|
small-molecule | Antagonist | acetylcholine | small-molecule | No | No | Thorsen TS, Matt R, Weis WI, Kobilka BK | 10.1016/J.STR.2014.08.022 | 2014-11-26 | Yes | |
P2RY1 | P2Y1 | P2Y | A | Human | X-ray | 4XNW | 4XNW_refined | 2.7 | A | Intermediate | 44 | 78 | - | - | - | - | Rubredoxin | - |
MRS2500
|
small-molecule | Antagonist | ADP, ATP | small-molecule | No | No | Zhang D, Gao ZG, Zhang K, Kiselev E, Crane S, Wang J, Paoletta S, Yi C, Ma L, Zhang W, Han GW, Liu H, Cherezov V, Katritch V, Jiang H, Stevens RC, Jacobson KA, Zhao Q, Wu B | 10.1038/NATURE14287 | 2015-04-01 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 4UHR | 4UHR_refined | 2.6 | A | Active | 65 | 75 | - | - | - | - | - | - |
CGS 21680
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Lebon G, Edwards PC, Leslie AG, Tate CG | 10.1124/mol.114.097360 | 2015-04-08 | Yes | |
OPSD | Rhodopsin | Opsins | A | Human | X-ray | 4ZWJ | 4ZWJ_refined | 3.3 | A | Active | 100 | 94 | Visual | S-arrestin | - | 86 | T4-Lysozyme | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Kang Y, Zhou XE, Gao X, He Y, Liu W, Ishchenko A, Barty A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Ke J, Tan MH, Zhang C, Moeller A, West GM, Pascal BD, Van Eps N, Caro LN, Vishnivetskiy SA, Lee RJ, Suino-Powell KM, Gu X, Pal K, Ma J, Zhi X, Boutet S, Williams GJ, Messerschmidt M, Gati C, Zatsepin NA, Wang D, James D, Basu S, Roy-Chowdhury S, Conrad CE, Coe J, Liu H, Lisova S, Kupitz C, Grotjohann I, Fromme R, Jiang Y, Tan M, Yang H, Li J, Wang M, Zheng Z, Li D, Howe N, Zhao Y, Standfuss J, Diederichs K, Dong Y, Potter CS, Carragher B, Caffrey M, Jiang H, Chapman HN, Spence JC, Fromme P, Weierstall U, Ernst OP, Katritch V, Gurevich VV, Griffin PR, Hubbell WL, Stevens RC, Cherezov V, Melcher K, Xu HE | 10.1038/NATURE14656 | 2015-07-29 | Yes | |
OPRX | NOP | Opioid | A | Human | X-ray | 5DHH | 5DHH_refined | 3.0 | A | Inactive | 4 | 76 | - | - | - | - | BRIL | - |
SB 612111
|
small-molecule | Antagonist | nociceptin/orphanin FQ | peptide | No | No | Miller RL, Thompson AA, Trapella C, Guerrini R, Malfacini D, Patel N, Han GW, Cherezov V, Calo G, Katritch V, Stevens RC | 10.1016/J.STR.2015.07.024 | 2015-10-21 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5IU4 | 5IU4_refined | 1.7 | A | Inactive | 1 | 71 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Segala E, Guo D, Cheng RK, Bortolato A, Deflorian F, Doré AS, Errey JC, Heitman LH, IJzerman AP, Marshall FH, Cooke RM. | 10.1021/acs.jmedchem.6b00653 | 2016-06-29 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5IU8 | 5IU8_refined | 2.0 | A | Inactive | 1 | 71 | - | - | - | - | BRIL | - |
CHEMBL3934661
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Segala E, Guo D, Cheng RK, Bortolato A, Deflorian F, Doré AS, Errey JC, Heitman LH, IJzerman AP, Marshall FH, Cooke RM. | 10.1021/acs.jmedchem.6b00653 | 2016-06-29 | Yes | |
CNR1 | CB1 | Cannabinoid | A | Human | X-ray | 5U09 | 5U09_refined | 2.6 | A | Inactive | 11 | 60 | - | - | - | - | Glycogen synthase | - |
taranabant
|
small-molecule | Inverse agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Shao Z, Yin J, Chapman K, Grzemska M, Clark L, Wang J, Rosenbaum DM | 10.1038/NATURE20613 | 2016-12-07 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 5TE5 | 5TE5_refined | 4.0 | A | Inactive | 22 | 100 | - | - | - | - | - | - |
10,20-Methanoretinal
|
small-molecule | Agonist | - | - | No | No | Gulati S, Jastrzebska B, Banerjee S, Placeres AL, Miszta P, Gao S, Gunderson K, Tochtrop GP, Filipek S, Katayama K, Kiser PD, Mogi M, Stewart PL, Palczewski K | 10.1073/PNAS.1617446114 | 2017-03-15 | Yes | |
AGTR2 | AT2 | Angiotensin | A | Human | X-ray | 5UNG | 5UNG_refined | 2.8 | B | Active | 99 | 83 | - | - | - | - | BRIL | - |
compound 1 [PMID: 28379944]
|
small-molecule | Antagonist | angiotensin-(1-7), angiotensin II, angiotensin III | peptide | No | No | - | - | 2017-04-05 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | X-ray | 5NX2 | - | 3.7 | A | Intermediate | 29 | 84 | - | - | - | - | - | - |
Truncated protein agonist
|
peptide | Agonist | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Jazayeri A, Rappas M, Brown AJH, Kean J, Errey JC, Robertson NJ, Fiez-Vandal C, Andrews SP, Congreve M, Bortolato A, Mason JS, Baig AH, Teobald I, Dore AS, Weir M, Cooke RM, Marshall FH | 10.1038/NATURE22800 | 2017-06-14 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5N2R | 5N2R_refined | 2.8 | A | Inactive | 1 | 71 | - | - | - | - | BRIL | - |
PSB36
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Cheng RKY, Segala E, Robertson N, Deflorian F, Dore AS, Errey JC, Fiez-Vandal C, Marshall FH, Cooke RM | 10.1016/j.str.2017.06.012 | 2017-07-26 | Yes | |
OPSD | Rhodopsin | Opsins | A | Human | X-ray | 5W0P | 5W0P_refined | 3.0 | D | Active | 100 | 93 | Visual | S-arrestin | - | 90 | T4-Lysozyme | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Zhou XE, He Y, de Waal PW, Gao X, Kang Y, Van Eps N, Yin Y, Pal K, Goswami D, White TA, Barty A, Latorraca NR, Chapman HN, Hubbell WL, Dror RO, Stevens RC, Cherezov V, Gurevich VV, Griffin PR, Ernst OP, Melcher K, Xu HE | 10.1016/J.CELL.2017.07.002 | 2017-08-09 | Yes | |
EDNRB | ETB | Endothelin | A | Human | X-ray | 5X93 | 5X93_refined | 2.2 | A | Inactive | 4 | 71 | - | - | - | - | T4-Lysozyme | - |
K-8794
|
small-molecule | Antagonist | endothelin-1, endothelin-2, endothelin-3 | peptide | No | No | Shihoya W, Nishizawa T, Yamashita K, Inoue A, Hirata K, Kadji FMN, Okuta A, Tani K, Aoki J, Fujiyoshi Y, Doi T, Nureki O | 10.1038/NSMB.3450 | 2017-08-16 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5OLZ | 5OLZ_refined | 1.9 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
CHEMBL2024114
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Rucktooa P, Cheng RKY, Segala E, Geng T, Errey JC, Brown GA, Cooke RM, Marshall FH, Dore AS | 10.1038/S41598-017-18570-W | 2018-01-17 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5OM1 | 5OM1_refined | 2.1 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
CHEMBL2024114
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Rucktooa P, Cheng RKY, Segala E, Geng T, Errey JC, Brown GA, Cooke RM, Marshall FH, Dore AS | 10.1038/S41598-017-18570-W | 2018-01-17 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5WF5 | 5WF5_refined | 2.6 | A | Active | 65 | 69 | - | - | - | - | T4-Lysozyme | - |
UK-432,097
|
small-molecule | Agonist | adenosine | small-molecule | No | No | White KL, Eddy MT, Gao ZG, Han GW, Lian T, Deary A, Patel N, Jacobson KA, Katritch V, Stevens RC | 10.1016/J.STR.2017.12.013 | 2018-02-21 | Yes | |
Q98SW5 | SMO | Frizzled | F | African clawed frog | X-ray | 6D35 | 6D35_refined | 3.9 | A | Active | 78 | 58 | - | - | - | - | BRIL | - |
Cholesterol
|
small-molecule | Agonist | - | - | No | No | - | - | 2018-05-23 | Yes | |
Q80KM9 | US28 | Unclassified | A | strain AD169 | X-ray | 5WB2 | 5WB2_refined | 3.5 | A | Active | 100 | 82 | - | - | - | - | - | Nanobody |
CX3CL1
|
peptide | Agonist | - | - | No | No | Miles TF, Spiess K, Jude KM, Tsutsumi N, Burg JS, Ingram JR, Waghray D, Hjorto GM, Larsen O, Ploegh HL, Rosenkilde MM, Garcia KC | 10.7554/ELIFE.35850 | 2018-06-13 | Yes | |
PD2R2 | DP2 | Prostanoid | A | Human | X-ray | 6D26 | 6D26_refined | 2.8 | A | Inactive | 25 | 82 | - | - | - | - | T4-Lysozyme | - |
fevipiprant
|
small-molecule | Antagonist | PGE2, PGD3, PGF2α, thromboxane A2, PGJ2, PGI2, PGD2 | small-molecule | No | No | Wang L, Yao D, Deepak RNVK, Liu H, Xiao Q, Fan H, Gong W, Wei Z, Zhang C | 10.1016/J.MOLCEL.2018.08.009 | 2018-10-03 | Yes | |
PD2R2 | DP2 | Prostanoid | A | Human | X-ray | 6D27 | 6D27_refined | 2.7 | A | Inactive | 25 | 81 | - | - | - | - | T4-Lysozyme | - |
CHEMBL179036
|
small-molecule | Antagonist | PGE2, PGD3, PGF2α, thromboxane A2, PGJ2, PGI2, PGD2 | small-molecule | No | No | Wang L, Yao D, Deepak RNVK, Liu H, Xiao Q, Fan H, Gong W, Wei Z, Zhang C | 10.1016/J.MOLCEL.2018.08.009 | 2018-10-03 | Yes | |
ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | X-ray | 5ZK3 | 5ZK3_refined | 2.6 | A | Inactive | 2 | 59 | - | - | - | - | BRIL | - |
CHEMBL558910
|
small-molecule | Antagonist | acetylcholine | small-molecule | No | No | - | - | 2018-11-21 | Yes | |
PE2R3 | EP3 | Prostanoid | A | Human | X-ray | 6AK3 | 6AK3_refined | 2.9 | B | Active | 91 | 69 | - | - | - | - | BRIL | - |
PGE2
|
small-molecule | Agonist | PGE2, PGF2α, thromboxane A2, PGI2, PGE1, PGD2 | small-molecule | No | No | - | 10.1038/S41589-018-0171-8 | 2018-12-05 | Yes | |
CCR5 | CCR5 | Chemokine | A | Human | Cryo-EM | 6MEO | 6MEO_refined | 3.9 | B | Inactive | 16 | 89 | - | - | - | - | - | T-cell surface glycoprotein CD4 |
Envelope glycoprotein gp160
|
protein | Antagonist | CCL2, CCL8, CCL11, CCL13, CCL14, CCL7, CCL5, CCL4, CCL16, CCL3 | peptide | No | No | - | 10.1038/S41586-018-0804-9 | 2018-12-12 | Yes | |
CNR2 | CB2 | Cannabinoid | A | Human | X-ray | 5ZTY | 5ZTY_refined | 2.8 | A | Inactive | 11 | 80 | - | - | - | - | T4-Lysozyme | - |
AM10257
|
small-molecule | Antagonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | - | 10.1016/J.CELL.2018.12.011 | 2019-01-30 | Yes | |
PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 6NBH | - | 3.5 | R | Active | 100 | 64 | Gs | αs | - | 57 | - | Nanobody-35 |
Long-acting parathyroid hormone analog
|
peptide | Agonist | PTH, PTHrP-(1-36), TIP39, PTHrP | peptide | No | No | - | - | 2019-04-17 | Yes | |
ACM1 | M1 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 6OIJ | 6OIJ_refined | 3.3 | R | Active | 100 | 64 | Gq/11 | α11 | - | 63 | - | Antibody fragment |
iperoxo
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | - | 10.1126/SCIENCE.AAW5188 | 2019-05-08 | Yes | |
SMO | SMO | Frizzled | F | Human | Cryo-EM | 6OT0 | - | 3.9 | R | Active | 100 | 46 | Gi/o | αi1 | - | 100 | - | Fab light chain Fab heavy chain |
24,25-Epoxy-cholesterol
|
small-molecule | Agonist | - | - | No | No | - | 10.1038/S41586-019-1286-0 | 2019-06-12 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 6PS5 | 6PS5_refined | 2.9 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
propranolol
|
small-molecule | Antagonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | - | 10.1107/S2052252519013137 | 2019-11-13 | Yes | |
ADA2C | α2C | Adrenoceptors | A | Human | X-ray | 6KUW | 6KUW_refined | 2.8 | A | Inactive | 1 | 60 | - | - | - | - | GlgA glycogen synthase | - |
(8Ar,12aS,13aR)-12-ethylsulfonyl-3-methoxy-5,6,8,8a,9,10,11,12a,13,13a-decahydroisoquinolino[2,1-g][1,6]naphthyridine
|
small-molecule | Antagonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | - | - | 2019-12-04 | Yes | |
CLTR2 | CysLT2 | Leukotriene | A | Human | X-ray | 6RZ6 | 6RZ6_refined | 2.4 | A | Intermediate | 44 | 82 | - | - | - | - | BRIL | - |
ONO-2570366
|
small-molecule | Antagonist | LTE4, LTD4, LTC4 | small-molecule | No | No | Gusach A, Luginina A, Marin E, Brouillette RL, Besserer-Offroy E, Longpre JM, Ishchenko A, Popov P, Patel N, Fujimoto T, Maruyama T, Stauch B, Ergasheva M, Romanovskaia D, Stepko A, Kovalev K, Shevtsov M, Gordeliy V, Han GW, Katritch V, Borshchevskiy V, Sarret P, Mishin A, Cherezov V | 10.1038/S41467-019-13348-2 | 2019-12-11 | Yes | |
OX2R | OX2 | Orexin | A | Human | X-ray | 6TPN | 6TPN_refined | 2.6 | A | Inactive | 1 | 71 | - | - | - | - | GlgA glycogen synthase | - |
HTL6641
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | Yes | |
EDNRB | ETB | Endothelin | A | Human | X-ray | 6LRY | 6LRY_refined | 3.0 | A | Inactive | 15 | 70 | - | - | - | - | T4-Lysozyme | - |
sarafotoxin S6b
|
peptide | Agonist | endothelin-1, endothelin-2, endothelin-3 | peptide | No | No | Izume T, Miyauchi H, Shihoya W, Nureki O | 10.1016/J.BBRC.2019.12.091 | 2020-02-12 | Yes | |
CNR2 | CB2 | Cannabinoid | A | Human | Cryo-EM | 6PT0 | 6PT0_refined | 3.2 | R | Active | 100 | 83 | Gi/o | αi1 | - | 100 | - | scFv16 |
WIN55212-2
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Xing C, Zhuang Y, Xu TH, Feng Z, Zhou XE, Chen M, Wang L, Meng X, Xue Y, Wang J, Liu H, McGuire TF, Zhao G, Melcher K, Zhang C, Xu HE, Xie XQ | 10.1016/J.CELL.2020.01.007 | 2020-02-12 | Yes | |
GPR52 | GPR52 | A orphans | A | Human | X-ray | 6LI2 | 6LI2_refined | 2.8 | A | Intermediate | 40 | 80 | - | - | - | - | Rubredoxin | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Lin X, Li M, Wang N, Wu Y, Luo Z, Guo S, Han GW, Li S, Yue Y, Wei X, Xie X, Chen Y, Zhao S, Wu J, Lei M, Xu F | 10.1038/S41586-020-2019-0 | 2020-02-26 | Yes | |
GLR | glucagon | Glucagon | B1 | Human | Cryo-EM | 6LMK | 6LMK_refined | 3.7 | R | Active | 100 | 83 | Gs | αs | - | 59 | - | Nanobody-35 |
glucagon
|
peptide | Agonist | glucagon | peptide | No | No | - | - | 2020-04-01 | Yes | |
ADA2B | α2B | Adrenoceptors | A | Human | Cryo-EM | 6K42 | - | 4.1 | R | Active | 100 | 60 | Gi/o | αi1 | - | 62 | T4-Lysozyme | scFv |
dexmedetomidine
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Yuan D, Liu Z, Kaindl J, Maeda S, Zhao J, Sun X, Xu J, Gmeiner P, Wang HW, Kobilka BK | 10.1038/S41589-020-0492-2 | 2020-04-15 | Yes | |
CCR6 | CCR6 | Chemokine | A | Human | Cryo-EM | 6WWZ | 6WWZ_refined | 3.3 | R | Active | 100 | 83 | Gi/o | αo | - | 59 | - | scFv16 |
CCL20
|
peptide | Agonist | CCL20, beta-defensin 4A | peptide | No | No | Wasilko DJ, Johnson ZL, Ammirati M, Che Y, Griffor MC, Han S, Wu H | 10.1038/S41467-020-16820-6 | 2020-06-24 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 7BZ2 | 7BZ2_refined | 3.8 | R | Active | 100 | 69 | Gs | αs | - | 50 | - | Nanobody-35 |
arformoterol
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | Zhang Y, Yang F, Ling S, Lv P, Zhou Y, Fang W, Sun W, Zhang L, Shi P, Tian C | 10.1038/S41421-020-0176-9 | 2020-08-05 | Yes | |
CXCR2 | CXCR2 | Chemokine | A | Human | Cryo-EM | 6LFO | 6LFO_refined | 3.4 | R | Active | 100 | 85 | Gi/o | αi1 | - | 65 | - | scFv16 |
Interleukin-8
|
protein | Agonist | CXCL3, CXCL1, CXCL6, CXCL2, CXCL7, CXCL5, CXCL8 | peptide | No | No | Liu K, Wu L, Yuan S, Wu M, Xu Y, Sun Q, Li S, Zhao S, Hua T, Liu ZJ | 10.1038/S41586-020-2492-5 | 2020-09-02 | Yes | |
SMO | SMO | Frizzled | F | Human | Cryo-EM | 6XBM | - | 3.2 | R | Active | 100 | 42 | Gi/o | αi1 | - | 61 | - | scFv16 |
24,25-Epoxy-cholesterol
24,25-Epoxy-cholesterol |
small-molecule small-molecule |
Agonist PAM |
- | - | No | No | Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X | 10.1038/S41589-020-0646-2 | 2020-09-30 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Human | X-ray | 7BVQ | 7BVQ_refined | 2.5 | A | Inactive | 0 | 60 | - | - | - | - | T4-Lysozyme | - |
Carazolol
|
small-molecule | Inverse agonist | noradrenaline, (-)-adrenaline, L-NOREPINEPHRINE, (-)-noradrenaline | small-molecule | No | No | Xu X, Kaindl J, Clark MJ, Hubner H, Hirata K, Sunahara RK, Gmeiner P, Kobilka BK, Liu X | 10.1038/S41422-020-00424-2 | 2020-12-02 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7LCK | 7LCK_refined | 3.2 | R | Active | 98 | 84 | - | - | - | - | - | - |
danuglipron
|
small-molecule | Agonist | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Zhang X, Johnson RM, Drulyte I, Yu L, Kotecha A, Danev R, Wootten D, Sexton PM, Belousoff MJ | 10.1016/J.STR.2021.04.008 | 2021-01-20 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 6ZIN | - | 2.6 | A | Inactive | 32 | 76 | - | - | - | - | DARPin D12 | - |
meclinertant
|
small-molecule | Inverse agonist | neuromedin N, neurotensin | peptide | No | No | Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PRE, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Pluckthun A | 10.1126/sciadv.abe5504 | 2021-02-10 | Yes | |
CALRL | calcitonin-like | Calcitonin | B1 | Human | Cryo-EM | 7KNT | 7KNT_refined | 3.2 | R | Inactive | 10 | 74 | - | - | - | - | - | RAMP1 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Josephs TM, Belousoff MJ, Liang YL, Piper SJ, Cao J, Garama DJ, Leach K, Gregory KJ, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM | 10.1126/SCIENCE.ABF7258 | 2021-02-24 | Yes | |
DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7CKW | 7CKW_refined | 3.2 | R | Active | 100 | 61 | Gs | αs | - | 60 | - | Nanobody-35 |
fenoldopam
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, 5-hydroxytryptamine, dopamine | small-molecule | No | No | Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z | 10.1016/J.CELL.2021.01.028 | 2021-03-03 | Yes | |
5HT1D | 5-HT1D | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7E32 | - | 2.9 | R | Active | 100 | 76 | Gi/o | αi1 | - | 62 | - | scFv16 |
5-hydroxytryptamine
|
small-molecule | Agonist | 5-hydroxytryptamine, 5-HT-moduline | small-molecule | No | No | Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE | 10.1038/S41586-021-03376-8 | 2021-04-21 | Yes | |
MC4R | MC4 | Melanocortin | A | Human | Cryo-EM | 7AUE | 7AUE_refined | 3.0 | R | Active | 100 | 79 | Gs | αs | - | 59 | - | scFv16 |
setmelanotide
|
peptide | Agonist | agouti-related protein, β-MSH, α-MSH, γ-MSH, ACTH | peptide | No | No | Israeli H, Degtjarik O, Fierro F, Chunilal V, Gill AK, Roth NJ, Botta J, Prabahar V, Peleg Y, Chan LF, Ben-Zvi D, McCormick PJ, Niv MY, Shalev-Benami M | 10.1126/SCIENCE.ABF7958 | 2021-04-28 | Yes | |
CCKAR | CCK1 | Cholecystokinin | A | Human | Cryo-EM | 7MBY | - | 2.4 | R | Active | 100 | 66 | Gq/11 | αq | Gq-Gs-Gi1 chimera | 55 | - | - |
CHEMBL216166
|
protein | Agonist | desulfated cholecystokinin-8, CCK-33, CCK-8, CCK-58, CCK-4, CCK-39, gastrin-17 | peptide | No | No | Mobbs JI, Belousoff MJ, Harikumar KG, Piper SJ, Xu X, Furness SGB, Venugopal H, Christopoulos A, Danev R, Wootten D, Thal DM, Miller LJ, Sexton PM | 10.1371/JOURNAL.PBIO.3001295 | 2021-05-26 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | Cryo-EM | 7MTA | 7MTA_refined | 4.1 | R | Active | 98 | 93 | - | - | - | - | - | Fab heavy chain Fab light chain GRK1 |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | - | - | 2021-07-07 | Yes | |
GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 7MTQ | - | 3.7 | B | Inactive | - | 85 | - | - | - | - | - | - |
LY341495
|
small-molecule | Antagonist | L-glutamic acid | small-molecule | No | No | - | 10.1038/S41586-021-03680-3 | 2021-07-07 | Yes | |
CCR5 | CCR5 | Chemokine | A | Human | Cryo-EM | 7F1S | 7F1S_refined | 2.8 | R | Active | 100 | 78 | Gi/o | αi1 | - | 61 | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | CCL2, CCL8, CCL11, CCL13, CCL14, CCL7, CCL5, CCL4, CCL16, CCL3 | peptide | No | No | - | 10.1038/S41467-021-24438-5 | 2021-07-14 | Yes | |
CCKAR | CCK1 | Cholecystokinin | A | Human | Cryo-EM | 7EZM | - | 2.9 | D | Active | 100 | 71 | Gq/11 | αq | - | 63 | - | scFv16 |
CCK-8
|
peptide | Agonist | desulfated cholecystokinin-8, CCK-33, CCK-8, CCK-58, CCK-4, CCK-39, gastrin-17 | peptide | No | No | Liu Q, Yang D, Zhuang Y, Croll TI, Cai X, Dai A, He X, Duan J, Yin W, Ye C, Zhou F, Wu B, Zhao Q, Xu HE, Wang MW, Jiang Y | 10.1038/S41589-021-00841-3 | 2021-08-25 | Yes | |
GRM5 | mGlu5 | Metabotropic glutamate | C | Human | Cryo-EM | 7FD8 | 7FD8_refined | 3.8 | A | Active | - | 63 | - | - | - | - | - | - |
quisqualate
|
small-molecule | Agonist | L-glutamic acid | small-molecule | No | No | Nasrallah C, Cannone G, Briot J, Rottier K, Berizzi AE, Huang CY, Quast RB, Hoh F, Baneres JL, Malhaire F, Berto L, Dumazer A, Font-Ingles J, Gomez-Santacana X, Catena J, Kniazeff J, Goudet C, Llebaria A, Pin JP, Vinothkumar KR, Lebon G | 10.1016/J.CELREP.2021.109648 | 2021-09-08 | Yes | |
AA1R | A1 | Adenosine | A | Human | Cryo-EM | 7LD3 | - | 3.2 | R | Active | 100 | 88 | Gi/o | αi2 | - | 59 | - | - |
{2-Amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone
adenosine |
small-molecule small-molecule |
Ago-PAM Agonist |
adenosine | small-molecule | No | No | - | - | 2021-09-08 | Yes | |
GASR | CCK2 | Cholecystokinin | A | Human | Cryo-EM | 7F8W | 7F8W_refined | 3.1 | R | Active | 100 | 62 | Gq/11 | αq | Gq-Gi1 chimera | 62 | - | scFv16 |
desulfated gastrin-17
|
peptide | Agonist | desulfated cholecystokinin-8, desulfated gastrin-17, CCK-33, CCK-8, CCK-58, desulfated gastrin-71, desulfated gastrin-14, CCK-4, desulfated gastrin-34, gastrin-34, gastrin-14, CCK-39, gastrin-17, gastrin-71 | peptide | No | No | Zhang X, He C, Wang M, Zhou Q, Yang D, Zhu Y, Feng W, Zhang H, Dai A, Chu X, Wang J, Yang Z, Jiang Y, Sensfuss U, Tan Q, Han S, Reedtz-Runge S, Xu HE, Zhao S, Wang MW, Wu B, Zhao Q | 10.1038/S41589-021-00866-8 | 2021-10-13 | Yes | |
CCKAR | CCK1 | Cholecystokinin | A | Human | X-ray | 7F8Y | 7F8Y_refined | 2.5 | A | Inactive | 1 | 65 | - | - | - | - | T4-Lysozyme | - |
DEVAZEPIDE
|
small-molecule | Antagonist | desulfated cholecystokinin-8, CCK-33, CCK-8, CCK-58, CCK-4, CCK-39, gastrin-17 | peptide | No | No | Zhang X, He C, Wang M, Zhou Q, Yang D, Zhu Y, Feng W, Zhang H, Dai A, Chu X, Wang J, Yang Z, Jiang Y, Sensfuss U, Tan Q, Han S, Reedtz-Runge S, Xu HE, Zhao S, Wang MW, Wu B, Zhao Q | 10.1038/S41589-021-00866-8 | 2021-10-13 | Yes | |
MC4R | MC4 | Melanocortin | A | Human | Cryo-EM | 7F58 | 7F58_refined | 3.1 | R | Active | 100 | 82 | Gs | αs | - | 58 | - | Nanobody-35 |
THIQ
|
small-molecule | Agonist | agouti-related protein, β-MSH, α-MSH, γ-MSH, ACTH | peptide | No | No | Zhang H, Chen LN, Yang D, Mao C, Shen Q, Feng W, Shen DD, Dai A, Xie S, Zhou Y, Qin J, Sun JP, Scharf DH, Hou T, Zhou T, Wang MW, Zhang Y | 10.1038/S41422-021-00552-3 | 2021-11-03 | Yes | |
MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7VDH | - | 2.9 | R | Active | 100 | 81 | Gi/o | αi1 | - | 62 | - | scFv16 |
compound 48/80
|
small-molecule | Agonist | PAMP-20 | peptide | No | No | Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP | 10.1038/S41586-021-04077-Y | 2021-12-01 | Yes | |
MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7VV4 | 7VV4_refined | 3.0 | R | Active | 97 | 80 | - | - | - | - | - | - |
Cortistatin 14
|
peptide | Agonist | PAMP-20 | peptide | No | No | Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP | 10.1038/S41586-021-04077-Y | 2021-12-01 | Yes | |
MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7VV5 | 7VV5_refined | 2.8 | R | Active | 100 | 81 | Gi/o | αi1 | - | 64 | - | scFv16 |
compound 48/80
|
small-molecule | Agonist | PAMP-20 | peptide | No | No | Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP | 10.1038/S41586-021-04077-Y | 2021-12-01 | Yes | |
S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7WF7 | 7WF7_refined | 3.4 | A | Active | 100 | 71 | Gi/o | αi1 | - | 40 | - | scFv16 |
sphingosine 1-phosphate
|
small-molecule | Agonist | sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate, sphingosine 1-phosphate | small-molecule | No | No | Xu Z, Ikuta T, Kawakami K, Kise R, Qian Y, Xia R, Sun MX, Zhang A, Guo C, Cai XH, Huang Z, Inoue A, He Y | 10.1038/S41589-021-00930-3 | 2022-01-05 | Yes | |
5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | X-ray | 7WC9 | 7WC9_refined | 2.5 | A | Inactive | 1 | 59 | - | - | - | - | BRIL | - |
IHCH-7086
|
small-molecule | Agonist | 5-hydroxytryptamine, tryptamine | small-molecule | No | No | Cao D, Yu J, Wang H, Luo Z, Liu X, He L, Qi J, Fan L, Tang L, Chen Z, Li J, Cheng J, Wang S | 10.1126/SCIENCE.ABL8615 | 2022-01-26 | Yes | |
GHRHR | GHRH | Glucagon | B1 | Human | Cryo-EM | 7V9M | 7V9M_refined | 3.3 | R | Active | 100 | 63 | Gs | αs | - | 57 | - | Nanobody-35 |
Somatoliberin
|
peptide | Agonist | GHRH | peptide | No | No | Cong Z, Zhou F, Zhang C, Zou X, Zhang H, Wang Y, Zhou Q, Cai X, Liu Q, Li J, Shao L, Mao C, Wang X, Wu J, Xia T, Zhao LH, Jiang H, Zhang Y, Xu HE, Cheng X, Yang D, Wang MW | 10.1073/PNAS.2106606118 | 2021-10-20 | Yes | |
FPR2 | FPR2/ALX | Formylpeptide | A | Human | Cryo-EM | 7T6V | 7T6V_refined | 3.1 | R | Active | 100 | 85 | Gi/o | αi1 | - | 61 | - | scFv16 |
synthetic peptide
|
peptide | Agonist | resolvin D1, serum amyloid A, 15-deoxy-LXA4, LTC4, LL-37, humanin, LTD4, aspirin triggered lipoxin A4, annexin I, aspirin-triggered resolvin D1, fMet-Leu-Phe, PrP106-126, LXA4 | peptide | No | No | Zhuang Y, Wang L, Guo J, Sun D, Wang Y, Liu W, Xu HE, Zhang C | 10.1038/S41467-022-28586-0 | 2022-03-30 | Yes | |
SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7T11 | 7T11_refined | 2.7 | R | Active | 100 | 77 | Gi/o | αi3 | - | 62 | - | scFv16 |
Octreotide
|
peptide | Agonist | SRIF-14, CST-17, cortistatin-14, SRIF-28 | peptide | No | No | Robertson MJ, Meyerowitz JG, Panova O, Borrelli K, Skiniotis G | 10.1038/S41594-022-00727-5 | 2022-03-09 | Yes | |
LT4R1 | BLT1 | Leukotriene | A | Human | Cryo-EM | 7VKT | 7VKT_refined | 2.9 | A | Active | 100 | 82 | Gi/o | αi1 | - | 64 | - | scFv16 |
LTB4
|
small-molecule | Agonist | 12R-HETE, LTB4, 20-hydroxy-LTB4 | small-molecule | No | No | Wang N, He X, Zhao J, Jiang H, Cheng X, Xia Y, Eric Xu H, He Y | 10.1038/S41467-022-28820-9 | 2022-03-09 | Yes | |
CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 7TYL | - | 3.3 | R | Active | 100 | 78 | Gs | αs | - | 58 | - | Nanobody-35 |
Amylin rat
|
peptide | Agonist | β-CGRP, α-CGRP, calcitonin, calcitonin (salmon), amylin, adrenomedullin, adrenomedullin 2/intermedin | peptide | No | No | Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | Yes | |
CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 7TYW | - | 3.0 | R | Active | 100 | 78 | Gs | αs | - | 58 | - | Nanobody-35 |
calcitonin (salmon synthetic)
|
small-molecule | Agonist | β-CGRP, α-CGRP, calcitonin, calcitonin (salmon), amylin, adrenomedullin, adrenomedullin 2/intermedin | peptide | No | No | Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | Yes | |
GIPR | GIP | Glucagon | B1 | Human | Cryo-EM | 7VAB | 7VAB_refined | 3.2 | R | Active | 100 | 58 | Gs | αs | Mini-Gs | 60 | - | Nanobody-35 |
tirzepatide
|
peptide | Agonist | gastric inhibitory polypeptide | peptide | No | No | Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW | 10.1038/S41467-022-28683-0 | 2022-03-02 | Yes | |
GALR1 | GAL1 | Galanin | A | Human | Cryo-EM | 7WQ3 | 7WQ3_refined | 2.7 | R | Active | 100 | 83 | Gi/o | αi1 | - | 64 | - | scFv16 |
galanin
|
peptide | Agonist | galanin-like peptide, galanin | peptide | No | No | Duan J, Shen DD, Zhao T, Guo S, He X, Yin W, Xu P, Ji Y, Chen LN, Liu J, Zhang H, Liu Q, Shi Y, Cheng X, Jiang H, Eric Xu H, Zhang Y, Xie X, Jiang Y | 10.1038/S41467-022-29072-3 | 2022-04-20 | Yes | |
GP183 | GPR183 | A orphans | A | Human | Cryo-EM | 7TUZ | 7TUZ_refined | 3.1 | R | Active | 100 | 79 | Gi/o | αi1 | - | 64 | - | scFv16 |
(2S,4aS,4bS,7R,8S,8aS,9R,10aR)-7-[(2R,3R)-7-hydroxy-3,7-dimethyloctan-2-yl]-4a,7,8-trimethyltetradecahydrophenanthrene-2,9-diol
|
small-molecule | Agonist | 7α,25-dihydroxycholesterol, 7α,27-dihydroxycholesterol, 7β, 27-dihydroxycholesterol, 7β, 25-dihydroxycholesterol, 7α-hydroxycholesterol, 25-hydroxycholesterol, 27-hydroxycholesterol, 7β-hydroxycholesterol | small-molecule | No | No | Chen H, Huang W, Li X | 10.1016/J.STR.2022.04.006 | 2022-04-13 | Yes | |
GIPR | GIP | Glucagon | B1 | Human | Cryo-EM | 7RBT | 7RBT_refined | 3.1 | R | Active | 100 | 81 | Gs | αs | - | 56 | - | scFv16 Nanobody-35 |
tirzepatide
2-fluoro-4-[(1R)-6-methoxy-1-methyl-2-{(1S)-1-[4-(propan-2-yl)phenyl]ethyl}-1,2,3,4-tetrahydroisoquinolin-5-yl]-6-[(2-methylpropyl)amino]phenol |
peptide small-molecule |
Agonist PAM |
gastric inhibitory polypeptide | peptide | No | No | Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW | 10.1073/PNAS.2116506119 | 2022-04-13 | Yes | |
VIPR2 | VPAC2 | VIP and PACAP | B1 | Human | Cryo-EM | 7WBJ | - | 3.4 | R | Active | 100 | 82 | Gs | αs | - | 60 | - | Nanobody-35 |
PACAP-27
|
peptide | Agonist | VIP, PACAP-27, secretin, PHI, GHRH, PACAP-38 | peptide | No | No | Xu Y, Feng W, Zhou Q, Liang A, Li J, Dai A, Zhao F, Yan J, Chen CW, Li H, Zhao LH, Xia T, Jiang Y, Xu HE, Yang D, Wang MW | 10.1038/S41467-022-30041-Z | 2022-05-18 | Yes | |
BKRB2 | B2 | Bradykinin | A | Human | Cryo-EM | 7F6I | 7F6I_refined | 2.8 | A | Active | 100 | 78 | Gq/11 | αq | - | 63 | - | - |
kallidin
|
peptide | Agonist | [Hyp3]bradykinin, [des-Arg10]kallidin, bradykinin, Lys-[Hyp3]-bradykinin, kallidin, [des-Arg9]bradykinin, T-kinin | peptide | No | No | Shen J, Zhang D, Fu Y, Chen A, Yang X, Zhang H | 10.1038/S41467-022-28399-1 | 2022-01-05 | Yes | |
GALR2 | GAL2 | Galanin | A | Human | Cryo-EM | 7XJK | 7XJK_refined | 3.3 | F | Active | 100 | 72 | Gq/11 | αq | - | 58 | - | scFv16 |
Galanin, Human
|
peptide | Agonist | galanin-like peptide, spexin-1, galanin | peptide | No | No | - | - | 2022-06-29 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7X8R | - | 2.6 | R | Active | 100 | 64 | Gs | αs | - | 59 | - | Nanobody-35 |
CHEMBL2158411
|
small-molecule | Agonist | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Cong Z, Zhou Q, Li Y, Chen LN, Zhang ZC, Liang A, Liu Q, Wu X, Dai A, Xia T, Wu W, Zhang Y, Yang D, Wang MW | 10.1073/PNAS.2200155119 | 2022-06-29 | Yes | |
5HT4R | 5-HT4 | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7XT8 | - | 3.1 | R | Active | 100 | 76 | Gs | αs | - | 60 | BRIL | Nanobody-35 |
5-hydroxytryptamine
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Huang S, Xu P, Shen DD, Simon IA, Mao C, Tan Y, Zhang H, Harpsoe K, Li H, Zhang Y, You C, Yu X, Jiang Y, Zhang Y, Gloriam DE, Xu HE | 10.1016/J.MOLCEL.2022.05.031 | 2022-07-27 | Yes | |
CX3C1 | CX3CR1 | Chemokine | A | Human | Cryo-EM | 7XBW | 7XBW_refined | 2.8 | R | Active | 16 | 81 | Gi/o | αi1 | - | 61 | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | CX3CL1 | peptide | No | No | Lu M, Zhao W, Han S, Lin X, Xu T, Tan Q, Wang M, Yi C, Chu X, Yang W, Zhu Y, Wu B, Zhao Q | 10.1126/SCIADV.ABN8048 | 2022-07-13 | Yes | |
ACKR3 | ACKR3 | Chemokine | A | Human | Cryo-EM | 7SK3 | 7SK3_refined | 3.8 | A | Active | 95 | 84 | - | - | - | - | - | CID25 Fab light chain CID25 Fab heavy chain CID24 Fab light chain CID24 Fab heavy chain |
CXCL12α
|
peptide | Agonist | CXCL12α, CXCL11 | peptide | No | No | Yen YC, Schafer CT, Gustavsson M, Eberle SA, Dominik PK, Deneka D, Zhang P, Schall TJ, Kossiakoff AA, Tesmer JJG, Handel TM | 10.1126/SCIADV.ABN8063 | 2022-07-27 | Yes | |
5HT2C | 5-HT2C | 5-Hydroxytryptamine | A | Human | Cryo-EM | 8DPF | - | 2.8 | A | Active | 100 | 58 | Gq/11 | αq | Gi2-mini-Gq chimera | 57 | - | scFv16 |
lorcaserin
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Gumpper RH, Fay JF, Roth BL | 10.1016/J.CELREP.2022.111211 | 2022-08-24 | Yes | |
TRFR | TRH1 | Thyrotropin-releasing hormone | A | Human | Cryo-EM | 7X1T | - | 3.3 | A | Active | 100 | 68 | Gq/11 | αq | - | 57 | - | scFv16 |
taltirelin
|
small-molecule | Agonist | TRH | peptide | No | No | Yang F, Zhang H, Meng X, Li Y, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C | 10.1038/S41422-022-00646-6 | 2022-08-31 | Yes | |
S1PR5 | S1P5 | Lysophospholipid (S1P) | A | Human | X-ray | 7YXA | 7YXA_refined | 2.2 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
4-[6-(2-naphthalen-1-ylethoxy)-2,3,4,5-tetrahydro-1H-3-benzazepin-3-ium-3-yl]butanoic acid
|
small-molecule | Antagonist | sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate, sphingosine 1-phosphate | small-molecule | No | No | Lyapina E, Marin E, Gusach A, Orekhov P, Gerasimov A, Luginina A, Vakhrameev D, Ergasheva M, Kovaleva M, Khusainov G, Khorn P, Shevtsov M, Kovalev K, Bukhdruker S, Okhrimenko I, Popov P, Hu H, Weierstall U, Liu W, Cho Y, Gushchin I, Rogachev A, Bourenkov G, Park S, Park G, Hyun HJ, Park J, Gordeliy V, Borshchevskiy V, Mishin A, Cherezov V | 10.1038/S41467-022-32447-1 | 2022-08-10 | Yes | |
PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 7VVM | 7VVM_refined | 3.2 | R | Active | 100 | 60 | Gs | αs | - | 58 | - | Nanobody-35 |
Parathyroid hormone
|
peptide | Agonist | PTH, PTHrP-(1-36), TIP39, PTHrP | peptide | No | No | Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O | 10.1016/J.MOLCEL.2022.07.003 | 2022-08-03 | Yes | |
HRH3 | H3 | Histamine | A | Human | X-ray | 7F61 | 7F61_refined | 2.6 | A | Inactive | 8 | 68 | - | - | - | - | BRIL | - |
N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]cyclobutane-1-carboxamide
|
small-molecule | Antagonist | histamine | small-molecule | No | No | Peng X, Yang L, Liu Z, Lou S, Mei S, Li M, Chen Z, Zhang H | 10.1038/S41467-022-33880-Y | 2022-10-26 | Yes | |
CRFR2 | CRF2 | Corticotropin-releasing factor | B1 | Human | Cryo-EM | 7TS0 | 7TS0_refined | 2.8 | P | Active | 100 | 72 | Gi/o | αo | - | 63 | - | scFv16 |
Urocortin
|
peptide | Agonist | urocortin 2, corticotrophin-releasing hormone, urocortin 3, urocortin 1 | peptide | No | No | Zhao LH, Lin J, Ji SY, Zhou XE, Mao C, Shen DD, He X, Xiao P, Sun J, Melcher K, Zhang Y, Yu X, Xu HE | 10.1038/S41467-022-33851-3 | 2022-11-09 | Yes | |
OPRM | μ | Opioid | A | Mouse | Cryo-EM | 7U2K | - | 3.3 | D | Active | 100 | 71 | Gi/o | αi1 | - | 61 | - | - |
CHEMBL147044
|
small-molecule | Agonist | - | - | No | No | Faouzi A, Wang H, Zaidi SA, DiBerto JF, Che T, Qu Q, Robertson MJ, Madasu MK, El Daibani A, Varga BR, Zhang T, Ruiz C, Liu S, Xu J, Appourchaux K, Slocum ST, Eans SO, Cameron MD, Al-Hasani R, Pan YX, Roth BL, McLaughlin JP, Skiniotis G, Katritch V, Kobilka BK, Majumdar S | 10.1038/S41586-022-05588-Y | 2022-12-07 | Yes | |
AGRF1 | ADGRF1 | ADGRF | B2 | Human | Cryo-EM | 7WZ7 | - | 2.8 | R | Active | - | 30 | G12/13 | α12 | Mini-G12 | 55 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Zhu X, Qian Y, Li X, Xu Z, Xia R, Wang N, Liang J, Yin H, Zhang A, Guo C, Wang G, He Y | 10.1038/S41467-022-33173-4 | 2022-09-28 | Yes | |
LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | Cryo-EM | 7YU5 | 7YU5_refined | 3.3 | R | Active | 100 | 80 | Gi/o | αi1 | - | 63 | - | scFv16 |
[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate
|
small-molecule | Agonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | Akasaka H, Tanaka T, Sano FK, Matsuzaki Y, Shihoya W, Nureki O | 10.1038/S41467-022-33121-2 | 2022-10-05 | Yes | |
LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | Cryo-EM | 7YU8 | - | 4.5 | R | Active | 100 | 80 | Gi/o | αi1 | - | 63 | - | scFv16 |
[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate
|
small-molecule | Agonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | Akasaka H, Tanaka T, Sano FK, Matsuzaki Y, Shihoya W, Nureki O | 10.1038/S41467-022-33121-2 | 2022-10-05 | Yes | |
ACM4 | M4 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 8E9X | - | 2.7 | A | Active | 100 | 57 | Gi/o | αo | Mini-Go | 61 | - | scFv16 |
CHEMBL73538
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | - | - | 2022-11-30 | Yes | |
OPRD | δ | Opioid | A | Human | Cryo-EM | 8F7S | 8F7S_refined | 3.0 | R | Active | 100 | 78 | Gi/o | αi1 | - | 62 | - | - |
DELTORPHIN II
|
protein | Agonist | dynorphin A-(1-8), [Met]enkephalin, endomorphin-1, dynorphin A, [Leu]enkephalin, β-endorphin, dynorphin A-(1-13), dynorphin B, α-neoendorphin | peptide | No | No | Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE | 10.1016/J.CELL.2022.12.026 | 2022-12-14 | Yes | |
RL3R2 | RXFP4 | Relaxin family peptide | A | Human | Cryo-EM | 7YJ4 | - | 3.2 | R | Active | 100 | 76 | Gi/o | αi2 | - | 58 | - | scFv16 |
Insulin-like peptide INSL5 A chain
Insulin-like peptide INSL5 B chain |
peptide peptide |
Agonist | relaxin-3, INSL5, relaxin-3 (B chain) | peptide | No | No | - | - | 2023-03-01 | Yes | |
NPY2R | Y2 | Neuropeptide Y | A | Human | Cryo-EM | 7YON | 7YON_refined | 3.0 | R | Active | 100 | 79 | Gi/o | αi1 | - | 62 | - | scFv16 |
Peptide YY
|
peptide | Agonist | neuropeptide Y, neuropeptide Y-(3-36), peptide YY, pancreatic polypeptide, PYY-(3-36) | peptide | No | No | Kang H, Park C, Choi YK, Bae J, Kwon S, Kim J, Choi C, Seok C, Im W, Choi HJ | 10.1016/J.STR.2022.11.010 | 2023-03-22 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Rat | Cryo-EM | 8FN0 | - | 2.9 | A | Active | 100 | 67 | Gi/o | αo | Mini-Go | 60 | - | scFv16 |
neurotensin
CHEMBL4576388 |
peptide small-molecule |
Agonist PAM |
neuromedin N, neurotensin | peptide | No | No | - | - | 2023-03-29 | Yes | |
AA2BR | A2B | Adenosine | A | Human | Cryo-EM | 8HDO | - | 2.9 | R | Active | 100 | 83 | Gs | αs | Mini-Gs | 59 | - | Nanobody-35 |
BAY 60-6583
|
small-molecule | Agonist | adenosine | small-molecule | No | No | - | 10.1038/S41421-022-00503-1 | 2023-01-18 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 3DQB | 3DQB_refined | 3.2 | A | Active | 100 | 94 | Gi/o | αt1 | Only H5 | 3 | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | 10.1038/NATURE07330 | 2008-09-23 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 2Y03 | 2Y03_refined | 2.9 | B | Inactive | 0 | 62 | - | - | - | - | - | - |
LEVISOPRENALINE
|
small-molecule | Agonist | - | - | No | No | - | - | 2011-01-12 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 3PXO | - | 3.0 | A | Active | 98 | 94 | - | - | - | - | - | - |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | - | - | 2011-03-09 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 3UZA | 3UZA_refined | 3.3 | A | Inactive | 1 | 71 | - | - | - | - | - | - |
compound 4g [PMID: 22220592]
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Congreve M, Andrews SP, Doré AS, Hollenstein K, Hurrell E, Langmead CJ, Mason JS, Ng IW, Tehan B, Zhukov A, Weir M, Marshall FH. | 10.1021/jm201376w | 2012-03-21 | Yes | |
OPRX | NOP | Opioid | A | Human | X-ray | 4EA3 | 4EA3_refined | 3.0 | A | Inactive | 4 | 75 | - | - | - | - | BRIL | - |
compound 24 [PMID: 16451050]
|
small-molecule | Antagonist | nociceptin/orphanin FQ | peptide | No | No | Thompson AA, Liu W, Chun E, Katritch V, Wu H, Vardy E, Huang XP, Trapella C, Guerrini R, Calo G, Roth BL, Cherezov V, Stevens RC | 10.1038/NATURE11085 | 2012-04-25 | Yes | |
5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | Human | X-ray | 4IB4 | 4IB4_refined | 2.7 | A | Intermediate | 44 | 59 | - | - | - | - | BRIL | - |
ergotamine
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Wacker D, Wang C, Katritch V, Han GW, Huang XP, Vardy E, McCorvy JD, Jiang Y, Chu M, Siu FY, Liu W, Xu HE, Cherezov V, Roth BL, Stevens RC | 10.1126/science.1232808 | 2013-03-13 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 4BWB | - | 3.6 | A | Inactive | 3 | 72 | - | - | - | - | - | - |
neurotensin
|
peptide | Agonist | neuromedin N, neurotensin | peptide | No | No | Egloff P, Hillenbrand M, Klenk C, Batyuk A, Heine P, Balada S, Schlinkmann KM, Scott DJ, Schutz M, Pluckthun A | 10.1073/PNAS.1317903111 | 2014-01-29 | Yes | |
ACM3 | M3 | Acetylcholine (muscarinic) | A | Rat | X-ray | 4U16 | 4U16_refined | 3.7 | B | Inactive | 2 | 47 | - | - | - | - | T4-Lysozyme | - |
N-methyl scopolamine
|
small-molecule | Antagonist | acetylcholine | small-molecule | No | No | Thorsen TS, Matt R, Weis WI, Kobilka BK | 10.1016/J.STR.2014.08.022 | 2014-11-26 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 4XES | 4XES_refined | 2.6 | A | Active | 79 | 72 | - | - | - | - | T4-Lysozyme | - |
neurotensin
|
peptide | Agonist | neuromedin N, neurotensin | peptide | No | No | Krumm BE, White JF, Shah P, Grisshammer R | 10.1038/NCOMMS8895 | 2015-07-29 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 5D5B | 5D5B_refined | 3.8 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
Carazolol
|
small-molecule | Inverse agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | Huang CY, Olieric V, Ma P, Howe N, Vogeley L, Liu X, Warshamanage R, Weinert T, Panepucci E, Kobilka B, Diederichs K, Wang M, Caffrey M | 10.1107/S2059798315021683 | 2016-01-13 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5K2C | 5K2C_refined | 1.9 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Batyuk A, Galli L, Ishchenko A, Han GW, Gati C, Popov PA, Lee MY, Stauch B, White TA, Barty A, Aquila A, Hunter MS, Liang M, Boutet S, Pu M, Liu ZJ, Nelson G, James D, Li C, Zhao Y, Spence JC, Liu W, Fromme P, Katritch V, Weierstall U, Stevens RC, Cherezov V | 10.1126/SCIADV.1600292 | 2016-09-21 | Yes | |
CNR1 | CB1 | Cannabinoid | A | Human | X-ray | 5TGZ | 5TGZ_refined | 2.8 | A | Inactive | 11 | 61 | - | - | - | - | Flavodoxin | - |
AM6538
|
small-molecule | Antagonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Hua T, Vemuri K, Pu M, Qu L, Han GW, Wu Y, Zhao S, Shui W, Li S, Korde A, Laprairie RB, Stahl EL, Ho JH, Zvonok N, Zhou H, Kufareva I, Wu B, Zhao Q, Hanson MA, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ | 10.1016/J.CELL.2016.10.004 | 2016-11-02 | Yes | |
GLR | glucagon | Glucagon | B1 | Human | X-ray | 5XF1 | 5XF1_refined | 3.2 | B | Inactive | 0 | 81 | - | - | - | - | T4-Lysozyme | Antibody |
NNC0640
|
small-molecule | NAM | glucagon | peptide | No | No | Zhang H, Qiao A, Yang D, Yang L, Dai A, de Graaf C, Reedtz-Runge S, Dharmarajan V, Zhang H, Han GW, Grant TD, Sierra RG, Weierstall U, Nelson G, Liu W, Wu Y, Ma L, Cai X, Lin G, Wu X, Geng Z, Dong Y, Song G, Griffin PR, Lau J, Cherezov V, Yang H, Hanson MA, Stevens RC, Zhao Q, Jiang H, Wang MW, Wu B | 10.1038/NATURE22363 | 2017-05-24 | Yes | |
FFAR1 | FFA1 | Free fatty acid | A | Human | X-ray | 5TZY | 5TZY_refined | 3.2 | A | Intermediate | 44 | 91 | - | - | - | - | T4-Lysozyme | - |
MK-8666
(2S,3R)-3-Cyclopropyl-3-[(2R)-2-[1-[(1S)-1-[5-fluoro-2-(trifluoromethoxy)phenyl]ethyl]piperidin-4-yl]-3,4-dihydro-2H-chromen-7-yl]-2-methylpropanoic acid |
small-molecule small-molecule |
Agonist PAM |
oleic acid, docosahexaenoic acid, α-linolenic acid, myristic acid | small-molecule | No | No | Lu J, Byrne N, Wang J, Bricogne G, Brown FK, Chobanian HR, Colletti SL, Di Salvo J, Thomas-Fowlkes B, Guo Y, Hall DL, Hadix J, Hastings NB, Hermes JD, Ho T, Howard AD, Josien H, Kornienko M, Lumb KJ, Miller MW, Patel SB, Pio B, Plummer CW, Sherborne BS, Sheth P, Souza S, Tummala S, Vonrhein C, Webb M, Allen SJ, Johnston JM, Weinglass AB, Sharma S, Soisson SM | 10.1038/NSMB.3417 | 2017-06-07 | Yes | |
OPRK | κ | Opioid | A | Human | X-ray | 6B73 | 6B73_refined | 3.1 | A | Active | 100 | 73 | - | - | - | - | BRIL | Nanobody |
MP1104
|
small-molecule | Agonist | dynorphin A-(1-8), β-neoendorphin, big dynorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, β-endorphin, dynorphin A-(1-13), dynorphin B, α-neoendorphin | peptide | No | No | Che T, Majumdar S, Zaidi SA, Ondachi P, McCorvy JD, Wang S, Mosier PD, Uprety R, Vardy E, Krumm BE, Han GW, Lee MY, Pardon E, Steyaert J, Huang XP, Strachan RT, Tribo AR, Pasternak GW, Carroll FI, Stevens RC, Cherezov V, Katritch V, Wacker D, Roth BL | 10.1016/J.CELL.2017.12.011 | 2018-01-17 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5WF6 | 5WF6_refined | 2.9 | A | Active | 65 | 68 | - | - | - | - | T4-Lysozyme | - |
UK-432,097
|
small-molecule | Agonist | adenosine | small-molecule | No | No | White KL, Eddy MT, Gao ZG, Han GW, Lian T, Deary A, Patel N, Jacobson KA, Katritch V, Stevens RC | 10.1016/J.STR.2017.12.013 | 2018-02-21 | Yes | |
OPSD | Rhodopsin | Opsins | A | Human | Cryo-EM | 6CMO | 6CMO_refined | 4.5 | R | Active | 81 | 92 | Gi/o | αi1 | - | 100 | BRIL | Fab |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Kang Y, Kuybeda O, de Waal PW, Mukherjee S, Van Eps N, Dutka P, Zhou XE, Bartesaghi A, Erramilli S, Morizumi T, Gu X, Yin Y, Liu P, Jiang Y, Meng X, Zhao G, Melcher K, Ernst OP, Kossiakoff AA, Subramaniam S, Xu HE | 10.1038/S41586-018-0215-Y | 2018-06-20 | Yes | |
5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | Human | X-ray | 6DRX | 6DRX_refined | 3.1 | A | Intermediate | 44 | 59 | - | - | - | - | BRIL | - |
lisuride
|
small-molecule | Antagonist | 5-hydroxytryptamine | small-molecule | No | No | McCorvy JD, Wacker D, Wang S, Agegnehu B, Liu J, Lansu K, Tribo AR, Olsen RHJ, Che T, Jin J, Roth BL | 10.1038/s41594-018-0116-7 | 2018-08-29 | Yes | |
PE2R4 | EP4 | Prostanoid | A | Human | X-ray | 5YHL | 5YHL_refined | 4.2 | A | Inactive | 9 | 57 | - | - | - | - | - | Fab |
ONO-AE3-208-Br
|
small-molecule | Antagonist | PGE2, PGF2α, thromboxane A2, PGI2, PGE1, PGD2 | small-molecule | No | No | - | 10.1038/S41589-018-0131-3 | 2018-12-05 | Yes | |
CCR2 | CCR2 | Chemokine | A | Human | X-ray | 6GPX | 6GPX_refined | 2.7 | B | Inactive | 16 | 70 | - | - | - | - | Rubredoxin | - |
MK-0812
|
small-molecule | Antagonist | CCL2, CCL8, CCL11, CCL13, CCL24, CCL7, CCL26, CCL16 | peptide | No | No | - | - | 2019-01-02 | Yes | |
MTR1B | MT2 | Melatonin | A | Human | X-ray | 6ME7 | 6ME7_refined | 3.2 | A | Inactive | 1 | 79 | - | - | - | - | Rubredoxin | - |
CHEMBL15060
|
small-molecule | Agonist | melatonin | small-molecule | No | No | - | - | 2019-04-24 | Yes | |
SUCR1 | succinate | Succinate | A | Rat | X-ray | 6RNK | 6RNK_refined | 1.9 | A | Active | 65 | 90 | - | - | - | - | - | Nanobody-6 |
NF-56-EJ40
|
small-molecule | Antagonist | - | - | No | No | - | - | 2019-08-14 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 6PS0 | 6PS0_refined | 3.4 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
carazolol
|
small-molecule | Antagonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | - | - | 2019-11-13 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Human | Cryo-EM | 6PWC | 6PWC_refined | 4.9 | R | Active | 100 | 77 | Beta | Beta-arrestin-1 | - | 84 | - | Fab30 heavy chain Fab30 light chain |
CHEMBL48981
|
protein | Agonist | neuromedin N, large neurotensin, neurotensin, large neuromedin N | peptide | No | No | Yin W, Li Z, Jin M, Yin YL, de Waal PW, Pal K, Yin Y, Gao X, He Y, Gao J, Wang X, Zhang Y, Zhou H, Melcher K, Jiang Y, Cong Y, Edward Zhou X, Yu X, Eric Xu H | 10.1038/S41422-019-0256-2 | 2019-12-04 | Yes | |
OX1R | OX1 | Orexin | A | Human | X-ray | 6TP4 | - | 3.0 | A | Inactive | 1 | 70 | - | - | - | - | - | - |
ACT-462206
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | Yes | |
CNR1 | CB1 | Cannabinoid | A | Human | Cryo-EM | 6KPG | 6KPG_refined | 3.0 | R | Active | 100 | 60 | Gi/o | αi1 | - | 64 | - | scFv16 |
AM841
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Hua T, Li X, Wu L, Iliopoulos-Tsoutsouvas C, Wang Y, Wu M, Shen L, Brust CA, Nikas SP, Song F, Song X, Yuan S, Sun Q, Wu Y, Jiang S, Grim TW, Benchama O, Stahl EL, Zvonok N, Zhao S, Bohn LM, Makriyannis A, Liu ZJ | 10.1016/J.CELL.2020.01.008 | 2020-02-12 | Yes | |
ACM4 | M4 | Acetylcholine (muscarinic) | A | Human | X-ray | 6KP6 | 6KP6_refined | 3.0 | A | Inactive | 2 | 59 | - | - | - | - | GlgA glycogen synthase | - |
Apo (no ligand)
|
none | Apo (no ligand) | acetylcholine | small-molecule | No | No | Wang J, Wu M, Wu L, Xu Y, Li F, Wu Y, Popov P, Wang L, Bai F, Zhao S, Liu ZJ, Hua T | 10.1107/S2052252520000597 | 2020-03-11 | Yes | |
ADA2B | α2B | Adrenoceptors | A | Human | Cryo-EM | 6K41 | - | 2.9 | R | Active | 100 | 54 | Gi/o | αo | - | 60 | T4-Lysozyme | scFv |
dexmedetomidine
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Yuan D, Liu Z, Kaindl J, Maeda S, Zhao J, Sun X, Xu J, Gmeiner P, Wang HW, Kobilka BK | 10.1038/S41589-020-0492-2 | 2020-04-15 | Yes | |
DRD2 | D2 | Dopamine | A | Human | Cryo-EM | 6VMS | - | 3.8 | R | Active | 100 | 63 | Gi/o | αi1 | - | 64 | T4-Lysozyme | scFv16 |
bromocriptine
|
small-molecule | Agonist | dopamine | small-molecule | No | No | Yin J, Chen KM, Clark MJ, Hijazi M, Kumari P, Bai XC, Sunahara RK, Barth P, Rosenbaum DM | 10.1038/S41586-020-2379-5 | 2020-06-17 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 6S0Q | 6S0Q_refined | 2.7 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | - | 10.1107/S2052252520011379 | 2020-07-15 | Yes | |
SCTR | secretin | Glucagon | B1 | Human | Cryo-EM | 6WI9 | 6WI9_refined | 4.3 | R | Active | 100 | 84 | Gs | αs | - | 49 | - | Nanobody-35 |
SECRETIN
|
protein | Agonist | secretin, VIP | peptide | No | No | Dong M, Deganutti G, Piper SJ, Liang YL, Khoshouei M, Belousoff MJ, Harikumar KG, Reynolds CA, Glukhova A, Furness SGB, Christopoulos A, Danev R, Wootten D, Sexton PM, Miller LJ | 10.1038/S41467-020-17791-4 | 2020-08-12 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 6X19 | - | 2.1 | R | Active | 100 | 84 | Gs | αs | - | 89 | - | Nanobody-35 |
CHU-128
|
small-molecule | Agonist | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Senel P, Stewart GD, Liang YL, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D | 10.1016/J.MOLCEL.2020.09.020 | 2020-09-09 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 6LPJ | 6LPJ_refined | 1.8 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Ihara K, Hato M, Nakane T, Yamashita K, Kimura-Someya T, Hosaka T, Ishizuka-Katsura Y, Tanaka R, Tanaka T, Sugahara M, Hirata K, Yamamoto M, Nureki O, Tono K, Nango E, Iwata S, Shirouzu M | 10.1038/S41598-020-76277-X | 2020-11-25 | Yes | |
DRD2 | D2 | Dopamine | A | Human | X-ray | 7DFP | 7DFP_refined | 3.1 | A | Inactive | 1 | 57 | - | - | - | - | BRIL | Fab heavy chain Fab light chain |
spiperone
|
small-molecule | Antagonist | dopamine | small-molecule | No | No | Im D, Inoue A, Fujiwara T, Nakane T, Yamanaka Y, Uemura T, Mori C, Shiimura Y, Kimura KT, Asada H, Nomura N, Tanaka T, Yamashita A, Nango E, Tono K, Kadji FMN, Aoki J, Iwata S, Shimamura T | 10.1038/S41467-020-20221-0 | 2020-12-30 | Yes | |
AGRG3 | ADGRG3 | ADGRG | B2 | Human | Cryo-EM | 7D77 | - | 2.9 | R | Active | - | 48 | Gi/o | αo | - | 61 | - | scFv16 |
HYDROCORTISONE
|
small-molecule | Agonist | - | - | No | No | Ping YQ, Mao C, Xiao P, Zhao RJ, Jiang Y, Yang Z, An WT, Shen DD, Yang F, Zhang H, Qu C, Shen Q, Tian C, Li ZJ, Li S, Wang GY, Tao X, Wen X, Zhong YN, Yang J, Yi F, Yu X, Xu HE, Zhang Y, Sun JP | 10.1038/S41586-020-03083-W | 2021-02-03 | Yes | |
OX2R | OX2 | Orexin | A | Human | Cryo-EM | 7L1V | - | 3.0 | R | Active | 100 | 64 | Gs | αs | Engineered G alpha | 58 | - | scFv16 Nanobody-51 |
compound 1 [PMID: 33547286]
|
small-molecule | Agonist | orexin-B, orexin-A | peptide | No | No | Hong C, Byrne NJ, Zamlynny B, Tummala S, Xiao L, Shipman JM, Partridge AT, Minnick C, Breslin MJ, Rudd MT, Stachel SJ, Rada VL, Kern JC, Armacost KA, Hollingsworth SA, O'Brien JA, Hall DL, McDonald TP, Strickland C, Brooun A, Soisson SM, Hollenstein K | 10.1038/S41467-021-21087-6 | 2021-02-10 | Yes | |
CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7DTV | 7DTV_refined | 3.5 | A | Active | - | 72 | - | - | - | - | - | - |
Calcium
L-tryptophan |
small-molecule small-molecule |
Agonist PAM |
spermine, L-tryptophan, Ca2+, Mg2+ | small-molecule | No | No | Ling S, Shi P, Liu S, Meng X, Zhou Y, Sun W, Chang S, Zhang X, Zhang L, Shi C, Sun D, Liu L, Tian C | 10.1038/S41422-021-00474-0 | 2021-03-10 | Yes | |
5HT1E | 5-HT1E | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7E33 | 7E33_refined | 2.9 | R | Active | 100 | 70 | Gi/o | αi1 | - | 61 | - | scFv16 |
BRL-54443
|
small-molecule | Agonist | 5-hydroxytryptamine, tryptamine | small-molecule | No | No | Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE | 10.1038/S41586-021-03376-8 | 2021-04-14 | Yes | |
CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7M3G | 7M3G_refined | 2.5 | A | Active | - | 76 | - | - | - | - | - | - |
Calcium
L-tryptophan evocalcet |
small-molecule small-molecule small-molecule |
Agonist PAM PAM |
spermine, L-tryptophan, Ca2+, Mg2+ | small-molecule | No | No | - | - | 2021-06-30 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7E14 | - | 2.9 | R | Active | 100 | 81 | Gs | αs | - | 49 | - | Nanobody-35 |
N-Tert-butyl-6,7-dichloroquinoxalin-2-amine
orforglipron |
small-molecule small-molecule |
Ago-PAM Agonist |
glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | - | 10.1038/S41467-021-24058-Z | 2021-07-07 | Yes | |
GRM5 | mGlu5 | Metabotropic glutamate | C | Human | X-ray | 7P2L | 7P2L_refined | 2.5 | A | Inactive | - | 21 | - | - | - | - | T4-Lysozyme | - |
alloswitch-1
|
small-molecule | NAM | L-glutamic acid | small-molecule | No | No | Nasrallah C, Cannone G, Briot J, Rottier K, Berizzi AE, Huang CY, Quast RB, Hoh F, Baneres JL, Malhaire F, Berto L, Dumazer A, Font-Ingles J, Gomez-Santacana X, Catena J, Kniazeff J, Goudet C, Llebaria A, Pin JP, Vinothkumar KR, Lebon G | 10.1016/J.CELREP.2021.109648 | 2021-09-08 | Yes | |
S1PR3 | S1P3 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7EW4 | 7EW4_refined | 3.2 | R | Active | 100 | 76 | Gi/o | αi1 | - | 64 | - | scFv16 |
CYM-5541
|
small-molecule | Agonist | sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate, sphingosine 1-phosphate | small-molecule | No | No | Zhao C, Cheng L, Wang W, Wang H, Luo Y, Feng Y, Wang X, Fu H, Cai Y, Yang S, Fu P, Yan W, Shao Z | 10.1038/S41422-021-00567-W | 2021-09-29 | Yes | |
ACM1 | M1 | Acetylcholine (muscarinic) | A | Human | X-ray | 6ZG9 | 6ZG9_refined | 2.5 | A | Inactive | 2 | 62 | - | - | - | - | T4-Lysozyme | - |
7-fluoro-5-methyl-3-[1-(oxan-4-yl)piperidin-4-yl]-1H-benzimidazol-2-one
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | Brown AJH, Bradley SJ, Marshall FH, Brown GA, Bennett KA, Brown J, Cansfield JE, Cross DM, de Graaf C, Hudson BD, Dwomoh L, Dias JM, Errey JC, Hurrell E, Liptrot J, Mattedi G, Molloy C, Nathan PJ, Okrasa K, Osborne G, Patel JC, Pickworth M, Robertson N, Shahabi S, Bundgaard C, Phillips K, Broad LM, Goonawardena AV, Morairty SR, Browning M, Perini F, Dawson GR, Deakin JFW, Smith RT, Sexton PM, Warneck J, Vinson M, Tasker T, Tehan BG, Teobald B, Christopoulos A, Langmead CJ, Jazayeri A, Cooke RM, Rucktooa P, Congreve MS, Weir M, Tobin AB | 10.1016/J.CELL.2021.11.001 | 2021-10-06 | Yes | |
MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7S8O | - | 2.6 | R | Active | 100 | 78 | Gi/o | αi1 | - | 62 | BRIL | scFv16 |
(R)-ZINC-3573
|
small-molecule | Agonist | PAMP-20 | peptide | No | No | Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL | 10.1038/S41586-021-04126-6 | 2021-11-17 | Yes | |
GP158 | GPR158 | C Orphans | C | Human | Cryo-EM | 7EWP | 7EWP_refined | 4.3 | A | Inactive | - | 47 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Jeong E, Kim Y, Jeong J, Cho Y | 10.1038/S41467-021-27147-1 | 2021-12-01 | Yes | |
GP139 | GPR139 | A orphans | A | Human | Cryo-EM | 7VUJ | 7VUJ_refined | 3.8 | R | Active | 100 | 79 | Gs | αs | - | 59 | - | Nanobody-35 |
JNJ-63533054
|
small-molecule | Agonist | L-tryptophan, L-phenylalanine | small-molecule | No | No | Zhou Y, Daver H, Trapkov B, Wu L, Wu M, Harpsoe K, Gentry PR, Liu K, Larionova M, Liu J, Chen N, Brauner-Osborne H, Gloriam DE, Hua T, Liu ZJ | 10.1038/S41422-021-00591-W | 2021-12-29 | Yes | |
5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | X-ray | 7WC4 | 7WC4_refined | 3.2 | A | Inactive | 1 | 61 | - | - | - | - | BRIL | - |
5-hydroxytryptamine
|
small-molecule | Agonist | 5-hydroxytryptamine, tryptamine | small-molecule | No | No | Cao D, Yu J, Wang H, Luo Z, Liu X, He L, Qi J, Fan L, Tang L, Chen Z, Li J, Cheng J, Wang S | 10.1126/SCIENCE.ABL8615 | 2022-01-26 | Yes | |
CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7SIM | 7SIM_refined | 2.7 | A | Active | - | 72 | - | - | - | - | - | - |
Cyclomethyltryptophan
|
small-molecule | Agonist | spermine, L-tryptophan, Ca2+, Mg2+ | small-molecule | No | No | Park J, Zuo H, Frangaj A, Fu Z, Yen LY, Zhang Z, Mosyak L, Slavkovich VN, Liu J, Ray KM, Cao B, Vallese F, Geng Y, Chen S, Grassucci R, Dandey VP, Tan YZ, Eng E, Lee Y, Kloss B, Liu Z, Hendrickson WA, Potter CS, Carragher B, Graziano J, Conigrave AD, Frank J, Clarke OB, Fan QR | 10.1073/PNAS.2115849118 | 2022-01-19 | Yes | |
MSHR | MC1 | Melanocortin | A | Human | Cryo-EM | 7F4D | - | 3.0 | R | Active | 100 | 83 | Gs | αs | - | 59 | - | Nanobody-35 |
INTERMEDINE
|
protein | Agonist | γ-MSH, ACTH, β-MSH, α-MSH | peptide | No | No | Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE | 10.1038/S41422-021-00557-Y | 2021-09-08 | Yes | |
LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | Cryo-EM | 7TD2 | - | 3.1 | R | Active | 100 | 80 | Gi/o | αi1 | - | 62 | - | - |
lysophosphatidic acid
|
small-molecule | Agonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY | 10.1038/S41467-022-28417-2 | 2022-02-09 | Yes | |
CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 7TYN | - | 2.6 | R | Active | 100 | 79 | Gs | αs | - | 58 | - | Nanobody-35 |
calcitonin (salmon synthetic)
|
small-molecule | Agonist | β-CGRP, α-CGRP, calcitonin, calcitonin (salmon), amylin, adrenomedullin, adrenomedullin 2/intermedin | peptide | No | No | Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM | 10.1126/SCIENCE.ABM9609 | 2022-03-30 | Yes | |
FPR2 | FPR2/ALX | Formylpeptide | A | Human | Cryo-EM | 7WVW | - | 3.1 | R | Active | 100 | 85 | Gi/o | αi2 | - | 63 | BRIL | - |
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU
|
peptide | Agonist | resolvin D1, serum amyloid A, 15-deoxy-LXA4, LTC4, LL-37, humanin, LTD4, aspirin triggered lipoxin A4, annexin I, aspirin-triggered resolvin D1, fMet-Leu-Phe, PrP106-126, LXA4 | peptide | No | No | Zhu Y, Lin X, Zong X, Han S, Wang M, Su Y, Ma L, Chu X, Yi C, Zhao Q, Wu B | 10.1038/S41467-022-29361-X | 2022-04-13 | Yes | |
FPR2 | FPR2/ALX | Formylpeptide | A | Human | Cryo-EM | 7WVX | - | 2.8 | R | Active | 100 | 85 | Gi/o | αi2 | - | 61 | BRIL | - |
humanin
|
peptide | Agonist | resolvin D1, serum amyloid A, 15-deoxy-LXA4, LTC4, LL-37, humanin, LTD4, aspirin triggered lipoxin A4, annexin I, aspirin-triggered resolvin D1, fMet-Leu-Phe, PrP106-126, LXA4 | peptide | No | No | Zhu Y, Lin X, Zong X, Han S, Wang M, Su Y, Ma L, Chu X, Yi C, Zhao Q, Wu B | 10.1038/S41467-022-29361-X | 2022-04-13 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | Cryo-EM | 7S0G | - | 3.9 | R | Active | 100 | 57 | Gs | αs | Gi1-Gs chimera | 56 | - | - |
LEVISOPRENALINE
|
small-molecule | Agonist | - | - | No | No | Alegre KO, Paknejad N, Su M, Lou JS, Huang J, Jordan KD, Eng ET, Meyerson JR, Hite RK, Huang XY | 10.1038/S41594-021-00679-2 | 2021-11-17 | Yes | |
ACM4 | M4 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 7V69 | - | 3.4 | R | Active | 100 | 58 | Gi/o | αi1 | - | 62 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | acetylcholine | small-molecule | No | No | Wang J, Wu M, Chen Z, Wu L, Wang T, Cao D, Wang H, Liu S, Xu Y, Li F, Liu J, Chen N, Zhao S, Cheng J, Wang S, Hua T | 10.1038/S41467-022-30595-Y | 2022-05-11 | Yes | |
DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7F1O | - | 3.1 | F | Active | 100 | 62 | Gs | αs | - | 60 | - | Nanobody-35 |
dopamine
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, 5-hydroxytryptamine, dopamine | small-molecule | No | No | Teng X, Chen S, Wang Q, Chen Z, Wang X, Huang N, Zheng S | 10.1126/SCIADV.ABO4158 | 2022-06-15 | Yes | |
DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7X2C | 7X2C_refined | 3.2 | F | Active | 100 | 63 | Gs | αs | - | 58 | - | Nanobody-35 |
fenoldopam
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, 5-hydroxytryptamine, dopamine | small-molecule | No | No | Teng X, Chen S, Nie Y, Xiao P, Yu X, Shao Z, Zheng S | 10.1038/S41467-022-30929-W | 2022-06-29 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7X8S | 7X8S_refined | 3.1 | R | Active | 100 | 65 | Gs | αs | - | 60 | - | Nanobody-35 |
WB4-24
|
small-molecule | Agonist | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Cong Z, Zhou Q, Li Y, Chen LN, Zhang ZC, Liang A, Liu Q, Wu X, Dai A, Xia T, Wu W, Zhang Y, Yang D, Wang MW | 10.1073/PNAS.2200155119 | 2022-06-29 | Yes | |
5HT6R | 5-HT6 | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7XTB | 7XTB_refined | 3.3 | R | Active | 100 | 63 | Gs | αs | - | 60 | BRIL | Nanobody-35 |
5-hydroxytryptamine
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Huang S, Xu P, Shen DD, Simon IA, Mao C, Tan Y, Zhang H, Harpsoe K, Li H, Zhang Y, You C, Yu X, Jiang Y, Zhang Y, Gloriam DE, Xu HE | 10.1016/J.MOLCEL.2022.05.031 | 2022-07-27 | Yes | |
GPBAR | GPBA | Bile acid | A | Human | Cryo-EM | 7XTQ | 7XTQ_refined | 3.2 | R | Active | 100 | 83 | Gs | αs | - | 58 | - | Nanobody-35 |
CHEMBL2181246
|
small-molecule | Agonist | deoxycholic acid, chenodeoxycholic acid, lithocholic acid, cholic acid | small-molecule | No | No | Ma L, Yang F, Wu X, Mao C, Guo L, Miao T, Zang SK, Jiang X, Shen DD, Wei T, Zhou H, Wei Q, Li S, Shu Q, Feng S, Jiang C, Chu B, Du L, Sun JP, Yu X, Zhang Y, Zhang P | 10.1073/PNAS.2117054119 | 2022-07-06 | Yes | |
MRGRD | MRGPRD | A orphans | A | Human | Cryo-EM | 7Y15 | 7Y15_refined | 2.9 | R | Active | 100 | 82 | Gi/o | αi1 | - | 62 | BRIL | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | β-alanine | small-molecule | No | No | Suzuki S, Iida M, Hiroaki Y, Tanaka K, Kawamoto A, Kato T, Oshima A | 10.1038/S42003-022-03668-3 | 2022-07-20 | Yes | |
OXYR | OT | Vasopressin and oxytocin | A | Human | Cryo-EM | 7QVM | - | 3.3 | R | Active | 100 | 64 | Gi/o | αo | - | 59 | - | scFv16 |
oxytocin
|
peptide | Agonist | oxytocin, vasopressin | peptide | No | No | Waltenspuhl Y, Ehrenmann J, Vacca S, Thom C, Medalia O, Pluckthun A | 10.1038/S41467-022-31325-0 | 2022-08-10 | Yes | |
TSHR | TSH | Glycoprotein hormone | A | Human | Cryo-EM | 7XW6 | - | 2.8 | R | Active | 100 | 74 | Gs | αs | - | 59 | - | Nanobody-35 |
M22 antibody light chain
M22 antibody heavy chain N-[4-[[5-[(2S)-3-benzyl-5-hydroxy-4-oxo-1,2-dihydroquinazolin-2-yl]-2-methoxyphenyl]methoxy]phenyl]acetamide |
protein protein small-molecule |
Agonist | TSH | peptide | No | No | Duan J, Xu P, Luan X, Ji Y, He X, Song N, Yuan Q, Jin Y, Cheng X, Jiang H, Zheng J, Zhang S, Jiang Y, Xu HE | 10.1038/S41586-022-05173-3 | 2022-08-17 | Yes | |
AGRG2 | ADGRG2 | ADGRG | B2 | Mouse | Cryo-EM | 7XKF | - | 2.4 | R | Active | - | 26 | Gs | αs | - | 57 | - | Nanobody-35 |
PRASTERONE
|
small-molecule | Agonist | - | - | No | No | Lin H, Xiao P, Bu RQ, Guo S, Yang Z, Yuan D, Zhu ZL, Zhang CX, He QT, Zhang C, Ping YQ, Zhao RJ, Ma CS, Liu CH, Zhang XN, Jiang D, Huang S, Xi YT, Zhang DL, Xue CY, Yang BS, Li JY, Lin HC, Zeng XH, Zhao H, Xu WM, Yi F, Liu Z, Sun JP, Yu X | 10.1038/S41589-022-01084-6 | 2022-08-10 | Yes | |
V2R | V2 | Vasopressin and oxytocin | A | Human | Cryo-EM | 7R0C | - | 4.7 | A | Active | 100 | 76 | Beta | Beta-arrestin-1 | - | 84 | - | scFv30 |
vasopressin
|
peptide | Agonist | oxytocin, vasopressin | peptide | No | No | Bous J, Fouillen A, Orcel H, Trapani S, Cong X, Fontanel S, Saint-Paul J, Lai-Kee-Him J, Urbach S, Sibille N, Sounier R, Granier S, Mouillac B, Bron P | 10.1126/SCIADV.ABO7761 | 2022-09-14 | Yes | |
AGRF1 | ADGRF1 | ADGRF | B2 | Human | Cryo-EM | 7WXW | - | 2.8 | R | Active | - | 30 | Gs | αs | Mini-Gs | 59 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Zhu X, Qian Y, Li X, Xu Z, Xia R, Wang N, Liang J, Yin H, Zhang A, Guo C, Wang G, He Y | 10.1038/S41467-022-33173-4 | 2022-09-28 | Yes | |
T2R46 | TAS2R46 | Taste 2 | T | Human | Cryo-EM | 7XP4 | - | 3.0 | R | Active | - | 97 | Gi/o | αgust | - | 63 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Xu W, Wu L, Liu S, Liu X, Cao X, Zhou C, Zhang J, Fu Y, Guo Y, Wu Y, Tan Q, Wang L, Liu J, Jiang L, Fan Z, Pei Y, Yu J, Cheng J, Zhao S, Hao X, Liu ZJ, Hua T | 10.1126/SCIENCE.ABO1633 | 2022-10-12 | Yes | |
VIPR1 | VPAC1 | VIP and PACAP | B1 | Human | Cryo-EM | 8E3Y | - | 2.3 | R | Active | 100 | 81 | Gs | αs | - | 56 | - | Nanobody-35 |
[Ac-His1]PACAP-27
|
peptide | Agonist | VIP, PACAP-27, secretin, PHI, PHM, GHRH, PACAP-38 | peptide | No | No | - | - | 2022-11-23 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 8A6E | 8A6E_refined | 1.8 | A | Inactive | 22 | 87 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Agonist | - | - | No | No | Gruhl T, Weinert T, Rodrigues MJ, Milne CJ, Ortolani G, Nass K, Nango E, Sen S, Johnson PJM, Cirelli C, Furrer A, Mous S, Skopintsev P, James D, Dworkowski F, Bath P, Kekilli D, Ozerov D, Tanaka R, Glover H, Bacellar C, Brunle S, Casadei CM, Diethelm AD, Gashi D, Gotthard G, Guixa-Gonzalez R, Joti Y, Kabanova V, Knopp G, Lesca E, Ma P, Martiel I, Muhle J, Owada S, Pamula F, Sarabi D, Tejero O, Tsai CJ, Varma N, Wach A, Boutet S, Tono K, Nogly P, Deupi X, Iwata S, Neutze R, Standfuss J, Schertler G, Panneels V | 10.1038/S41586-023-05863-6 | 2023-03-29 | Yes | |
GPR21 | GPR21 | A orphans | A | Human | Cryo-EM | 8HJ2 | 8HJ2_refined | 3.8 | R | Active | 100 | 81 | Gs | αs | Mini-Gs | 61 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | - | 2023-03-15 | Yes | |
ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 7T96 | 7T96_refined | 3.2 | A | Active | 100 | 59 | Gi/o | αo | - | 62 | - | scFv16 |
acetylcholine
LY2119620 |
small-molecule small-molecule |
Agonist PAM |
acetylcholine | small-molecule | No | No | - | - | 2023-01-25 | Yes | |
HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | X-ray | 7ZLY | - | 2.7 | A | Active | 65 | 83 | - | - | - | - | BRIL | - |
Apo (no ligand)
|
none | Apo (no ligand) | β-D-hydroxybutyric acid, butyric acid | small-molecule | No | No | Yang Y, Kang HJ, Gao R, Wang J, Han GW, DiBerto JF, Wu L, Tong J, Qu L, Wu Y, Pileski R, Li X, Zhang XC, Zhao S, Kenakin T, Wang Q, Stevens RC, Peng W, Roth BL, Rao Z, Liu ZJ | 10.1038/S41467-023-37177-6 | 2023-04-12 | Yes | |
SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7YAE | 7YAE_refined | 3.4 | E | Active | 100 | 76 | Gi/o | αi1 | - | 64 | - | scFv16 |
Octreotide
|
peptide | Agonist | SRIF-14, CST-17, cortistatin-14, SRIF-28 | peptide | No | No | Zhao J, Fu H, Yu J, Hong W, Tian X, Qi J, Sun S, Zhao C, Wu C, Xu Z, Cheng L, Chai R, Yan W, Wei X, Shao Z | 10.1038/S41467-023-36673-Z | 2023-04-19 | Yes | |
PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 7Y36 | - | 2.8 | R | Active | 100 | 63 | Gs | αs | - | 57 | - | Nanobody-35 |
teriparatide
|
peptide | Agonist | PTH, PTHrP-(1-36), TIP39, PTHrP | peptide | No | No | - | - | 2023-07-05 | Yes | |
PF2R | FP | Prostanoid | A | Human | Cryo-EM | 8IUL | - | 2.8 | R | Active | 100 | 82 | Gq/11 | αq | - | 60 | - | scFv16 |
latanoprost (free acid form)
|
small-molecule | Agonist | PGE2, PGF2α, thromboxane A2, PGI2, PGD2 | small-molecule | No | No | Wu C, Xu Y, He Q, Li D, Duan J, Li C, You C, Chen H, Fan W, Jiang Y, Eric Xu H | 10.1038/S41467-023-38411-X | 2023-07-12 | Yes | |
GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 8JD2 | - | 2.8 | 2 | Active | - | 86 | - | - | - | - | - | - |
L-glutamic acid
|
small-molecule | Agonist | L-glutamic acid | small-molecule | No | No | Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B | 10.1038/S41422-023-00830-2 | 2023-06-21 | Yes | |
OPSD | Rhodopsin | Opsins | A | Japanese flying squid | X-ray | 2Z73 | 2Z73_refined | 2.5 | A | Inactive | 16 | 78 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | - | 10.1038/NATURE06925 | 2008-05-13 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 3D4S | 3D4S_refined | 2.8 | A | Inactive | 0 | 67 | - | - | - | - | T4-Lysozyme | - |
timolol
|
small-molecule | Inverse agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | - | 10.1016/J.STR.2008.05.001 | 2008-06-17 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 3EML | - | 2.6 | A | Inactive | 1 | 70 | - | - | - | - | T4-Lysozyme | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | - | 10.1126/SCIENCE.1164772 | 2008-10-14 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 3NY8 | 3NY8_refined | 2.8 | A | Inactive | 0 | 67 | - | - | - | - | T4-Lysozyme | - |
ICI 118551
|
small-molecule | Inverse agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | - | - | 2010-08-11 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 3CAP | - | 2.9 | A | Active | 98 | 94 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | 10.1038/NATURE07063 | 2008-06-24 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 3NY9 | 3NY9_refined | 2.8 | A | Inactive | 0 | 67 | - | - | - | - | T4-Lysozyme | - |
CHEMBL1233771
|
small-molecule | Inverse agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | - | 10.1021/JA105108Q | 2010-08-11 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 3NYA | 3NYA_refined | 3.2 | A | Inactive | 0 | 67 | - | - | - | - | T4-Lysozyme | - |
CHEMBL1160734
|
small-molecule | Antagonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | - | - | 2010-08-11 | Yes | |
CXCR4 | CXCR4 | Chemokine | A | Human | X-ray | 3OE0 | - | 2.9 | A | Inactive | 4 | 78 | - | - | - | - | T4-Lysozyme | - |
CVX15
|
peptide | Antagonist | CXCL12γ, CXCL12ε, CXCL12, CXCL12δ, CXCL12β, CXCL12φ, CXCL12α | peptide | No | No | - | - | 2010-10-27 | Yes | |
CXCR4 | CXCR4 | Chemokine | A | Human | X-ray | 3OE6 | 3OE6_refined | 3.2 | A | Inactive | 4 | 77 | - | - | - | - | T4-Lysozyme | - |
isothiourea-1t
|
small-molecule | Antagonist | CXCL12γ, CXCL12ε, CXCL12, CXCL12δ, CXCL12β, CXCL12φ, CXCL12α | peptide | No | No | - | - | 2010-10-27 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 2VT4 | - | 2.7 | B | Inactive | 0 | 57 | - | - | - | - | - | - |
(S)-Cyanopindolol
|
small-molecule | Antagonist | - | - | No | No | - | 10.1038/NATURE07101 | 2008-06-24 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 3KJ6 | - | 3.4 | A | Inactive | 1 | 54 | - | - | - | - | - | Antibody | - | - | - | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | - | 10.1038/NATURE08650 | 2010-02-16 | Yes | |
CXCR4 | CXCR4 | Chemokine | A | Human | X-ray | 3ODU | 3ODU_refined | 2.5 | A | Inactive | 4 | 83 | - | - | - | - | T4-Lysozyme | - |
isothiourea-1t
|
small-molecule | Antagonist | CXCL12γ, CXCL12ε, CXCL12, CXCL12δ, CXCL12β, CXCL12φ, CXCL12α | peptide | No | No | - | - | 2010-10-27 | Yes | |
CXCR4 | CXCR4 | Chemokine | A | Human | X-ray | 3OE8 | 3OE8_refined | 3.1 | A | Inactive | 4 | 76 | - | - | - | - | T4-Lysozyme | - |
isothiourea-1t
|
small-molecule | Antagonist | CXCL12γ, CXCL12ε, CXCL12, CXCL12δ, CXCL12β, CXCL12φ, CXCL12α | peptide | No | No | - | 10.1126/SCIENCE.1194396 | 2010-10-27 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 3OAX | - | 2.6 | A | Inactive | 22 | 100 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | - | 10.1016/J.BPJ.2010.08.003 | 2011-01-19 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 3P0G | 3P0G_refined | 3.5 | A | Active | 99 | 69 | - | - | - | - | T4-Lysozyme | Nanobody |
CHEMBL1615159
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | - | 10.1038/NATURE09648 | 2011-01-19 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 3PQR | 3PQR_refined | 2.9 | A | Active | 100 | 94 | Gi/o | αt1 | Only H5 | 3 | - | - |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | - | 10.1038/NATURE09789 | 2011-03-09 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 2X72 | 2X72_refined | 3.0 | A | Active | 100 | 94 | Gi/o | αt1 | Only H5 | 3 | - | - |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | - | 10.1038/NATURE09795 | 2011-03-16 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 2YDV | 2YDV_refined | 2.6 | A | Active | 65 | 75 | - | - | - | - | - | - |
NECA
|
small-molecule | Agonist | adenosine | small-molecule | No | No | - | - | 2011-05-18 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 2YCZ | 2YCZ_refined | 3.7 | B | Inactive | 0 | 60 | - | - | - | - | - | - |
Iodocyanopindolol
|
small-molecule | Antagonist | - | - | No | No | - | - | 2011-06-01 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 2YCY | - | 3.2 | A | Inactive | 0 | 60 | - | - | - | - | - | - |
(S)-Cyanopindolol
|
small-molecule | Antagonist | - | - | No | No | - | - | 2011-06-08 | Yes | |
HRH1 | H1 | Histamine | A | Human | X-ray | 3RZE | 3RZE_refined | 3.1 | A | Inactive | 2 | 55 | - | - | - | - | T4-Lysozyme | - |
doxepin
|
small-molecule | Antagonist | histamine | small-molecule | No | No | - | 10.1038/NATURE10236 | 2011-06-15 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 3REY | 3REY_refined | 3.3 | A | Inactive | 1 | 71 | - | - | - | - | - | - |
xanthine amine congener
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | - | - | 2011-09-07 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 3SN6 | - | 3.2 | R | Active | 100 | 69 | Gs | αs | - | 89 | T4-Lysozyme | Antibody |
CHEMBL1615159
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | - | 10.1038/NATURE10361 | 2011-07-20 | Yes | |
ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | X-ray | 3UON | 3UON_refined | 3.0 | A | Inactive | 2 | 60 | - | - | - | - | T4-Lysozyme | - |
CHEMBL558910
|
small-molecule | Antagonist | acetylcholine | small-molecule | No | No | Haga K, Kruse AC, Asada H, Yurugi-Kobayashi T, Shiroishi M, Zhang C, Weis WI, Okada T, Kobilka BK, Haga T, Kobayashi T | 10.1038/NATURE10753 | 2012-02-01 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 3VG9 | 3VG9_refined | 2.7 | A | Inactive | 1 | 72 | - | - | - | - | - | Antibody fab fragment light chain Antibody fab fragment heavy chain |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Hino T, Arakawa T, Iwanari H, Yurugi-Kobayashi T, Ikeda-Suno C, Nakada-Nakura Y, Kusano-Arai O, Weyand S, Shimamura T, Nomura N, Cameron AD, Kobayashi T, Hamakubo T, Iwata S, Murata T | 10.1038/NATURE10750 | 2012-02-01 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 3VGA | - | 3.1 | A | Inactive | 1 | 72 | - | - | - | - | - | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | - | - | 2012-02-01 | Yes | |
S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | X-ray | 3V2Y | 3V2Y_refined | 2.8 | A | Inactive | 1 | 76 | - | - | - | - | T4-Lysozyme | - |
W146
|
small-molecule | Antagonist | sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate, sphingosine 1-phosphate | small-molecule | No | No | - | - | 2012-02-15 | Yes | |
OPRD | δ | Opioid | A | Mouse | X-ray | 4EJ4 | 4EJ4_refined | 3.4 | A | Inactive | 4 | 76 | - | - | - | - | T4-Lysozyme | - |
naltrindole
|
small-molecule | Antagonist | [Leu]enkephalin, α-neoendorphin, [Met]enkephalin | peptide | No | No | Granier S, Manglik A, Kruse AC, Kobilka TS, Thian FS, Weis WI, Kobilka BK | 10.1038/NATURE11111 | 2012-05-16 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 4AMJ | 4AMJ_refined | 2.3 | B | Inactive | 0 | 62 | - | - | - | - | - | - |
CHEMBL3799125
|
small-molecule | Inverse agonist | - | - | No | No | Warne T, Edwards PC, Leslie AG, Tate CG | 10.1016/J.STR.2012.03.014 | 2012-05-23 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 4EIY | 4EIY_refined | 1.8 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Liu W, Chun E, Thompson AA, Chubukov P, Xu F, Katritch V, Han GW, Roth CB, Heitman LH, IJzerman AP, Cherezov V, Stevens RC | 10.1126/SCIENCE.1219218 | 2012-07-25 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 4GBR | 4GBR_refined | 4.0 | A | Inactive | 0 | 69 | - | - | - | - | T4-Lysozyme | - |
Carazolol
|
small-molecule | Inverse agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | Zou Y, Weis WI, Kobilka BK | 10.1371/JOURNAL.PONE.0046039 | 2012-10-24 | Yes | |
5HT1B | 5-HT1B | 5-Hydroxytryptamine | A | Human | X-ray | 4IAQ | 4IAQ_refined | 2.8 | A | Inactive | 15 | 70 | - | - | - | - | BRIL | - |
dihydroergotamine
|
small-molecule | Agonist | 5-hydroxytryptamine, 5-HT-moduline, tryptamine | small-molecule | No | No | - | - | 2013-03-13 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 3ZPQ | 3ZPQ_refined | 2.8 | B | Inactive | 0 | 62 | - | - | - | - | - | - |
CHEMBL200234
|
small-molecule | Antagonist | - | - | No | Yes | Christopher JA, Brown J, Doré AS, Errey JC, Koglin M, Marshall FH, Myszka DG, Rich RL, Tate CG, Tehan B, Warne T, Congreve M. | 10.1021/jm400140q | 2013-04-03 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 3ZPR | 3ZPR_refined | 2.7 | B | Inactive | 0 | 61 | - | - | - | - | - | - |
CHEMBL1559535
|
small-molecule | Antagonist | - | - | No | Yes | Christopher JA, Brown J, Doré AS, Errey JC, Koglin M, Marshall FH, Myszka DG, Rich RL, Tate CG, Tehan B, Warne T, Congreve M. | 10.1021/jm400140q | 2013-04-03 | Yes | |
CRFR1 | CRF1 | Corticotropin-releasing factor | B1 | Human | X-ray | 4K5Y | - | 3.0 | C | Inactive | 17 | 60 | - | - | - | - | T4-Lysozyme | - |
CP 376,395
|
small-molecule | Antagonist | urocortin 2, corticotrophin-releasing hormone, urocortin 1 | peptide | No | No | Hollenstein K, Kean J, Bortolato A, Cheng RK, Dore AS, Jazayeri A, Cooke RM, Weir M, Marshall FH | 10.1038/NATURE12357 | 2013-07-17 | Yes | |
CCR5 | CCR5 | Chemokine | A | Human | X-ray | 4MBS | 4MBS_refined | 2.7 | A | Inactive | 16 | 83 | - | - | - | - | Rubredoxin | - |
maraviroc
|
small-molecule | Antagonist | CCL2, CCL8, CCL11, CCL13, CCL14, CCL7, CCL5, CCL4, CCL16, CCL3 | peptide | No | No | Tan Q, Zhu Y, Li J, Chen Z, Han GW, Kufareva I, Li T, Ma L, Fenalti G, Li J, Zhang W, Xie X, Yang H, Jiang H, Cherezov V, Liu H, Stevens RC, Zhao Q, Wu B | 10.1126/SCIENCE.1241475 | 2013-09-11 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 4J4Q | 4J4Q_refined | 2.7 | A | Active | 100 | 94 | Gi/o | αt1 | Only H5 | 3 | - | - |
B-Octylglucoside
|
small-molecule | unknown | - | - | No | No | Park JH, Morizumi T, Li Y, Hong JE, Pai EF, Hofmann KP, Choe HW, Ernst OP | 10.1002/ANIE.201302374 | 2013-10-30 | Yes | |
ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | X-ray | 4MQS | 4MQS_refined | 3.5 | A | Active | 99 | 59 | - | - | - | - | - | Nanobody |
iperoxo
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | Kruse AC, Ring AM, Manglik A, Hu J, Hu K, Eitel K, Hubner H, Pardon E, Valant C, Sexton PM, Christopoulos A, Felder CC, Gmeiner P, Steyaert J, Weis WI, Garcia KC, Wess J, Kobilka BK | 10.1038/NATURE12735 | 2013-11-27 | Yes | |
ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | X-ray | 4MQT | 4MQT_refined | 3.7 | A | Active | 99 | 59 | - | - | - | - | - | Nanobody |
iperoxo
LY2119620 |
small-molecule small-molecule |
Agonist PAM |
acetylcholine | small-molecule | No | No | Kruse AC, Ring AM, Manglik A, Hu J, Hu K, Eitel K, Hubner H, Pardon E, Valant C, Sexton PM, Christopoulos A, Felder CC, Gmeiner P, Steyaert J, Weis WI, Garcia KC, Wess J, Kobilka BK | 10.1038/NATURE12735 | 2013-11-27 | Yes | |
SMO | SMO | Frizzled | F | Human | X-ray | 4N4W | 4N4W_refined | 2.8 | A | Inactive | 0 | 44 | - | - | - | - | BRIL | - |
SANT-1
|
small-molecule | Antagonist | - | - | No | No | Wang C, Wu H, Evron T, Vardy E, Han GW, Huang XP, Hufeisen SJ, Mangano TJ, Urban DJ, Katritch V, Cherezov V, Caron MG, Roth BL, Stevens RC | 10.1038/NCOMMS5355 | 2014-01-22 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 4BUO | 4BUO_refined | 2.8 | A | Inactive | 3 | 72 | - | - | - | - | - | - |
neurotensin
|
peptide | Agonist | neuromedin N, neurotensin | peptide | No | No | - | - | 2014-01-29 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 4BV0 | 4BV0_refined | 3.1 | A | Inactive | 3 | 70 | - | - | - | - | - | - |
neurotensin
|
peptide | Agonist | neuromedin N, neurotensin | peptide | No | No | Egloff P, Hillenbrand M, Klenk C, Batyuk A, Heine P, Balada S, Schlinkmann KM, Scott DJ, Schutz M, Pluckthun A | 10.1073/PNAS.1317903111 | 2014-01-29 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 4BVN | 4BVN_refined | 2.1 | A | Inactive | 0 | 60 | - | - | - | - | - | - |
(S)-Cyanopindolol
|
small-molecule | Antagonist | - | - | No | Yes | Miller-Gallacher JL, Nehme R, Warne T, Edwards PC, Schertler GF, Leslie AG, Tate CG | 10.1371/JOURNAL.PONE.0092727 | 2014-04-02 | Yes | |
GRM5 | mGlu5 | Metabotropic glutamate | C | Human | X-ray | 4OO9 | 4OO9_refined | 2.6 | A | Inactive | - | 20 | - | - | - | - | T4-Lysozyme | - |
MAVOGLURANT
|
small-molecule | NAM | L-glutamic acid | small-molecule | No | No | Dore AS, Okrasa K, Patel JC, Serrano-Vega M, Bennett K, Cooke RM, Errey JC, Jazayeri A, Khan S, Tehan B, Weir M, Wiggin GR, Marshall FH | 10.1038/NATURE13396 | 2014-07-02 | Yes | |
FFAR1 | FFA1 | Free fatty acid | A | Human | X-ray | 4PHU | 4PHU_refined | 2.3 | A | Intermediate | 44 | 90 | - | - | - | - | T4-Lysozyme | - |
fasiglifam
|
small-molecule | Allosteric agonist | oleic acid, docosahexaenoic acid, α-linolenic acid, myristic acid | small-molecule | No | No | Srivastava A, Yano J, Hirozane Y, Kefala G, Gruswitz F, Snell G, Lane W, Ivetac A, Aertgeerts K, Nguyen J, Jennings A, Okada K | 10.1038/NATURE13494 | 2014-07-16 | Yes | |
SMO | SMO | Frizzled | F | Human | X-ray | 4QIM | 4QIM_refined | 2.6 | A | Inactive | 7 | 45 | - | - | - | - | BRIL | - |
ANTA XV
|
small-molecule | Antagonist | - | - | No | No | Wang C, Wu H, Evron T, Vardy E, Han GW, Huang XP, Hufeisen SJ, Mangano TJ, Urban DJ, Katritch V, Cherezov V, Caron MG, Roth BL, Stevens RC | 10.1038/NCOMMS5355 | 2014-07-23 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 4PXF | 4PXF_refined | 2.8 | A | Active | 100 | 93 | Visual | S-arrestin | Fragment | 2 | - | - |
B-Octylglucoside
|
small-molecule | unknown | - | - | No | No | Szczepek M, Beyriere F, Hofmann KP, Elgeti M, Kazmin R, Rose A, Bartl FJ, von Stetten D, Heck M, Sommer ME, Hildebrand PW, Scheerer P | 10.1038/NCOMMS5801 | 2014-09-17 | Yes | |
ACM3 | M3 | Acetylcholine (muscarinic) | A | Rat | X-ray | 4U15 | 4U15_refined | 2.8 | B | Inactive | 2 | 47 | - | - | - | - | T4-Lysozyme | - |
tiotropium
|
small-molecule | Antagonist | acetylcholine | small-molecule | No | No | Thorsen TS, Matt R, Weis WI, Kobilka BK | 10.1016/J.STR.2014.08.022 | 2014-11-26 | Yes | |
OPRD | δ | Opioid | A | Human | X-ray | 4RWA | 4RWA_refined | 3.3 | A | Inactive | 4 | 77 | - | - | - | - | BRIL | - |
DIPP-NH2
|
peptide | Antagonist | dynorphin A-(1-8), [Met]enkephalin, endomorphin-1, dynorphin A, [Leu]enkephalin, β-endorphin, dynorphin A-(1-13), dynorphin B, α-neoendorphin | peptide | No | No | Fenalti G, Zatsepin NA, Betti C, Giguere P, Han GW, Ishchenko A, Liu W, Guillemyn K, Zhang H, James D, Wang D, Weierstall U, Spence JC, Boutet S, Messerschmidt M, Williams GJ, Gati C, Yefanov OM, White TA, Oberthuer D, Metz M, Yoon CH, Barty A, Chapman HN, Basu S, Coe J, Conrad CE, Fromme R, Fromme P, Tourwe D, Schiller PW, Roth BL, Ballet S, Katritch V, Stevens RC, Cherezov V | 10.1038/NSMB.2965 | 2015-01-14 | Yes | |
OPRD | δ | Opioid | A | Human | X-ray | 4RWD | 4RWD_refined | 2.7 | A | Inactive | 4 | 79 | - | - | - | - | BRIL | - |
DIPP-NH2
|
peptide | Antagonist | dynorphin A-(1-8), [Met]enkephalin, endomorphin-1, dynorphin A, [Leu]enkephalin, β-endorphin, dynorphin A-(1-13), dynorphin B, α-neoendorphin | peptide | No | Yes | Fenalti G, Zatsepin NA, Betti C, Giguere P, Han GW, Ishchenko A, Liu W, Guillemyn K, Zhang H, James D, Wang D, Weierstall U, Spence JC, Boutet S, Messerschmidt M, Williams GJ, Gati C, Yefanov OM, White TA, Oberthuer D, Metz M, Yoon CH, Barty A, Chapman HN, Basu S, Coe J, Conrad CE, Fromme R, Fromme P, Tourwe D, Schiller PW, Roth BL, Ballet S, Katritch V, Stevens RC, Cherezov V | 10.1038/NSMB.2965 | 2015-01-14 | Yes | |
P2RY1 | P2Y1 | P2Y | A | Human | X-ray | 4XNV | - | 2.2 | A | Intermediate | 44 | 78 | - | - | - | - | Rubredoxin | - |
BMS compound 16 [PMID:23368907]
|
small-molecule | NAM | ADP, ATP | small-molecule | No | No | Zhang D, Gao ZG, Zhang K, Kiselev E, Crane S, Wang J, Paoletta S, Yi C, Ma L, Zhang W, Han GW, Liu H, Cherezov V, Katritch V, Jiang H, Stevens RC, Jacobson KA, Zhao Q, Wu B | 10.1038/NATURE14287 | 2015-04-01 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 4UG2 | 4UG2_refined | 2.6 | A | Active | 65 | 71 | - | - | - | - | - | - |
CGS 21680
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Lebon G, Edwards PC, Leslie AG, Tate CG | 10.1124/mol.114.097360 | 2015-04-08 | Yes | |
AGTR1 | AT1 | Angiotensin | A | Human | X-ray | 4YAY | 4YAY_refined | 2.9 | A | Inactive | 5 | 79 | - | - | - | - | BRIL | - |
ZD-7155
|
small-molecule | Antagonist | angiotensin A, angiotensin III, angiotensin IV, angiotensin II | peptide | No | No | Zhang H, Unal H, Gati C, Han GW, Liu W, Zatsepin NA, James D, Wang D, Nelson G, Weierstall U, Sawaya MR, Xu Q, Messerschmidt M, Williams GJ, Boutet S, Yefanov OM, White TA, Wang C, Ishchenko A, Tirupula KC, Desnoyer R, Coe J, Conrad CE, Fromme P, Stevens RC, Katritch V, Karnik SS, Cherezov V | 10.1016/J.CELL.2015.04.011 | 2015-04-22 | Yes | |
LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | X-ray | 4Z34 | 4Z34_refined | 3.0 | A | Inactive | 1 | 80 | - | - | - | - | BRIL | - |
ONO-9780307
|
small-molecule | Antagonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | Chrencik JE, Roth CB, Terakado M, Kurata H, Omi R, Kihara Y, Warshaviak D, Nakade S, Asmar-Rovira G, Mileni M, Mizuno H, Griffith MT, Rodgers C, Han GW, Velasquez J, Chun J, Stevens RC, Hanson MA | 10.1016/J.CELL.2015.06.002 | 2015-06-03 | Yes | |
LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | X-ray | 4Z35 | 4Z35_refined | 2.9 | A | Inactive | 1 | 80 | - | - | - | - | BRIL | - |
ONO-9910539
|
small-molecule | Antagonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | Chrencik JE, Roth CB, Terakado M, Kurata H, Omi R, Kihara Y, Warshaviak D, Nakade S, Asmar-Rovira G, Mileni M, Mizuno H, Griffith MT, Rodgers C, Han GW, Velasquez J, Chun J, Stevens RC, Hanson MA | 10.1016/J.CELL.2015.06.002 | 2015-06-03 | Yes | |
OPSD | Rhodopsin | Opsins | A | Japanese flying squid | X-ray | 4WW3 | 4WW3_refined | 2.8 | A | Inactive | 16 | 78 | - | - | - | - | - | - |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | Murakami M, Kouyama T | 10.1371/JOURNAL.PONE.0126970 | 2015-06-17 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 4XEE | 4XEE_refined | 2.9 | A | Active | 79 | 71 | - | - | - | - | T4-Lysozyme | - |
neurotensin
|
peptide | Agonist | neuromedin N, neurotensin | peptide | No | No | Krumm BE, White JF, Shah P, Grisshammer R | 10.1038/NCOMMS8895 | 2015-07-29 | Yes | |
OPRM | μ | Opioid | A | Mouse | X-ray | 5C1M | 5C1M_refined | 2.1 | A | Active | 100 | 74 | - | - | - | - | - | Antibody |
BU72
|
small-molecule | Agonist | - | - | No | No | Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK | 10.1038/NATURE14886 | 2015-08-05 | Yes | |
AGTR1 | AT1 | Angiotensin | A | Human | X-ray | 4ZUD | 4ZUD_refined | 2.8 | A | Inactive | 5 | 75 | - | - | - | - | BRIL | - |
OLMESARTAN
|
small-molecule | Inverse agonist | angiotensin A, angiotensin III, angiotensin IV, angiotensin II | peptide | No | No | Zhang H, Unal H, Desnoyer R, Han GW, Patel N, Katritch V, Karnik SS, Cherezov V, Stevens RC | 10.1074/JBC.M115.689000 | 2015-10-07 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 5F8U | 5F8U_refined | 3.4 | A | Inactive | 0 | 57 | - | - | - | - | - | - |
(S)-Cyanopindolol
|
small-molecule | Antagonist | - | - | No | No | Leslie AG, Warne T, Tate CG | 10.1038/NSMB.3130 | 2015-12-23 | Yes | |
OX1R | OX1 | Orexin | A | Human | X-ray | 4ZJ8 | 4ZJ8_refined | 2.8 | A | Inactive | 1 | 72 | - | - | - | - | GlgA glycogen synthase | - |
suvorexant
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Yin J, Babaoglu K, Brautigam CA, Clark L, Shao Z, Scheuermann TH, Harrell CM, Gotter AL, Roecker AJ, Winrow CJ, Renger JJ, Coleman PJ, Rosenbaum DM | 10.1038/NSMB.3183 | 2016-03-09 | Yes | |
OX1R | OX1 | Orexin | A | Human | X-ray | 4ZJC | 4ZJC_refined | 2.8 | A | Inactive | 1 | 72 | - | - | - | - | GlgA glycogen synthase | - |
SB-674042
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | - | - | 2016-03-09 | Yes | |
OPSD | Rhodopsin | Opsins | A | Human | X-ray | 5DGY | 5DGY_refined | 7.7 | A | Active | 100 | 94 | Visual | S-arrestin | - | 86 | T4-Lysozyme | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Zhou XE, Gao X, Barty A, Kang Y, He Y, Liu W, Ishchenko A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Suino-Powell KM, Boutet S, Williams GJ, Wang M, Li D, Caffrey M, Chapman HN, Spence JC, Fromme P, Weierstall U, Stevens RC, Cherezov V, Melcher K, Xu HE | 10.1038/SDATA.2016.21 | 2016-03-23 | Yes | |
GLR | glucagon | Glucagon | B1 | Human | X-ray | 5EE7 | 5EE7_refined | 2.5 | A | Inactive | 0 | 54 | - | - | - | - | T4-Lysozyme | - |
Octaethylene glycol monoethyl ether
MK-0893 |
small-molecule small-molecule |
Antagonist NAM |
glucagon | peptide | No | No | Jazayeri A, Dore AS, Lamb D, Krishnamurthy H, Southall SM, Baig AH, Bortolato A, Koglin M, Robertson NJ, Errey JC, Andrews SP, Teobald I, Brown AJ, Cooke RM, Weir M, Marshall FH | 10.1038/NATURE17414 | 2016-04-20 | Yes | |
CRFR1 | CRF1 | Corticotropin-releasing factor | B1 | Human | X-ray | 4Z9G | - | 3.2 | A | Inactive | 17 | 63 | - | - | - | - | T4-Lysozyme | - |
CP 376,395
|
small-molecule | Antagonist | urocortin 2, corticotrophin-releasing hormone, urocortin 1 | peptide | No | No | Dore AS, Bortolato A, Hollenstein K, Cheng RKY, Read RJ, Marshall FH | 10.2174/1874467210666170110114727 | 2016-06-29 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5IU7 | 5IU7_refined | 1.9 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
2-(Furan-2-yl)-5-N-[2-(4-phenylpiperidin-1-yl)ethyl]-1H-[1,2,4]triazolo[1,5-a][1,3,5]triazin-8-ium-5,7-diamine
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Segala E, Guo D, Cheng RK, Bortolato A, Deflorian F, Doré AS, Errey JC, Heitman LH, IJzerman AP, Marshall FH, Cooke RM. | 10.1021/acs.jmedchem.6b00653 | 2016-06-29 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5IUA | 5IUA_refined | 2.2 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
2-(Furan-2-yl)-5-N-[3-(4-phenylpiperazin-1-yl)propyl]-1H-[1,2,4]triazolo[1,5-a][1,3,5]triazin-8-ium-5,7-diamine
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Segala E, Guo D, Cheng RK, Bortolato A, Deflorian F, Doré AS, Errey JC, Heitman LH, IJzerman AP, Marshall FH, Cooke RM. | 10.1021/acs.jmedchem.6b00653 | 2016-06-29 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 5JQH | 5JQH_refined | 3.2 | A | Inactive | 0 | 70 | - | - | - | - | T4-Lysozyme | Nanobody |
Carazolol
|
small-molecule | Inverse agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, Kobilka BK, Costa T, Lefkowitz RJ | 10.1038/NATURE18636 | 2016-07-13 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5G53 | 5G53_refined | 3.4 | A | Active | 100 | 68 | Gs | αs | Engineered G protein | 50 | - | - |
NECA
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Carpenter B, Nehme R, Warne T, Leslie AG, Tate CG | 10.1038/NATURE18966 | 2016-08-03 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 5DYS | 5DYS_refined | 2.3 | A | Active | 98 | 94 | - | - | - | - | - | - |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | Singhal A, Guo Y, Matkovic M, Schertler G, Deupi X, Yan EC, Standfuss J | 10.15252/EMBR.201642671 | 2016-08-10 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 5D6L | 5D6L_refined | 3.2 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
Carazolol
|
small-molecule | Inverse agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | Ma P, Weichert D, Aleksandrov LA, Jensen TJ, Riordan JR, Liu X, Kobilka BK, Caffrey M | 10.1038/NPROT.2017.057 | 2016-08-17 | Yes | |
EDNRB | ETB | Endothelin | A | Human | X-ray | 5GLI | 5GLI_refined | 2.5 | A | Inactive | 4 | 71 | - | - | - | - | T4-Lysozyme | - |
Apo (no ligand)
|
none | Apo (no ligand) | endothelin-1, endothelin-2, endothelin-3 | peptide | No | No | - | 10.1038/nature19319 | 2016-09-07 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5K2A | 5K2A_refined | 2.5 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Batyuk A, Galli L, Ishchenko A, Han GW, Gati C, Popov PA, Lee MY, Stauch B, White TA, Barty A, Aquila A, Hunter MS, Liang M, Boutet S, Pu M, Liu ZJ, Nelson G, James D, Li C, Zhao Y, Spence JC, Liu W, Fromme P, Katritch V, Weierstall U, Stevens RC, Cherezov V | 10.1126/SCIADV.1600292 | 2016-09-21 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5K2B | 5K2B_refined | 2.5 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Batyuk A, Galli L, Ishchenko A, Han GW, Gati C, Popov PA, Lee MY, Stauch B, White TA, Barty A, Aquila A, Hunter MS, Liang M, Boutet S, Pu M, Liu ZJ, Nelson G, James D, Li C, Zhao Y, Spence JC, Liu W, Fromme P, Katritch V, Weierstall U, Stevens RC, Cherezov V | 10.1126/SCIADV.1600292 | 2016-09-21 | Yes | |
CCR2 | CCR2 | Chemokine | A | Human | X-ray | 5T1A | 5T1A_refined | 2.8 | A | Inactive | 16 | 76 | - | - | - | - | T4-Lysozyme | - |
CCR2-RA-[R]
BMS-681 |
small-molecule small-molecule |
Allosteric antagonist Antagonist |
CCL2, CCL8, CCL11, CCL13, CCL24, CCL7, CCL26, CCL16 | peptide | No | No | Zheng Y, Qin L, Zacarias NV, de Vries H, Han GW, Gustavsson M, Dabros M, Zhao C, Cherney RJ, Carter P, Stamos D, Abagyan R, Cherezov V, Stevens RC, IJzerman AP, Heitman LH, Tebben A, Kufareva I, Handel TM | 10.1038/NATURE20605 | 2016-12-14 | Yes | |
5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | Human | X-ray | 5TVN | 5TVN_refined | 2.9 | A | Intermediate | 44 | 61 | - | - | - | - | BRIL | - |
Lysergide
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Wacker D, Wang S, McCorvy JD, Betz RM, Venkatakrishnan AJ, Levit A, Lansu K, Schools ZL, Che T, Nichols DE, Shoichet BK, Dror RO, Roth BL | 10.1016/J.CELL.2016.12.033 | 2017-02-01 | Yes | |
AGTR2 | AT2 | Angiotensin | A | Human | X-ray | 5UNH | 5UNH_refined | 2.9 | B | Active | 99 | 75 | - | - | - | - | BRIL | - |
compound 2 [PMID: 28379944]
|
small-molecule | Antagonist | angiotensin-(1-7), angiotensin II, angiotensin III | peptide | No | No | Zhang H, Han GW, Batyuk A, Ishchenko A, White KL, Patel N, Sadybekov A, Zamlynny B, Rudd MT, Hollenstein K, Tolstikova A, White TA, Hunter MS, Weierstall U, Liu W, Babaoglu K, Moore EL, Katz RD, Shipman JM, Garcia-Calvo M, Sharma S, Sheth P, Soisson SM, Stevens RC, Katritch V, Cherezov V | 10.1038/NATURE22035 | 2017-04-05 | Yes | |
PAR2 | PAR2 | Proteinase-activated | A | Human | X-ray | 5NDZ | 5NDZ_refined | 3.6 | A | Intermediate | 44 | 74 | - | - | - | - | BRIL | - |
AZ3451
|
small-molecule | Allosteric antagonist | - | - | No | Yes | Cheng RKY, Fiez-Vandal C, Schlenker O, Edman K, Aggeler B, Brown DG, Brown GA, Cooke RM, Dumelin CE, Dore AS, Geschwindner S, Grebner C, Hermansson NO, Jazayeri A, Johansson P, Leong L, Prihandoko R, Rappas M, Soutter H, Snijder A, Sundstrom L, Tehan B, Thornton P, Troast D, Wiggin G, Zhukov A, Marshall FH, Dekker N | 10.1038/NATURE22309 | 2017-05-03 | Yes | |
PAR2 | PAR2 | Proteinase-activated | A | Human | X-ray | 5NJ6 | 5NJ6_refined | 4.0 | A | Intermediate | 44 | 74 | - | - | - | - | BRIL | Fab3949 | - | - | - | - | - | No | No | Cheng RKY, Fiez-Vandal C, Schlenker O, Edman K, Aggeler B, Brown DG, Brown GA, Cooke RM, Dumelin CE, Dore AS, Geschwindner S, Grebner C, Hermansson NO, Jazayeri A, Johansson P, Leong L, Prihandoko R, Rappas M, Soutter H, Snijder A, Sundstrom L, Tehan B, Thornton P, Troast D, Wiggin G, Zhukov A, Marshall FH, Dekker N | 10.1038/NATURE22309 | 2017-05-03 | Yes | |
CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 5UZ7 | - | 4.1 | R | Active | 100 | 56 | Gs | αs | - | 47 | - | - |
calcitonin (salmon synthetic)
|
small-molecule | Agonist | β-CGRP, α-CGRP, calcitonin, calcitonin (salmon), amylin, adrenomedullin, adrenomedullin 2/intermedin | peptide | No | No | Liang YL, Khoshouei M, Radjainia M, Zhang Y, Glukhova A, Tarrasch J, Thal DM, Furness SGB, Christopoulos G, Coudrat T, Danev R, Baumeister W, Miller LJ, Christopoulos A, Kobilka BK, Wootten D, Skiniotis G, Sexton PM | 10.1038/NATURE22327 | 2017-05-03 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5UVI | 5UVI_refined | 3.2 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Martin-Garcia JM, Conrad CE, Nelson G, Stander N, Zatsepin NA, Zook J, Zhu L, Geiger J, Chun E, Kissick D, Hilgart MC, Ogata C, Ishchenko A, Nagaratnam N, Roy-Chowdhury S, Coe J, Subramanian G, Schaffer A, James D, Ketwala G, Venugopalan N, Xu S, Corcoran S, Ferguson D, Weierstall U, Spence JCH, Cherezov V, Fromme P, Fischetti RF, Liu W | 10.1107/S205225251700570X | 2017-05-24 | Yes | |
SMO | SMO | Frizzled | F | Human | X-ray | 5V56 | 5V56_refined | 2.9 | B | Inactive | 1 | 61 | - | - | - | - | Flavodoxin | - |
N-methyl-N-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-4-nitro-2-(trifluoromethyl)benzamide
|
small-molecule | Antagonist | - | - | No | No | - | - | 2017-05-24 | Yes | |
SMO | SMO | Frizzled | F | Human | X-ray | 5V57 | 5V57_refined | 3.0 | A | Inactive | 1 | 62 | - | - | - | - | Flavodoxin | - |
N-methyl-N-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-4-nitro-2-(trifluoromethyl)benzamide
|
small-molecule | Antagonist | - | - | No | No | Zhang X, Zhao F, Wu Y, Yang J, Han GW, Zhao S, Ishchenko A, Ye L, Lin X, Ding K, Dharmarajan V, Griffin PR, Gati C, Nelson G, Hunter MS, Hanson MA, Cherezov V, Stevens RC, Tan W, Tao H, Xu F | 10.1038/NCOMMS15383 | 2017-05-24 | Yes | |
G1SGD4 | GLP-1 | Glucagon | B1 | Rabbit | Cryo-EM | 5VAI | - | 4.1 | R | Active | 100 | 84 | Gs | αs | - | 59 | - | - |
CHEMBL410972
|
protein | Agonist | - | - | No | No | Zhang Y, Sun B, Feng D, Hu H, Chu M, Qu Q, Tarrasch JT, Li S, Sun Kobilka T, Kobilka BK, Skiniotis G | 10.1038/NATURE22394 | 2017-05-24 | Yes | |
GLR | glucagon | Glucagon | B1 | Human | X-ray | 5XEZ | 5XEZ_refined | 3.0 | B | Inactive | 0 | 82 | - | - | - | - | T4-Lysozyme | Antibody |
NNC0640
|
small-molecule | NAM | glucagon | peptide | No | No | Zhang H, Qiao A, Yang D, Yang L, Dai A, de Graaf C, Reedtz-Runge S, Dharmarajan V, Zhang H, Han GW, Grant TD, Sierra RG, Weierstall U, Nelson G, Liu W, Wu Y, Ma L, Cai X, Lin G, Wu X, Geng Z, Dong Y, Song G, Griffin PR, Lau J, Cherezov V, Yang H, Hanson MA, Stevens RC, Zhao Q, Jiang H, Wang MW, Wu B | 10.1038/NATURE22363 | 2017-05-24 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5JTB | 5JTB_refined | 2.8 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Melnikov I, Polovinkin V, Kovalev K, Gushchin I, Shevtsov M, Shevchenko V, Mishin A, Alekseev A, Rodriguez-Valera F, Borshchevskiy V, Cherezov V, Leonard GA, Gordeliy V, Popov A | 10.1126/SCIADV.1602952 | 2017-05-31 | Yes | |
APJ | apelin | Apelin | A | Human | X-ray | 5VBL | - | 2.6 | B | Inactive | 4 | 79 | - | - | - | - | Rubredoxin | - |
AMG3054
|
peptide | Agonist | apelin-13, apelin-17, apelin-36, Elabela/Toddler-21, [Pyr1]apelin-13, Elabela/Toddler-11, apelin receptor early endogenous ligand, Elabela/Toddler-32 | peptide | No | No | Ma Y, Yue Y, Ma Y, Zhang Q, Zhou Q, Song Y, Shen Y, Li X, Ma X, Li C, Hanson MA, Han GW, Sickmier EA, Swaminath G, Zhao S, Stevens RC, Hu LA, Zhong W, Zhang M, Xu F | 10.1016/J.STR.2017.04.008 | 2017-05-31 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5MZP | 5MZP_refined | 2.1 | A | Inactive | 1 | 71 | - | - | - | - | BRIL | - |
caffeine
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Cheng RKY, Segala E, Robertson N, Deflorian F, Dore AS, Errey JC, Fiez-Vandal C, Marshall FH, Cooke RM | 10.1016/j.str.2017.06.012 | 2017-07-26 | Yes | |
5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | Human | X-ray | 5TUD | 5TUD_refined | 3.0 | D | Active | 87 | 58 | - | - | - | - | BRIL | Antibody |
ergotamine
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Ishchenko A, Wacker D, Kapoor M, Zhang A, Han GW, Basu S, Patel N, Messerschmidt M, Weierstall U, Liu W, Katritch V, Roth BL, Stevens RC, Cherezov V | 10.1073/PNAS.1700891114 | 2017-07-26 | Yes | |
Q08BG4 | LPA6 | Lysophospholipid (LPA) | A | Zebrafish | X-ray | 5XSZ | 5XSZ_refined | 3.2 | A | Active | 65 | 78 | - | - | - | - | T4-Lysozyme | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Taniguchi R, Inoue A, Sayama M, Uwamizu A, Yamashita K, Hirata K, Yoshida M, Tanaka Y, Kato HE, Nakada-Nakura Y, Otani Y, Nishizawa T, Doi T, Ohwada T, Ishitani R, Aoki J, Nureki O | 10.1038/NATURE23448 | 2017-08-16 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5NLX | - | 2.1 | A | Inactive | 1 | 73 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Weinert T, Olieric N, Cheng R, Brunle S, James D, Ozerov D, Gashi D, Vera L, Marsh M, Jaeger K, Dworkowski F, Panepucci E, Basu S, Skopintsev P, Dore AS, Geng T, Cooke RM, Liang M, Prota AE, Panneels V, Nogly P, Ermler U, Schertler G, Hennig M, Steinmetz MO, Wang M, Standfuss J | 10.1038/S41467-017-00630-4 | 2017-09-27 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5NM2 | 5NM2_refined | 2.0 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Weinert T, Olieric N, Cheng R, Brunle S, James D, Ozerov D, Gashi D, Vera L, Marsh M, Jaeger K, Dworkowski F, Panepucci E, Basu S, Skopintsev P, Dore AS, Geng T, Cooke RM, Liang M, Prota AE, Panneels V, Nogly P, Ermler U, Schertler G, Hennig M, Steinmetz MO, Wang M, Standfuss J | 10.1038/S41467-017-00630-4 | 2017-09-27 | Yes | |
DRD4 | D4 | Dopamine | A | Human | X-ray | 5WIU | - | 2.0 | A | Inactive | 1 | 64 | - | - | - | - | BRIL | - |
[3H]NEMONAPRIDE
|
small-molecule | Antagonist | dopamine | small-molecule | No | No | Wang S, Wacker D, Levit A, Che T, Betz RM, McCorvy JD, Venkatakrishnan AJ, Huang XP, Dror RO, Shoichet BK, Roth BL | 10.1126/SCIENCE.AAN5468 | 2017-10-18 | Yes | |
DRD4 | D4 | Dopamine | A | Human | X-ray | 5WIV | - | 2.1 | A | Inactive | 1 | 65 | - | - | - | - | BRIL | - |
[3H]NEMONAPRIDE
|
small-molecule | Antagonist | dopamine | small-molecule | No | Yes | Wang S, Wacker D, Levit A, Che T, Betz RM, McCorvy JD, Venkatakrishnan AJ, Huang XP, Dror RO, Shoichet BK, Roth BL | 10.1126/SCIENCE.AAN5468 | 2017-10-18 | Yes | |
OX2R | OX2 | Orexin | A | Human | X-ray | 5WQC | 5WQC_refined | 2.0 | A | Inactive | 1 | 68 | - | - | - | - | Glycogen synthase | - |
EMPA
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Suno R, Kimura KT, Nakane T, Yamashita K, Wang J, Fujiwara T, Yamanaka Y, Im D, Horita S, Tsujimoto H, Tawaramoto MS, Hirokawa T, Nango E, Tono K, Kameshima T, Hatsui T, Joti Y, Yabashi M, Shimamoto K, Yamamoto M, Rosenbaum DM, Iwata S, Shimamura T, Kobayashi T | 10.1016/J.STR.2017.11.005 | 2017-11-29 | Yes | |
CXCR4 | CXCR4 | Chemokine | A | Human | X-ray | 3OE9 | 3OE9_refined | 3.1 | A | Inactive | 4 | 74 | - | - | - | - | T4-Lysozyme | - |
isothiourea-1t
|
small-molecule | Antagonist | CXCL12γ, CXCL12ε, CXCL12, CXCL12δ, CXCL12β, CXCL12φ, CXCL12α | peptide | No | No | - | 10.1126/SCIENCE.1194396 | 2010-10-27 | Yes | |
S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | X-ray | 3V2W | 3V2W_refined | 3.4 | A | Inactive | 1 | 68 | - | - | - | - | T4-Lysozyme | - |
W146
|
small-molecule | Antagonist | sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate, sphingosine 1-phosphate | small-molecule | No | No | Hanson MA, Roth CB, Jo E, Griffith MT, Scott FL, Reinhart G, Desale H, Clemons B, Cahalan SM, Schuerer SC, Sanna MG, Han GW, Kuhn P, Rosen H, Stevens RC | 10.1126/SCIENCE.1215904 | 2012-02-15 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 3ZEV | 3ZEV_refined | 3.0 | A | Inactive | 3 | 72 | - | - | - | - | - | - |
neurotensin
|
peptide | Agonist | neuromedin N, neurotensin | peptide | No | No | Egloff P, Hillenbrand M, Klenk C, Batyuk A, Heine P, Balada S, Schlinkmann KM, Scott DJ, Schutz M, Pluckthun A | 10.1073/PNAS.1317903111 | 2014-01-29 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 5A8E | 5A8E_refined | 2.4 | A | Inactive | 0 | 59 | - | - | - | - | - | - |
7-methylcyanopindolol
|
small-molecule | Inverse agonist | - | - | No | Yes | Sato T, Baker J, Warne T, Brown GA, Leslie AG, Congreve M, Tate CG | 10.1124/MOL.115.101030 | 2015-09-30 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5IUB | 5IUB_refined | 2.1 | A | Inactive | 1 | 71 | - | - | - | - | BRIL | - |
CHEMBL184061
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Segala E, Guo D, Cheng RK, Bortolato A, Deflorian F, Doré AS, Errey JC, Heitman LH, IJzerman AP, Marshall FH, Cooke RM. | 10.1021/acs.jmedchem.6b00653 | 2016-06-29 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | X-ray | 5VEX | 5VEX_refined | 3.0 | B | Inactive | 0 | 57 | - | - | - | - | T4-Lysozyme | - |
NNC0640
|
small-molecule | NAM | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Song G, Yang D, Wang Y, de Graaf C, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han GW, Lau J, Wu B, Hanson MA, Liu ZJ, Wang MW, Stevens RC | 10.1038/NATURE22378 | 2017-05-17 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 5WKT | 5WKT_refined | 3.2 | A | Active | 100 | 94 | Gi/o | αt1 | Only H5 | 3 | - | - |
B-Octylglucoside
|
small-molecule | unknown | - | - | No | No | Broecker J, Morizumi T, Ou WL, Klingel V, Kuo A, Kissick DJ, Ishchenko A, Lee MY, Xu S, Makarov O, Cherezov V, Ogata CM, Ernst OP | 10.1038/NPROT.2017.135 | 2017-12-13 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 6FK6 | 6FK6_refined | 2.4 | A | Active | 98 | 94 | - | - | - | - | - | - |
COMPOUND SUMMARY
|
small-molecule | Agonist | - | - | No | No | Mattle D, Kuhn B, Aebi J, Bedoucha M, Kekilli D, Grozinger N, Alker A, Rudolph MG, Schmid G, Schertler GFX, Hennig M, Standfuss J, Dawson RJP | 10.1073/PNAS.1718084115 | 2018-04-04 | Yes | |
AGTR2 | AT2 | Angiotensin | A | Human | X-ray | 5XJM | 5XJM_refined | 3.2 | A | Active | 100 | 78 | - | - | - | - | BRIL | Fab |
CHEMBL404594
|
protein | Agonist | angiotensin-(1-7), angiotensin II, angiotensin III | peptide | No | No | Asada H, Horita S, Hirata K, Shiroishi M, Shiimura Y, Iwanari H, Hamakubo T, Shimamura T, Nomura N, Kusano-Arai O, Uemura T, Suno C, Kobayashi T, Iwata S | 10.1038/S41594-018-0079-8 | 2018-07-11 | Yes | |
CCR5 | CCR5 | Chemokine | A | Human | Cryo-EM | 6MET | 6MET_refined | 4.5 | B | Inactive | 16 | 89 | - | - | - | - | - | T-cell surface glycoprotein CD4 |
Envelope glycoprotein gp160
|
protein | Antagonist | CCL2, CCL8, CCL11, CCL13, CCL14, CCL7, CCL5, CCL4, CCL16, CCL3 | peptide | No | No | - | - | 2018-12-12 | Yes | |
DRD3 | D3 | Dopamine | A | Human | X-ray | 3PBL | 3PBL_refined | 2.9 | A | Inactive | 1 | 68 | - | - | - | - | T4-Lysozyme | - |
eticlopride
|
small-molecule | Antagonist | dopamine | small-molecule | No | No | - | 10.1126/SCIENCE.1197410 | 2010-11-03 | Yes | |
OPRK | κ | Opioid | A | Human | X-ray | 4DJH | 4DJH_refined | 2.9 | A | Inactive | 4 | 76 | - | - | - | - | T4-Lysozyme | - |
JDTic
|
small-molecule | Antagonist | dynorphin A-(1-8), β-neoendorphin, big dynorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, β-endorphin, dynorphin A-(1-13), dynorphin B, α-neoendorphin | peptide | No | No | Wu H, Wacker D, Mileni M, Katritch V, Han GW, Vardy E, Liu W, Thompson AA, Huang XP, Carroll FI, Mascarella SW, Westkaemper RB, Mosier PD, Roth BL, Cherezov V, Stevens RC | 10.1038/NATURE10939 | 2012-03-21 | Yes | |
P2Y12 | P2Y12 | P2Y | A | Human | X-ray | 4PXZ | 4PXZ_refined | 2.5 | A | Intermediate | 44 | 84 | - | - | - | - | BRIL | - |
2MeSADP
|
small-molecule | Agonist | ADP, ATP | small-molecule | No | No | Zhang J, Zhang K, Gao ZG, Paoletta S, Zhang D, Han GW, Li T, Ma L, Zhang W, Muller CE, Yang H, Jiang H, Cherezov V, Katritch V, Jacobson KA, Stevens RC, Wu B, Zhao Q | 10.1038/NATURE13288 | 2014-04-30 | Yes | |
OPRX | NOP | Opioid | A | Human | X-ray | 5DHG | 5DHG_refined | 3.0 | A | Inactive | 4 | 76 | - | - | - | - | BRIL | - |
CHEMBL1783826
|
small-molecule | Antagonist | nociceptin/orphanin FQ | peptide | No | No | Miller RL, Thompson AA, Trapella C, Guerrini R, Malfacini D, Patel N, Han GW, Cherezov V, Calo G, Katritch V, Stevens RC | 10.1016/J.STR.2015.07.024 | 2015-10-21 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5K2D | 5K2D_refined | 1.9 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Batyuk A, Galli L, Ishchenko A, Han GW, Gati C, Popov PA, Lee MY, Stauch B, White TA, Barty A, Aquila A, Hunter MS, Liang M, Boutet S, Pu M, Liu ZJ, Nelson G, James D, Li C, Zhao Y, Spence JC, Liu W, Fromme P, Katritch V, Weierstall U, Stevens RC, Cherezov V | 10.1126/SCIADV.1600292 | 2016-09-21 | Yes | |
FFAR1 | FFA1 | Free fatty acid | A | Human | X-ray | 5TZR | 5TZR_refined | 2.2 | A | Intermediate | 44 | 91 | - | - | - | - | T4-Lysozyme | - |
MK-8666
|
small-molecule | Allosteric agonist | oleic acid, docosahexaenoic acid, α-linolenic acid, myristic acid | small-molecule | No | No | Lu J, Byrne N, Wang J, Bricogne G, Brown FK, Chobanian HR, Colletti SL, Di Salvo J, Thomas-Fowlkes B, Guo Y, Hall DL, Hadix J, Hastings NB, Hermes JD, Ho T, Howard AD, Josien H, Kornienko M, Lumb KJ, Miller MW, Patel SB, Pio B, Plummer CW, Sherborne BS, Sheth P, Souza S, Tummala S, Vonrhein C, Webb M, Allen SJ, Johnston JM, Weinglass AB, Sharma S, Soisson SM | 10.1038/NSMB.3417 | 2017-06-07 | Yes | |
OX2R | OX2 | Orexin | A | Human | X-ray | 5WS3 | 5WS3_refined | 2.3 | A | Inactive | 1 | 70 | - | - | - | - | Glycogen synthase | - |
EMPA
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Suno R, Kimura KT, Nakane T, Yamashita K, Wang J, Fujiwara T, Yamanaka Y, Im D, Horita S, Tsujimoto H, Tawaramoto MS, Hirokawa T, Nango E, Tono K, Kameshima T, Hatsui T, Joti Y, Yabashi M, Shimamoto K, Yamamoto M, Rosenbaum DM, Iwata S, Shimamura T, Kobayashi T | 10.1016/J.STR.2017.11.005 | 2017-12-13 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 6FKA | 6FKA_refined | 2.7 | A | Active | 98 | 94 | - | - | - | - | - | - |
(2~{S})-2-(3,4-dichlorophenyl)-3-methyl-1-spiro[1,3-benzodioxole-2,4'-piperidine]-1'-yl-butan-1-one
|
small-molecule | Agonist | - | - | No | No | Mattle D, Kuhn B, Aebi J, Bedoucha M, Kekilli D, Grozinger N, Alker A, Rudolph MG, Schmid G, Schertler GFX, Hennig M, Standfuss J, Dawson RJP | 10.1073/PNAS.1718084115 | 2018-04-04 | Yes | |
5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | Human | X-ray | 6DS0 | 6DS0_refined | 3.2 | A | Intermediate | 44 | 59 | - | - | - | - | BRIL | - |
LY266097
|
small-molecule | Antagonist | 5-hydroxytryptamine | small-molecule | No | No | McCorvy JD, Wacker D, Wang S, Agegnehu B, Liu J, Lansu K, Tribo AR, Olsen RHJ, Che T, Jin J, Roth BL | 10.1038/s41594-018-0116-7 | 2018-08-29 | Yes | |
ACM3 | M3 | Acetylcholine (muscarinic) | A | Rat | X-ray | 5ZHP | 5ZHP_refined | 3.1 | B | Inactive | 2 | 47 | - | - | - | - | T4-Lysozyme | - |
(1R,2R,4S,5S,7s)-7-({[4-fluoro-2-(thiophen-2-yl)phenyl]carbamoyl}oxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]nonan-9-ium
|
small-molecule | Antagonist | acetylcholine | small-molecule | No | No | - | 10.1073/PNAS.1813988115 | 2018-11-28 | Yes | |
MTR1B | MT2 | Melatonin | A | Human | X-ray | 6ME8 | 6ME8_refined | 3.1 | B | Inactive | 1 | 78 | - | - | - | - | Rubredoxin | - |
CHEMBL15060
|
small-molecule | Agonist | melatonin | small-molecule | No | No | - | - | 2019-04-24 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | X-ray | 6KK7 | 6KK7_refined | 3.1 | B | Inactive | 0 | 56 | - | - | - | - | T4-Lysozyme | - |
PF-06372222
|
small-molecule | NAM | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | - | - | 2019-11-13 | Yes | |
OX1R | OX1 | Orexin | A | Human | X-ray | 6TOT | 6TOT_refined | 2.2 | B | Inactive | 1 | 71 | - | - | - | - | - | - |
lemborexant
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-15 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 6OBA | 6OBA_refined | 3.1 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
CHEMBL1160734
AS408 |
small-molecule small-molecule |
Antagonist NAM |
noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | Liu X, Kaindl J, Korczynska M, Stossel A, Dengler D, Stanek M, Hubner H, Clark MJ, Mahoney J, Matt RA, Xu X, Hirata K, Shoichet BK, Sunahara RK, Kobilka BK, Gmeiner P | 10.1038/S41589-020-0549-2 | 2020-03-25 | Yes | |
GABR2 | GABAB2 | GABAB | C | Human | Cryo-EM | 7C7Q | - | 3.0 | B | Active | - | 71 | - | - | - | - | - | - |
(-)-baclofen
BHFF |
small-molecule small-molecule |
Agonist PAM |
- | - | No | No | Mao C, Shen C, Li C, Shen DD, Xu C, Zhang S, Zhou R, Shen Q, Chen LN, Jiang Z, Liu J, Zhang Y | 10.1038/S41422-020-0350-5 | 2020-07-01 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 6ZDV | 6ZDV_refined | 2.1 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
2-Methyl-3-(4-methylthiazol-2-yl)-4-oxo-6-propyl-4H-chromen-7-yl acetate
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Jespers W, Verdon G, Azuaje J, Majellaro M, Keranen H, Garcia-Mera X, Congreve M, Deflorian F, de Graaf C, Zhukov A, Dore AS, Mason JS, Aqvist J, Cooke RM, Sotelo E, Gutierrez-de-Teran H | 10.1002/ANIE.202003788 | 2020-09-16 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 6XOX | - | 3.1 | R | Active | 100 | 82 | Gs | αs | - | 56 | - | scFv16 Nanobody-35 |
orforglipron
|
small-molecule | Agonist | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Kawai T, Sun B, Yoshino H, Feng D, Suzuki Y, Fukazawa M, Nagao S, Wainscott DB, Showalter AD, Droz BA, Kobilka TS, Coghlan MP, Willard FS, Kawabe Y, Kobilka BK, Sloop KW | 10.1073/PNAS.2014879117 | 2020-11-18 | Yes | |
DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7JVP | - | 2.9 | R | Active | 100 | 63 | Gs | αs | - | 60 | - | Nanobody-35 |
39YLC3L0ZU
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, 5-hydroxytryptamine, dopamine | small-molecule | No | No | - | - | 2021-02-24 | Yes | |
V2R | V2 | Vasopressin and oxytocin | A | Human | Cryo-EM | 7KH0 | - | 2.8 | R | Active | 100 | 74 | Gs | αs | - | 58 | - | scFv16 Nanobody-35 |
vasopressin
|
peptide | Agonist | oxytocin, vasopressin | peptide | No | No | Wang L, Xu J, Cao S, Sun D, Liu H, Lu Q, Liu Z, Du Y, Zhang C | 10.1038/S41422-021-00483-Z | 2021-05-26 | Yes | |
CCR5 | CCR5 | Chemokine | A | Human | Cryo-EM | 7F1Q | - | 2.9 | R | Active | 100 | 85 | Gi/o | αi1 | - | 61 | - | - |
CCL3
|
peptide | Agonist | CCL2, CCL8, CCL11, CCL13, CCL14, CCL7, CCL5, CCL4, CCL16, CCL3 | peptide | No | No | - | - | 2021-07-14 | Yes | |
GHSR | ghrelin | Ghrelin | A | Human | Cryo-EM | 7F9Z | 7F9Z_refined | 3.2 | R | Active | 100 | 77 | Gq/11 | αq | Engineered G alpha | 59 | - | Nanobody-35 scFv16 |
GHRP-6
|
peptide | Agonist | [des-Gln14]ghrelin, ghrelin | peptide | No | No | - | - | 2021-08-18 | Yes | |
ACM1 | M1 | Acetylcholine (muscarinic) | A | Human | X-ray | 6ZFZ | 6ZFZ_refined | 2.2 | A | Inactive | 2 | 62 | - | - | - | - | T4-Lysozyme | - |
CHEMBL3354065
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | Brown AJH, Bradley SJ, Marshall FH, Brown GA, Bennett KA, Brown J, Cansfield JE, Cross DM, de Graaf C, Hudson BD, Dwomoh L, Dias JM, Errey JC, Hurrell E, Liptrot J, Mattedi G, Molloy C, Nathan PJ, Okrasa K, Osborne G, Patel JC, Pickworth M, Robertson N, Shahabi S, Bundgaard C, Phillips K, Broad LM, Goonawardena AV, Morairty SR, Browning M, Perini F, Dawson GR, Deakin JFW, Smith RT, Sexton PM, Warneck J, Vinson M, Tasker T, Tehan BG, Teobald B, Christopoulos A, Langmead CJ, Jazayeri A, Cooke RM, Rucktooa P, Congreve MS, Weir M, Tobin AB | 10.1016/J.CELL.2021.11.001 | 2021-10-06 | Yes | |
CNR1 | CB1 | Cannabinoid | A | Human | X-ray | 7V3Z | 7V3Z_refined | 3.3 | A | Active | 91 | 60 | - | - | - | - | Flavodoxin | - |
CP55940
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Wang X, Liu D, Shen L, Li F, Li Y, Yang L, Xu T, Tao H, Yao D, Wu L, Hirata K, Bohn LM, Makriyannis A, Liu X, Hua T, Liu ZJ, Wang J | 10.1021/JACS.1C06847 | 2021-11-24 | Yes | |
NK1R | NK1 | Tachykinin | A | Human | Cryo-EM | 7P02 | - | 2.9 | R | Active | 100 | 71 | Gs | αs | Gs-Gi1 chimera | 57 | - | scFv16 |
substance P
|
peptide | Agonist | neurokinin B, neuropeptide-γ, hemokinin 1, substance P, neurokinin A, neuropeptide K | peptide | No | No | Thom C, Ehrenmann J, Vacca S, Waltenspuhl Y, Schoppe J, Medalia O, Pluckthun A | 10.1126/SCIADV.ABK2872 | 2021-12-15 | Yes | |
S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7EVY | - | 3.0 | D | Active | 100 | 71 | Gi/o | αi1 | - | 64 | - | scFv16 |
siponimod
|
small-molecule | Agonist | sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate, sphingosine 1-phosphate | small-molecule | No | No | Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z | 10.1038/S41422-021-00566-X | 2021-09-29 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 7PX4 | 7PX4_refined | 2.3 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
Preladenant conjugate PSB-2113
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Claff T, Klapschinski TA, Tiruttani Subhramanyam UK, Vaassen VJ, Schlegel JG, Vielmuth C, Voss JH, Labahn J, Muller CE | 10.1002/ANIE.202115545 | 2022-03-02 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7VBI | - | 3.0 | R | Active | 100 | 83 | Gs | αs | Mini-Gs | 58 | - | - |
tirzepatide
|
peptide | Agonist | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW | 10.1038/S41467-022-28683-0 | 2022-03-02 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | Cryo-EM | 7S0F | - | 3.0 | R | Active | 100 | 56 | Gi/o | αi1 | - | 63 | - | - |
LEVISOPRENALINE
|
small-molecule | Agonist | - | - | No | No | Alegre KO, Paknejad N, Su M, Lou JS, Huang J, Jordan KD, Eng ET, Meyerson JR, Hite RK, Huang XY | 10.1038/S41594-021-00679-2 | 2021-11-17 | Yes | |
DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7F1Z | - | 3.5 | F | Active | 100 | 62 | Gs | αs | - | 60 | - | - |
dopamine
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, 5-hydroxytryptamine, dopamine | small-molecule | No | No | Teng X, Chen S, Wang Q, Chen Z, Wang X, Huang N, Zheng S | 10.1126/SCIADV.ABO4158 | 2022-06-15 | Yes | |
5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7RAN | - | 3.5 | A | Active | 100 | 57 | Gq/11 | αq | Gi2-mini-Gq chimera | 60 | - | scFv16 |
3-[(3R)-3-methyl-1,2,3,6-tetrahydropyridin-1-ium-5-yl]-1H-pyrrolo[2,3-b]pyridine
|
small-molecule | Agonist | 5-hydroxytryptamine, tryptamine | small-molecule | No | No | Kaplan AL, Confair DN, Kim K, Barros-Alvarez X, Rodriguiz RM, Yang Y, Kweon OS, Che T, McCorvy JD, Kamber DN, Phelan JP, Martins LC, Pogorelov VM, DiBerto JF, Slocum ST, Huang XP, Kumar JM, Robertson MJ, Panova O, Seven AB, Wetsel AQ, Wetsel WC, Irwin JJ, Skiniotis G, Shoichet BK, Roth BL, Ellman JA | 10.1038/S41586-022-05258-Z | 2022-07-06 | Yes | |
CX3C1 | CX3CR1 | Chemokine | A | Human | Cryo-EM | 7XBX | - | 3.4 | R | Active | 16 | 81 | Gi/o | αi1 | - | 61 | - | - |
CX3CL1
|
peptide | Agonist | CX3CL1 | peptide | No | No | - | - | 2022-07-13 | Yes | |
S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7VIE | 7VIE_refined | 2.9 | F | Active | 100 | 73 | Gi/o | αi1 | - | 64 | - | scFv16 |
sphingosine 1-phosphate
|
small-molecule | Agonist | sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate, sphingosine 1-phosphate | small-molecule | No | No | Yu L, He L, Gan B, Ti R, Xiao Q, Hu H, Zhu L, Wang S, Ren R | 10.1073/PNAS.2117716119 | 2022-09-28 | Yes | |
T2R46 | TAS2R46 | Taste 2 | T | Human | Cryo-EM | 7XP6 | - | 3.0 | R | Active | - | 92 | Gi/o | αgust | - | 63 | - | Nanobody-35 |
strychnine
|
small-molecule | Agonist | - | - | No | No | Xu W, Wu L, Liu S, Liu X, Cao X, Zhou C, Zhang J, Fu Y, Guo Y, Wu Y, Tan Q, Wang L, Liu J, Jiang L, Fan Z, Pei Y, Yu J, Cheng J, Zhao S, Hao X, Liu ZJ, Hua T | 10.1126/SCIENCE.ABO1633 | 2022-10-12 | Yes | |
OPRM | μ | Opioid | A | Human | Cryo-EM | 8EF5 | - | 3.3 | R | Active | 100 | 72 | Gi/o | αi1 | - | 64 | - | scFv16 |
fentanyl
|
small-molecule | Agonist | dynorphin A-(1-8), [Met]enkephalin, endomorphin-1, dynorphin A, [Leu]enkephalin, β-endorphin, dynorphin A-(1-13), dynorphin B, endomorphin-2 | peptide | No | No | Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE | 10.1016/J.CELL.2022.09.041 | 2022-11-09 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 7ZBC | - | 1.8 | A | Inactive | 22 | 87 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | Gruhl T, Weinert T, Rodrigues MJ, Milne CJ, Ortolani G, Nass K, Nango E, Sen S, Johnson PJM, Cirelli C, Furrer A, Mous S, Skopintsev P, James D, Dworkowski F, Bath P, Kekilli D, Ozerov D, Tanaka R, Glover H, Bacellar C, Brunle S, Casadei CM, Diethelm AD, Gashi D, Gotthard G, Guixa-Gonzalez R, Joti Y, Kabanova V, Knopp G, Lesca E, Ma P, Martiel I, Muhle J, Owada S, Pamula F, Sarabi D, Tejero O, Tsai CJ, Varma N, Wach A, Boutet S, Tono K, Nogly P, Deupi X, Iwata S, Neutze R, Standfuss J, Schertler G, Panneels V | 10.1038/S41586-023-05863-6 | 2023-03-29 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 8GNG | 8GNG_refined | 3.2 | X | Inactive | 1 | 69 | - | - | - | - | - | Antibody fab fragment light chain Antibody fab fragment heavy chain |
istradefylline
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | - | - | 2023-03-22 | Yes | |
FFAR4 | FFA4 | Free fatty acid | A | Human | Cryo-EM | 8ID9 | 8ID9_refined | 3.0 | R | Active | 100 | 78 | Gi/o | αi1 | - | 56 | - | scFv16 |
EPA
|
small-molecule | Agonist | linoleic acid, oleic acid, α-linolenic acid, myristic acid | small-molecule | No | No | - | 10.1126/SCIENCE.ADD6220 | 2023-03-15 | Yes | |
CNR2 | CB2 | Cannabinoid | A | Human | Cryo-EM | 8GUS | - | 3.0 | R | Active | 100 | 81 | Gi/o | αi1 | - | 62 | - | scFv16 |
CHEMBL2179724
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Li X, Chang H, Bouma J, de Paus LV, Mukhopadhyay P, Paloczi J, Mustafa M, van der Horst C, Kumar SS, Wu L, Yu Y, van den Berg RJBHN, Janssen APA, Lichtman A, Liu ZJ, Pacher P, van der Stelt M, Heitman LH, Hua T | 10.1038/S41467-023-37112-9 | 2023-05-10 | Yes | |
SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7YAC | 7YAC_refined | 3.2 | E | Active | 100 | 76 | Gi/o | αi1 | - | 64 | - | scFv16 |
Paltusotine
|
small-molecule | Agonist | SRIF-14, CST-17, cortistatin-14, SRIF-28 | peptide | No | No | Zhao J, Fu H, Yu J, Hong W, Tian X, Qi J, Sun S, Zhao C, Wu C, Xu Z, Cheng L, Chai R, Yan W, Wei X, Shao Z | 10.1038/S41467-023-36673-Z | 2023-04-19 | Yes | |
AGRE5 | ADGRE5 | ADGRE | B2 | Human | Cryo-EM | 7YDJ | - | 3.0 | R | Active | - | 33 | G12/13 | α12 | Mini-G12 | 55 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | - | 2023-07-12 | Yes | |
CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 8F0J | - | 2.0 | R | Active | 100 | 78 | Gs | αs | - | 58 | - | Nanobody-35 |
Pramlintide analogue San45
|
peptide | Agonist | β-CGRP, α-CGRP, calcitonin, calcitonin (salmon), amylin, adrenomedullin, adrenomedullin 2/intermedin | peptide | No | No | Cao J, Belousoff MJ, Gerrard E, Danev R, Fletcher MM, Dal Maso E, Schreuder H, Lorenz K, Evers A, Tiwari G, Besenius M, Li Z, Johnson RM, Wootten D, Sexton PM | 10.1038/S41589-023-01393-4 | 2023-08-02 | Yes | |
GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 8JD3 | - | 3.3 | 2 | Active | - | 89 | Gi/o | αi1 | - | 62 | - | - |
L-glutamic acid
JNJ-40411813 |
small-molecule small-molecule |
Agonist PAM |
L-glutamic acid | small-molecule | No | No | Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B | 10.1038/S41422-023-00830-2 | 2023-06-21 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 2Y00 | 2Y00_refined | 2.5 | B | Inactive | 0 | 62 | - | - | - | - | - | - |
Dobutamine
|
small-molecule | Agonist (partial) | - | - | No | No | - | 10.1038/NATURE09746 | 2011-01-12 | Yes | |
ACM3 | M3 | Acetylcholine (muscarinic) | A | Rat | X-ray | 4DAJ | - | 3.4 | A | Inactive | 2 | 46 | - | - | - | - | T4-Lysozyme | - |
tiotropium
|
small-molecule | Antagonist | acetylcholine | small-molecule | No | No | Kruse AC, Hu J, Pan AC, Arlow DH, Rosenbaum DM, Rosemond E, Green HF, Liu T, Chae PS, Dror RO, Shaw DE, Weis WI, Wess J, Kobilka BK | 10.1038/NATURE10867 | 2012-02-22 | Yes | |
CXCR4 | CXCR4 | Chemokine | A | Human | X-ray | 4RWS | 4RWS_refined | 3.1 | A | Inactive | 4 | 78 | - | - | - | - | T4-Lysozyme | - |
vMIP-II
|
peptide | Antagonist | CXCL12γ, CXCL12ε, CXCL12, CXCL12δ, CXCL12β, CXCL12φ, CXCL12α | peptide | No | No | Qin L, Kufareva I, Holden LG, Wang C, Zheng Y, Zhao C, Fenalti G, Wu H, Han GW, Cherezov V, Abagyan R, Stevens RC, Handel TM | 10.1126/SCIENCE.1261064 | 2015-02-11 | Yes | |
AGTR2 | AT2 | Angiotensin | A | Human | X-ray | 5UNF | 5UNF_refined | 2.8 | A | Active | 99 | 79 | - | - | - | - | BRIL | - |
compound 1 [PMID: 28379944]
|
small-molecule | Antagonist | angiotensin-(1-7), angiotensin II, angiotensin III | peptide | No | No | Zhang H, Han GW, Batyuk A, Ishchenko A, White KL, Patel N, Sadybekov A, Zamlynny B, Rudd MT, Hollenstein K, Tolstikova A, White TA, Hunter MS, Weierstall U, Liu W, Babaoglu K, Moore EL, Katz RD, Shipman JM, Garcia-Calvo M, Sharma S, Sheth P, Soisson SM, Stevens RC, Katritch V, Cherezov V | 10.1038/NATURE22035 | 2017-04-05 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5VRA | 5VRA_refined | 2.4 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | - | - | 2017-12-13 | Yes | |
NPY1R | Y1 | Neuropeptide Y | A | Human | X-ray | 5ZBQ | 5ZBQ_refined | 2.7 | A | Inactive | 1 | 80 | - | - | - | - | T4-Lysozyme | - |
CHEMBL3747822
|
small-molecule | Antagonist | pancreatic polypeptide, neuropeptide Y, peptide YY | peptide | No | No | Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kogler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B | 10.1038/S41586-018-0046-X | 2018-04-25 | Yes | |
ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | X-ray | 5YC8 | 5YC8_refined | 2.5 | A | Inactive | 2 | 60 | - | - | - | - | BRIL | - |
N-methyl scopolamine
|
small-molecule | Antagonist | acetylcholine | small-molecule | No | No | Suno R, Lee S, Maeda S, Yasuda S, Yamashita K, Hirata K, Horita S, Tawaramoto MS, Tsujimoto H, Murata T, Kinoshita M, Yamamoto M, Kobilka BK, Vaidehi N, Iwata S, Kobayashi T | 10.1038/S41589-018-0152-Y | 2018-11-21 | Yes | |
GRM5 | mGlu5 | Metabotropic glutamate | C | Human | Cryo-EM | 6N52 | 6N52_refined | 4.0 | A | Inactive | - | 64 | - | - | - | - | - | Nanobody-43 | - | - | - | L-glutamic acid | small-molecule | No | No | - | - | 2019-01-23 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | Cryo-EM | 6OYA | - | 3.3 | R | Active | 100 | 94 | Gi/o | αt1 | - | 59 | - | Camelid antibody VHH fragment |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | - | - | 2019-07-24 | Yes | |
OPRD | δ | Opioid | A | Human | X-ray | 6PT2 | 6PT2_refined | 2.8 | A | Active | 65 | 78 | - | - | - | - | BRIL | - |
KGCHM07
|
peptide | Agonist | dynorphin A-(1-8), [Met]enkephalin, endomorphin-1, dynorphin A, [Leu]enkephalin, β-endorphin, dynorphin A-(1-13), dynorphin B, α-neoendorphin | peptide | No | No | - | - | 2019-12-11 | Yes | |
GPR52 | GPR52 | A orphans | A | Human | Cryo-EM | 6LI3 | - | 3.3 | R | Active | 100 | 79 | Gs | αs | Mini-Gs | 61 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Lin X, Li M, Wang N, Wu Y, Luo Z, Guo S, Han GW, Li S, Yue Y, Wei X, Xie X, Chen Y, Zhao S, Wu J, Lei M, Xu F | 10.1038/S41586-020-2019-0 | 2020-02-26 | Yes | |
GABR2 | GABAB2 | GABAB | C | Human | Cryo-EM | 6UO9 | - | 4.8 | B | Intermediate | - | 73 | - | - | - | - | - | - |
CHEMBL112710
|
small-molecule | Agonist | - | - | No | No | - | - | 2020-06-10 | Yes | |
FZD5 | FZD5 | Frizzled | F | Human | Cryo-EM | 6WW2 | 6WW2_refined | 3.7 | R | Inactive | 22 | 55 | - | - | - | - | BRIL | anti-BRIL Fab heavy chain anti-BRIL Fab light chain anti-Fab Nanobody |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Tsutsumi N, Mukherjee S, Waghray D, Janda CY, Jude KM, Miao Y, Burg JS, Aduri NG, Kossiakoff AA, Gati C, Garcia KC | 10.7554/ELIFE.58464 | 2020-08-19 | Yes | |
SMO | SMO | Frizzled | F | Human | Cryo-EM | 6XBL | - | 3.9 | R | Active | 100 | 59 | Gi/o | αi1 | - | 61 | - | scFv16 |
Cholesterol
SAG1.3 |
small-molecule small-molecule |
Agonist PAM |
- | - | No | No | Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X | 10.1038/S41589-020-0646-2 | 2020-09-30 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 6Z4V | - | 2.6 | A | Intermediate | 15 | 79 | - | - | - | - | DARPin D12 | - |
JMV431
|
peptide | Agonist | neuromedin N, neurotensin | peptide | No | No | Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PRE, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Pluckthun A | 10.1126/sciadv.abe5504 | 2021-02-10 | Yes | |
PE2R2 | EP2 | Prostanoid | A | Human | Cryo-EM | 7CX2 | - | 2.8 | R | Active | 100 | 74 | Gs | αs | - | 58 | - | Nanobody-35 |
PGE2
|
small-molecule | Agonist | PGE2, PGF2α, thromboxane A2, PGI2, PGE1, PGD2 | small-molecule | No | No | Qu C, Mao C, Xiao P, Shen Q, Zhong YN, Yang F, Shen DD, Tao X, Zhang H, Yan X, Zhao RJ, He J, Guan Y, Zhang C, Hou G, Zhang PJ, Hou G, Li Z, Yu X, Chai RJ, Guan YF, Sun JP, Zhang Y | 10.1126/SCIADV.ABF1268 | 2021-05-05 | Yes | |
CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7M3E | 7M3E_refined | 3.2 | B | Inactive | - | 75 | - | - | - | - | - | - |
Calcium
NPS 2143 L-tryptophan |
small-molecule small-molecule small-molecule |
Agonist NAM PAM |
spermine, L-tryptophan, Ca2+, Mg2+ | small-molecule | No | No | - | 10.1038/S41586-021-03691-0 | 2021-06-30 | Yes | |
AA2AR | A2A | Adenosine | A | Human | MicroED | 7RM5 | 7RM5_refined | 2.8 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Martynowycz MW, Shiriaeva A, Ge X, Hattne J, Nannenga BL, Cherezov V, Gonen T | 10.1073/PNAS.2106041118 | 2021-09-08 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7RTB | 7RTB_refined | 2.1 | R | Active | 100 | 83 | Gs | αs | - | 60 | - | Nanobody-35 |
Peptide-19
|
peptide | Agonist | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Johnson RM, Zhang X, Piper SJ, Nettleton TJ, Vandekolk TH, Langmead CJ, Danev R, Sexton PM, Wootten D | 10.1016/J.BBRC.2021.09.016 | 2021-10-06 | Yes | |
5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | X-ray | 7VOE | 7VOE_refined | 2.9 | A | Inactive | 1 | 58 | - | - | - | - | BRIL | - |
aripiprazole
|
small-molecule | Agonist (partial) | 5-hydroxytryptamine, tryptamine | small-molecule | No | No | Chen Z, Fan L, Wang H, Yu J, Lu D, Qi J, Nie F, Luo Z, Liu Z, Cheng J, Wang S | 10.1038/S41593-021-00971-W | 2021-12-22 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7LLL | - | 3.7 | R | Active | 100 | 79 | Gs | αs | - | 59 | - | Nanobody-35 |
exendin-4
|
peptide | Agonist | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Deganutti G, Liang YL, Zhang X, Khoshouei M, Clydesdale L, Belousoff MJ, Venugopal H, Truong TT, Glukhova A, Keller AN, Gregory KJ, Leach K, Christopoulos A, Danev R, Reynolds CA, Zhao P, Sexton PM, Wootten D | 10.1038/S41467-021-27760-0 | 2022-01-12 | Yes | |
LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | Cryo-EM | 7TD0 | - | 2.8 | R | Active | 100 | 80 | Gi/o | αi1 | - | 62 | - | - |
lysophosphatidic acid
|
small-molecule | Agonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY | 10.1038/S41467-022-28417-2 | 2022-02-09 | Yes | |
FPR1 | FPR1 | Formylpeptide | A | Human | Cryo-EM | 7WVU | 7WVU_refined | 3.3 | R | Active | 100 | 85 | Gi/o | αi1 | - | 62 | - | - |
FME-LEU-PHE
|
peptide | Agonist | cathepsin G, spinorphin, annexin I, fMet-Leu-Phe | peptide | No | No | Zhu Y, Lin X, Zong X, Han S, Wang M, Su Y, Ma L, Chu X, Yi C, Zhao Q, Wu B | 10.1038/S41467-022-29361-X | 2022-04-13 | Yes | |
AGRF1 | ADGRF1 | ADGRF | B2 | Human | Cryo-EM | 7WU5 | - | 3.0 | R | Active | - | 31 | Gi/o | αi1 | Mini-Gi1 | 58 | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Qu X, Qiu N, Wang M, Zhang B, Du J, Zhong Z, Xu W, Chu X, Ma L, Yi C, Han S, Shui W, Zhao Q, Wu B | 10.1038/S41586-022-04580-W | 2022-04-27 | Yes | |
ADRB3 | β3 | Adrenoceptors | A | Dog | Cryo-EM | 7XJI | - | 3.9 | R | Active | 100 | 68 | Gs | αs | - | 59 | - | Nanobody-35 |
3-[3-[2-[[(2~{S})-2-(3-chlorophenyl)-2-oxidanyl-ethyl]amino]ethylamino]phenyl]benzoic acid
|
small-molecule | Agonist | - | - | No | No | Nureki I, Kobayashi K, Tanaka T, Demura K, Inoue A, Shihoya W, Nureki O | 10.1016/J.BBRC.2022.04.065 | 2022-05-04 | Yes | |
SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7UL5 | 7UL5_refined | 3.1 | A | Inactive | 4 | 77 | - | - | - | - | - | Nanobody-6 |
Apo (no ligand)
|
none | Apo (no ligand) | SRIF-14, CST-17, cortistatin-14, SRIF-28 | peptide | No | No | Robertson MJ, Papasergi-Scott MM, He F, Seven AB, Meyerowitz JG, Panova O, Peroto MC, Che T, Skiniotis G | 10.1038/S41594-022-00859-8 | 2022-06-29 | Yes | |
5HT5A | 5-HT5A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7UM7 | 7UM7_refined | 2.8 | A | Active | 100 | 72 | Gi/o | αo | Mini-Go | 60 | - | scFv16 |
methylergonovine
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Zhang S, Chen H, Zhang C, Yang Y, Popov P, Liu J, Krumm BE, Cao C, Kim K, Xiong Y, Katritch V, Shoichet BK, Jin J, Fay JF, Roth BL | 10.1038/S41594-022-00796-6 | 2022-07-20 | Yes | |
ACKR3 | ACKR3 | Chemokine | A | Human | Cryo-EM | 7SK4 | 7SK4_refined | 3.3 | A | Active | 95 | 84 | - | - | - | - | - | CID25 Fab light chain CID25 Fab heavy chain CID24 Fab light chain CID24 Fab heavy chain |
Stromal cell-derived factor 1
|
peptide | Agonist | CXCL12α, CXCL11 | peptide | No | No | Yen YC, Schafer CT, Gustavsson M, Eberle SA, Dominik PK, Deneka D, Zhang P, Schall TJ, Kossiakoff AA, Tesmer JJG, Handel TM | 10.1126/SCIADV.ABN8063 | 2022-07-27 | Yes | |
OPRM | μ | Opioid | A | Human | Cryo-EM | 8EFQ | - | 3.3 | R | Active | 100 | 71 | Gi/o | αi1 | - | 61 | - | - |
DAMGO
|
peptide | Agonist | dynorphin A-(1-8), [Met]enkephalin, endomorphin-1, dynorphin A, [Leu]enkephalin, β-endorphin, dynorphin A-(1-13), dynorphin B, endomorphin-2 | peptide | No | No | Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE | 10.1016/J.CELL.2022.09.041 | 2022-11-09 | Yes | |
5HT6R | 5-HT6 | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7YS6 | 7YS6_refined | 3.0 | A | Active | 100 | 61 | Gs | αs | - | 59 | - | scFv16 |
5-hydroxytryptamine
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | - | - | 2023-03-29 | Yes | |
ACTHR | MC2 | Melanocortin | A | Human | Cryo-EM | 8GY7 | - | 3.3 | R | Active | 100 | 92 | Gs | αs | - | 59 | BRIL | - |
ACTH
|
peptide | Agonist | ACTH | peptide | No | No | - | 10.1038/S41422-022-00751-6 | 2023-01-11 | Yes | |
TAAR9 | TAAR9 | A orphans | A | Mouse | Cryo-EM | 8IW4 | - | 3.5 | R | Active | 100 | 85 | Gs | αs | - | 45 | - | scFv16 |
SPERMIDINE
|
small-molecule | Agonist | - | - | No | No | Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP | 10.1038/S41586-023-06106-4 | 2023-05-31 | Yes | |
OPRK | κ | Opioid | A | Human | Cryo-EM | 7Y1F | 7Y1F_refined | 3.3 | R | Active | 100 | 75 | Gi/o | αi1 | - | 61 | - | scFv16 |
dynorphin A-(1-8)
|
peptide | Agonist | dynorphin A-(1-8), β-neoendorphin, big dynorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, β-endorphin, dynorphin A-(1-13), dynorphin B, α-neoendorphin | peptide | No | No | Chen Y, Chen B, Wu T, Zhou F, Xu F | 10.1093/PROCEL/PWAC033 | 2023-05-24 | Yes | |
PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 8FLU | - | 2.8 | R | Active | 100 | 61 | Gs | αs | - | 58 | - | Nanobody-35 |
PTH
|
peptide | Agonist | PTH, PTHrP-(1-36), TIP39, PTHrP | peptide | No | No | Cary BP, Gerrard EJ, Belousoff MJ, Fletcher MM, Jiang Y, Russell IC, Piper SJ, Wootten D, Sexton PM | 10.1016/J.STR.2023.04.002 | 2023-04-26 | Yes | |
GPR52 | GPR52 | A orphans | A | Human | Cryo-EM | 8HMP | - | 2.8 | R | Active | 100 | 79 | Gs | αs | - | 61 | - | Nanobody-35 |
derivative 17 [Nakahata et al., 2018]
|
small-molecule | Agonist | - | - | No | No | Fan Y, Lin X, Pan B, Chen B, Liu D, Wuthrich K, Xu F | 10.1002/MCO2.260 | 2023-06-21 | Yes | |
GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 8JCY | - | 2.9 | 2 | Inactive | - | 87 | - | - | - | - | - | - |
LY341495
|
small-molecule | Antagonist | L-glutamic acid | small-molecule | No | No | Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B | 10.1038/S41422-023-00830-2 | 2023-06-21 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 3QAK | 3QAK_refined | 2.7 | A | Active | 65 | 69 | - | - | - | - | T4-Lysozyme | - |
UK-432,097
|
small-molecule | Agonist | adenosine | small-molecule | No | No | - | 10.1126/SCIENCE.1202793 | 2011-03-09 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 4LDO | 4LDO_refined | 3.2 | A | Active | 99 | 69 | - | - | - | - | T4-Lysozyme | Nanobody |
(-)-adrenaline
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | Ring AM, Manglik A, Kruse AC, Enos MD, Weis WI, Garcia KC, Kobilka BK | 10.1038/NATURE12572 | 2013-09-25 | Yes | |
OX2R | OX2 | Orexin | A | Human | X-ray | 4S0V | 4S0V_refined | 2.5 | A | Inactive | 1 | 64 | - | - | - | - | Glycogen synthase | - |
suvorexant
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Yin J, Mobarec JC, Kolb P, Rosenbaum DM | 10.1038/NATURE14035 | 2015-01-14 | Yes | |
ACM4 | M4 | Acetylcholine (muscarinic) | A | Human | X-ray | 5DSG | 5DSG_refined | 2.6 | B | Inactive | 2 | 60 | - | - | - | - | T4-Lysozyme | - |
tiotropium
|
small-molecule | Antagonist | acetylcholine | small-molecule | No | No | Thal DM, Sun B, Feng D, Nawaratne V, Leach K, Felder CC, Bures MG, Evans DA, Weis WI, Bachhawat P, Kobilka TS, Sexton PM, Kobilka BK, Christopoulos A | 10.1038/NATURE17188 | 2016-03-16 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 5TE3 | 5TE3_refined | 2.7 | A | Active | 98 | 94 | - | - | - | - | - | - |
B-Octylglucoside
|
small-molecule | unknown | - | - | No | No | Gulati S, Jastrzebska B, Banerjee S, Placeres AL, Miszta P, Gao S, Gunderson K, Tochtrop GP, Filipek S, Katayama K, Kiser PD, Mogi M, Stewart PL, Palczewski K | 10.1073/PNAS.1617446114 | 2017-03-15 | Yes | |
AA1R | A1 | Adenosine | A | Human | X-ray | 5N2S | 5N2S_refined | 3.3 | A | Inactive | 1 | 86 | - | - | - | - | BRIL | - |
PSB36
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Cheng RKY, Segala E, Robertson N, Deflorian F, Dore AS, Errey JC, Fiez-Vandal C, Marshall FH, Cooke RM | 10.1016/j.str.2017.06.012 | 2017-07-26 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5OLO | 5OLO_refined | 3.1 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
tozadenant
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Rucktooa P, Cheng RKY, Segala E, Geng T, Errey JC, Brown GA, Cooke RM, Marshall FH, Dore AS | 10.1038/S41598-017-18570-W | 2018-01-17 | Yes | |
OPRM | μ | Opioid | A | Mouse | Cryo-EM | 6DDE | - | 3.5 | R | Active | 100 | 71 | Gi/o | αi1 | - | 61 | - | Antibody |
DAMGO
|
peptide | Agonist | - | - | No | No | Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK | 10.1038/S41586-018-0219-7 | 2018-06-13 | Yes | |
NK1R | NK1 | Tachykinin | A | Human | X-ray | 6HLO | 6HLO_refined | 2.4 | A | Inactive | 1 | 70 | - | - | - | - | GlgA glycogen synthase | - |
aprepitant
|
small-molecule | Antagonist | neurokinin B, neuropeptide-γ, hemokinin 1, substance P, neurokinin A, neuropeptide K | peptide | No | No | - | - | 2019-01-16 | Yes | |
B1B1U5 | Rhodopsin | Opsins | A | Hasarius adansoni | X-ray | 6I9K | - | 2.2 | A | Inactive | 17 | 83 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | - | 10.1073/PNAS.1902192116 | 2019-07-03 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 6PS1 | 6PS1_refined | 3.2 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
timolol
|
small-molecule | Antagonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | - | - | 2019-11-13 | Yes | |
OX2R | OX2 | Orexin | A | Human | X-ray | 6TPG | 6TPG_refined | 2.7 | A | Inactive | 1 | 69 | - | - | - | - | GlgA glycogen synthase | - |
EMPA
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | Yes | |
GPR52 | GPR52 | A orphans | A | Human | X-ray | 6LI0 | 6LI0_refined | 2.2 | A | Intermediate | 40 | 81 | - | - | - | - | Flavodoxin | - |
derivative 17 [Nakahata et al., 2018]
|
small-molecule | Agonist | - | - | No | No | Lin X, Li M, Wang N, Wu Y, Luo Z, Guo S, Han GW, Li S, Yue Y, Wei X, Xie X, Chen Y, Zhao S, Wu J, Lei M, Xu F | 10.1038/S41586-020-2019-0 | 2020-02-26 | Yes | |
CALRL | calcitonin-like | Calcitonin | B1 | Human | Cryo-EM | 6UVA | - | 2.3 | R | Active | 100 | 75 | Gs | αs | - | 48 | - | Nanobody-35 RAMP3 |
adrenomedullin 2/intermedin
|
peptide | Agonist | - | - | No | No | Liang YL, Belousoff MJ, Fletcher MM, Zhang X, Khoshouei M, Deganutti G, Koole C, Furness SGB, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Danev R, Wootten D, Sexton PM | 10.1021/ACSPTSCI.9B00080 | 2020-04-01 | Yes | |
5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | X-ray | 6WGT | 6WGT_refined | 3.4 | B | Inactive | 1 | 59 | - | - | - | - | BRIL | - |
Lysergide
|
small-molecule | Agonist | 5-hydroxytryptamine, tryptamine | small-molecule | No | No | Kim K, Che T, Panova O, DiBerto JF, Lyu J, Krumm BE, Wacker D, Robertson MJ, Seven AB, Nichols DE, Shoichet BK, Skiniotis G, Roth BL | 10.1016/J.CELL.2020.08.024 | 2020-09-23 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 6LPL | 6LPL_refined | 2.0 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Ihara K, Hato M, Nakane T, Yamashita K, Kimura-Someya T, Hosaka T, Ishizuka-Katsura Y, Tanaka R, Tanaka T, Sugahara M, Hirata K, Yamamoto M, Nureki O, Tono K, Nango E, Iwata S, Shirouzu M | 10.1038/S41598-020-76277-X | 2020-11-25 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 6Z8N | 6Z8N_refined | 2.8 | A | Intermediate | 15 | 80 | - | - | - | - | DARPin D12 | - |
(2~{S})-4-methyl-2-[(1-quinolin-8-ylsulfonylindol-3-yl)carbonylamino]pentanoic acid
|
small-molecule | Agonist | neuromedin N, neurotensin | peptide | No | No | Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PRE, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Pluckthun A | 10.1126/sciadv.abe5504 | 2021-02-10 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 7ARO | 7ARO_refined | 3.1 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
CHEMBL124345
|
small-molecule | Agonist (partial) | adenosine | small-molecule | No | Yes | Amelia T, van Veldhoven JPD, Falsini M, Liu R, Heitman LH, van Westen GJP, Segala E, Verdon G, Cheng RKY, Cooke RM, van der Es D, IJzerman AP. | 10.1021/acs.jmedchem.0c01856 | 2021-04-07 | Yes | |
CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7DD5 | - | 3.2 | A | Inactive | - | 74 | - | - | - | - | - | - |
Calcium
NPS 2143 L-tryptophan |
small-molecule small-molecule small-molecule |
Agonist NAM PAM |
spermine, L-tryptophan, Ca2+, Mg2+ | small-molecule | No | No | Wen T, Wang Z, Chen X, Ren Y, Lu X, Xing Y, Lu J, Chang S, Zhang X, Shen Y, Yang X | 10.1126/SCIADV.ABG1483 | 2021-06-16 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7EVM | - | 2.5 | R | Active | 100 | 61 | Gs | αs | - | 60 | - | Nanobody-35 |
N-Tert-butyl-6,7-dichloroquinoxalin-2-amine
|
small-molecule | Ago-PAM | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | - | 10.1038/S41467-021-24058-Z | 2021-08-11 | Yes | |
S1PR5 | S1P5 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7EW1 | 7EW1_refined | 3.4 | A | Active | 100 | 68 | Gi/o | αi1 | - | 64 | - | scFv16 |
siponimod
|
small-molecule | Agonist | sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate, sphingosine 1-phosphate | small-molecule | No | No | Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z | 10.1038/S41422-021-00566-X | 2021-09-29 | Yes | |
MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7S8M | - | 2.5 | R | Active | 100 | 77 | Gi/o | αi1 | - | 62 | BRIL | scFv16 |
Cortistatin 14
|
peptide | Agonist | PAMP-20 | peptide | No | No | Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL | 10.1038/S41586-021-04126-6 | 2021-11-17 | Yes | |
CCKAR | CCK1 | Cholecystokinin | A | Human | X-ray | 7F8X | 7F8X_refined | 3.0 | A | Inactive | 1 | 66 | - | - | - | - | T4-Lysozyme | - |
NN9056
|
peptide | Agonist | desulfated cholecystokinin-8, CCK-33, CCK-8, CCK-58, CCK-4, CCK-39, gastrin-17 | peptide | No | No | Zhang X, He C, Wang M, Zhou Q, Yang D, Zhu Y, Feng W, Zhang H, Dai A, Chu X, Wang J, Yang Z, Jiang Y, Sensfuss U, Tan Q, Han S, Reedtz-Runge S, Xu HE, Zhao S, Wang MW, Wu B, Zhao Q | 10.1038/S41589-021-00866-8 | 2021-12-29 | Yes | |
US28 | US28 | Unclassified | A | strain AD169 | Cryo-EM | 7RKM | - | 3.5 | R | Active | 100 | 83 | Gi/o | αi1 | - | 61 | - | scFv16 |
Fractalkine
|
peptide | Agonist | - | - | No | No | Tsutsumi N, Maeda S, Qu Q, Vogele M, Jude KM, Suomivuori CM, Panova O, Waghray D, Kato HE, Velasco A, Dror RO, Skiniotis G, Kobilka BK, Garcia KC | 10.1126/SCIADV.ABL5442 | 2022-01-26 | Yes | |
ADA2A | α2A | Adrenoceptors | A | Human | Cryo-EM | 7EJA | - | 3.6 | R | Active | 100 | 58 | Gi/o | αo | - | 59 | - | scFv16 |
dexmedetomidine
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Xu J, Cao S, Hubner H, Weikert D, Chen G, Lu Q, Yuan D, Gmeiner P, Liu Z, Du Y | 10.1126/SCIADV.ABJ5347 | 2022-04-13 | Yes | |
S1PR2 | S1P2 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7T6B | 7T6B_refined | 3.2 | R | Active | 100 | 75 | G12/13 | α13 | - | 60 | - | scFv16 |
sphingosine 1-phosphate
|
small-molecule | Agonist | sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate, sphingosine 1-phosphate | small-molecule | No | No | Chen H, Chen K, Huang W, Staudt LM, Cyster JG, Li X | 10.1126/SCIADV.ABN0067 | 2022-04-06 | Yes | |
OX2R | OX2 | Orexin | A | Human | Cryo-EM | 7SQO | - | 3.2 | R | Active | 100 | 61 | Gi/o | αi1 | - | 61 | - | scFv16 |
methyl (2R,3S)-3-[(methanesulfonyl)amino]-2-({[(1s,4S)-4-phenylcyclohexyl]oxy}methyl)piperidine-1-carboxylate
|
small-molecule | Agonist | orexin-B, orexin-A | peptide | No | No | Yin J, Kang Y, McGrath AP, Chapman K, Sjodt M, Kimura E, Okabe A, Koike T, Miyanohana Y, Shimizu Y, Rallabandi R, Lian P, Bai X, Flinspach M, De Brabander JK, Rosenbaum DM | 10.1038/S41467-022-30601-3 | 2022-05-25 | Yes | |
OPRM | μ | Opioid | A | Mouse | Cryo-EM | 7UL4 | 7UL4_refined | 2.8 | A | Inactive | 4 | 72 | - | - | - | - | - | Megabody-6 |
alvimopan
|
small-molecule | Antagonist | - | - | No | No | Robertson MJ, Papasergi-Scott MM, He F, Seven AB, Meyerowitz JG, Panova O, Peroto MC, Che T, Skiniotis G | 10.1038/S41594-022-00859-8 | 2022-06-29 | Yes | |
APJ | apelin | Apelin | A | Human | Cryo-EM | 7W0O | 7W0O_refined | 3.8 | R | Active | 100 | 77 | Gi/o | αi1 | - | 64 | BRIL | scFv16 |
apelin receptor early endogenous ligand
|
peptide | Agonist | apelin-13, apelin-17, apelin-36, Elabela/Toddler-21, [Pyr1]apelin-13, Elabela/Toddler-11, apelin receptor early endogenous ligand, Elabela/Toddler-32 | peptide | No | No | Yue Y, Liu L, Wu LJ, Wu Y, Wang L, Li F, Liu J, Han GW, Chen B, Lin X, Brouillette RL, Breault E, Longpre JM, Shi S, Lei H, Sarret P, Stevens RC, Hanson MA, Xu F | 10.1038/S41594-022-00797-5 | 2022-07-27 | Yes | |
SSR2 | SST2 | Somatostatin | A | Human | X-ray | 7XNA | - | 2.7 | A | Inactive | 4 | 78 | - | - | - | - | - | - |
CYN 154806
|
peptide | Antagonist | SRIF-14, CST-17, cortistatin-14, SRIF-28 | peptide | No | No | Zhao W, Han S, Qiu N, Feng W, Lu M, Zhang W, Wang M, Zhou Q, Chen S, Xu W, Du J, Chu X, Yi C, Dai A, Hu L, Shen MY, Sun Y, Zhang Q, Ma Y, Zhong W, Yang D, Wang MW, Wu B, Zhao Q | 10.1038/S41422-022-00679-X | 2022-08-03 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 8CU7 | 8CU7_refined | 2.1 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
LJ-4517
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Shiriaeva A, Park D, Kim G, Lee Y, Hou X, Jarhad DB, Kim G, Yu J, Hyun YE, Kim W, Gao ZG, Jacobson KA, Han GW, Stevens RC, Jeong LS, Choi S, Cherezov V. | 10.1021/acs.jmedchem.2c00462 | 2022-08-31 | Yes | |
TSHR | TSH | Glycoprotein hormone | A | Human | Cryo-EM | 7UTZ | - | 2.4 | R | Active | 100 | 79 | Gs | αs | Mini-Gs | 56 | - | Nanobody-35 |
Thyrotropin subunit beta
Glycoprotein hormones alpha chain analog TR1402 |
protein protein |
Agonist | TSH | peptide | No | No | Faust B, Billesbolle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A | 10.1038/S41586-022-05159-1 | 2022-08-03 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 2Y01 | - | 2.6 | A | Inactive | 0 | 59 | - | - | - | - | - | - |
Dobutamine
|
small-molecule | Agonist (partial) | - | - | No | No | - | - | 2011-03-30 | Yes | |
PAR1 | PAR1 | Proteinase-activated | A | Human | X-ray | 3VW7 | 3VW7_refined | 2.2 | A | Intermediate | 44 | 66 | - | - | - | - | T4-Lysozyme | - |
vorapaxar
|
small-molecule | Antagonist | thrombin | peptide | No | No | Zhang C, Srinivasan Y, Arlow DH, Fung JJ, Palmer D, Zheng Y, Green HF, Pandey A, Dror RO, Shaw DE, Weis WI, Coughlin SR, Kobilka BK | 10.1038/NATURE11701 | 2012-12-12 | Yes | |
SMO | SMO | Frizzled | F | Human | X-ray | 4QIN | 4QIN_refined | 2.6 | A | Inactive | 11 | 43 | - | - | - | - | BRIL | - |
SAG1.5
|
small-molecule | Agonist | - | - | No | No | Wang C, Wu H, Evron T, Vardy E, Han GW, Huang XP, Hufeisen SJ, Mangano TJ, Urban DJ, Katritch V, Cherezov V, Caron MG, Roth BL, Stevens RC | 10.1038/NCOMMS5355 | 2014-07-23 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 5D5A | 5D5A_refined | 2.5 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
Carazolol
|
small-molecule | Inverse agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | Huang CY, Olieric V, Ma P, Howe N, Vogeley L, Liu X, Warshamanage R, Weinert T, Panepucci E, Kobilka B, Diederichs K, Wang M, Caffrey M | 10.1107/S2059798315021683 | 2016-01-13 | Yes | |
CCR9 | CCR9 | Chemokine | A | Human | X-ray | 5LWE | - | 2.8 | B | Inactive | 55 | 67 | - | - | - | - | - | - |
vercirnon
|
small-molecule | Allosteric antagonist | CCL25 | peptide | No | No | Oswald C, Rappas M, Kean J, Dore AS, Errey JC, Bennett K, Deflorian F, Christopher JA, Jazayeri A, Mason JS, Congreve M, Cooke RM, Marshall FH | 10.1038/NATURE20606 | 2016-12-07 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | X-ray | 5VEW | 5VEW_refined | 2.7 | A | Inactive | 0 | 57 | - | - | - | - | T4-Lysozyme | - |
PF-06372222
|
small-molecule | NAM | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Song G, Yang D, Wang Y, de Graaf C, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han GW, Lau J, Wu B, Hanson MA, Liu ZJ, Wang MW, Stevens RC | 10.1038/NATURE22378 | 2017-05-24 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 6AQF | 6AQF_refined | 2.5 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Eddy MT, Lee MY, Gao ZG, White KL, Didenko T, Horst R, Audet M, Stanczak P, McClary KM, Han GW, Jacobson KA, Stevens RC, Wuthrich K | 10.1016/J.CELL.2017.12.004 | 2018-01-10 | Yes | |
NPY1R | Y1 | Neuropeptide Y | A | Human | X-ray | 5ZBH | 5ZBH_refined | 3.0 | A | Inactive | 1 | 78 | - | - | - | - | T4-Lysozyme | - |
BMS-193885
|
small-molecule | Antagonist | pancreatic polypeptide, neuropeptide Y, peptide YY | peptide | No | No | Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kogler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B | 10.1038/S41586-018-0046-X | 2018-04-25 | Yes | |
CCR5 | CCR5 | Chemokine | A | Human | X-ray | 6AKX | 6AKX_refined | 2.8 | B | Inactive | 16 | 82 | - | - | - | - | Rubredoxin | - |
CHEMBL4238063
|
small-molecule | Antagonist | CCL2, CCL8, CCL11, CCL13, CCL14, CCL7, CCL5, CCL4, CCL16, CCL3 | peptide | No | No | Peng P, Chen H, Zhu Y, Wang Z, Li J, Luo RH, Wang J, Chen L, Yang LM, Jiang H, Xie X, Wu B, Zheng YT, Liu H. | 10.1021/acs.jmedchem.8b01077 | 2018-10-24 | Yes | |
CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 6NIY | - | 3.3 | R | Active | 100 | 55 | Gs | αs | - | 43 | - | - |
calcitonin (salmon synthetic)
|
small-molecule | Agonist | β-CGRP, α-CGRP, calcitonin, calcitonin (salmon), amylin, adrenomedullin, adrenomedullin 2/intermedin | peptide | No | No | - | 10.1021/ACSPTSCI.8B00056 | 2019-01-23 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 6JZH | 6JZH_refined | 2.3 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | - | 10.1107/S1600576719012846 | 2019-10-30 | Yes | |
OX1R | OX1 | Orexin | A | Human | X-ray | 6TQ9 | 6TQ9_refined | 2.7 | B | Inactive | 1 | 71 | - | - | - | - | - | - |
SB-408124
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | Yes | |
AGTR1 | AT1 | Angiotensin | A | Human | X-ray | 6OS2 | - | 2.7 | A | Active | 95 | 85 | - | - | - | - | BRIL | Nanobody-Nb.AT110i1_le |
TRV026
|
peptide | Agonist | angiotensin A, angiotensin III, angiotensin IV, angiotensin II | peptide | No | No | Wingler LM, Skiba MA, McMahon C, Staus DP, Kleinhenz ALW, Suomivuori CM, Latorraca NR, Dror RO, Lefkowitz RJ, Kruse AC | 10.1126/SCIENCE.AAY9813 | 2020-02-19 | Yes | |
GABR2 | GABAB2 | GABAB | C | Human | Cryo-EM | 6VJM | - | 4.0 | B | Inactive | - | 73 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | - | 2020-06-10 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7C2E | - | 4.2 | R | Active | 100 | 82 | Gs | αs | - | 49 | - | Nanobody-35 |
2-[[4-[6-[(4-cyano-2-fluoranyl-phenyl)methoxy]pyridin-2-yl]-3,6-dihydro-2~{H}-pyridin-1-yl]methyl]-3-[[(2~{S})-oxetan-2-yl]methyl]imidazo[4,5-b]pyridine-5-carboxylic acid
|
small-molecule | Agonist | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Ma H, Huang W, Wang X, Zhao L, Jiang Y, Liu F, Guo W, Sun X, Zhong W, Yuan D, Xu HE | 10.1038/S41422-020-0384-8 | 2020-08-26 | Yes | |
GABR2 | GABAB2 | GABAB | C | Human | Cryo-EM | 7CUM | - | 3.5 | B | Inactive | - | 72 | - | - | - | - | - | - |
CGP 54626A
Unknown ligand |
small-molecule none |
NAM | - | - | No | No | Kim Y, Jeong E, Jeong JH, Kim Y, Cho Y | 10.1016/J.JMB.2020.09.023 | 2020-11-11 | Yes | |
CCKAR | CCK1 | Cholecystokinin | A | Human | Cryo-EM | 7MBX | - | 2.0 | R | Active | 100 | 68 | Gs | αs | - | 61 | - | Nanobody-35 |
CHEMBL216166
|
protein | Agonist | desulfated cholecystokinin-8, CCK-33, CCK-8, CCK-58, CCK-4, CCK-39, gastrin-17 | peptide | No | No | Mobbs JI, Belousoff MJ, Harikumar KG, Piper SJ, Xu X, Furness SGB, Venugopal H, Christopoulos A, Danev R, Wootten D, Thal DM, Miller LJ, Sexton PM | 10.1371/JOURNAL.PBIO.3001295 | 2021-05-26 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7DUQ | - | 2.5 | R | Active | 100 | 83 | Gs | αs | - | 61 | - | Nanobody-35 |
N-Tert-butyl-6,7-dichloroquinoxalin-2-amine
CHEMBL410972 |
small-molecule protein |
Ago-PAM Agonist |
glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | - | 10.1038/S41467-021-24058-Z | 2021-07-14 | Yes | |
LSHR | LH | Glycoprotein hormone | A | Human | Cryo-EM | 7FII | - | 4.3 | R | Active | 100 | 82 | Gs | αs | - | 91 | - | - |
Choriogonadotropin beta
Glycoprotein alpha |
protein protein |
Agonist | hCG, LH | peptide | No | No | Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE | 10.1038/S41586-021-03924-2 | 2021-09-29 | Yes | |
S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7EVZ | - | 3.1 | D | Active | 100 | 71 | Gi/o | αi1 | - | 64 | - | scFv16 |
cenerimod
|
small-molecule | Agonist | sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate, sphingosine 1-phosphate | small-molecule | No | No | Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z | 10.1038/S41422-021-00566-X | 2021-09-29 | Yes | |
S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7TD3 | - | 3.0 | R | Active | 100 | 76 | Gi/o | αi1 | - | 63 | - | - |
sphingosine 1-phosphate
|
small-molecule | Agonist | sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate, sphingosine 1-phosphate | small-molecule | No | No | Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY | 10.1038/S41467-022-28417-2 | 2022-02-09 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7FIM | - | 3.4 | R | Active | 100 | 83 | Gs | αs | - | 57 | - | Nanobody-35 |
tirzepatide
|
peptide | Agonist | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW | 10.1038/S41467-022-28683-0 | 2022-03-02 | Yes | |
AGRG4 | ADGRG4 | ADGRG | B2 | Human | Cryo-EM | 7WUJ | - | 3.3 | E | Active | - | 9 | Gs | αs | Mini-Gs | 59 | - | scFv16 Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Xiao P, Guo S, Wen X, He QT, Lin H, Huang SM, Gou L, Zhang C, Yang Z, Zhong YN, Yang CC, Li Y, Gong Z, Tao XN, Yang ZS, Lu Y, Li SL, He JY, Wang C, Zhang L, Kong L, Sun JP, Yu X | 10.1038/S41586-022-04590-8 | 2022-04-27 | Yes | |
ADRB3 | β3 | Adrenoceptors | A | Dog | Cryo-EM | 7XJH | - | 3.3 | R | Active | 100 | 68 | Gs | αs | - | 59 | - | Nanobody-35 |
LEVISOPRENALINE
|
small-molecule | Agonist | - | - | No | No | Nagiri C, Kobayashi K, Tomita A, Kato M, Kobayashi K, Yamashita K, Nishizawa T, Inoue A, Shihoya W, Nureki O | 10.1016/J.MOLCEL.2021.06.024 | 2022-05-04 | Yes | |
DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7X2F | 7X2F_refined | 3.0 | F | Active | 100 | 63 | Gs | αs | - | 58 | - | Nanobody-35 |
dopamine
mevidalen |
small-molecule small-molecule |
Agonist PAM |
noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, 5-hydroxytryptamine, dopamine | small-molecule | No | No | Teng X, Chen S, Nie Y, Xiao P, Yu X, Shao Z, Zheng S | 10.1038/S41467-022-30929-W | 2022-06-15 | Yes | |
GASR | CCK2 | Cholecystokinin | A | Human | Cryo-EM | 7XOX | 7XOX_refined | 3.1 | R | Active | 100 | 62 | Gq/11 | αq | - | 61 | - | scFv16 |
CCK-8
|
peptide | Agonist | desulfated cholecystokinin-8, desulfated gastrin-17, CCK-33, CCK-8, CCK-58, desulfated gastrin-71, desulfated gastrin-14, CCK-4, desulfated gastrin-34, gastrin-34, gastrin-14, CCK-39, gastrin-17, gastrin-71 | peptide | No | No | Ding Y, Zhang H, Liao YY, Chen LN, Ji SY, Qin J, Mao C, Shen DD, Lin L, Wang H, Zhang Y, Li XM | 10.1038/S41421-022-00420-3 | 2022-07-20 | Yes | |
SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7XAV | 7XAV_refined | 2.9 | A | Active | 100 | 76 | Gi/o | αi1 | - | 63 | - | scFv16 |
lanreotide
|
peptide | Agonist | SRIF-14, CST-17, cortistatin-14, SRIF-28 | peptide | No | No | Bo Q, Yang F, Li Y, Meng X, Zhang H, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C | 10.1038/S41421-022-00405-2 | 2022-08-31 | Yes | |
PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 7VVO | 7VVO_refined | 4.1 | R | Active | 100 | 51 | Gs | αs | - | 58 | - | Nanobody-35 |
Parathyroid hormone
|
peptide | Agonist | PTH, PTHrP-(1-36), TIP39, PTHrP | peptide | No | No | Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O | 10.1016/J.MOLCEL.2022.07.003 | 2022-08-03 | Yes | |
5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7SRQ | 7SRQ_refined | 2.7 | R | Intermediate | 44 | 53 | - | - | - | - | - | - |
Lysergide
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Cao C, Barros-Alvarez X, Zhang S, Kim K, Damgen MA, Panova O, Suomivuori CM, Fay JF, Zhong X, Krumm BE, Gumpper RH, Seven AB, Robertson MJ, Krogan NJ, Huttenhain R, Nichols DE, Dror RO, Skiniotis G, Roth BL | 10.1016/J.NEURON.2022.08.006 | 2022-09-21 | Yes | |
FPR1 | FPR1 | Formylpeptide | A | Human | Cryo-EM | 7VFX | 7VFX_refined | 2.8 | R | Active | 100 | 84 | Gi/o | αi1 | - | 62 | - | scFv16 |
Peptide agonist fMet-Ile-Phe-Leu
|
peptide | Agonist | cathepsin G, spinorphin, annexin I, fMet-Leu-Phe | peptide | No | No | Chen G, Wang X, Liao Q, Ge Y, Jiao H, Chen Q, Liu Y, Lyu W, Zhu L, van Zundert GCP, Robertson MJ, Skiniotis G, Du Y, Hu H, Ye RD | 10.1038/S41467-022-32822-Y | 2022-09-21 | Yes | |
5HT5A | 5-HT5A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7X5H | 7X5H_refined | 3.1 | R | Active | 100 | 77 | Gi/o | αi1 | - | 63 | BRIL | scFv16 |
5-CT
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Tan Y, Xu P, Huang S, Yang G, Zhou F, He X, Ma H, Xu HE, Jiang Y | 10.1038/S41421-022-00412-3 | 2022-09-14 | Yes | |
OPRM | μ | Opioid | A | Human | Cryo-EM | 8EFO | - | 2.8 | R | Active | 100 | 72 | Gi/o | αi1 | - | 64 | - | scFv16 |
PZM21
|
small-molecule | Agonist | dynorphin A-(1-8), [Met]enkephalin, endomorphin-1, dynorphin A, [Leu]enkephalin, β-endorphin, dynorphin A-(1-13), dynorphin B, endomorphin-2 | peptide | No | No | Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE | 10.1016/J.CELL.2022.09.041 | 2022-11-09 | Yes | |
C5AR1 | C5a1 | Complement peptide | A | Human | Cryo-EM | 7Y67 | 7Y67_refined | 2.8 | D | Active | 100 | 79 | Gi/o | αi1 | - | 63 | - | scFv16 |
C089
|
peptide | Agonist | C3a, C5a, ribosomal protein S19, C5a des-Arg | peptide | No | No | Feng Y, Zhao C, Deng Y, Wang H, Ma L, Liu S, Tian X, Wang B, Bin Y, Chen P, Yan W, Fu P, Shao Z | 10.1038/S41422-023-00779-2 | 2023-03-01 | Yes | |
GPR20 | GPR20 | A orphans | A | Human | Cryo-EM | 8HS3 | - | 3.1 | R | Active | 100 | 78 | Gi/o | αi1 | - | 62 | BRIL | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | - | 2023-03-08 | Yes | |
TAAR9 | TAAR9 | A orphans | A | Mouse | Cryo-EM | 8IW1 | - | 3.4 | R | Active | 100 | 78 | Gs | αolf | Golf-Gi chimera | 59 | - | scFv16 |
2-Phenylethanaminium
|
small-molecule | Agonist | - | - | No | No | Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP | 10.1038/S41586-023-06106-4 | 2023-05-31 | Yes | |
GALR1 | GAL1 | Galanin | A | Human | Cryo-EM | 7XJJ | 7XJJ_refined | 3.3 | E | Active | 100 | 77 | Gi/o | αo | - | 61 | - | scFv16 |
galanin
|
peptide | Agonist | galanin-like peptide, galanin | peptide | No | No | - | - | 2023-05-03 | Yes | |
TAAR9 | TAAR9 | A orphans | A | Mouse | Cryo-EM | 8ITF | - | 3.5 | R | Active | 100 | 86 | Gs | αs | - | 59 | - | scFv16 Nanobody-35 |
N,N-Dimethylcyclohexylamine
|
small-molecule | Agonist | - | - | No | No | Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP | 10.1038/S41586-023-06106-4 | 2023-05-31 | Yes | |
ADA1A | α1A | Adrenoceptors | A | Human | Cryo-EM | 7YMJ | - | 3.4 | A | Inactive | 4 | 60 | - | - | - | - | - | Nanobody-6 |
tamsulosin
|
small-molecule | Antagonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Toyoda Y, Zhu A, Kong F, Shan S, Zhao J, Wang N, Sun X, Zhang L, Yan C, Kobilka BK, Liu X | 10.1038/S41467-023-39310-X | 2023-07-05 | Yes | |
PF2R | FP | Prostanoid | A | Human | Cryo-EM | 8IUK | - | 2.7 | R | Active | 100 | 82 | Gq/11 | αq | - | 60 | - | scFv16 Nanobody-35 |
PGF2α
|
small-molecule | Agonist | PGE2, PGF2α, thromboxane A2, PGI2, PGD2 | small-molecule | No | No | Wu C, Xu Y, He Q, Li D, Duan J, Li C, You C, Chen H, Fan W, Jiang Y, Eric Xu H | 10.1038/S41467-023-38411-X | 2023-07-12 | Yes | |
GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 8JD1 | - | 3.7 | 2 | Inactive | - | 86 | - | - | - | - | - | - |
L-glutamic acid
|
small-molecule | Agonist | L-glutamic acid | small-molecule | No | No | Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B | 10.1038/S41422-023-00830-2 | 2023-06-21 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 2YDO | 2YDO_refined | 3.0 | A | Active | 65 | 73 | - | - | - | - | - | - |
adenosine
|
small-molecule | Agonist | adenosine | small-molecule | No | No | - | 10.1038/NATURE10136 | 2011-05-18 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 4GRV | 4GRV_refined | 2.8 | A | Active | 79 | 69 | - | - | - | - | T4-Lysozyme | - |
JMV431
|
peptide | Agonist | neuromedin N, neurotensin | peptide | No | No | White JF, Noinaj N, Shibata Y, Love J, Kloss B, Xu F, Gvozdenovic-Jeremic J, Shah P, Shiloach J, Tate CG, Grisshammer R | 10.1038/NATURE11558 | 2012-10-17 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 4QKX | 4QKX_refined | 3.3 | A | Active | 99 | 69 | - | - | - | - | T4-Lysozyme | Nanobody |
Q27453560
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | Weichert D, Kruse AC, Manglik A, Hiller C, Zhang C, Hubner H, Kobilka BK, Gmeiner P | 10.1073/PNAS.1410415111 | 2014-07-23 | Yes | |
ACM1 | M1 | Acetylcholine (muscarinic) | A | Human | X-ray | 5CXV | 5CXV_refined | 2.7 | A | Inactive | 2 | 62 | - | - | - | - | T4-Lysozyme | - |
0HK
|
small-molecule | Antagonist | acetylcholine | small-molecule | No | No | Thal DM, Sun B, Feng D, Nawaratne V, Leach K, Felder CC, Bures MG, Evans DA, Weis WI, Bachhawat P, Kobilka TS, Sexton PM, Kobilka BK, Christopoulos A | 10.1038/NATURE17188 | 2016-03-09 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5UIG | 5UIG_refined | 3.5 | A | Inactive | 19 | 70 | - | - | - | - | BRIL | - |
5-Amino-N-[(2-Methoxyphenyl)methyl]-2-(3-Methylphenyl)-2h-1,2,3-Triazole-4-Carboximidamide
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Sun B, Bachhawat P, Chu ML, Wood M, Ceska T, Sands ZA, Mercier J, Lebon F, Kobilka TS, Kobilka BK | 10.1073/PNAS.1621423114 | 2017-02-08 | Yes | |
CCR5 | CCR5 | Chemokine | A | Human | X-ray | 5UIW | - | 2.2 | A | Inactive | 16 | 85 | - | - | - | - | Rubredoxin | - |
5P7-CCL5
|
protein | Antagonist | CCL2, CCL8, CCL11, CCL13, CCL14, CCL7, CCL5, CCL4, CCL16, CCL3 | peptide | No | No | Zheng Y, Han GW, Abagyan R, Wu B, Stevens RC, Cherezov V, Kufareva I, Handel TM | 10.1016/J.IMMUNI.2017.05.002 | 2017-06-28 | Yes | |
C5AR1 | C5a1 | Complement peptide | A | Human | X-ray | 6C1Q | 6C1Q_refined | 2.9 | B | Inactive | 6 | 82 | - | - | - | - | BRIL | - |
PMX53
NDT9513727 |
peptide small-molecule |
Antagonist NAM |
C3a, C5a, ribosomal protein S19, C5a des-Arg | peptide | No | No | Liu H, Kim HR, Deepak RNVK, Wang L, Chung KY, Fan H, Wei Z, Zhang C | 10.1038/S41594-018-0067-Z | 2018-05-30 | Yes | |
ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | X-ray | 5ZKB | 5ZKB_refined | 3.0 | A | Inactive | 2 | 60 | - | - | - | - | BRIL | - |
AF-DX 384
|
small-molecule | Antagonist | acetylcholine | small-molecule | No | No | Suno R, Lee S, Maeda S, Yasuda S, Yamashita K, Hirata K, Horita S, Tawaramoto MS, Tsujimoto H, Murata T, Kinoshita M, Yamamoto M, Kobilka BK, Vaidehi N, Iwata S, Kobayashi T | 10.1038/S41589-018-0152-Y | 2018-11-21 | Yes | |
NK1R | NK1 | Tachykinin | A | Human | X-ray | 6J20 | 6J20_refined | 2.7 | A | Inactive | 1 | 71 | - | - | - | - | T4-Lysozyme | - |
aprepitant
|
small-molecule | Antagonist | neurokinin B, neuropeptide-γ, hemokinin 1, substance P, neurokinin A, neuropeptide K | peptide | No | No | - | 10.1038/S41467-019-08568-5 | 2019-03-06 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Human | Cryo-EM | 6OSA | - | 3.0 | R | Active | 100 | 77 | Gi/o | αi1 | Non-canonical conformation | 62 | - | - |
JMV449
|
peptide | Agonist | neuromedin N, large neurotensin, neurotensin, large neuromedin N | peptide | No | No | - | - | 2019-07-10 | Yes | |
OX1R | OX1 | Orexin | A | Human | X-ray | 6TO7 | - | 2.3 | A | Inactive | 1 | 71 | - | - | - | - | - | - |
suvorexant
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | Yes | |
AGTR1 | AT1 | Angiotensin | A | Human | X-ray | 6OS0 | 6OS0_refined | 2.9 | A | Active | 95 | 85 | - | - | - | - | BRIL | Nanobody-Nb.AT110i1 |
angiotensin II
|
peptide | Agonist | angiotensin A, angiotensin III, angiotensin IV, angiotensin II | peptide | No | No | Wingler LM, Skiba MA, McMahon C, Staus DP, Kleinhenz ALW, Suomivuori CM, Latorraca NR, Dror RO, Lefkowitz RJ, Kruse AC | 10.1126/SCIENCE.AAY9813 | 2020-02-19 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | Cryo-EM | 6TKO | 6TKO_refined | 3.3 | A | Active | 100 | 58 | Beta | Beta-arrestin-1 | - | 82 | - | Fab30 heavy chain Fab30 light chain |
arformoterol
|
small-molecule | Agonist | - | - | No | No | - | 10.1038/S41586-020-2419-1 | 2020-06-17 | Yes | |
GHSR | ghrelin | Ghrelin | A | Human | X-ray | 6KO5 | 6KO5_refined | 3.3 | A | Inactive | 1 | 80 | - | - | - | - | BRIL | Fab7881 heavy chain Fab7881 light chain |
CHEMBL1956994
|
small-molecule | Antagonist | [des-Gln14]ghrelin, ghrelin | peptide | No | No | Shiimura Y, Horita S, Hamamoto A, Asada H, Hirata K, Tanaka M, Mori K, Uemura T, Kobayashi T, Iwata S, Kojima M | 10.1038/S41467-020-17554-1 | 2020-08-12 | Yes | |
5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | X-ray | 6WH4 | 6WH4_refined | 3.4 | C | Inactive | 1 | 59 | - | - | - | - | BRIL | - |
CHEMBL428892
|
small-molecule | Inverse agonist | 5-hydroxytryptamine, tryptamine | small-molecule | No | No | Kim K, Che T, Panova O, DiBerto JF, Lyu J, Krumm BE, Wacker D, Robertson MJ, Seven AB, Nichols DE, Shoichet BK, Skiniotis G, Roth BL | 10.1016/J.CELL.2020.08.024 | 2020-09-23 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 7DHR | 7DHR_refined | 3.8 | R | Active | 100 | 69 | Gs | αs | - | 49 | - | Nanobody-35 |
LEVISOPRENALINE
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | Jin Y, Zhao Q, Zhu W, Feng Y, Xiao T, Zhang P, Jiang L, Hou Y, Guo C, Huang H, Chen Y, Tong X, Cao J, Li F, Zhu X, Qin J, Gao D, Liu XY, Zhang H, Chen L, Thomas RK, Wong KK, Zhang L, Wang Y, Hu L, Ji H | 10.1093/NSR/NWAA284 | 2020-12-16 | Yes | |
DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7JV5 | - | 3.0 | R | Active | 100 | 63 | Gs | αs | - | 60 | - | Nanobody-35 |
CHEMBL1160787
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, 5-hydroxytryptamine, dopamine | small-molecule | No | No | Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE | 10.1016/J.CELL.2021.01.027 | 2021-02-24 | Yes | |
PE2R2 | EP2 | Prostanoid | A | Human | Cryo-EM | 7CX3 | - | 2.8 | R | Active | 100 | 74 | Gs | αs | - | 58 | - | Nanobody-35 |
taprenepag
|
small-molecule | Agonist | PGE2, PGF2α, thromboxane A2, PGI2, PGE1, PGD2 | small-molecule | No | No | Qu C, Mao C, Xiao P, Shen Q, Zhong YN, Yang F, Shen DD, Tao X, Zhang H, Yan X, Zhao RJ, He J, Guan Y, Zhang C, Hou G, Zhang PJ, Hou G, Li Z, Yu X, Chai RJ, Guan YF, Sun JP, Zhang Y | 10.1126/SCIADV.ABF1268 | 2021-05-05 | Yes | |
Q3KSP2 | BILF1 | Unclassified | A | strain GD1 | Cryo-EM | 7JHJ | - | 3.2 | R | Active | 100 | 89 | Gi/o | αi1 | - | 62 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | 10.1016/J.IMMUNI.2021.06.001 | 2021-07-07 | Yes | |
PTH2R | PTH2 | Parathyroid hormone | B1 | Human | Cryo-EM | 7F16 | - | 2.8 | R | Active | 100 | 68 | Gs | αs | - | 58 | - | Nanobody-35 |
TIP39
|
peptide | Agonist | PTHrP-(1-34) (human), TIP39, PTHrP-(1-36), PTHrP, PTH | peptide | No | No | Wang X, Cheng X, Zhao L, Wang Y, Ye C, Zou X, Dai A, Cong Z, Chen J, Zhou Q, Xia T, Jiang H, Xu HE, Yang D, Wang MW | 10.1073/PNAS.2101279118 | 2021-08-18 | Yes | |
NK1R | NK1 | Tachykinin | A | Human | Cryo-EM | 7RMH | 7RMH_refined | 3.1 | R | Active | 100 | 70 | Gs | αs | - | 55 | - | Nanobody-35 |
substance P
|
peptide | Agonist | neurokinin B, neuropeptide-γ, hemokinin 1, substance P, neurokinin A, neuropeptide K | peptide | No | No | Harris JA, Faust B, Gondin AB, Damgen MA, Suomivuori CM, Veldhuis NA, Cheng Y, Dror RO, Thal DM, Manglik A | 10.1038/S41589-021-00890-8 | 2021-11-03 | Yes | |
GP139 | GPR139 | A orphans | A | Human | Cryo-EM | 7VUI | 7VUI_refined | 3.3 | R | Active | 100 | 79 | Gs | αs | - | 59 | - | Nanobody-35 |
JNJ-63533054
|
small-molecule | Agonist | L-tryptophan, L-phenylalanine | small-molecule | No | No | Zhou Y, Daver H, Trapkov B, Wu L, Wu M, Harpsoe K, Gentry PR, Liu K, Larionova M, Liu J, Chen N, Brauner-Osborne H, Gloriam DE, Hua T, Liu ZJ | 10.1038/S41422-021-00591-W | 2021-12-29 | Yes | |
CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7SIL | 7SIL_refined | 2.7 | A | Active | - | 72 | - | - | - | - | - | - |
tecalcet
Cyclomethyltryptophan |
small-molecule small-molecule |
Agonist | spermine, L-tryptophan, Ca2+, Mg2+ | small-molecule | No | No | Park J, Zuo H, Frangaj A, Fu Z, Yen LY, Zhang Z, Mosyak L, Slavkovich VN, Liu J, Ray KM, Cao B, Vallese F, Geng Y, Chen S, Grassucci R, Dandey VP, Tan YZ, Eng E, Lee Y, Kloss B, Liu Z, Hendrickson WA, Potter CS, Carragher B, Graziano J, Conigrave AD, Frank J, Clarke OB, Fan QR | 10.1073/PNAS.2115849118 | 2022-01-19 | Yes | |
MTR1A | MT1 | Melatonin | A | Human | Cryo-EM | 7VGZ | 7VGZ_refined | 3.3 | B | Active | 100 | 81 | Gi/o | αi1 | - | 62 | - | scFv16 |
ramelteon
|
small-molecule | Agonist | melatonin | small-molecule | No | No | - | - | 2022-03-02 | Yes | |
ADA2A | α2A | Adrenoceptors | A | Human | Cryo-EM | 7EJ8 | - | 3.0 | R | Active | 100 | 57 | Gi/o | αo | - | 61 | - | scFv16 |
brimonidine
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Xu J, Cao S, Hubner H, Weikert D, Chen G, Lu Q, Yuan D, Gmeiner P, Liu Z, Du Y | 10.1126/SCIADV.ABJ5347 | 2022-04-13 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 7EZC | 7EZC_refined | 3.8 | B | Active | 65 | 70 | - | - | - | - | BRIL | - |
UK-432,097
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Cui M, Zhou Q, Xu Y, Weng Y, Yao D, Zhao S, Song G | 10.1107/S2052252522001907 | 2022-04-13 | Yes | |
NMUR2 | NMU2 | Neuromedin U | A | Human | Cryo-EM | 7W57 | - | 3.2 | R | Active | 100 | 72 | Gq/11 | αq | - | 59 | - | scFv16 |
Neuromedin-S
|
peptide | Agonist | neuromedin U-25, neuromedin U-23, neuromedin S-33, neuromedin S-36 | peptide | No | No | You C, Zhang Y, Xu P, Huang S, Yin W, Eric Xu H, Jiang Y | 10.1038/S41467-022-29683-W | 2022-04-20 | Yes | |
MRGRD | MRGPRD | A orphans | A | Human | Cryo-EM | 7Y12 | - | 3.1 | R | Active | 100 | 82 | Gi/o | αi1 | - | 62 | BRIL | scFv16 |
β-alanine
|
small-molecule | Agonist | β-alanine | small-molecule | No | No | Suzuki S, Iida M, Hiroaki Y, Tanaka K, Kawamoto A, Kato T, Oshima A | 10.1038/S42003-022-03668-3 | 2022-07-20 | Yes | |
TSHR | TSH | Glycoprotein hormone | A | Human | Cryo-EM | 7XW5 | - | 3.0 | R | Active | 100 | 75 | Gs | αs | - | 60 | - | Nanobody-35 |
Glycoprotein hormones alpha chain
Thyrotropin subunit beta N-[4-[[5-[(2S)-3-benzyl-5-hydroxy-4-oxo-1,2-dihydroquinazolin-2-yl]-2-methoxyphenyl]methoxy]phenyl]acetamide |
protein protein small-molecule |
Agonist | TSH | peptide | No | No | Duan J, Xu P, Luan X, Ji Y, He X, Song N, Yuan Q, Jin Y, Cheng X, Jiang H, Zheng J, Zhang S, Jiang Y, Xu HE | 10.1038/S41586-022-05173-3 | 2022-08-24 | Yes | |
TAAR9 | TAAR9 | A orphans | A | Mouse | Cryo-EM | 8IWM | - | 3.2 | R | Active | 97 | 78 | - | - | - | - | - | - |
2-Phenylethanaminium
|
small-molecule | Agonist | - | - | No | No | Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP | 10.1038/S41586-023-06106-4 | 2023-05-31 | Yes | |
TAAR9 | TAAR9 | A orphans | A | Mouse | Cryo-EM | 8IWE | - | 3.4 | R | Active | 97 | 85 | - | - | - | - | - | - |
SPERMIDINE
|
small-molecule | Agonist | - | - | No | No | Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP | 10.1038/S41586-023-06106-4 | 2023-05-31 | Yes | |
HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | X-ray | 7ZL9 | - | 2.7 | A | Active | 65 | 83 | - | - | - | - | BRIL | - |
Apo (no ligand)
|
none | Apo (no ligand) | β-D-hydroxybutyric acid, butyric acid | small-molecule | No | No | Yang Y, Kang HJ, Gao R, Wang J, Han GW, DiBerto JF, Wu L, Tong J, Qu L, Wu Y, Pileski R, Li X, Zhang XC, Zhao S, Kenakin T, Wang Q, Stevens RC, Peng W, Roth BL, Rao Z, Liu ZJ | 10.1038/S41467-023-37177-6 | 2023-04-12 | Yes | |
OPRK | κ | Opioid | A | Human | Cryo-EM | 8DZS | - | 2.7 | A | Active | 100 | 71 | Gi/o | αz | - | 59 | - | scFv16 |
CHEMBL277863
|
small-molecule | Agonist | dynorphin A-(1-8), β-neoendorphin, big dynorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, β-endorphin, dynorphin A-(1-13), dynorphin B, α-neoendorphin | peptide | No | No | Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T | 10.1038/S41586-023-06030-7 | 2023-05-03 | Yes | |
DRD3 | D3 | Dopamine | A | Human | Cryo-EM | 8IRT | - | 2.7 | R | Active | 100 | 68 | Gi/o | αi1 | - | 63 | BRIL | scFv16 |
rotigotine
|
small-molecule | Agonist | dopamine | small-molecule | No | No | Xu P, Huang S, Krumm BE, Zhuang Y, Mao C, Zhang Y, Wang Y, Huang XP, Liu YF, He X, Li H, Yin W, Jiang Y, Zhang Y, Roth BL, Xu HE | 10.1038/S41422-023-00808-0 | 2023-06-07 | Yes | |
GPR84 | GPR84 | A orphans | A | Human | Cryo-EM | 8J18 | - | 2.9 | R | Active | 100 | 73 | Gi/o | αi1 | - | 62 | - | scFv16 |
(3R)-3-HYDROXYDODECANOIC ACID
|
small-molecule | Agonist | - | - | No | No | Liu H, Zhang Q, He X, Jiang M, Wang S, Yan X, Cheng X, Liu Y, Nan FJ, Xu HE, Xie X, Yin W | 10.1038/S41467-023-38985-6 | 2023-06-21 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Human | Cryo-EM | 8JPB | - | 3.1 | R | Active | 100 | 71 | Gq/11 | αq | GRK2 bound | 88 | - | GRK2 |
JMV431
CHEMBL4576388 |
peptide small-molecule |
Agonist PAM |
neuromedin N, large neurotensin, neurotensin, large neuromedin N | peptide | No | No | Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE | 10.1038/S41586-023-06395-9 | 2023-08-09 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 2YCW | 2YCW_refined | 3.0 | A | Inactive | 0 | 61 | - | - | - | - | - | - |
Carazolol
|
small-molecule | Antagonist | - | - | No | No | - | 10.1073/PNAS.1100185108 | 2011-06-01 | Yes | |
GLR | glucagon | Glucagon | B1 | Human | X-ray | 4L6R | 4L6R_refined | 3.3 | A | Inactive | 7 | 61 | - | - | - | - | BRIL | - | - | - | - | glucagon | peptide | No | No | Siu FY, He M, de Graaf C, Han GW, Yang D, Zhang Z, Zhou C, Xu Q, Wacker D, Joseph JS, Liu W, Lau J, Cherezov V, Katritch V, Wang MW, Stevens RC | 10.1038/nature12393 | 2013-07-24 | Yes | |
GRM1 | mGlu1 | Metabotropic glutamate | C | Human | X-ray | 4OR2 | 4OR2_refined | 2.8 | B | Inactive | - | 22 | - | - | - | - | BRIL | - |
FITM
|
small-molecule | NAM | L-glutamic acid | small-molecule | No | No | Wu H, Wang C, Gregory KJ, Han GW, Cho HP, Xia Y, Niswender CM, Katritch V, Meiler J, Cherezov V, Conn PJ, Stevens RC | 10.1126/science.1249489 | 2014-03-19 | Yes | |
GRM5 | mGlu5 | Metabotropic glutamate | C | Human | X-ray | 5CGD | 5CGD_refined | 2.6 | A | Inactive | - | 20 | - | - | - | - | T4-Lysozyme | - |
CHEMBL3603923
|
small-molecule | NAM | L-glutamic acid | small-molecule | No | No | Christopher JA, Aves SJ, Bennett KA, Doré AS, Errey JC, Jazayeri A, Marshall FH, Okrasa K, Serrano-Vega MJ, Tehan BG, Wiggin GR, Congreve M. | 10.1021/acs.jmedchem.5b00892 | 2015-08-12 | Yes | |
SMO | SMO | Frizzled | F | Human | X-ray | 5L7I | 5L7I_refined | 3.3 | B | Inactive | 4 | 59 | - | - | - | - | BRIL | - |
vismodegib
|
small-molecule | Antagonist | - | - | No | No | - | - | 2016-07-20 | Yes | |
EDNRB | ETB | Endothelin | A | Human | X-ray | 5XPR | 5XPR_refined | 3.6 | A | Inactive | 4 | 69 | - | - | - | - | T4-Lysozyme | - |
bosentan
|
small-molecule | Antagonist | endothelin-1, endothelin-2, endothelin-3 | peptide | No | No | Shihoya W, Nishizawa T, Yamashita K, Inoue A, Hirata K, Kadji FMN, Okuta A, Tani K, Aoki J, Fujiyoshi Y, Doi T, Nureki O | 10.1038/NSMB.3450 | 2017-08-16 | Yes | |
5HT2C | 5-HT2C | 5-Hydroxytryptamine | A | Human | X-ray | 6BQH | 6BQH_refined | 2.7 | A | Inactive | 1 | 63 | - | - | - | - | BRIL | - |
ritanserin
|
small-molecule | Inverse agonist | 5-hydroxytryptamine | small-molecule | No | No | Peng Y, McCorvy JD, Harpsoe K, Lansu K, Yuan S, Popov P, Qu L, Pu M, Che T, Nikolajsen LF, Huang XP, Wu Y, Shen L, Bjorn-Yoshimoto WE, Ding K, Wacker D, Han GW, Cheng J, Katritch V, Jensen AA, Hanson MA, Zhao S, Gloriam DE, Roth BL, Stevens RC, Liu ZJ | 10.1016/j.cell.2018.01.001 | 2018-02-14 | Yes | |
PTAFR | PAF | Platelet-activating factor | A | Human | X-ray | 5ZKQ | 5ZKQ_refined | 2.9 | B | Intermediate | 44 | 83 | - | - | - | - | T4-Lysozyme | - |
ABT-491
|
small-molecule | Inverse agonist | PAF | small-molecule | No | No | Cao C, Tan Q, Xu C, He L, Yang L, Zhou Y, Zhou Y, Qiao A, Lu M, Yi C, Han GW, Wang X, Li X, Yang H, Rao Z, Jiang H, Zhao Y, Liu J, Stevens RC, Zhao Q, Zhang XC, Wu B | 10.1038/S41594-018-0068-Y | 2018-06-20 | Yes | |
PE2R4 | EP4 | Prostanoid | A | Human | X-ray | 5YWY | 5YWY_refined | 3.2 | A | Inactive | 9 | 57 | - | - | - | - | - | Fab |
ONO-AE3-208
|
small-molecule | Antagonist | PGE2, PGF2α, thromboxane A2, PGI2, PGE1, PGD2 | small-molecule | No | No | - | - | 2018-12-05 | Yes | |
MTR1B | MT2 | Melatonin | A | Human | X-ray | 6ME6 | 6ME6_refined | 2.8 | B | Inactive | 1 | 78 | - | - | - | - | Rubredoxin | - |
CHEMBL15060
|
small-molecule | Agonist | melatonin | small-molecule | No | No | - | 10.1038/S41586-019-1144-0 | 2019-04-24 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | X-ray | 6KK1 | 6KK1_refined | 2.8 | B | Inactive | 0 | 57 | - | - | - | - | T4-Lysozyme | - |
PF-06372222
|
small-molecule | NAM | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | - | - | 2019-11-13 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 6ORV | 6ORV_refined | 3.0 | E | Active | 100 | 61 | Gs | αs | - | 49 | - | Nanobody-35 |
CHEMBL3950796
|
small-molecule | Agonist | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Zhao P, Liang YL, Belousoff MJ, Deganutti G, Fletcher MM, Willard FS, Bell MG, Christe ME, Sloop KW, Inoue A, Truong TT, Clydesdale L, Furness SGB, Christopoulos A, Wang MW, Miller LJ, Reynolds CA, Danev R, Sexton PM, Wootten D | 10.1038/s41586-019-1902-z | 2020-01-08 | Yes | |
FPR2 | FPR2/ALX | Formylpeptide | A | Human | X-ray | 6LW5 | 6LW5_refined | 2.8 | A | Active | 100 | 91 | - | - | - | - | BRIL | - |
CHEMBL552527
|
protein | Agonist | resolvin D1, serum amyloid A, 15-deoxy-LXA4, LTC4, LL-37, humanin, LTD4, aspirin triggered lipoxin A4, annexin I, aspirin-triggered resolvin D1, fMet-Leu-Phe, PrP106-126, LXA4 | peptide | No | No | Chen T, Xiong M, Zong X, Ge Y, Zhang H, Wang M, Won Han G, Yi C, Ma L, Ye RD, Xu Y, Zhao Q, Wu B | 10.1038/S41467-020-15009-1 | 2020-03-25 | Yes | |
GABR2 | GABAB2 | GABAB | C | Human | Cryo-EM | 7C7S | - | 2.9 | B | Inactive | - | 71 | - | - | - | - | - | - |
CGP 54626A
|
small-molecule | Antagonist | - | - | No | No | Mao C, Shen C, Li C, Shen DD, Xu C, Zhang S, Zhou R, Shen Q, Chen LN, Jiang Z, Liu J, Zhang Y | 10.1038/S41422-020-0350-5 | 2020-07-01 | Yes | |
GPBAR | GPBA | Bile acid | A | Human | Cryo-EM | 7CFN | 7CFN_refined | 3.0 | R | Active | 100 | 83 | Gs | αs | - | 59 | - | Nanobody-35 |
INT-777
INT-777 |
small-molecule small-molecule |
Agonist PAM |
deoxycholic acid, chenodeoxycholic acid, lithocholic acid, cholic acid | small-molecule | No | No | Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen DD, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun JP, Xie X, Yu X, Zhang Y | 10.1038/S41586-020-2569-1 | 2020-09-09 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Human | X-ray | 7BU6 | 7BU6_refined | 2.7 | A | Active | 99 | 58 | - | - | - | - | T4-Lysozyme | Camelid antibody fragment Nb6B9 |
Noradrenaline
|
small-molecule | Agonist | noradrenaline, (-)-adrenaline, L-NOREPINEPHRINE, (-)-noradrenaline | small-molecule | No | No | Xu X, Kaindl J, Clark MJ, Hubner H, Hirata K, Sunahara RK, Gmeiner P, Kobilka BK, Liu X | 10.1038/S41422-020-00424-2 | 2020-12-02 | Yes | |
AGRG3 | ADGRG3 | ADGRG | B2 | Human | Cryo-EM | 7D76 | - | 3.1 | R | Active | - | 48 | Gi/o | αo | - | 61 | - | - |
Beclomethasone
|
small-molecule | Agonist | - | - | No | No | Ping YQ, Mao C, Xiao P, Zhao RJ, Jiang Y, Yang Z, An WT, Shen DD, Yang F, Zhang H, Qu C, Shen Q, Tian C, Li ZJ, Li S, Wang GY, Tao X, Wen X, Zhong YN, Yang J, Yi F, Yu X, Xu HE, Zhang Y, Sun JP | 10.1038/S41586-020-03083-W | 2021-02-03 | Yes | |
CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7DTU | 7DTU_refined | 4.4 | A | Intermediate | - | 72 | - | - | - | - | - | - |
L-tryptophan
|
small-molecule | PAM | spermine, L-tryptophan, Ca2+, Mg2+ | small-molecule | No | No | - | - | 2021-03-10 | Yes | |
CCR5 | CCR5 | Chemokine | A | Human | Cryo-EM | 7O7F | 7O7F_refined | 3.2 | C | Active | 100 | 85 | Gi/o | αi1 | - | 62 | - | Fab heavy chain Fab light chain |
CCL5
|
peptide | Agonist | CCL2, CCL8, CCL11, CCL13, CCL14, CCL7, CCL5, CCL4, CCL16, CCL3 | peptide | No | No | - | 10.1126/SCIADV.ABG8685 | 2021-06-30 | Yes | |
MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7S8N | 7S8N_refined | 2.9 | R | Active | 100 | 76 | Gq/11 | αq | Gq-Gs chimera | 57 | - | scFv16 |
(R)-ZINC-3573
|
small-molecule | Agonist | PAMP-20 | peptide | No | No | Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL | 10.1038/S41586-021-04126-6 | 2021-11-17 | Yes | |
MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7VV0 | 7VV0_refined | 3.5 | R | Active | 97 | 80 | - | - | - | - | - | - |
PAMP-12
|
peptide | Agonist | PAMP-20 | peptide | No | No | Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP | 10.1038/S41586-021-04077-Y | 2021-12-01 | Yes | |
5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | X-ray | 7WC5 | 7WC5_refined | 3.2 | A | Inactive | 1 | 60 | - | - | - | - | BRIL | - |
psilocin
|
small-molecule | Agonist | 5-hydroxytryptamine, tryptamine | small-molecule | No | No | - | - | 2022-01-26 | Yes | |
MSHR | MC1 | Melanocortin | A | Human | Cryo-EM | 7F4I | 7F4I_refined | 3.1 | R | Active | 100 | 84 | Gs | αs | - | 59 | - | Nanobody-35 |
bremelanotide
|
peptide | Agonist | γ-MSH, ACTH, β-MSH, α-MSH | peptide | No | No | Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE | 10.1038/S41422-021-00557-Y | 2021-09-08 | Yes | |
S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7TD4 | - | 2.6 | R | Active | 100 | 76 | Gi/o | αi1 | - | 63 | - | - |
siponimod
|
small-molecule | Agonist | sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate, sphingosine 1-phosphate | small-molecule | No | No | Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY | 10.1038/S41467-022-28417-2 | 2022-02-09 | Yes | |
GRM3 | mGlu3 | Metabotropic glutamate | C | Human | Cryo-EM | 7WI6 | 7WI6_refined | 3.7 | A | Inactive | - | 82 | - | - | - | - | - | - |
LY341495
|
small-molecule | Antagonist | L-glutamic acid, NAAG | small-molecule | No | No | Fang W, Yang F, Xu C, Ling S, Lin L, Zhou Y, Sun W, Wang X, Liu P, Rondard P, Shi P, Pin JP, Tian C, Liu J | 10.1038/S41422-022-00623-Z | 2022-03-16 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7RG9 | 7RG9_refined | 3.2 | R | Active | 100 | 58 | Gs | αs | - | 56 | - | scFv16 Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW | 10.1073/PNAS.2116506119 | 2022-04-13 | Yes | |
ACM4 | M4 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 7V68 | - | 3.4 | R | Active | 100 | 58 | Gi/o | αi1 | - | 62 | - | scFv16 |
iperoxo
LY2119620 |
small-molecule small-molecule |
Agonist PAM |
acetylcholine | small-molecule | No | No | Wang J, Wu M, Chen Z, Wu L, Wang T, Cao D, Wang H, Liu S, Xu Y, Li F, Liu J, Chen N, Zhao S, Cheng J, Wang S, Hua T | 10.1038/S41467-022-30595-Y | 2022-05-11 | Yes | |
TRFR | TRH1 | Thyrotropin-releasing hormone | A | Human | Cryo-EM | 7WKD | - | 3.0 | R | Active | 100 | 66 | Gq/11 | αq | - | 60 | - | scFv16 |
TRH
|
peptide | Agonist | TRH | peptide | No | No | Xu Y, Cai H, You C, He X, Yuan Q, Jiang H, Cheng X, Jiang Y, Xu HE | 10.1038/S41422-022-00641-X | 2022-06-15 | Yes | |
MRGRD | MRGPRD | A orphans | A | Human | Cryo-EM | 7Y13 | 7Y13_refined | 3.1 | R | Intermediate | 55 | 82 | - | - | - | - | BRIL | - |
Apo (no ligand)
|
none | Apo (no ligand) | β-alanine | small-molecule | No | No | Suzuki S, Iida M, Hiroaki Y, Tanaka K, Kawamoto A, Kato T, Oshima A | 10.1038/S42003-022-03668-3 | 2022-07-20 | Yes | |
SSR2 | SST2 | Somatostatin | A | Human | X-ray | 7XN9 | 7XN9_refined | 2.6 | A | Inactive | 4 | 79 | - | - | - | - | - | - |
L-054,522
|
small-molecule | Antagonist | SRIF-14, CST-17, cortistatin-14, SRIF-28 | peptide | No | No | Zhao W, Han S, Qiu N, Feng W, Lu M, Zhang W, Wang M, Zhou Q, Chen S, Xu W, Du J, Chu X, Yi C, Dai A, Hu L, Shen MY, Sun Y, Zhang Q, Ma Y, Zhong W, Yang D, Wang MW, Wu B, Zhao Q | 10.1038/S41422-022-00679-X | 2022-08-03 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 8DU3 | 8DU3_refined | 2.5 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
CHEMBL5206530
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Bolteau R, Duroux R, Laversin A, Vreulz B, Shiriaeva A, Stauch B, Han GW, Cherezov V, Renault N, Barczyk A, Ravez S, Coevoet M, Melnyk P, Liberelle M, Yous S. | 10.1016/j.ejmech.2022.114620 | 2022-08-10 | Yes | |
TSHR | TSH | Glycoprotein hormone | A | Human | Cryo-EM | 7T9N | - | 2.9 | R | Active | 100 | 73 | Gs | αs | Mini-Gs | 56 | - | M22 Fab light chain M22 Fab heavy chain Nanobody-35 |
M22 antibody light chain
M22 antibody heavy chain |
protein protein |
Agonist | TSH | peptide | No | No | Faust B, Billesbolle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A | 10.1038/S41586-022-05159-1 | 2022-08-03 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 2YCX | - | 3.3 | A | Inactive | 0 | 59 | - | - | - | - | - | - |
(S)-Cyanopindolol
|
small-molecule | Antagonist | - | - | No | No | - | - | 2011-06-01 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 4BEY | 4BEY_refined | 2.9 | A | Active | 100 | 94 | Gi/o | αt1 | Only H5 | 3 | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Singhal A, Ostermaier MK, Vishnivetskiy SA, Panneels V, Homan KT, Tesmer JJ, Veprintsev D, Deupi X, Gurevich VV, Schertler GF, Standfuss J | 10.1038/EMBOR.2013.44 | 2013-05-08 | Yes | |
P2Y12 | P2Y12 | P2Y | A | Human | X-ray | 4PY0 | 4PY0_refined | 3.1 | A | Intermediate | 44 | 83 | - | - | - | - | BRIL | - |
2MeSATP
|
small-molecule | Agonist (partial) | ADP, ATP | small-molecule | No | No | Zhang J, Zhang K, Gao ZG, Paoletta S, Zhang D, Han GW, Li T, Ma L, Zhang W, Muller CE, Yang H, Jiang H, Cherezov V, Katritch V, Jacobson KA, Stevens RC, Wu B, Zhao Q | 10.1038/NATURE13288 | 2014-04-30 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 4X1H | 4X1H_refined | 2.3 | A | Active | 100 | 94 | Gi/o | αt1 | Only H5 | 3 | - | - |
B-Nonylglucoside
|
small-molecule | unknown | - | - | No | No | Blankenship E, Vahedi-Faridi A, Lodowski DT | 10.1016/J.STR.2015.09.015 | 2015-11-04 | Yes | |
EDNRB | ETB | Endothelin | A | Human | X-ray | 5GLH | 5GLH_refined | 2.8 | A | Inactive | 15 | 66 | - | - | - | - | T4-Lysozyme | - |
ENDOTHELIN
|
protein | Agonist | endothelin-1, endothelin-2, endothelin-3 | peptide | No | No | - | 10.1038/nature19319 | 2016-09-07 | Yes | |
CNR1 | CB1 | Cannabinoid | A | Human | X-ray | 5XR8 | 5XR8_refined | 3.0 | A | Active | 91 | 60 | - | - | - | - | Flavodoxin | - |
AM841
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Hua T, Vemuri K, Nikas SP, Laprairie RB, Wu Y, Qu L, Pu M, Korde A, Jiang S, Ho JH, Han GW, Ding K, Li X, Liu H, Hanson MA, Zhao S, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ | 10.1038/NATURE23272 | 2017-07-12 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5OM4 | 5OM4_refined | 2.0 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
CHEMBL2024114
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Rucktooa P, Cheng RKY, Segala E, Geng T, Errey JC, Brown GA, Cooke RM, Marshall FH, Dore AS | 10.1038/S41598-017-18570-W | 2018-01-17 | Yes | |
C5AR1 | C5a1 | Complement peptide | A | Human | X-ray | 6C1R | 6C1R_refined | 2.2 | B | Inactive | 6 | 83 | - | - | - | - | BRIL | - |
PMX53
avacopan |
peptide small-molecule |
Antagonist NAM |
C3a, C5a, ribosomal protein S19, C5a des-Arg | peptide | No | No | - | - | 2018-05-30 | Yes | |
ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | X-ray | 5ZKC | 5ZKC_refined | 2.3 | A | Inactive | 2 | 60 | - | - | - | - | BRIL | - |
N-methyl scopolamine
|
small-molecule | Antagonist | acetylcholine | small-molecule | No | No | Suno R, Lee S, Maeda S, Yasuda S, Yamashita K, Hirata K, Horita S, Tawaramoto MS, Tsujimoto H, Murata T, Kinoshita M, Yamamoto M, Kobilka BK, Vaidehi N, Iwata S, Kobayashi T | 10.1038/S41589-018-0152-Y | 2018-11-21 | Yes | |
5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | X-ray | 6A94 | 6A94_refined | 2.9 | A | Inactive | 1 | 60 | - | - | - | - | BRIL | - |
zotepine
|
small-molecule | Antagonist | 5-hydroxytryptamine, tryptamine | small-molecule | No | No | - | - | 2019-02-13 | Yes | |
SMO | SMO | Frizzled | F | Mouse | X-ray | 6O3C | 6O3C_refined | 2.8 | A | Active | 95 | 61 | - | - | - | - | - | Nanobody-Smo8 |
SAG21k
|
small-molecule | Agonist | - | - | No | No | - | 10.1038/S41586-019-1355-4 | 2019-07-03 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 6PS4 | 6PS4_refined | 2.6 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
ICI 118551
|
small-molecule | Antagonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | - | 10.1107/S2052252519013137 | 2019-11-13 | Yes | |
OX1R | OX1 | Orexin | A | Human | X-ray | 6TQ4 | 6TQ4_refined | 2.3 | B | Inactive | 1 | 70 | - | - | - | - | - | - |
CHEMBL4590386
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | Yes | |
GPR52 | GPR52 | A orphans | A | Human | X-ray | 6LI1 | 6LI1_refined | 2.9 | A | Intermediate | 40 | 81 | - | - | - | - | Flavodoxin | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Lin X, Li M, Wang N, Wu Y, Luo Z, Guo S, Han GW, Li S, Yue Y, Wei X, Xie X, Chen Y, Zhao S, Wu J, Lei M, Xu F | 10.1038/S41586-020-2019-0 | 2020-02-26 | Yes | |
GLR | glucagon | Glucagon | B1 | Human | Cryo-EM | 6LML | 6LML_refined | 3.9 | R | Active | 100 | 83 | Gi/o | αi1 | - | 63 | - | scFv16 |
glucagon
|
peptide | Agonist | glucagon | peptide | No | No | Qiao A, Han S, Li X, Li Z, Zhao P, Dai A, Chang R, Tai L, Tan Q, Chu X, Ma L, Thorsen TS, Reedtz-Runge S, Yang D, Wang MW, Sexton PM, Wootten D, Sun F, Zhao Q, Wu B | 10.1126/SCIENCE.AAZ5346 | 2020-04-01 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | Cryo-EM | 7JJO | - | 2.6 | R | Active | 100 | 58 | Gs | αs | - | 51 | - | Nanobody-35 |
LEVISOPRENALINE
|
small-molecule | Agonist | - | - | No | No | Su M, Zhu L, Zhang Y, Paknejad N, Dey R, Huang J, Lee MY, Williams D, Jordan KD, Eng ET, Ernst OP, Meyerson JR, Hite RK, Walz T, Liu W, Huang XY | 10.1016/J.MOLCEL.2020.08.001 | 2020-09-02 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 6LPK | 6LPK_refined | 1.8 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Ihara K, Hato M, Nakane T, Yamashita K, Kimura-Someya T, Hosaka T, Ishizuka-Katsura Y, Tanaka R, Tanaka T, Sugahara M, Hirata K, Yamamoto M, Nureki O, Tono K, Nango E, Iwata S, Shirouzu M | 10.1038/S41598-020-76277-X | 2020-11-25 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 6Z4Q | - | 2.9 | A | Inactive | 32 | 75 | - | - | - | - | DARPin D12 | - |
SR142948A
|
small-molecule | Inverse agonist | neuromedin N, neurotensin | peptide | No | No | - | - | 2021-02-10 | Yes | |
5HT1A | 5-HT1A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7E2Y | - | 3.0 | R | Active | 100 | 65 | Gi/o | αi1 | - | 62 | - | - |
5-hydroxytryptamine
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE | 10.1038/S41586-021-03376-8 | 2021-04-14 | Yes | |
CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7M3J | 7M3J_refined | 4.1 | A | Inactive | - | 72 | - | - | - | - | - | - |
NPS 2143
|
small-molecule | NAM | spermine, L-tryptophan, Ca2+, Mg2+ | small-molecule | No | No | - | - | 2021-06-30 | Yes | |
GRM5 | mGlu5 | Metabotropic glutamate | C | Human | Cryo-EM | 7FD9 | 7FD9_refined | 4.0 | A | Inactive | - | 63 | - | - | - | - | - | - |
LY341495
|
small-molecule | Antagonist | L-glutamic acid | small-molecule | No | No | Nasrallah C, Cannone G, Briot J, Rottier K, Berizzi AE, Huang CY, Quast RB, Hoh F, Baneres JL, Malhaire F, Berto L, Dumazer A, Font-Ingles J, Gomez-Santacana X, Catena J, Kniazeff J, Goudet C, Llebaria A, Pin JP, Vinothkumar KR, Lebon G | 10.1016/J.CELREP.2021.109648 | 2021-09-08 | Yes | |
GASR | CCK2 | Cholecystokinin | A | Human | Cryo-EM | 7F8V | - | 3.3 | R | Active | 100 | 62 | Gi/o | αi2 | - | 61 | - | - |
desulfated gastrin-17
|
peptide | Agonist | desulfated cholecystokinin-8, desulfated gastrin-17, CCK-33, CCK-8, CCK-58, desulfated gastrin-71, desulfated gastrin-14, CCK-4, desulfated gastrin-34, gastrin-34, gastrin-14, CCK-39, gastrin-17, gastrin-71 | peptide | No | No | Zhang X, He C, Wang M, Zhou Q, Yang D, Zhu Y, Feng W, Zhang H, Dai A, Chu X, Wang J, Yang Z, Jiang Y, Sensfuss U, Tan Q, Han S, Reedtz-Runge S, Xu HE, Zhao S, Wang MW, Wu B, Zhao Q | 10.1038/S41589-021-00866-8 | 2021-10-13 | Yes | |
MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7VV3 | - | 3.0 | R | Active | 100 | 79 | Gi/o | αi1 | - | 62 | - | scFv16 |
Cortistatin 14
|
peptide | Agonist | PAMP-20 | peptide | No | No | Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP | 10.1038/S41586-021-04077-Y | 2021-12-01 | Yes | |
US28 | US28 | Unclassified | A | strain AD169 | Cryo-EM | 7RKF | - | 4.0 | R | Active | 100 | 84 | Gq/11 | α11 | - | 97 | - | scFv16 |
Fractalkine
|
peptide | Agonist | - | - | No | No | Tsutsumi N, Maeda S, Qu Q, Vogele M, Jude KM, Suomivuori CM, Panova O, Waghray D, Kato HE, Velasco A, Dror RO, Skiniotis G, Kobilka BK, Garcia KC | 10.1126/SCIADV.ABL5442 | 2022-01-26 | Yes | |
GLR | glucagon | Glucagon | B1 | Human | Cryo-EM | 7V35 | 7V35_refined | 3.4 | R | Active | 100 | 82 | Gs | αs | - | 53 | - | Nanobody-35 |
Peptide-20
|
peptide | Agonist | glucagon | peptide | No | No | Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW | 10.1038/S41467-022-28683-0 | 2022-03-02 | Yes | |
NMUR2 | NMU2 | Neuromedin U | A | Human | Cryo-EM | 7W55 | - | 2.8 | R | Active | 100 | 73 | Gq/11 | αq | - | 60 | - | scFv16 |
Neuromedin U-25 (human)
|
peptide | Agonist | neuromedin U-25, neuromedin U-23, neuromedin S-33, neuromedin S-36 | peptide | No | No | You C, Zhang Y, Xu P, Huang S, Yin W, Eric Xu H, Jiang Y | 10.1038/S41467-022-29683-W | 2022-04-20 | Yes | |
GASR | CCK2 | Cholecystokinin | A | Human | Cryo-EM | 7XOW | 7XOW_refined | 3.1 | R | Active | 100 | 62 | Gq/11 | αq | - | 61 | - | scFv16 |
desulfated gastrin-17
|
peptide | Agonist | desulfated cholecystokinin-8, desulfated gastrin-17, CCK-33, CCK-8, CCK-58, desulfated gastrin-71, desulfated gastrin-14, CCK-4, desulfated gastrin-34, gastrin-34, gastrin-14, CCK-39, gastrin-17, gastrin-71 | peptide | No | No | Ding Y, Zhang H, Liao YY, Chen LN, Ji SY, Qin J, Mao C, Shen DD, Lin L, Wang H, Zhang Y, Li XM | 10.1038/S41421-022-00420-3 | 2022-07-20 | Yes | |
SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7XMR | 7XMR_refined | 3.1 | R | Active | 100 | 77 | Gi/o | αi1 | - | 63 | - | - |
SOMATOSTATIN
|
protein | Agonist | SRIF-14, CST-17, cortistatin-14, SRIF-28 | peptide | No | No | - | - | 2022-08-03 | Yes | |
AGRG2 | ADGRG2 | ADGRG | B2 | Mouse | Cryo-EM | 7YP7 | - | 3.1 | R | Active | - | 24 | Gs | αs | - | 59 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | - | 2022-08-24 | Yes | |
OPRM | μ | Opioid | A | Mouse | Cryo-EM | 7T2G | - | 2.5 | R | Active | 100 | 70 | Gi/o | αi1 | - | 62 | BRIL | - |
CHEMBL58362
|
small-molecule | Agonist | - | - | No | No | Qu Q, Huang W, Aydin D, Paggi JM, Seven AB, Wang H, Chakraborty S, Che T, DiBerto JF, Robertson MJ, Inoue A, Suomivuori CM, Roth BL, Majumdar S, Dror RO, Kobilka BK, Skiniotis G | 10.1038/S41589-022-01208-Y | 2022-12-07 | Yes | |
AGRL3 | ADGRL3 | ADGRL | B2 | Mouse | Cryo-EM | 7WY8 | - | 2.8 | R | Active | - | 17 | Gs | αs | Mini-Gs | 59 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Qian Y, Ma Z, Liu C, Li X, Zhu X, Wang N, Xu Z, Xia R, Liang J, Duan Y, Yin H, Xiong Y, Zhang A, Guo C, Chen Z, Huang Z, He Y | 10.1016/J.MOLCEL.2022.10.009 | 2022-10-26 | Yes | |
LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | Cryo-EM | 7YU6 | 7YU6_refined | 3.5 | R | Active | 100 | 80 | Gi/o | αi1 | - | 63 | - | scFv16 |
[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate
|
small-molecule | Agonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | Akasaka H, Tanaka T, Sano FK, Matsuzaki Y, Shihoya W, Nureki O | 10.1038/S41467-022-33121-2 | 2022-10-05 | Yes | |
OPRX | NOP | Opioid | A | Human | Cryo-EM | 8F7X | 8F7X_refined | 3.3 | R | Active | 100 | 77 | Gi/o | αi1 | - | 62 | - | scFv16 |
nociceptin/orphanin FQ
|
peptide | Agonist | nociceptin/orphanin FQ | peptide | No | No | Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE | 10.1016/J.CELL.2022.12.026 | 2022-12-14 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Rat | Cryo-EM | 8FN1 | - | 2.9 | A | Active | 100 | 66 | Gi/o | αo | - | 60 | - | scFv16 |
neurotensin
|
peptide | Agonist | neuromedin N, neurotensin | peptide | No | No | - | - | 2023-03-29 | Yes | |
FFAR4 | FFA4 | Free fatty acid | A | Human | Cryo-EM | 8ID4 | - | 3.1 | R | Active | 100 | 79 | Gi/o | αi1 | - | 64 | - | scFv16 |
linoleic acid
|
small-molecule | Agonist | linoleic acid, oleic acid, α-linolenic acid, myristic acid | small-molecule | No | No | - | 10.1126/SCIENCE.ADD6220 | 2023-03-15 | Yes | |
AGRF1 | ADGRF1 | ADGRF | B2 | Human | Cryo-EM | 8G2Y | - | 3.4 | R | Active | - | 28 | Gq/11 | αq | Gs-mini-Gq chimera | 52 | - | Nanobody-35 |
[1-Myristoyl-glycerol-3-YL]phosphonylcholine
|
small-molecule | Agonist | - | - | No | No | Jones DTD, Dates AN, Rawson SD, Burruss MM, Lipper CH, Blacklow SC | 10.1038/S41467-023-38083-7 | 2023-05-10 | Yes | |
ACM4 | M4 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 7TRQ | - | 2.5 | R | Active | 100 | 57 | Gi/o | αi1 | - | 64 | - | scFv16 |
iperoxo
VU0467154 |
small-molecule small-molecule |
Agonist PAM |
acetylcholine | small-molecule | No | No | - | - | 2023-05-17 | Yes | |
P2RY1 | P2Y1 | P2Y | A | Human | Cryo-EM | 7XXH | 7XXH_refined | 2.9 | R | Active | 100 | 81 | Gq/11 | α11 | - | 63 | - | scFv16 |
2MeSADP
|
small-molecule | Agonist | ADP, ATP | small-molecule | No | No | - | - | 2023-06-07 | Yes | |
NMBR | BB1 | Bombesin | A | Human | Cryo-EM | 8H0P | - | 3.2 | R | Active | 100 | 75 | Gq/11 | αq | - | 56 | - | scFv16 |
NMB30
|
peptide | Agonist | gastrin-releasing peptide, neuromedin B, gastrin releasing peptide(14-27) (human), GRP-(18-27) | peptide | No | No | Li C, Xu Y, Liu H, Cai H, Jiang Y, Xu HE, Yin W | 10.1038/S41422-022-00743-6 | 2023-08-09 | Yes | |
GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 8JCW | - | 3.0 | 2 | Inactive | - | 87 | - | - | - | - | - | - |
LY341495
|
small-molecule | Antagonist | L-glutamic acid | small-molecule | No | No | Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B | 10.1038/S41422-023-00830-2 | 2023-06-21 | Yes | |
OPSD | Rhodopsin | Opsins | A | Japanese flying squid | X-ray | 3AYM | - | 2.8 | B | Inactive | 17 | 77 | - | - | - | - | - | - |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | - | 10.1016/J.JMB.2011.08.044 | 2011-08-17 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 4LDE | 4LDE_refined | 2.8 | A | Active | 99 | 69 | - | - | - | - | T4-Lysozyme | Nanobody |
CHEMBL1615159
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | Ring AM, Manglik A, Kruse AC, Enos MD, Weis WI, Garcia KC, Kobilka BK | 10.1038/NATURE12572 | 2013-09-25 | Yes | |
US28 | US28 | Unclassified | A | strain AD169 | X-ray | 4XT3 | 4XT3_refined | 3.8 | A | Active | 100 | 81 | - | - | - | - | - | - |
CX3CL1
|
peptide | Agonist (partial) | - | - | No | No | Burg JS, Ingram JR, Venkatakrishnan AJ, Jude KM, Dukkipati A, Feinberg EN, Angelini A, Waghray D, Dror RO, Ploegh HL, Garcia KC | 10.1126/SCIENCE.AAA5026 | 2015-03-04 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 5T04 | 5T04_refined | 3.3 | A | Active | 79 | 69 | - | - | - | - | T4-Lysozyme | - |
neurotensin
|
peptide | Agonist | neuromedin N, neurotensin | peptide | No | No | Krumm BE, Lee S, Bhattacharya S, Botos I, White CF, Du H, Vaidehi N, Grisshammer R | 10.1038/SREP38564 | 2016-12-21 | Yes | |
CNR1 | CB1 | Cannabinoid | A | Human | X-ray | 5XRA | 5XRA_refined | 2.8 | A | Active | 91 | 60 | - | - | - | - | Flavodoxin | - |
AM11542
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Hua T, Vemuri K, Nikas SP, Laprairie RB, Wu Y, Qu L, Pu M, Korde A, Jiang S, Ho JH, Han GW, Ding K, Li X, Liu H, Hanson MA, Zhao S, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ | 10.1038/NATURE23272 | 2017-07-12 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5OLV | 5OLV_refined | 2.0 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
CHEMBL1671936
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Rucktooa P, Cheng RKY, Segala E, Geng T, Errey JC, Brown GA, Cooke RM, Marshall FH, Dore AS | 10.1038/S41598-017-18570-W | 2018-01-17 | Yes | |
Q80KM9 | US28 | Unclassified | A | strain AD169 | X-ray | 5WB1 | 5WB1_refined | 3.5 | A | Active | 100 | 82 | - | - | - | - | - | Nanobody | - | - | - | - | - | No | No | Miles TF, Spiess K, Jude KM, Tsutsumi N, Burg JS, Ingram JR, Waghray D, Hjorto GM, Larsen O, Ploegh HL, Rosenkilde MM, Garcia KC | 10.7554/ELIFE.35850 | 2018-06-13 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 6H7O | 6H7O_refined | 2.8 | A | Active | 99 | 60 | - | - | - | - | Thioredoxin 1 | Camelid antibody fragment Nb6B9 |
(S)-Cyanopindolol
|
small-molecule | Agonist | - | - | No | No | Warne T, Edwards PC, Dore AS, Leslie AGW, Tate CG | 10.1126/SCIENCE.AAU5595 | 2018-10-17 | Yes | |
AGTR1 | AT1 | Angiotensin | A | Human | X-ray | 6DO1 | 6DO1_refined | 2.9 | A | Active | 95 | 85 | - | - | - | - | BRIL | Nanobody-Nb.AT110i1 |
CHEMBL404594
|
protein | Agonist | angiotensin A, angiotensin III, angiotensin IV, angiotensin II | peptide | No | No | - | 10.1016/J.CELL.2018.12.006 | 2019-01-30 | Yes | |
CNR1 | CB1 | Cannabinoid | A | Human | X-ray | 6KQI | 6KQI_refined | 3.3 | A | Inactive | 11 | 60 | - | - | - | - | GlgA glycogen synthase | - |
CP55940
Org27569 |
small-molecule small-molecule |
Agonist NAM |
2-arachidonoylglycerol, anandamide | small-molecule | No | No | - | 10.1038/S41589-019-0387-2 | 2019-10-23 | Yes | |
OX1R | OX1 | Orexin | A | Human | X-ray | 6TP6 | 6TP6_refined | 2.3 | B | Inactive | 1 | 71 | - | - | - | - | - | - |
filorexant
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | Yes | |
DRD2 | D2 | Dopamine | A | Human | X-ray | 6LUQ | 6LUQ_refined | 3.1 | A | Inactive | 1 | 59 | - | - | - | - | T4-Lysozyme | - |
haloperidol
|
small-molecule | Antagonist | dopamine | small-molecule | No | No | Fan L, Tan L, Chen Z, Qi J, Nie F, Luo Z, Cheng J, Wang S | 10.1038/S41467-020-14884-Y | 2020-03-04 | Yes | |
MC4R | MC4 | Melanocortin | A | Human | X-ray | 6W25 | - | 2.8 | A | Intermediate | 49 | 79 | - | - | - | - | GlgA glycogen synthase | - |
SHU9119
Calcium |
peptide small-molecule |
Antagonist Cofactor |
agouti-related protein, β-MSH, α-MSH, γ-MSH, ACTH | peptide | No | No | Yu J, Gimenez LE, Hernandez CC, Wu Y, Wein AH, Han GW, McClary K, Mittal SR, Burdsall K, Stauch B, Wu L, Stevens SN, Peisley A, Williams SY, Chen V, Millhauser GL, Zhao S, Cone RD, Stevens RC | 10.1126/SCIENCE.AAZ8995 | 2020-04-29 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 6VCB | - | 3.3 | R | Active | 100 | 82 | Gs | αs | - | 57 | - | Nanobody-35 |
glucagon-like peptide 1-(7-37)
CHEMBL5197819 |
peptide small-molecule |
Agonist PAM |
glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Bueno AB, Sun B, Willard FS, Feng D, Ho JD, Wainscott DB, Showalter AD, Vieth M, Chen Q, Stutsman C, Chau B, Ficorilli J, Agejas FJ, Cumming GR, Jimenez A, Rojo I, Kobilka TS, Kobilka BK, Sloop KW | 10.1038/S41589-020-0589-7 | 2020-07-22 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Rat | Cryo-EM | 7L0P | - | 4.1 | C | Active | 100 | 73 | Gi/o | αi1 | - | 63 | - | - |
neurotensin
|
peptide | Agonist | neuromedin N, neurotensin | peptide | No | No | Zhang M, Gui M, Wang ZF, Gorgulla C, Yu JJ, Wu H, Sun ZJ, Klenk C, Merklinger L, Morstein L, Hagn F, Pluckthun A, Brown A, Nasr ML, Wagner G | 10.1038/S41594-020-00554-6 | 2021-01-06 | Yes | |
DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7CKX | - | 3.5 | R | Active | 100 | 61 | Gs | αs | - | 60 | - | Nanobody-35 |
A77636
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, 5-hydroxytryptamine, dopamine | small-molecule | No | No | Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z | 10.1016/J.CELL.2021.01.028 | 2021-03-03 | Yes | |
V2R | V2 | Vasopressin and oxytocin | A | Human | Cryo-EM | 7BB6 | - | 4.2 | A | Active | 100 | 73 | Gs | αs | - | 54 | - | Nanobody-35 |
vasopressin
|
peptide | Agonist | oxytocin, vasopressin | peptide | No | No | Bous J, Orcel H, Floquet N, Leyrat C, Lai-Kee-Him J, Gaibelet G, Ancelin A, Saint-Paul J, Trapani S, Louet M, Sounier R, Demene H, Granier S, Bron P, Mouillac B | 10.1126/SCIADV.ABG5628 | 2021-06-02 | Yes | |
GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 7MTR | 7MTR_refined | 3.3 | A | Active | - | 88 | - | - | - | - | - | - |
2-methoxy-6-propyl-N-(2-{4-[(1H-tetrazol-5-yl)methoxy]phenyl}ethyl)thieno[2,3-d]pyrimidin-4-amine
L-glutamic acid |
small-molecule small-molecule |
Ago-PAM Agonist |
L-glutamic acid | small-molecule | No | No | - | - | 2021-07-07 | Yes | |
CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7E6U | 7E6U_refined | 6.0 | A | Inactive | - | 72 | - | - | - | - | - | Nanobody-2D11 |
Apo (no ligand)
|
none | Apo (no ligand) | spermine, L-tryptophan, Ca2+, Mg2+ | small-molecule | No | No | - | - | 2021-09-22 | Yes | |
GP158 | GPR158 | C Orphans | C | Human | Cryo-EM | 7EWR | 7EWR_refined | 4.7 | A | Inactive | - | 47 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Jeong E, Kim Y, Jeong J, Cho Y | 10.1038/S41467-021-27147-1 | 2021-12-01 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7LLY | 7LLY_refined | 3.3 | R | Active | 100 | 77 | Gs | αs | - | 50 | - | Nanobody-35 |
Pro-glucagon
|
peptide | Agonist | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Deganutti G, Liang YL, Zhang X, Khoshouei M, Clydesdale L, Belousoff MJ, Venugopal H, Truong TT, Glukhova A, Keller AN, Gregory KJ, Leach K, Christopoulos A, Danev R, Reynolds CA, Zhao P, Sexton PM, Wootten D | 10.1038/S41467-021-27760-0 | 2022-01-12 | Yes | |
LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | Cryo-EM | 7TD1 | - | 3.1 | R | Active | 100 | 80 | Gi/o | αi1 | - | 62 | - | - |
lysophosphatidic acid
|
small-molecule | Agonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY | 10.1038/S41467-022-28417-2 | 2022-02-09 | Yes | |
FPR2 | FPR2/ALX | Formylpeptide | A | Human | Cryo-EM | 7WVV | 7WVV_refined | 2.9 | R | Active | 100 | 85 | Gi/o | αi2 | - | 63 | BRIL | - |
synthetic peptide
|
peptide | Agonist | resolvin D1, serum amyloid A, 15-deoxy-LXA4, LTC4, LL-37, humanin, LTD4, aspirin triggered lipoxin A4, annexin I, aspirin-triggered resolvin D1, fMet-Leu-Phe, PrP106-126, LXA4 | peptide | No | No | Zhu Y, Lin X, Zong X, Han S, Wang M, Su Y, Ma L, Chu X, Yi C, Zhao Q, Wu B | 10.1038/S41467-022-29361-X | 2022-04-13 | Yes | |
GPR88 | GPR88 | A orphans | A | Human | Cryo-EM | 7EJX | - | 2.4 | R | Active | 100 | 60 | Gi/o | αi1 | - | 61 | - | scFv16 |
compound 2 [PMID: 24793972]
|
small-molecule | Allosteric agonist | - | - | No | No | Chen G, Xu J, Inoue A, Schmidt MF, Bai C, Lu Q, Gmeiner P, Liu Z, Du Y | 10.1038/S41467-022-30081-5 | 2022-04-13 | Yes | |
OX2R | OX2 | Orexin | A | Human | Cryo-EM | 7SR8 | - | 3.3 | R | Active | 100 | 64 | Gq/11 | αq | - | 58 | - | scFv16 |
methyl (2R,3S)-3-[(methanesulfonyl)amino]-2-({[(1s,4S)-4-phenylcyclohexyl]oxy}methyl)piperidine-1-carboxylate
|
small-molecule | Agonist | orexin-B, orexin-A | peptide | No | No | Yin J, Kang Y, McGrath AP, Chapman K, Sjodt M, Kimura E, Okabe A, Koike T, Miyanohana Y, Shimizu Y, Rallabandi R, Lian P, Bai X, Flinspach M, De Brabander JK, Rosenbaum DM | 10.1038/S41467-022-30601-3 | 2022-06-08 | Yes | |
CNR1 | CB1 | Cannabinoid | A | Human | X-ray | 7FEE | 7FEE_refined | 2.7 | A | Inactive | 11 | 61 | - | - | - | - | GlgA glycogen synthase | - |
CP55940
6-methyl-3-[(1S)-2-nitro-1-thiophen-2-yl-ethyl]-2-phenyl-1H-indole |
small-molecule small-molecule |
Agonist PAM |
2-arachidonoylglycerol, anandamide | small-molecule | No | No | Yang X, Wang X, Xu Z, Wu C, Zhou Y, Wang Y, Lin G, Li K, Wu M, Xia A, Liu J, Cheng L, Zou J, Yan W, Shao Z, Yang S | 10.1038/S41589-022-01038-Y | 2022-06-15 | Yes | |
ACKR3 | ACKR3 | Chemokine | A | Human | Cryo-EM | 7SK7 | - | 3.3 | A | Active | 95 | 74 | - | - | - | - | - | CID25 Fab light chain CID25 Fab heavy chain anti-Fab Nanobody |
Stromal cell-derived factor 1
(1R)-4-[7-(3-carboxypropoxy)-6-methylquinolin-8-yl]-1-{[2-(4-hydroxypiperidin-1-yl)-1,3-thiazol-4-yl]methyl}-1,4-diazepan-1-ium |
peptide small-molecule |
Agonist Agonist (partial) |
CXCL12α, CXCL11 | peptide | No | No | Yen YC, Schafer CT, Gustavsson M, Eberle SA, Dominik PK, Deneka D, Zhang P, Schall TJ, Kossiakoff AA, Tesmer JJG, Handel TM | 10.1126/SCIADV.ABN8063 | 2022-07-27 | Yes | |
ACM3 | M3 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 8E9W | - | 2.7 | A | Active | 100 | 47 | Gq/11 | αq | Mini-Gq | 57 | - | scFv16 |
CHEMBL73538
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | - | - | 2022-11-30 | Yes | |
PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 8HAO | - | 3.8 | R | Active | 100 | 61 | Gs | αs | - | 60 | - | Nanobody-35 |
teriparatide
|
peptide | Agonist | PTH, PTHrP-(1-36), TIP39, PTHrP | peptide | No | No | Zhao LH, Yuan QN, Dai AT, He XH, Chen CW, Zhang C, Xu YW, Zhou Y, Wang MW, Yang DH, Xu HE | 10.1038/S41401-022-01032-Z | 2022-12-21 | Yes | |
ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 7T8X | 7T8X_refined | 3.2 | A | Active | 100 | 59 | Gi/o | αo | - | 62 | - | Antibody fragment |
acetylcholine
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | - | - | 2023-01-25 | Yes | |
GP174 | GPR174 | A orphans | A | Human | Cryo-EM | 7XV3 | 7XV3_refined | 2.8 | R | Active | 100 | 87 | Gs | αs | - | 59 | - | - |
(2~{S})-2-$l^{4}-azanyl-3-[[(2~{R})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid
|
small-molecule | Agonist | lysophosphatidylserine | small-molecule | No | No | Liang J, Inoue A, Ikuta T, Xia R, Wang N, Kawakami K, Xu Z, Qian Y, Zhu X, Zhang A, Guo C, Huang Z, He Y | 10.1038/S41467-023-36575-0 | 2023-02-15 | Yes | |
MTLR | motilin | Motilin | A | Human | Cryo-EM | 8IBU | 8IBU_refined | 3.5 | R | Active | 100 | 66 | Gq/11 | αq | - | 60 | BRIL | scFv16 |
erythromycin
|
small-molecule | Agonist | motilin | peptide | No | No | You C, Zhang Y, Xu Y, Xu P, Li Z, Li H, Huang S, Chen Z, Li J, Xu HE, Jiang Y | 10.1126/SCIADV.ADE9020 | 2023-04-12 | Yes | |
CML1 | chemerin | Chemerin receptor | A | Human | Cryo-EM | 7YKD | - | 2.8 | A | Active | 100 | 76 | Gi/o | αi1 | - | 61 | - | scFv16 |
chemerin C-terminal peptide
|
peptide | Agonist | chemerin C-terminal peptide, chemerin, 18R-HEPE, resolvin E1, EPA | peptide | No | No | Wang J, Chen G, Liao Q, Lyu W, Liu A, Zhu L, Du Y, Ye RD | 10.1073/PNAS.2214324120 | 2023-04-19 | Yes | |
FFAR4 | FFA4 | Free fatty acid | A | Human | Cryo-EM | 8IYS | - | 3.0 | R | Active | 100 | 82 | Gq/11 | αq | - | 99 | - | scFv16 |
TUG-891
|
small-molecule | Agonist | linoleic acid, oleic acid, α-linolenic acid, myristic acid | small-molecule | No | No | Yin H, Inoue A, Ma Z, Zhu X, Xia R, Xu Z, Wang N, Duan Y, Zhang A, Guo C, He Y | 10.1038/S41422-023-00835-X | 2023-06-21 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Human | Cryo-EM | 8JPF | - | 3.0 | R | Active | 79 | 71 | - | - | - | - | - | - |
JMV431
CHEMBL4576388 |
peptide small-molecule |
Agonist PAM |
neuromedin N, large neurotensin, neurotensin, large neuromedin N | peptide | No | No | Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE | 10.1038/S41586-023-06395-9 | 2023-08-09 | Yes | |
OPSD | Rhodopsin | Opsins | A | Japanese flying squid | X-ray | 3AYN | - | 2.7 | B | Inactive | 17 | 77 | - | - | - | - | - | - |
Retinal (9-cis)
|
small-molecule | Inverse agonist | - | - | No | No | - | - | 2011-08-17 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 4LDL | 4LDL_refined | 3.1 | A | Active | 99 | 69 | - | - | - | - | T4-Lysozyme | Nanobody |
hydroxybenzylisoproterenol
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | - | - | 2013-09-25 | Yes | |
US28 | US28 | Unclassified | A | strain AD169 | X-ray | 4XT1 | - | 2.9 | A | Active | 100 | 82 | - | - | - | - | - | Nanobody |
CX3CL1
|
peptide | Agonist (partial) | - | - | No | No | Burg JS, Ingram JR, Venkatakrishnan AJ, Jude KM, Dukkipati A, Feinberg EN, Angelini A, Waghray D, Dror RO, Ploegh HL, Garcia KC | 10.1126/SCIENCE.AAA5026 | 2015-03-04 | Yes | |
AA1R | A1 | Adenosine | A | Human | X-ray | 5UEN | 5UEN_refined | 3.2 | B | Inactive | 1 | 91 | - | - | - | - | BRIL | - |
DU172
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Glukhova A, Thal DM, Nguyen AT, Vecchio EA, Jorg M, Scammells PJ, May LT, Sexton PM, Christopoulos A | 10.1016/j.cell.2017.01.042 | 2017-03-01 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 5X7D | 5X7D_refined | 2.7 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
4-carbamoyl-N-[(2R)-2-cyclohexyl-2-phenylacetyl]-L-phenylalanyl-3-bromo-N-methyl-L-phenylalaninamide
Carazolol |
small-molecule small-molecule |
Allosteric antagonist Antagonist |
noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | Liu X, Ahn S, Kahsai AW, Meng KC, Latorraca NR, Pani B, Venkatakrishnan AJ, Masoudi A, Weis WI, Dror RO, Chen X, Lefkowitz RJ, Kobilka BK | 10.1038/NATURE23652 | 2017-08-16 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 6FK9 | 6FK9_refined | 2.6 | A | Active | 98 | 94 | - | - | - | - | - | - |
(2~{S})-3-methyl-2-phenyl-1-spiro[1,3-benzodioxole-2,4'-piperidine]-1'-yl-butan-1-one
|
small-molecule | Agonist | - | - | No | No | Mattle D, Kuhn B, Aebi J, Bedoucha M, Kekilli D, Grozinger N, Alker A, Rudolph MG, Schmid G, Schertler GFX, Hennig M, Standfuss J, Dawson RJP | 10.1073/PNAS.1718084115 | 2018-04-04 | Yes | |
5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | Human | X-ray | 6DRZ | 6DRZ_refined | 3.1 | A | Intermediate | 44 | 61 | - | - | - | - | BRIL | - |
methysergide
|
small-molecule | Antagonist | 5-hydroxytryptamine | small-molecule | No | No | McCorvy JD, Wacker D, Wang S, Agegnehu B, Liu J, Lansu K, Tribo AR, Olsen RHJ, Che T, Jin J, Roth BL | 10.1038/s41594-018-0116-7 | 2018-08-29 | Yes | |
EDNRB | ETB | Endothelin | A | Human | X-ray | 6IGK | 6IGK_refined | 2.0 | A | Inactive | 4 | 70 | - | - | - | - | T4-Lysozyme | - |
endothelin-3
|
peptide | Agonist | endothelin-1, endothelin-2, endothelin-3 | peptide | No | No | Shihoya W, Izume T, Inoue A, Yamashita K, Kadji FMN, Hirata K, Aoki J, Nishizawa T, Nureki O | 10.1038/S41467-018-07094-0 | 2018-11-21 | Yes | |
MTR1A | MT1 | Melatonin | A | Human | X-ray | 6ME2 | 6ME2_refined | 2.8 | A | Inactive | 1 | 83 | - | - | - | - | GlgA glycogen synthase | - |
ramelteon
|
small-molecule | Agonist | melatonin | small-molecule | No | No | - | 10.1038/S41586-019-1141-3 | 2019-04-24 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | Cryo-EM | 6OY9 | - | 3.9 | R | Active | 100 | 94 | Gi/o | αt1 | - | 64 | - | - |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | - | 10.1016/J.MOLCEL.2019.06.007 | 2019-07-24 | Yes | |
ACM5 | M5 | Acetylcholine (muscarinic) | A | Human | X-ray | 6OL9 | 6OL9_refined | 2.5 | A | Inactive | 2 | 53 | - | - | - | - | T4-Lysozyme | - |
tiotropium
|
small-molecule | Inverse agonist | acetylcholine | small-molecule | No | No | Vuckovic Z, Gentry PR, Berizzi AE, Hirata K, Varghese S, Thompson G, van der Westhuizen ET, Burger WAC, Rahmani R, Valant C, Langmead CJ, Lindsley CW, Baell JB, Tobin AB, Sexton PM, Christopoulos A, Thal DM | 10.1073/PNAS.1914446116 | 2019-12-11 | Yes | |
CNR2 | CB2 | Cannabinoid | A | Human | X-ray | 6KPC | 6KPC_refined | 3.2 | A | Inactive | 11 | 79 | - | - | - | - | T4-Lysozyme | - |
AM12033
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Hua T, Li X, Wu L, Iliopoulos-Tsoutsouvas C, Wang Y, Wu M, Shen L, Brust CA, Nikas SP, Song F, Song X, Yuan S, Sun Q, Wu Y, Jiang S, Grim TW, Benchama O, Stahl EL, Zvonok N, Zhao S, Bohn LM, Makriyannis A, Liu ZJ | 10.1016/J.CELL.2020.01.008 | 2020-02-12 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | X-ray | 6LN2 | 6LN2_refined | 3.2 | A | Inactive | 0 | 83 | - | - | - | - | - | Fab7F38 light chain Fab7F38 heavy chain |
PF-06372222
|
small-molecule | NAM | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Wu F, Yang L, Hang K, Laursen M, Wu L, Han GW, Ren Q, Roed NK, Lin G, Hanson MA, Jiang H, Wang MW, Reedtz-Runge S, Song G, Stevens RC | 10.1038/S41467-020-14934-5 | 2020-03-18 | Yes | |
GABR1 | GABAB1 | GABAB | C | Human | Cryo-EM | 6W2Y | - | 3.2 | B | Inactive | - | 69 | - | - | - | - | - | - |
CGP55845
1-Stearoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine |
small-molecule small-molecule |
Inverse agonist NAM |
GABA | small-molecule | No | No | - | - | 2020-07-01 | Yes | |
GNRHR | GnRH1 | Gonadotrophin-releasing hormone | A | Human | X-ray | 7BR3 | 7BR3_refined | 2.8 | A | Inactive | 35 | 84 | - | - | - | - | GlgA glycogen synthase | - |
elagolix
|
small-molecule | Antagonist | GnRH II, GnRH I | peptide | No | No | Yan W, Cheng L, Wang W, Wu C, Yang X, Du X, Ma L, Qi S, Wei Y, Lu Z, Yang S, Shao Z | 10.1038/S41467-020-19109-W | 2020-10-07 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 7DHI | - | 3.3 | R | Active | 100 | 70 | Gs | αs | - | 55 | - | Nanobody-35 |
levosalbutamol
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | - | - | 2020-12-16 | Yes | |
DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7JVQ | 7JVQ_refined | 3.0 | R | Active | 100 | 64 | Gs | αs | Engineered G alpha | 60 | - | Nanobody-35 |
apomorphine
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, 5-hydroxytryptamine, dopamine | small-molecule | No | No | Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE | 10.1016/J.CELL.2021.01.027 | 2021-02-24 | Yes | |
PE2R2 | EP2 | Prostanoid | A | Human | Cryo-EM | 7CX4 | 7CX4_refined | 2.9 | R | Active | 100 | 74 | Gs | αs | - | 58 | - | Nanobody-35 |
evatanepag
|
small-molecule | Agonist | PGE2, PGF2α, thromboxane A2, PGI2, PGE1, PGD2 | small-molecule | No | No | Qu C, Mao C, Xiao P, Shen Q, Zhong YN, Yang F, Shen DD, Tao X, Zhang H, Yan X, Zhao RJ, He J, Guan Y, Zhang C, Hou G, Zhang PJ, Hou G, Li Z, Yu X, Chai RJ, Guan YF, Sun JP, Zhang Y | 10.1126/SCIADV.ABF1268 | 2021-05-05 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | Cryo-EM | 7MTB | 7MTB_refined | 4.0 | R | Active | 98 | 93 | - | - | - | - | - | Fab light chain Fab heavy chain GRK1 |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | - | - | 2021-07-07 | Yes | |
AA1R | A1 | Adenosine | A | Human | Cryo-EM | 7LD4 | 7LD4_refined | 3.3 | R | Active | 100 | 88 | Gi/o | αi2 | - | 59 | - | - |
adenosine
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Draper-Joyce CJ, Bhola R, Wang J, Bhattarai A, Nguyen ATN, Cowie-Kent I, O'Sullivan K, Chia LY, Venugopal H, Valant C, Thal DM, Wootten D, Panel N, Carlsson J, Christie MJ, White PJ, Scammells P, May LT, Sexton PM, Danev R, Miao Y, Glukhova A, Imlach WL, Christopoulos A | 10.1038/S41586-021-03897-2 | 2021-09-08 | Yes | |
CCKAR | CCK1 | Cholecystokinin | A | Human | X-ray | 7F8U | 7F8U_refined | 2.8 | A | Inactive | 1 | 65 | - | - | - | - | T4-Lysozyme | - |
lintitript
|
small-molecule | Antagonist | desulfated cholecystokinin-8, CCK-33, CCK-8, CCK-58, CCK-4, CCK-39, gastrin-17 | peptide | No | No | Zhang X, He C, Wang M, Zhou Q, Yang D, Zhu Y, Feng W, Zhang H, Dai A, Chu X, Wang J, Yang Z, Jiang Y, Sensfuss U, Tan Q, Han S, Reedtz-Runge S, Xu HE, Zhao S, Wang MW, Wu B, Zhao Q | 10.1038/S41589-021-00866-8 | 2021-10-13 | Yes | |
GP158 | GPR158 | C Orphans | C | Human | Cryo-EM | 7SHF | 7SHF_refined | 3.4 | B | Inactive | - | 23 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Patil DN, Singh S, Laboute T, Strutzenberg TS, Qiu X, Wu D, Novick SJ, Robinson CV, Griffin PR, Hunt JF, Izard T, Singh AK, Martemyanov KA | 10.1126/SCIENCE.ABL4732 | 2021-12-01 | Yes | |
S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7EO4 | 7EO4_refined | 2.9 | A | Active | 100 | 74 | Gi/o | αi1 | - | 43 | - | scFv16 |
siponimod
|
small-molecule | Agonist | sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate, sphingosine 1-phosphate | small-molecule | No | No | Xu Z, Ikuta T, Kawakami K, Kise R, Qian Y, Xia R, Sun MX, Zhang A, Guo C, Cai XH, Huang Z, Inoue A, He Y | 10.1038/S41589-021-00930-3 | 2022-01-05 | Yes | |
NPY1R | Y1 | Neuropeptide Y | A | Human | Cryo-EM | 7VGX | 7VGX_refined | 3.2 | R | Active | 100 | 73 | Gi/o | αi1 | - | 63 | - | scFv16 |
neuropeptide Y
|
peptide | Agonist | pancreatic polypeptide, neuropeptide Y, peptide YY | peptide | No | No | Park C, Kim J, Ko SB, Choi YK, Jeong H, Woo H, Kang H, Bang I, Kim SA, Yoon TY, Seok C, Im W, Choi HJ | 10.1038/S41467-022-28510-6 | 2022-02-23 | Yes | |
GIPR | GIP | Glucagon | B1 | Human | Cryo-EM | 7FIY | - | 3.4 | R | Active | 100 | 77 | Gs | αs | - | 60 | - | Nanobody-35 |
tirzepatide
|
peptide | Agonist | gastric inhibitory polypeptide | peptide | No | No | Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW | 10.1038/S41467-022-28683-0 | 2022-03-02 | Yes | |
AGRG1 | ADGRG1 | ADGRG | B2 | Human | Cryo-EM | 7SF8 | - | 2.7 | A | Active | - | 37 | G12/13 | α13 | Gi2-mini-G13 chimera | 56 | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | - | 2022-04-27 | Yes | |
ACM4 | M4 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 7V6A | - | 3.6 | R | Active | 100 | 58 | Gi/o | αi1 | - | 62 | - | scFv16 |
methyl 4-[4-(3-methyl-2-oxidanylidene-benzimidazol-1-yl)piperidin-1-yl]piperidine-1-carboxylate
|
small-molecule | Allosteric agonist | acetylcholine | small-molecule | No | No | Wang J, Wu M, Chen Z, Wu L, Wang T, Cao D, Wang H, Liu S, Xu Y, Li F, Liu J, Chen N, Zhao S, Cheng J, Wang S, Hua T | 10.1038/S41467-022-30595-Y | 2022-05-11 | Yes | |
GALR2 | GAL2 | Galanin | A | Human | Cryo-EM | 7XJL | 7XJL_refined | 3.5 | F | Active | 100 | 72 | Gq/11 | αq | - | 58 | - | scFv16 |
Spexin
|
small-molecule | Agonist | galanin-like peptide, spexin-1, galanin | peptide | No | No | Jiang W, Zheng S | 10.1073/PNAS.2121465119 | 2022-06-29 | Yes | |
SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7WJ5 | 7WJ5_refined | 3.7 | R | Active | 100 | 76 | Gi/o | αi1 | - | 60 | BRIL | scFv16 |
SOMATOSTATIN
|
protein | Agonist | SRIF-14, CST-17, cortistatin-14, SRIF-28 | peptide | No | No | Heo Y, Yoon E, Jeon YE, Yun JH, Ishimoto N, Woo H, Park SY, Song JJ, Lee W | 10.7554/ELIFE.76823 | 2022-07-13 | Yes | |
TSHR | TSH | Glycoprotein hormone | A | Human | Cryo-EM | 7XW7 | 7XW7_refined | 5.5 | R | Inactive | 15 | 74 | - | - | - | - | - | - |
K1-70 scFv heavy chain
K1-70 scFv light chain |
protein protein |
Antagonist | TSH | peptide | No | No | Duan J, Xu P, Luan X, Ji Y, He X, Song N, Yuan Q, Jin Y, Cheng X, Jiang H, Zheng J, Zhang S, Jiang Y, Xu HE | 10.1038/S41586-022-05173-3 | 2022-08-17 | Yes | |
CRFR2 | CRF2 | Corticotropin-releasing factor | B1 | Human | Cryo-EM | 7TRY | - | 3.7 | P | Active | 100 | 79 | Gq/11 | α11 | - | 62 | - | - |
Urocortin
|
peptide | Agonist | urocortin 2, corticotrophin-releasing hormone, urocortin 3, urocortin 1 | peptide | No | No | Zhao LH, Lin J, Ji SY, Zhou XE, Mao C, Shen DD, He X, Xiao P, Sun J, Melcher K, Zhang Y, Yu X, Xu HE | 10.1038/S41467-022-33851-3 | 2022-11-09 | Yes | |
GPR88 | GPR88 | A orphans | A | Human | Cryo-EM | 7WZ4 | - | 3.0 | R | Active | 100 | 61 | Gi/o | αi1 | - | 61 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Chen G, Xu J, Inoue A, Schmidt MF, Bai C, Lu Q, Gmeiner P, Liu Z, Du Y | 10.1038/S41467-022-30081-5 | 2022-10-26 | Yes | |
MRGX1 | MRGPRX1 | A orphans | A | Human | Cryo-EM | 8DWG | - | 2.7 | R | Active | 100 | 77 | Gq/11 | αq | Gs-mini-Gq chimera | 57 | - | scFv16 |
Proenkephalin-A
CHEMBL5177388 |
peptide small-molecule |
Agonist PAM |
bovine adrenal medulla peptide 8-22 | peptide | No | No | - | - | 2022-11-02 | Yes | |
RL3R2 | RXFP4 | Relaxin family peptide | A | Human | Cryo-EM | 7YK7 | 7YK7_refined | 2.8 | R | Active | 100 | 75 | Gi/o | αi2 | - | 61 | - | scFv16 |
DC591053
|
small-molecule | Agonist | relaxin-3, INSL5, relaxin-3 (B chain) | peptide | No | No | Chen Y, Zhou Q, Wang J, Xu Y, Wang Y, Yan J, Wang Y, Zhu Q, Zhao F, Li C, Chen CW, Cai X, Bathgate RAD, Shen C, Eric Xu H, Yang D, Liu H, Wang MW | 10.1038/S41467-023-36182-Z | 2023-03-01 | Yes | |
AA2AR | A2A | Adenosine | A | Human | MicroED | 8FYN | 8FYN_refined | 2.0 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | - | 10.1038/S41467-023-36733-4 | 2023-03-08 | Yes | |
FFAR4 | FFA4 | Free fatty acid | A | Human | Cryo-EM | 8ID6 | - | 2.8 | R | Active | 100 | 80 | Gi/o | αi1 | - | 64 | - | scFv16 |
oleic acid
|
small-molecule | Agonist | linoleic acid, oleic acid, α-linolenic acid, myristic acid | small-molecule | No | No | - | 10.1126/SCIENCE.ADD6220 | 2023-03-15 | Yes | |
MTLR | motilin | Motilin | A | Human | Cryo-EM | 8IBV | 8IBV_refined | 3.2 | R | Active | 100 | 68 | Gq/11 | αq | - | 60 | BRIL | scFv16 |
motilin
|
peptide | Agonist | motilin | peptide | No | No | You C, Zhang Y, Xu Y, Xu P, Li Z, Li H, Huang S, Chen Z, Li J, Xu HE, Jiang Y | 10.1126/SCIADV.ADE9020 | 2023-04-12 | Yes | |
AGRE5 | ADGRE5 | ADGRE | B2 | Human | Cryo-EM | 7YDM | - | 2.9 | R | Active | - | 33 | Gq/11 | αq | Mini-Gq | 60 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | - | 2023-07-12 | Yes | |
CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 8F2B | - | 2.0 | R | Active | 100 | 78 | Gs | αs | - | 58 | - | Nanobody-35 RAMP3 |
Pramlintide analogue San45
|
peptide | Agonist | β-CGRP, α-CGRP, calcitonin, calcitonin (salmon), amylin, adrenomedullin, adrenomedullin 2/intermedin | peptide | No | No | Cao J, Belousoff MJ, Gerrard E, Danev R, Fletcher MM, Dal Maso E, Schreuder H, Lorenz K, Evers A, Tiwari G, Besenius M, Li Z, Johnson RM, Wootten D, Sexton PM | 10.1038/S41589-023-01393-4 | 2023-08-02 | Yes | |
TAA7F | TAAR7F | A orphans | A | Mouse | Cryo-EM | 8PM2 | - | 2.9 | R | Active | 100 | 73 | Gs | αs | - | 58 | - | Nanobody-35 |
N,N-Dimethylcyclohexylamine
|
small-molecule | Agonist | - | - | No | No | Gusach A, Lee Y, Khoshgrudi AN, Mukhaleva E, Ma N, Koers EJ, Chen Q, Edwards PC, Huang F, Kim J, Mancia F, Verprintsev DB, Vaidehi N, Weyand SN, Tate CG | 10.1101/2023.07.07.547762 | 2023-08-09 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 3PWH | 3PWH_refined | 3.3 | A | Inactive | 1 | 71 | - | - | - | - | - | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | - | 10.1016/J.STR.2011.06.014 | 2011-09-07 | Yes | |
SMO | SMO | Frizzled | F | Human | X-ray | 4JKV | 4JKV_refined | 2.5 | A | Inactive | 0 | 44 | - | - | - | - | BRIL | - |
taladegib
|
small-molecule | Antagonist | - | - | No | No | Wang C, Wu H, Katritch V, Han GW, Huang XP, Liu W, Siu FY, Roth BL, Cherezov V, Stevens RC | 10.1038/NATURE12167 | 2013-04-24 | Yes | |
LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | X-ray | 4Z36 | 4Z36_refined | 2.9 | A | Inactive | 1 | 79 | - | - | - | - | BRIL | - |
ONO-3080573
|
small-molecule | Antagonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | Chrencik JE, Roth CB, Terakado M, Kurata H, Omi R, Kihara Y, Warshaviak D, Nakade S, Asmar-Rovira G, Mileni M, Mizuno H, Griffith MT, Rodgers C, Han GW, Velasquez J, Chun J, Stevens RC, Hanson MA | 10.1016/J.CELL.2015.06.002 | 2015-06-03 | Yes | |
SMO | SMO | Frizzled | F | Human | X-ray | 5L7D | 5L7D_refined | 3.2 | B | Inactive | 4 | 59 | - | - | - | - | BRIL | - | - | - | - | - | - | No | No | Byrne EFX, Sircar R, Miller PS, Hedger G, Luchetti G, Nachtergaele S, Tully MD, Mydock-McGrane L, Covey DF, Rambo RP, Sansom MSP, Newstead S, Rohatgi R, Siebold C | 10.1038/NATURE18934 | 2016-07-20 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5MZJ | 5MZJ_refined | 2.0 | A | Inactive | 1 | 71 | - | - | - | - | BRIL | - |
theophylline
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Cheng RKY, Segala E, Robertson N, Deflorian F, Dore AS, Errey JC, Fiez-Vandal C, Marshall FH, Cooke RM | 10.1016/j.str.2017.06.012 | 2017-07-26 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5OLG | 5OLG_refined | 1.9 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Rucktooa P, Cheng RKY, Segala E, Geng T, Errey JC, Brown GA, Cooke RM, Marshall FH, Dore AS | 10.1038/S41598-017-18570-W | 2018-01-17 | Yes | |
FFAR1 | FFA1 | Free fatty acid | A | Human | X-ray | 5KW2 | 5KW2_refined | 2.8 | A | Intermediate | 44 | 82 | - | - | - | - | T4-Lysozyme | - |
(3~{S})-3-cyclopropyl-3-[2-[1-[2-[2,2-dimethylpropyl-(6-methylpyridin-2-yl)carbamoyl]-5-methoxy-phenyl]piperidin-4-yl]-1-benzofuran-6-yl]propanoic acid
|
small-molecule | Allosteric agonist | oleic acid, docosahexaenoic acid, α-linolenic acid, myristic acid | small-molecule | No | No | Ho JD, Chau B, Rodgers L, Lu F, Wilbur KL, Otto KA, Chen Y, Song M, Riley JP, Yang HC, Reynolds NA, Kahl SD, Lewis AP, Groshong C, Madsen RE, Conners K, Lineswala JP, Gheyi T, Saflor MD, Lee MR, Benach J, Baker KA, Montrose-Rafizadeh C, Genin MJ, Miller AR, Hamdouchi C | 10.1038/S41467-017-01240-W | 2018-05-02 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 6MXT | 6MXT_refined | 3.0 | A | Active | 98 | 69 | - | - | - | - | T4-Lysozyme | Nanobody-71 |
salmeterol
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues JPGLM, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C, Kobilka BK | 10.1038/s41589-018-0145-x | 2018-11-14 | Yes | |
5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | X-ray | 6A93 | 6A93_refined | 3.0 | A | Inactive | 1 | 60 | - | - | - | - | BRIL | - |
risperidone
|
small-molecule | Antagonist | 5-hydroxytryptamine, tryptamine | small-molecule | No | No | - | 10.1038/S41594-018-0180-Z | 2019-02-13 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Human | Cryo-EM | 6OS9 | 6OS9_refined | 3.0 | R | Active | 100 | 73 | Gi/o | αi1 | - | 62 | - | scFv16 |
JMV449
|
peptide | Agonist | neuromedin N, large neurotensin, neurotensin, large neuromedin N | peptide | No | No | - | 10.1038/S41586-019-1337-6 | 2019-07-10 | Yes | |
OX1R | OX1 | Orexin | A | Human | X-ray | 6TOD | - | 2.1 | A | Inactive | 1 | 71 | - | - | - | - | - | - |
EMPA
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | Yes | |
FPR2 | FPR2/ALX | Formylpeptide | A | Human | Cryo-EM | 6OMM | 6OMM_refined | 3.2 | R | Active | 100 | 85 | Gi/o | αi1 | - | 61 | - | - |
CHEMBL552527
|
protein | Agonist | resolvin D1, serum amyloid A, 15-deoxy-LXA4, LTC4, LL-37, humanin, LTD4, aspirin triggered lipoxin A4, annexin I, aspirin-triggered resolvin D1, fMet-Leu-Phe, PrP106-126, LXA4 | peptide | No | No | Zhuang Y, Liu H, Edward Zhou X, Kumar Verma R, de Waal PW, Jang W, Xu TH, Wang L, Meng X, Zhao G, Kang Y, Melcher K, Fan H, Lambert NA, Eric Xu H, Zhang C | 10.1038/S41467-020-14728-9 | 2020-02-26 | Yes | |
GABR2 | GABAB2 | GABAB | C | Human | Cryo-EM | 6WIV | - | 3.3 | B | Inactive | - | 71 | - | - | - | - | - | - |
[(2R)-3-[(Z)-icos-11-enoyl]oxy-2-[(Z)-octadec-9-enoyl]oxypropyl] 2-(trimethylazaniumyl)ethylphosphate
(2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-{[(9Z)-octadec-9-enoyl]oxy}propyl(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate |
small-molecule small-molecule |
NAM | - | - | No | No | Park J, Fu Z, Frangaj A, Liu J, Mosyak L, Shen T, Slavkovich VN, Ray KM, Taura J, Cao B, Geng Y, Zuo H, Kou Y, Grassucci R, Chen S, Liu Z, Lin X, Williams JP, Rice WJ, Eng ET, Huang RK, Soni RK, Kloss B, Yu Z, Javitch JA, Hendrickson WA, Slesinger PA, Quick M, Graziano J, Yu H, Fiehn O, Clarke OB, Frank J, Fan QR | 10.1038/S41586-020-2452-0 | 2020-07-01 | Yes | |
GABR2 | GABAB2 | GABAB | C | Human | Cryo-EM | 7CA5 | - | 7.6 | B | Inactive | - | 70 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Kim Y, Jeong E, Jeong JH, Kim Y, Cho Y | 10.1016/J.JMB.2020.09.023 | 2020-11-11 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 6Z4S | - | 2.7 | A | Inactive | 3 | 77 | - | - | - | - | DARPin D12 | - |
meclinertant
|
small-molecule | Inverse agonist | neuromedin N, neurotensin | peptide | No | No | Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PRE, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Pluckthun A | 10.1126/sciadv.abe5504 | 2021-02-10 | Yes | |
5HT1A | 5-HT1A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7E2X | - | 3.0 | R | Active | 100 | 66 | Gi/o | αi1 | - | 62 | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | 5-hydroxytryptamine | small-molecule | No | No | Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE | 10.1038/S41586-021-03376-8 | 2021-04-14 | Yes | |
GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 7EPD | 7EPD_refined | 3.9 | A | Inactive | - | 89 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | L-glutamic acid | small-molecule | No | No | Du J, Wang D, Fan H, Xu C, Tai L, Lin S, Han S, Tan Q, Wang X, Xu T, Zhang H, Chu X, Yi C, Liu P, Wang X, Zhou Y, Pin JP, Rondard P, Liu H, Liu J, Sun F, Wu B, Zhao Q | 10.1038/S41586-021-03641-W | 2021-06-23 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7KI0 | - | 2.5 | R | Active | 100 | 83 | Gs | αs | - | 53 | - | Nanobody-35 |
semaglutide
|
peptide | Agonist | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Zhang X, Belousoff MJ, Liang YL, Danev R, Sexton PM, Wootten D | 10.1016/J.CELREP.2021.109374 | 2021-08-04 | Yes | |
MC4R | MC4 | Melanocortin | A | Human | Cryo-EM | 7F54 | - | 3.0 | R | Active | 100 | 82 | Gs | αs | - | 58 | - | Nanobody-35 |
afamelanotide
|
peptide | Agonist | agouti-related protein, β-MSH, α-MSH, γ-MSH, ACTH | peptide | No | No | Zhang H, Chen LN, Yang D, Mao C, Shen Q, Feng W, Shen DD, Dai A, Xie S, Zhou Y, Qin J, Sun JP, Scharf DH, Hou T, Zhou T, Wang MW, Zhang Y | 10.1038/S41422-021-00552-3 | 2021-11-03 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7S1M | 7S1M_refined | 2.4 | R | Active | 100 | 82 | Gs | αs | - | 59 | - | Nanobody-35 |
exendin-4
|
peptide | Agonist | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Cary BP, Deganutti G, Zhao P, Truong TT, Piper SJ, Liu X, Belousoff MJ, Danev R, Sexton PM, Wootten D, Gellman SH | 10.1038/S41589-021-00945-W | 2022-01-05 | Yes | |
CCR1 | CCR1 | Chemokine | A | Human | Cryo-EM | 7VL8 | 7VL8_refined | 2.9 | R | Active | 100 | 80 | Gi/o | αi1 | - | 62 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | CCL8, CCL13, CCL14, CCL16, CCL5, CCL7, CCL4, CCL23, CCL15, CCL3 | peptide | No | No | Shao Z, Shen Q, Yao B, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Ma H, Chen ZH, Xu HE, Ying S, Zhang Y, Shen H | 10.1038/S41589-021-00918-Z | 2022-03-23 | Yes | |
GIPR | GIP | Glucagon | B1 | Human | Cryo-EM | 7FIN | - | 3.1 | R | Active | 100 | 82 | Gs | αs | - | 59 | - | Nanobody-35 |
Peptide-20
|
peptide | Agonist | gastric inhibitory polypeptide | peptide | No | No | Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW | 10.1038/S41467-022-28683-0 | 2022-02-23 | Yes | |
AGRD1 | ADGRD1 | ADGRD | B2 | Human | Cryo-EM | 7WU2 | - | 2.8 | R | Active | - | 32 | Gs | αs | Mini-Gs | 53 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Qu X, Qiu N, Wang M, Zhang B, Du J, Zhong Z, Xu W, Chu X, Ma L, Yi C, Han S, Shui W, Zhao Q, Wu B | 10.1038/S41586-022-04580-W | 2022-04-27 | Yes | |
AGRD1 | ADGRD1 | ADGRD | B2 | Human | Cryo-EM | 7EPT | - | 3.0 | R | Active | - | 31 | Gs | αs | - | 54 | - | Nanobody-35 | - | - | - | - | - | No | No | Ping YQ, Xiao P, Yang F, Zhao RJ, Guo SC, Yan X, Wu X, Zhang C, Lu Y, Zhao F, Zhou F, Xi YT, Yin W, Liu FZ, He DF, Zhang DL, Zhu ZL, Jiang Y, Du L, Feng SQ, Schoneberg T, Liebscher I, Xu HE, Sun JP | 10.1038/S41586-022-04619-Y | 2022-05-11 | Yes | |
DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7F0T | - | 3.1 | F | Active | 100 | 63 | Gs | αs | - | 58 | - | Nanobody-35 |
dopamine
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, 5-hydroxytryptamine, dopamine | small-molecule | No | No | Teng X, Chen S, Wang Q, Chen Z, Wang X, Huang N, Zheng S | 10.1126/SCIADV.ABO4158 | 2022-06-15 | Yes | |
SMO | SMO | Frizzled | F | Human | X-ray | 7ZI0 | 7ZI0_refined | 3.0 | A | Inactive | 4 | 61 | - | - | - | - | BRIL | - |
3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-{[3-(pyridin-4-yl)phenyl]methyl}-1-benzothiophene-2-carboxamide
|
small-molecule | Antagonist | - | - | No | No | Kinnebrew M, Woolley RE, Ansell TB, Byrne EFX, Frigui S, Luchetti G, Sircar R, Nachtergaele S, Mydock-McGrane L, Krishnan K, Newstead S, Sansom MSP, Covey DF, Siebold C, Rohatgi R | 10.1126/SCIADV.ABM5563 | 2022-06-15 | Yes | |
MRGRD | MRGPRD | A orphans | A | Human | Cryo-EM | 7Y14 | 7Y14_refined | 3.2 | R | Intermediate | 55 | 82 | - | - | - | - | BRIL | - |
β-alanine
|
small-molecule | Agonist | β-alanine | small-molecule | No | No | Suzuki S, Iida M, Hiroaki Y, Tanaka K, Kawamoto A, Kato T, Oshima A | 10.1038/S42003-022-03668-3 | 2022-07-20 | Yes | |
SSR4 | SST4 | Somatostatin | A | Human | Cryo-EM | 7XMS | - | 2.9 | R | Active | 100 | 71 | Gi/o | αi1 | - | 63 | - | scFv16 |
SOMATOSTATIN
|
protein | Agonist | SRIF-14, CST-17, cortistatin-14, SRIF-28 | peptide | No | No | Zhao W, Han S, Qiu N, Feng W, Lu M, Zhang W, Wang M, Zhou Q, Chen S, Xu W, Du J, Chu X, Yi C, Dai A, Hu L, Shen MY, Sun Y, Zhang Q, Ma Y, Zhong W, Yang D, Wang MW, Wu B, Zhao Q | 10.1038/S41422-022-00679-X | 2022-08-03 | Yes | |
SMO | SMO | Frizzled | F | Mouse | Cryo-EM | 8CXO | 8CXO_refined | 3.7 | A | Inactive | 15 | 43 | - | - | - | - | GlgA glycogen synthase | - |
Cholesterol
|
small-molecule | Agonist | - | - | No | No | Zhang K, Wu H, Hoppe N, Manglik A, Cheng Y | 10.1038/S41467-022-32125-2 | 2022-08-03 | Yes | |
5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7SRR | - | 2.9 | R | Active | 100 | 57 | Gq/11 | αq | Gi2-mini-Gq chimera | 58 | - | scFv16 |
Lysergide
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Cao C, Barros-Alvarez X, Zhang S, Kim K, Damgen MA, Panova O, Suomivuori CM, Fay JF, Zhong X, Krumm BE, Gumpper RH, Seven AB, Robertson MJ, Krogan NJ, Huttenhain R, Nichols DE, Dror RO, Skiniotis G, Roth BL | 10.1016/J.NEURON.2022.08.006 | 2022-09-21 | Yes | |
ADA2A | α2A | Adrenoceptors | A | Human | Cryo-EM | 7W7E | - | 3.4 | R | Active | 100 | 56 | Gi/o | αo | - | 59 | - | scFv16 |
5-(3-Bicyclo[4.2.0]octa-1,3,5-trienyl)-1,2,3,6-tetrahydropyridine
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Fink EA, Xu J, Hubner H, Braz JM, Seemann P, Avet C, Craik V, Weikert D, Schmidt MF, Webb CM, Tolmachova NA, Moroz YS, Huang XP, Kalyanaraman C, Gahbauer S, Chen G, Liu Z, Jacobson MP, Irwin JJ, Bouvier M, Du Y, Shoichet BK, Basbaum AI, Gmeiner P | 10.1126/SCIENCE.ABN7065 | 2022-09-28 | Yes | |
AGRL3 | ADGRL3 | ADGRL | B2 | Mouse | Cryo-EM | 7X10 | - | 2.9 | R | Active | - | 17 | G12/13 | α12 | - | 55 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Qian Y, Ma Z, Liu C, Li X, Zhu X, Wang N, Xu Z, Xia R, Liang J, Duan Y, Yin H, Xiong Y, Zhang A, Guo C, Chen Z, Huang Z, He Y | 10.1016/J.MOLCEL.2022.10.009 | 2022-11-09 | Yes | |
VIPR1 | VPAC1 | VIP and PACAP | B1 | Human | Cryo-EM | 8E3Z | 8E3Z_refined | 2.7 | R | Active | 100 | 81 | Gs | αs | - | 55 | - | Nanobody-35 |
Vasoactive intestinal polypeptide
|
small-molecule | Agonist | VIP, PACAP-27, secretin, PHI, PHM, GHRH, PACAP-38 | peptide | No | No | Piper SJ, Deganutti G, Lu J, Zhao P, Liang YL, Lu Y, Fletcher MM, Hossain MA, Christopoulos A, Reynolds CA, Danev R, Sexton PM, Wootten D | 10.1038/S41467-022-34629-3 | 2022-11-23 | Yes | |
C5AR1 | C5a1 | Complement peptide | A | Human | Cryo-EM | 7Y66 | - | 2.9 | D | Active | 100 | 80 | Gi/o | αi1 | - | 63 | - | scFv16 |
BM213
|
peptide | Agonist | C3a, C5a, ribosomal protein S19, C5a des-Arg | peptide | No | No | Feng Y, Zhao C, Deng Y, Wang H, Ma L, Liu S, Tian X, Wang B, Bin Y, Chen P, Yan W, Fu P, Shao Z | 10.1038/S41422-023-00779-2 | 2023-03-01 | Yes | |
GPR21 | GPR21 | A orphans | A | Human | Cryo-EM | 8HMV | 8HMV_refined | 2.9 | A | Active | 100 | 79 | Gs | αs | - | 58 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | 10.1002/MCO2.205 | 2023-03-01 | Yes | |
HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 7XK2 | 7XK2_refined | 3.1 | R | Active | 100 | 78 | Gi/o | αi1 | - | 63 | - | scFv16 |
MK 6892
|
small-molecule | Agonist | β-D-hydroxybutyric acid, butyric acid | small-molecule | No | No | Yang Y, Kang HJ, Gao R, Wang J, Han GW, DiBerto JF, Wu L, Tong J, Qu L, Wu Y, Pileski R, Li X, Zhang XC, Zhao S, Kenakin T, Wang Q, Stevens RC, Peng W, Roth BL, Rao Z, Liu ZJ | 10.1038/S41467-023-37177-6 | 2023-02-22 | Yes | |
NK2R | NK2 | Tachykinin | A | Human | Cryo-EM | 7XWO | 7XWO_refined | 2.7 | B | Active | 100 | 68 | Gq/11 | αq | - | 59 | BRIL | scFv16 |
HIS-LYS-THR-ASP-SER-PHE-VAL-GLY-LEU-MET-NH2
|
peptide | Agonist | neurokinin B, hemokinin 1, substance P, neurokinin A, neuropeptide γ, neuropeptide K | peptide | No | No | - | - | 2023-05-31 | Yes | |
C3AR | C3a | Complement peptide | A | Human | Cryo-EM | 8HK2 | - | 2.9 | A | Active | 100 | 59 | Gi/o | αi1 | - | 64 | - | scFv16 |
C3a anaphylatoxin
|
peptide | Agonist | C3a, C5a | peptide | No | No | Wang Y, Liu W, Xu Y, He X, Yuan Q, Luo P, Fan W, Zhu J, Zhang X, Cheng X, Jiang Y, Xu HE, Zhuang Y | 10.1038/S41589-023-01339-W | 2023-05-10 | Yes | |
FFAR4 | FFA4 | Free fatty acid | A | Human | Cryo-EM | 8H4K | - | 3.1 | R | Active | 100 | 83 | Gq/11 | αq | Mini-Gq | 60 | - | Nanobody-35 |
GW9508
|
small-molecule | Agonist | linoleic acid, oleic acid, α-linolenic acid, myristic acid | small-molecule | No | No | Yin H, Inoue A, Ma Z, Zhu X, Xia R, Xu Z, Wang N, Duan Y, Zhang A, Guo C, He Y | 10.1038/S41422-023-00835-X | 2023-06-21 | Yes | |
GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 8JCZ | - | 3.0 | 2 | Inactive | - | 87 | - | - | - | - | - | - |
LY341495
|
small-molecule | Antagonist | L-glutamic acid | small-molecule | No | No | Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B | 10.1038/S41422-023-00830-2 | 2023-06-21 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 4A4M | 4A4M_refined | 3.3 | A | Active | 100 | 94 | Gi/o | αt1 | Only H5 | 3 | - | - |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | - | 10.1073/PNAS.1114089108 | 2012-01-25 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 4GPO | 4GPO_refined | 3.5 | B | Inactive | 0 | 58 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Huang J, Chen S, Zhang JJ, Huang XY | 10.1038/NSMB.2504 | 2013-02-27 | Yes | |
SMO | SMO | Frizzled | F | Human | X-ray | 4O9R | 4O9R_refined | 3.2 | A | Inactive | 11 | 42 | - | - | - | - | BRIL | - |
cyclopamine
|
small-molecule | Antagonist | - | - | No | No | Weierstall U, James D, Wang C, White TA, Wang D, Liu W, Spence JC, Bruce Doak R, Nelson G, Fromme P, Fromme R, Grotjohann I, Kupitz C, Zatsepin NA, Liu H, Basu S, Wacker D, Han GW, Katritch V, Boutet S, Messerschmidt M, Williams GJ, Koglin JE, Marvin Seibert M, Klinker M, Gati C, Shoeman RL, Barty A, Chapman HN, Kirian RA, Beyerlein KR, Stevens RC, Li D, Shah ST, Howe N, Caffrey M, Cherezov V | 10.1038/NCOMMS4309 | 2014-03-05 | Yes | |
GRM5 | mGlu5 | Metabotropic glutamate | C | Human | X-ray | 5CGC | 5CGC_refined | 3.1 | A | Inactive | - | 20 | - | - | - | - | T4-Lysozyme | - |
CHEMBL3603915
|
small-molecule | NAM | L-glutamic acid | small-molecule | No | No | Christopher JA, Aves SJ, Bennett KA, Doré AS, Errey JC, Jazayeri A, Marshall FH, Okrasa K, Serrano-Vega MJ, Tehan BG, Wiggin GR, Congreve M. | 10.1021/acs.jmedchem.5b00892 | 2015-08-12 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 5EN0 | 5EN0_refined | 2.8 | A | Active | 100 | 94 | Gi/o | αgust | Only H5 | 3 | - | - |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | - | - | 2016-08-10 | Yes | |
PAR2 | PAR2 | Proteinase-activated | A | Human | X-ray | 5NDD | 5NDD_refined | 2.8 | A | Intermediate | 44 | 74 | - | - | - | - | BRIL | - |
AZ8838
|
small-molecule | Antagonist | - | - | No | Yes | Cheng RKY, Fiez-Vandal C, Schlenker O, Edman K, Aggeler B, Brown DG, Brown GA, Cooke RM, Dumelin CE, Dore AS, Geschwindner S, Grebner C, Hermansson NO, Jazayeri A, Johansson P, Leong L, Prihandoko R, Rappas M, Soutter H, Snijder A, Sundstrom L, Tehan B, Thornton P, Troast D, Wiggin G, Zhukov A, Marshall FH, Dekker N | 10.1038/NATURE22309 | 2017-05-03 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5NM4 | - | 1.7 | A | Inactive | 1 | 73 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Weinert T, Olieric N, Cheng R, Brunle S, James D, Ozerov D, Gashi D, Vera L, Marsh M, Jaeger K, Dworkowski F, Panepucci E, Basu S, Skopintsev P, Dore AS, Geng T, Cooke RM, Liang M, Prota AE, Panneels V, Nogly P, Ermler U, Schertler G, Hennig M, Steinmetz MO, Wang M, Standfuss J | 10.1038/S41467-017-00630-4 | 2017-09-27 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 6FKD | 6FKD_refined | 2.5 | A | Active | 98 | 94 | - | - | - | - | - | - |
5-chloro-2-(2-oxo-2-spiro[1,3-benzodioxole-2,4'-piperidine]-1'-ylethyl)-3H-pyridin-6-one
|
small-molecule | Agonist | - | - | No | No | Mattle D, Kuhn B, Aebi J, Bedoucha M, Kekilli D, Grozinger N, Alker A, Rudolph MG, Schmid G, Schertler GFX, Hennig M, Standfuss J, Dawson RJP | 10.1073/PNAS.1718084115 | 2018-04-04 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 6H7M | 6H7M_refined | 2.8 | A | Active | 99 | 60 | - | - | - | - | Thioredoxin 1 | Camelid antibody fragment Nb6B9 |
levosalbutamol
|
small-molecule | Agonist | - | - | No | No | Warne T, Edwards PC, Dore AS, Leslie AGW, Tate CG | 10.1126/SCIENCE.AAU5595 | 2018-10-17 | Yes | |
GRM5 | mGlu5 | Metabotropic glutamate | C | Human | Cryo-EM | 6N51 | 6N51_refined | 4.0 | B | Intermediate | - | 65 | - | - | - | - | - | Nanobody-43 |
quisqualate
|
small-molecule | Agonist | L-glutamic acid | small-molecule | No | No | - | 10.1038/S41586-019-0881-4 | 2019-01-23 | Yes | |
CCR7 | CCR7 | Chemokine | A | Human | X-ray | 6QZH | 6QZH_refined | 2.1 | A | Inactive | 5 | 71 | - | - | - | - | Sialidase NanA | - |
SCHEMBL13407377
|
small-molecule | Allosteric antagonist | CCL21, CCL19 | peptide | No | No | - | 10.1016/J.CELL.2019.07.028 | 2019-09-04 | Yes | |
OPRD | δ | Opioid | A | Human | X-ray | 6PT3 | 6PT3_refined | 3.3 | A | Active | 65 | 78 | - | - | - | - | BRIL | - |
DPI-287
|
small-molecule | Agonist | dynorphin A-(1-8), [Met]enkephalin, endomorphin-1, dynorphin A, [Leu]enkephalin, β-endorphin, dynorphin A-(1-13), dynorphin B, α-neoendorphin | peptide | No | No | Claff T, Yu J, Blais V, Patel N, Martin C, Wu L, Han GW, Holleran BJ, Van der Poorten O, White KL, Hanson MA, Sarret P, Gendron L, Cherezov V, Katritch V, Ballet S, Liu ZJ, Muller CE, Stevens RC | 10.1126/SCIADV.AAX9115 | 2019-12-11 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 6NWE | 6NWE_refined | 2.7 | A | Active | 100 | 94 | Gi/o | αt1 | Only H5 | 3 | - | - |
B-Octylglucoside
|
small-molecule | unknown | - | - | No | No | - | - | 2020-02-12 | Yes | |
CALRL | calcitonin-like | Calcitonin | B1 | Human | Cryo-EM | 6UUS | 6UUS_refined | 2.4 | R | Active | 100 | 74 | Gs | αs | - | 48 | - | Nanobody-35 RAMP3 |
Adrenomedullin
|
peptide | Agonist | - | - | No | No | Liang YL, Belousoff MJ, Fletcher MM, Zhang X, Khoshouei M, Deganutti G, Koole C, Furness SGB, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Danev R, Wootten D, Sexton PM | 10.1021/ACSPTSCI.9B00080 | 2020-04-01 | Yes | |
GPBAR | GPBA | Bile acid | A | Human | Cryo-EM | 7BW0 | 7BW0_refined | 3.9 | R | Active | 100 | 85 | Gs | αs | - | 57 | BRIL | Nanobody-35 | - | - | - | deoxycholic acid, chenodeoxycholic acid, lithocholic acid, cholic acid | small-molecule | No | No | Chen G, Wang X, Ge Y, Ma L, Chen Q, Liu H, Du Y, Ye RD, Hu H, Ren R | 10.1038/S41392-020-00262-Z | 2020-09-02 | Yes | |
GABR2 | GABAB2 | GABAB | C | Human | Cryo-EM | 7CA3 | - | 4.5 | B | Active | - | 72 | - | - | - | - | - | - |
BHFF
|
small-molecule | PAM | - | - | No | No | Kim Y, Jeong E, Jeong JH, Kim Y, Cho Y | 10.1016/J.JMB.2020.09.023 | 2020-11-11 | Yes | |
OX2R | OX2 | Orexin | A | Human | Cryo-EM | 7L1U | - | 3.2 | R | Active | 100 | 63 | Gs | αs | Engineered G alpha | 58 | - | scFv16 |
Orexin-A
|
peptide | Agonist | orexin-B, orexin-A | peptide | No | No | Hong C, Byrne NJ, Zamlynny B, Tummala S, Xiao L, Shipman JM, Partridge AT, Minnick C, Breslin MJ, Rudd MT, Stachel SJ, Rada VL, Kern JC, Armacost KA, Hollingsworth SA, O'Brien JA, Hall DL, McDonald TP, Strickland C, Brooun A, Soisson SM, Hollenstein K | 10.1038/S41467-021-21087-6 | 2021-02-10 | Yes | |
5HT1A | 5-HT1A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7E2Z | - | 3.1 | R | Active | 100 | 66 | Gi/o | αi1 | - | 62 | - | - |
aripiprazole
|
small-molecule | Agonist (partial) | 5-hydroxytryptamine | small-molecule | No | No | Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE | 10.1038/S41586-021-03376-8 | 2021-04-14 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | Cryo-EM | 7MT9 | 7MT9_refined | 7.0 | R | Active | 98 | 93 | - | - | - | - | - | GRK1 |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | - | - | 2021-07-07 | Yes | |
CCKAR | CCK1 | Cholecystokinin | A | Human | Cryo-EM | 7EZK | - | 3.1 | D | Active | 100 | 69 | Gs | αs | - | 58 | - | - |
CCK-8
|
peptide | Agonist | desulfated cholecystokinin-8, CCK-33, CCK-8, CCK-58, CCK-4, CCK-39, gastrin-17 | peptide | No | No | Liu Q, Yang D, Zhuang Y, Croll TI, Cai X, Dai A, He X, Duan J, Yin W, Ye C, Zhou F, Wu B, Zhao Q, Xu HE, Wang MW, Jiang Y | 10.1038/S41589-021-00841-3 | 2021-08-25 | Yes | |
MC4R | MC4 | Melanocortin | A | Human | Cryo-EM | 7F53 | - | 3.0 | R | Active | 100 | 82 | Gs | αs | - | 58 | - | Nanobody-35 |
α-MSH
|
peptide | Agonist | agouti-related protein, β-MSH, α-MSH, γ-MSH, ACTH | peptide | No | No | Zhang H, Chen LN, Yang D, Mao C, Shen Q, Feng W, Shen DD, Dai A, Xie S, Zhou Y, Qin J, Sun JP, Scharf DH, Hou T, Zhou T, Wang MW, Zhang Y | 10.1038/S41422-021-00552-3 | 2021-11-03 | Yes | |
GP139 | GPR139 | A orphans | A | Human | Cryo-EM | 7VUG | 7VUG_refined | 3.2 | R | Active | 100 | 80 | Gi/o | αi1 | - | 62 | - | scFv16 |
JNJ-63533054
|
small-molecule | Agonist | L-tryptophan, L-phenylalanine | small-molecule | No | No | Zhou Y, Daver H, Trapkov B, Wu L, Wu M, Harpsoe K, Gentry PR, Liu K, Larionova M, Liu J, Chen N, Brauner-Osborne H, Gloriam DE, Hua T, Liu ZJ | 10.1038/S41422-021-00591-W | 2021-12-29 | Yes | |
S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7EW7 | - | 3.3 | D | Active | 100 | 75 | Gi/o | αi1 | - | 64 | - | scFv16 |
SEW2871
|
small-molecule | Agonist | sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate, sphingosine 1-phosphate | small-molecule | No | No | Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z | 10.1038/S41422-021-00566-X | 2021-09-29 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 7PYR | 7PYR_refined | 2.6 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
Preladenant conjugate PSB-2115
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Claff T, Klapschinski TA, Tiruttani Subhramanyam UK, Vaassen VJ, Schlegel JG, Vielmuth C, Voss JH, Labahn J, Muller CE | 10.1002/ANIE.202115545 | 2022-03-02 | Yes | |
GRM3 | mGlu3 | Metabotropic glutamate | C | Human | Cryo-EM | 7WI8 | 7WI8_refined | 4.2 | A | Inactive | - | 82 | - | - | - | - | - | - |
LY341495
|
small-molecule | Antagonist | L-glutamic acid, NAAG | small-molecule | No | No | - | - | 2022-03-16 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7RGP | - | 2.9 | R | Active | 100 | 82 | Gs | αs | Engineered G alpha | 55 | - | scFv16 Nanobody-35 |
tirzepatide
|
peptide | Agonist | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW | 10.1073/PNAS.2116506119 | 2022-04-13 | Yes | |
HRH2 | H2 | Histamine | A | Human | Cryo-EM | 7UL3 | 7UL3_refined | 3.0 | A | Inactive | 4 | 75 | - | - | - | - | - | Nanobody-6M NabFab HC NabFab LC |
famotidine
|
small-molecule | Antagonist | histamine | small-molecule | No | No | Robertson MJ, Papasergi-Scott MM, He F, Seven AB, Meyerowitz JG, Panova O, Peroto MC, Che T, Skiniotis G | 10.1038/S41594-022-00859-8 | 2022-06-29 | Yes | |
5HT4R | 5-HT4 | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7XT9 | - | 3.2 | R | Active | 100 | 76 | Gs | αs | - | 60 | BRIL | - |
5-hydroxytryptamine
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | - | - | 2022-07-27 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | Cryo-EM | 8DCR | - | 2.6 | R | Active | 100 | 57 | Gs | αs | - | 51 | T4-Lysozyme | Nanobody-35 |
Dobutamine
|
small-molecule | Agonist | - | - | No | No | Su M, Paknejad N, Zhu L, Wang J, Do HN, Miao Y, Liu W, Hite RK, Huang XY | 10.1038/S41467-022-31823-1 | 2022-07-27 | Yes | |
PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 7VVK | - | 3.3 | R | Active | 100 | 56 | Gs | αs | - | 58 | - | Nanobody-35 |
teriparatide
|
peptide | Agonist | PTH, PTHrP-(1-36), TIP39, PTHrP | peptide | No | No | Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O | 10.1016/J.MOLCEL.2022.07.003 | 2022-08-03 | Yes | |
S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7VIG | 7VIG_refined | 2.9 | F | Active | 100 | 73 | Gi/o | αi1 | - | 63 | - | scFv16 |
icanbelimod
|
small-molecule | Agonist | sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate, sphingosine 1-phosphate | small-molecule | No | No | Yu L, He L, Gan B, Ti R, Xiao Q, Hu H, Zhu L, Wang S, Ren R | 10.1073/PNAS.2117716119 | 2022-09-28 | Yes | |
SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7Y26 | 7Y26_refined | 3.3 | E | Active | 100 | 73 | Gq/11 | αq | Mini-Gq | 60 | - | scFv16 |
Octreotide
|
peptide | Agonist | SRIF-14, CST-17, cortistatin-14, SRIF-28 | peptide | No | No | Chen S, Teng X, Zheng S | 10.1038/S41589-022-01130-3 | 2022-10-19 | Yes | |
ACM3 | M3 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 8EA0 | 8EA0_refined | 2.6 | A | Active | 99 | 48 | - | - | - | - | - | - |
iperoxo
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | Zhang S, Gumpper RH, Huang XP, Liu Y, Krumm BE, Cao C, Fay JF, Roth BL | 10.1038/S41586-022-05489-0 | 2022-11-30 | Yes | |
PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 8HAF | - | 3.3 | R | Active | 100 | 62 | Gs | αs | - | 60 | - | Nanobody-35 |
PTHrP-(1-36)
|
peptide | Agonist | PTH, PTHrP-(1-36), TIP39, PTHrP | peptide | No | No | Zhao LH, Yuan QN, Dai AT, He XH, Chen CW, Zhang C, Xu YW, Zhou Y, Wang MW, Yang DH, Xu HE | 10.1038/S41401-022-01032-Z | 2022-12-21 | Yes | |
GPR21 | GPR21 | A orphans | A | Human | Cryo-EM | 8HIX | - | 3.1 | R | Active | 100 | 81 | Gs | αs | Mini-Gs | 61 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | 10.1038/S41467-023-35882-W | 2023-03-15 | Yes | |
GRPR | BB2 | Bombesin | A | Human | Cryo-EM | 7W3Z | - | 3.0 | A | Active | 100 | 78 | Gq/11 | αq | - | 98 | - | scFv16 |
Gastrin-releasing peptide
|
peptide | Agonist | neuromedin B, gastrin releasing peptide(14-27) (human), gastrin-releasing peptide, neuromedin C, GRP-(18-27) | peptide | No | No | Peng S, Zhan Y, Zhang D, Ren L, Chen A, Chen ZF, Zhang H | 10.1073/PNAS.2216230120 | 2023-02-22 | Yes | |
AA2BR | A2B | Adenosine | A | Human | Cryo-EM | 7XY7 | - | 3.3 | R | Active | 100 | 85 | Gs | αs | Mini-Gs | 57 | BRIL | - |
NECA
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Chen Y, Zhang J, Weng Y, Xu Y, Lu W, Liu W, Liu M, Hua T, Song G | 10.1126/SCIADV.ADD3709 | 2023-05-03 | Yes | |
PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 8FLT | - | 3.0 | R | Active | 100 | 45 | Gs | αs | - | 59 | - | Nanobody-35 |
M-PTH(1-14)
|
peptide | Agonist | PTH, PTHrP-(1-36), TIP39, PTHrP | peptide | No | No | Cary BP, Gerrard EJ, Belousoff MJ, Fletcher MM, Jiang Y, Russell IC, Piper SJ, Wootten D, Sexton PM | 10.1016/J.STR.2023.04.002 | 2023-04-26 | Yes | |
CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 8F2A | - | 2.2 | R | Active | 100 | 78 | Gs | αs | - | 59 | - | Nanobody-35 |
Pramlintide analogue San385
|
peptide | Agonist | β-CGRP, α-CGRP, calcitonin, calcitonin (salmon), amylin, adrenomedullin, adrenomedullin 2/intermedin | peptide | No | No | Cao J, Belousoff MJ, Gerrard E, Danev R, Fletcher MM, Dal Maso E, Schreuder H, Lorenz K, Evers A, Tiwari G, Besenius M, Li Z, Johnson RM, Wootten D, Sexton PM | 10.1038/S41589-023-01393-4 | 2023-08-02 | Yes | |
GLR | glucagon | Glucagon | B1 | Human | Cryo-EM | 8JRU | - | 3.5 | R | Active | 100 | 53 | Beta | Beta-arrestin-1 | - | 83 | - | scFv30 Nanobody-32 |
Apo (no ligand)
|
none | Apo (no ligand) | glucagon | peptide | No | No | Chen K, Zhang C, Lin S, Yan X, Cai H, Yi C, Ma L, Chu X, Liu Y, Zhu Y, Han S, Zhao Q, Wu B | 10.1038/S41586-023-06420-X | 2023-08-16 | Yes | |
ADA1A | α1A | Adrenoceptors | A | Human | Cryo-EM | 8THL | - | 3.1 | R | Active | 100 | 52 | Gq/11 | αq | - | 55 | T4-Lysozyme | scFv16 |
(-)-adrenaline
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Su M, Wang J, Xiang G, Do HN, Levitz J, Miao Y, Huang XY | 10.1038/S41467-023-40524-2 | 2023-08-16 | Yes | |
Q9WTK1 | BLT1 | Leukotriene | A | Guinea pig | X-ray | 5X33 | 5X33_refined | 3.7 | A | Inactive | 5 | 78 | - | - | - | - | T4-Lysozyme | - |
BIIL 260
|
small-molecule | Antagonist | - | - | No | No | Hori T, Okuno T, Hirata K, Yamashita K, Kawano Y, Yamamoto M, Hato M, Nakamura M, Shimizu T, Yokomizo T, Miyano M, Yokoyama S | 10.1038/NCHEMBIO.2547 | 2018-01-03 | Yes | |
DRD2 | D2 | Dopamine | A | Human | X-ray | 6CM4 | 6CM4_refined | 2.9 | A | Inactive | 1 | 59 | - | - | - | - | T4-Lysozyme | - |
risperidone
|
small-molecule | Inverse agonist | dopamine | small-molecule | No | No | Wang S, Che T, Levit A, Shoichet BK, Wacker D, Roth BL | 10.1038/NATURE25758 | 2018-03-14 | Yes | |
FZD4 | FZD4 | Frizzled | F | Human | X-ray | 6BD4 | 6BD4_refined | 2.4 | A | Inactive | 22 | 61 | - | - | - | - | Rubredoxin | - | - | - | - | - | - | No | No | Yang S, Wu Y, Xu TH, de Waal PW, He Y, Pu M, Chen Y, DeBruine ZJ, Zhang B, Zaidi SA, Popov P, Guo Y, Han GW, Lu Y, Suino-Powell K, Dong S, Harikumar KG, Miller LJ, Katritch V, Xu HE, Shui W, Stevens RC, Melcher K, Zhao S, Xu F | 10.1038/S41586-018-0447-X | 2018-08-22 | Yes | |
PTH1R | PTH1 | Parathyroid hormone | B1 | Human | X-ray | 6FJ3 | - | 2.5 | A | Inactive | 0 | 62 | - | - | - | - | GlgA glycogen synthase | - |
ePTH
|
peptide | Agonist (partial) | PTH, PTHrP-(1-36), TIP39, PTHrP | peptide | No | No | Ehrenmann J, Schoppe J, Klenk C, Rappas M, Kummer L, Dore AS, Pluckthun A | 10.1038/S41594-018-0151-4 | 2018-11-21 | Yes | |
MTR1A | MT1 | Melatonin | A | Human | X-ray | 6ME4 | 6ME4_refined | 3.2 | A | Inactive | 1 | 83 | - | - | - | - | GlgA glycogen synthase | - |
2-iodo-melatonin
|
small-molecule | Agonist | melatonin | small-molecule | No | No | - | - | 2019-04-24 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | Cryo-EM | 6OFJ | 6OFJ_refined | 4.5 | A | Inactive | 22 | 93 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | 10.1074/JBC.RA119.010089 | 2019-08-21 | Yes | |
ADA2A | α2A | Adrenoceptors | A | Human | X-ray | 6KUX | 6KUX_refined | 2.7 | A | Inactive | 1 | 57 | - | - | - | - | BRIL | - |
RSC
|
small-molecule | Antagonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | - | - | 2019-12-04 | Yes | |
PACR | PAC1 | VIP and PACAP | B1 | Human | Cryo-EM | 6P9Y | - | 3.0 | R | Active | 100 | 55 | Gs | αs | - | 49 | - | Nanobody-35 |
[Ac-His1]PACAP-27
|
peptide | Agonist | VIP, PHV, PACAP-27, PHI, PHM, PACAP-38 | peptide | No | No | - | - | 2020-02-05 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 6PH7 | 6PH7_refined | 2.9 | A | Active | 100 | 94 | Gi/o | αt2 | Only H5 | 3 | - | - |
Nerol
|
small-molecule | unknown | - | - | No | No | - | - | 2020-07-01 | Yes | |
AGTR2 | AT2 | Angiotensin | A | Human | X-ray | 7C6A | 7C6A_refined | 3.4 | A | Active | 99 | 77 | - | - | - | - | BRIL | IgG heavy chain IgG light chain |
CHEMBL404594
|
protein | Agonist | angiotensin-(1-7), angiotensin II, angiotensin III | peptide | No | No | Miyagi H, Asada H, Suzuki M, Takahashi Y, Yasunaga M, Suno C, Iwata S, Saito JI | 10.1038/S41598-020-68355-X | 2020-07-29 | Yes | |
SMO | SMO | Frizzled | F | Human | Cryo-EM | 6XBJ | - | 3.9 | R | Active | 100 | 59 | Gi/o | αi1 | - | 61 | - | scFv16 |
Cholesterol
|
small-molecule | Agonist | - | - | No | No | Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X | 10.1038/S41589-020-0646-2 | 2020-09-30 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Rat | Cryo-EM | 7L0S | - | 4.5 | C | Active | 100 | 73 | Gi/o | αi1 | Non-canonical conformation | 95 | - | - |
neurotensin
|
peptide | Agonist | neuromedin N, neurotensin | peptide | No | No | Zhang M, Gui M, Wang ZF, Gorgulla C, Yu JJ, Wu H, Sun ZJ, Klenk C, Merklinger L, Morstein L, Hagn F, Pluckthun A, Brown A, Nasr ML, Wagner G | 10.1038/S41594-020-00554-6 | 2021-01-06 | Yes | |
CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7DTT | 7DTT_refined | 3.8 | A | Active | - | 72 | - | - | - | - | - | - |
Calcium
|
small-molecule | Agonist | spermine, L-tryptophan, Ca2+, Mg2+ | small-molecule | No | No | Ling S, Shi P, Liu S, Meng X, Zhou Y, Sun W, Chang S, Zhang X, Zhang L, Shi C, Sun D, Liu L, Tian C | 10.1038/S41422-021-00474-0 | 2021-03-10 | Yes | |
CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7M3F | 7M3F_refined | 2.8 | B | Active | - | 75 | - | - | - | - | - | - |
Calcium
L-tryptophan cinacalcet |
small-molecule small-molecule small-molecule |
Agonist PAM PAM |
spermine, L-tryptophan, Ca2+, Mg2+ | small-molecule | No | No | - | - | 2021-06-30 | Yes | |
S1PR3 | S1P3 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7EW3 | - | 3.1 | R | Active | 100 | 77 | Gi/o | αi1 | - | 64 | - | scFv16 |
Sphingosine 1-phosphate
|
lipid | Agonist | sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate, sphingosine 1-phosphate | small-molecule | No | No | - | - | 2021-09-29 | Yes | |
NK1R | NK1 | Tachykinin | A | Human | Cryo-EM | 7RMI | - | 3.2 | R | Active | 100 | 70 | Gs | αs | Gs-Gq chimera | 49 | - | Nanobody-35 |
substance P
|
peptide | Agonist | neurokinin B, neuropeptide-γ, hemokinin 1, substance P, neurokinin A, neuropeptide K | peptide | No | No | Harris JA, Faust B, Gondin AB, Damgen MA, Suomivuori CM, Veldhuis NA, Cheng Y, Dror RO, Thal DM, Manglik A | 10.1038/S41589-021-00890-8 | 2021-11-03 | Yes | |
GHSR | ghrelin | Ghrelin | A | Human | Cryo-EM | 7NA8 | - | 2.7 | R | Active | 100 | 78 | Gi/o | αi1 | - | 61 | - | Antibody fragment |
ibutamoren
|
small-molecule | Agonist | [des-Gln14]ghrelin, ghrelin | peptide | No | No | Liu H, Sun D, Myasnikov A, Damian M, Baneres JL, Sun J, Zhang C | 10.1038/S41467-021-26735-5 | 2021-12-15 | Yes | |
S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7EW0 | 7EW0_refined | 3.4 | D | Active | 100 | 71 | Gi/o | αi1 | - | 64 | - | scFv16 |
ozanimod
|
small-molecule | Agonist | sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate, sphingosine 1-phosphate | small-molecule | No | No | Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z | 10.1038/S41422-021-00566-X | 2021-09-29 | Yes | |
MTR1B | MT2 | Melatonin | A | Human | Cryo-EM | 7VH0 | 7VH0_refined | 3.5 | A | Active | 100 | 75 | Gi/o | αi1 | - | 61 | - | scFv16 |
ramelteon
|
small-molecule | Agonist | melatonin | small-molecule | No | No | Wang Q, Lu Q, Guo Q, Teng M, Gong Q, Li X, Du Y, Liu Z, Tao Y | 10.1038/S41467-022-28111-3 | 2022-03-02 | Yes | |
GRM3 | mGlu3 | Metabotropic glutamate | C | Human | Cryo-EM | 7WIH | 7WIH_refined | 3.7 | A | Active | - | 84 | - | - | - | - | - | - |
CHEMBL4081453
|
small-molecule | Agonist | L-glutamic acid, NAAG | small-molecule | No | No | Fang W, Yang F, Xu C, Ling S, Lin L, Zhou Y, Sun W, Wang X, Liu P, Rondard P, Shi P, Pin JP, Tian C, Liu J | 10.1038/S41422-022-00623-Z | 2022-03-16 | Yes | |
AGRF1 | ADGRF1 | ADGRF | B2 | Human | Cryo-EM | 7WU4 | - | 3.4 | R | Active | - | 31 | Gi/o | αi1 | Mini-Gi1 | 58 | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Qu X, Qiu N, Wang M, Zhang B, Du J, Zhong Z, Xu W, Chu X, Ma L, Yi C, Han S, Shui W, Zhao Q, Wu B | 10.1038/S41586-022-04580-W | 2022-04-27 | Yes | |
BKRB2 | B2 | Bradykinin | A | Human | Cryo-EM | 7F6H | 7F6H_refined | 2.9 | A | Active | 100 | 78 | Gq/11 | αq | - | 63 | - | - |
bradykinin
|
peptide | Agonist | [Hyp3]bradykinin, [des-Arg10]kallidin, bradykinin, Lys-[Hyp3]-bradykinin, kallidin, [des-Arg9]bradykinin, T-kinin | peptide | No | No | Shen J, Zhang D, Fu Y, Chen A, Yang X, Zhang H | 10.1038/S41467-022-28399-1 | 2022-01-05 | Yes | |
CNR1 | CB1 | Cannabinoid | A | Human | Cryo-EM | 7WV9 | - | 3.4 | R | Active | 100 | 61 | Gi/o | αi2 | - | 63 | - | scFv16 |
CP55940
6-methyl-3-[(1S)-2-nitro-1-thiophen-2-yl-ethyl]-2-phenyl-1H-indole |
small-molecule small-molecule |
Agonist PAM |
2-arachidonoylglycerol, anandamide | small-molecule | No | No | Yang X, Wang X, Xu Z, Wu C, Zhou Y, Wang Y, Lin G, Li K, Wu M, Xia A, Liu J, Cheng L, Zou J, Yan W, Shao Z, Yang S | 10.1038/S41589-022-01038-Y | 2022-06-15 | Yes | |
ACKR3 | ACKR3 | Chemokine | A | Human | Cryo-EM | 7SK5 | 7SK5_refined | 4.0 | A | Active | 95 | 83 | - | - | - | - | - | CID24 Fab heavy chain CID24 Fab light chain anti-Fab Nanobody |
Stromal cell-derived factor 1
|
peptide | Agonist | CXCL12α, CXCL11 | peptide | No | No | Yen YC, Schafer CT, Gustavsson M, Eberle SA, Dominik PK, Deneka D, Zhang P, Schall TJ, Kossiakoff AA, Tesmer JJG, Handel TM | 10.1126/SCIADV.ABN8063 | 2022-07-27 | Yes | |
SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7Y24 | - | 3.3 | E | Active | 100 | 77 | Gi/o | αo | - | 60 | - | scFv16 |
Octreotide
|
peptide | Agonist | SRIF-14, CST-17, cortistatin-14, SRIF-28 | peptide | No | No | Chen S, Teng X, Zheng S | 10.1038/S41589-022-01130-3 | 2022-10-19 | Yes | |
OPRM | μ | Opioid | A | Human | Cryo-EM | 8EF6 | 8EF6_refined | 3.2 | R | Active | 100 | 72 | Gi/o | αi1 | - | 64 | - | scFv16 |
morphine
|
small-molecule | Agonist | dynorphin A-(1-8), [Met]enkephalin, endomorphin-1, dynorphin A, [Leu]enkephalin, β-endorphin, dynorphin A-(1-13), dynorphin B, endomorphin-2 | peptide | No | No | Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE | 10.1016/J.CELL.2022.09.041 | 2022-11-09 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 7ZBE | 7ZBE_refined | 1.8 | A | Inactive | 22 | 87 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | Gruhl T, Weinert T, Rodrigues MJ, Milne CJ, Ortolani G, Nass K, Nango E, Sen S, Johnson PJM, Cirelli C, Furrer A, Mous S, Skopintsev P, James D, Dworkowski F, Bath P, Kekilli D, Ozerov D, Tanaka R, Glover H, Bacellar C, Brunle S, Casadei CM, Diethelm AD, Gashi D, Gotthard G, Guixa-Gonzalez R, Joti Y, Kabanova V, Knopp G, Lesca E, Ma P, Martiel I, Muhle J, Owada S, Pamula F, Sarabi D, Tejero O, Tsai CJ, Varma N, Wach A, Boutet S, Tono K, Nogly P, Deupi X, Iwata S, Neutze R, Standfuss J, Schertler G, Panneels V | 10.1038/S41586-023-05863-6 | 2023-03-29 | Yes | |
GPR35 | GPR35 | A orphans | A | Human | Cryo-EM | 8H8J | 8H8J_refined | 3.2 | C | Active | 100 | 92 | G12/13 | α13 | - | 60 | - | scFv16 |
lodoxamide
|
small-molecule | Agonist | 1-Lyso-2-oleoyl-phosphatidic acid, kynurenic acid, 2-Oleoyllysophosphatydic acid, 2-oleoyl-LPA | small-molecule | No | No | - | 10.1038/S41421-022-00499-8 | 2023-02-08 | Yes | |
RXFP1 | RXFP1 | Relaxin family peptide | A | Human | Cryo-EM | 7TMW | - | 3.2 | R | Active | 100 | 36 | Gs | αs | Gs fused to receptor | 57 | - | Nanobody-35 |
H2 relaxin
|
small-molecule | Agonist | relaxin-3, relaxin, relaxin-1 | peptide | No | No | - | - | 2023-02-15 | Yes | |
MRGX1 | MRGPRX1 | A orphans | A | Human | Cryo-EM | 8HJ5 | 8HJ5_refined | 3.0 | F | Active | 100 | 78 | Gq/11 | αq | - | 60 | BRIL | scFv16 Nanobody-35 |
compound 16 [PMID: 31498617]
|
small-molecule | Agonist | bovine adrenal medulla peptide 8-22 | peptide | No | No | - | - | 2023-05-31 | Yes | |
C3AR | C3a | Complement peptide | A | Human | Cryo-EM | 8HK3 | 8HK3_refined | 3.2 | C | Active | 100 | 59 | Gi/o | αi1 | - | 63 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | C3a, C5a | peptide | No | No | Wang Y, Liu W, Xu Y, He X, Yuan Q, Luo P, Fan W, Zhu J, Zhang X, Cheng X, Jiang Y, Xu HE, Zhuang Y | 10.1038/S41589-023-01339-W | 2023-05-10 | Yes | |
C5AR1 | C5a1 | Complement peptide | A | Human | Cryo-EM | 8HK5 | 8HK5_refined | 3.0 | A | Active | 100 | 84 | Gi/o | αi1 | - | 63 | - | - |
C5a
|
peptide | Agonist | C3a, C5a, ribosomal protein S19, C5a des-Arg | peptide | No | No | Wang Y, Liu W, Xu Y, He X, Yuan Q, Luo P, Fan W, Zhu J, Zhang X, Cheng X, Jiang Y, Xu HE, Zhuang Y | 10.1038/S41589-023-01339-W | 2023-05-10 | Yes | |
EDNRB | ETB | Endothelin | A | Human | Cryo-EM | 8IY6 | - | 3.1 | R | Active | 79 | 66 | - | - | - | - | - | - |
ENDOTHELIN
|
protein | Agonist | endothelin-1, endothelin-2, endothelin-3 | peptide | No | No | Sano FK, Akasaka H, Shihoya W, Nureki O | 10.7554/ELIFE.85821 | 2023-08-16 | Yes | |
GLR | glucagon | Glucagon | B1 | Human | Cryo-EM | 8JRV | - | 3.3 | R | Active | 100 | 64 | Beta | Beta-arrestin-1 | - | 85 | - | scFv30 Nanobody-32 |
glucagon
|
peptide | Agonist | glucagon | peptide | No | No | Chen K, Zhang C, Lin S, Yan X, Cai H, Yi C, Ma L, Chu X, Liu Y, Zhu Y, Han S, Zhao Q, Wu B | 10.1038/S41586-023-06420-X | 2023-08-16 | Yes | |
C5AR1 | C5a1 | Complement peptide | A | Human | X-ray | 5O9H | 5O9H_refined | 2.7 | A | Inactive | 6 | 84 | - | - | - | - | - | - |
NDT9513727
|
small-molecule | Antagonist | C3a, C5a, ribosomal protein S19, C5a des-Arg | peptide | No | No | Robertson N, Rappas M, Dore AS, Brown J, Bottegoni G, Koglin M, Cansfield J, Jazayeri A, Cooke RM, Marshall FH | 10.1038/NATURE25025 | 2018-01-10 | Yes | |
OPRM | μ | Opioid | A | Mouse | Cryo-EM | 6DDF | - | 3.5 | R | Active | 100 | 71 | Gi/o | αi1 | - | 61 | - | - |
DAMGO
|
peptide | Agonist | - | - | No | No | - | - | 2018-06-13 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 6IBL | 6IBL_refined | 2.7 | A | Active | 99 | 60 | - | - | - | - | Thioredoxin 1 | Camelid antibody fragment Nb80 |
arformoterol
|
small-molecule | Agonist | - | - | No | No | - | 10.1038/S41586-020-2419-1 | 2019-01-09 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | Cryo-EM | 6QNO | - | 4.4 | R | Active | 100 | 96 | Gi/o | αi1 | - | 60 | - | Fab antibody fragment light chain Fab antibody fragment heavy chain |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | - | 10.7554/ELIFE.46041 | 2019-07-10 | Yes | |
CLTR2 | CysLT2 | Leukotriene | A | Human | X-ray | 6RZ8 | 6RZ8_refined | 2.7 | A | Intermediate | 44 | 78 | - | - | - | - | BRIL | - |
ONO-2080365
|
small-molecule | Antagonist | LTE4, LTD4, LTC4 | small-molecule | No | No | Gusach A, Luginina A, Marin E, Brouillette RL, Besserer-Offroy E, Longpre JM, Ishchenko A, Popov P, Patel N, Fujimoto T, Maruyama T, Stauch B, Ergasheva M, Romanovskaia D, Stepko A, Kovalev K, Shevtsov M, Gordeliy V, Han GW, Katritch V, Borshchevskiy V, Sarret P, Mishin A, Cherezov V | 10.1038/S41467-019-13348-2 | 2019-12-11 | Yes | |
CRFR1 | CRF1 | Corticotropin-releasing factor | B1 | Human | Cryo-EM | 6PB0 | - | 3.0 | R | Active | 100 | 68 | Gs | αs | Gs-Gi1 chimera | 58 | - | Nanobody-35 |
Urocortin
|
peptide | Agonist | urocortin 2, corticotrophin-releasing hormone, urocortin 1 | peptide | No | No | Ma S, Shen Q, Zhao LH, Mao C, Zhou XE, Shen DD, de Waal PW, Bi P, Li C, Jiang Y, Wang MW, Sexton PM, Wootten D, Melcher K, Zhang Y, Xu HE | 10.1016/J.MOLCEL.2020.01.013 | 2020-02-12 | Yes | |
5HT1B | 5-HT1B | 5-Hydroxytryptamine | A | Human | X-ray | 7C61 | 7C61_refined | 3.0 | A | Inactive | 15 | 68 | - | - | - | - | BRIL | IgG heavy chain IgG light chain |
ergotamine
|
small-molecule | Antagonist | 5-hydroxytryptamine, 5-HT-moduline, tryptamine | small-molecule | No | No | - | - | 2020-07-29 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 6ZDR | 6ZDR_refined | 1.9 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
CHEMBL2030687
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | - | - | 2020-09-16 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 6WQA | 6WQA_refined | 2.0 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Lee MY, Geiger J, Ishchenko A, Han GW, Barty A, White TA, Gati C, Batyuk A, Hunter MS, Aquila A, Boutet S, Weierstall U, Cherezov V, Liu W | 10.1107/S2052252520012701 | 2020-11-18 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7LCJ | 7LCJ_refined | 2.8 | R | Active | 98 | 84 | - | - | - | - | - | - |
danuglipron
|
small-molecule | Agonist | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Zhang X, Johnson RM, Drulyte I, Yu L, Kotecha A, Danev R, Wootten D, Sexton PM, Belousoff MJ | 10.1016/J.STR.2021.04.008 | 2021-01-20 | Yes | |
DRD2 | D2 | Dopamine | A | Human | Cryo-EM | 7JVR | - | 2.8 | R | Active | 100 | 61 | Gi/o | αi1 | - | 63 | - | scFv16 |
bromocriptine
|
small-molecule | Agonist | dopamine | small-molecule | No | No | Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE | 10.1016/J.CELL.2021.01.027 | 2021-02-24 | Yes | |
S1PR3 | S1P3 | Lysophospholipid (S1P) | A | Human | X-ray | 7C4S | 7C4S_refined | 3.2 | A | Active | 73 | 75 | - | - | - | - | - | Fab light chain Fab heavy chain |
sphingosine 1-phosphate
|
small-molecule | Agonist | sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate, sphingosine 1-phosphate | small-molecule | No | No | Maeda S, Shiimura Y, Asada H, Hirata K, Luo F, Nango E, Tanaka N, Toyomoto M, Inoue A, Aoki J, Iwata S, Hagiwara M | 10.1126/SCIADV.ABF5325 | 2021-06-09 | Yes | |
GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 7MTS | - | 3.2 | A | Active | - | 90 | Gi/o | αi1 | - | 58 | - | - |
2-methoxy-6-propyl-N-(2-{4-[(1H-tetrazol-5-yl)methoxy]phenyl}ethyl)thieno[2,3-d]pyrimidin-4-amine
L-glutamic acid |
small-molecule small-molecule |
Ago-PAM Agonist |
L-glutamic acid | small-molecule | No | No | - | - | 2021-07-07 | Yes | |
ACM1 | M1 | Acetylcholine (muscarinic) | A | Human | X-ray | 6ZG4 | 6ZG4_refined | 2.3 | A | Inactive | 2 | 62 | - | - | - | - | T4-Lysozyme | - |
Ethyl (4S)-4-[4-[(1-methylcyclobutyl)carbamoyl]piperidin-1-yl]azepane-1-carboxylate
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | Brown AJH, Bradley SJ, Marshall FH, Brown GA, Bennett KA, Brown J, Cansfield JE, Cross DM, de Graaf C, Hudson BD, Dwomoh L, Dias JM, Errey JC, Hurrell E, Liptrot J, Mattedi G, Molloy C, Nathan PJ, Okrasa K, Osborne G, Patel JC, Pickworth M, Robertson N, Shahabi S, Bundgaard C, Phillips K, Broad LM, Goonawardena AV, Morairty SR, Browning M, Perini F, Dawson GR, Deakin JFW, Smith RT, Sexton PM, Warneck J, Vinson M, Tasker T, Tehan BG, Teobald B, Christopoulos A, Langmead CJ, Jazayeri A, Cooke RM, Rucktooa P, Congreve MS, Weir M, Tobin AB | 10.1016/J.CELL.2021.11.001 | 2021-10-06 | Yes | |
GP158 | GPR158 | C Orphans | C | Human | Cryo-EM | 7SHE | 7SHE_refined | 3.4 | A | Inactive | - | 45 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Patil DN, Singh S, Laboute T, Strutzenberg TS, Qiu X, Wu D, Novick SJ, Robinson CV, Griffin PR, Hunt JF, Izard T, Singh AK, Martemyanov KA | 10.1126/SCIENCE.ABL4732 | 2021-12-01 | Yes | |
S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7EO2 | 7EO2_refined | 2.9 | A | Active | 100 | 73 | Gi/o | αi1 | - | 62 | - | scFv16 |
(S)-FTY720-phosphate
|
small-molecule | Agonist | sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate, sphingosine 1-phosphate | small-molecule | No | No | Xu Z, Ikuta T, Kawakami K, Kise R, Qian Y, Xia R, Sun MX, Zhang A, Guo C, Cai XH, Huang Z, Inoue A, He Y | 10.1038/S41589-021-00930-3 | 2022-01-05 | Yes | |
FPR2 | FPR2/ALX | Formylpeptide | A | Human | Cryo-EM | 7T6S | 7T6S_refined | 3.0 | R | Active | 100 | 85 | Gi/o | αi1 | - | 61 | - | scFv16 |
N-(4-chlorophenyl)-N'-[1-methyl-3-oxo-2-phenyl-5-(propan-2-yl)-2,3-dihydro-1H-pyrazol-4-yl]urea
|
small-molecule | Agonist | resolvin D1, serum amyloid A, 15-deoxy-LXA4, LTC4, LL-37, humanin, LTD4, aspirin triggered lipoxin A4, annexin I, aspirin-triggered resolvin D1, fMet-Leu-Phe, PrP106-126, LXA4 | peptide | No | No | - | - | 2022-03-30 | Yes | |
CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 7TYO | - | 2.7 | R | Active | 100 | 76 | Gs | αs | - | 58 | - | Nanobody-35 |
Calcitonin human
|
peptide | Agonist | β-CGRP, α-CGRP, calcitonin, calcitonin (salmon), amylin, adrenomedullin, adrenomedullin 2/intermedin | peptide | No | No | Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | Yes | |
OPRM | μ | Opioid | A | Mouse | Cryo-EM | 7U2L | - | 3.2 | D | Active | 100 | 71 | Gi/o | αi1 | - | 61 | - | scFv16 |
N-(5-carbamimidamidopentyl)-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
|
small-molecule | Agonist | - | - | No | No | Faouzi A, Wang H, Zaidi SA, DiBerto JF, Che T, Qu Q, Robertson MJ, Madasu MK, El Daibani A, Varga BR, Zhang T, Ruiz C, Liu S, Xu J, Appourchaux K, Slocum ST, Eans SO, Cameron MD, Al-Hasani R, Pan YX, Roth BL, McLaughlin JP, Skiniotis G, Katritch V, Kobilka BK, Majumdar S | 10.1038/S41586-022-05588-Y | 2022-05-04 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7S15 | 7S15_refined | 3.8 | R | Active | 94 | 83 | - | - | - | - | - | - |
CHEMBL5191519
|
small-molecule | Agonist | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Griffith DA, Edmonds DJ, Fortin JP, Kalgutkar AS, Kuzmiski JB, Loria PM, Saxena AR, Bagley SW, Buckeridge C, Curto JM, Derksen DR, Dias JM, Griffor MC, Han S, Jackson VM, Landis MS, Lettiere D, Limberakis C, Liu Y, Mathiowetz AM, Patel JC, Piotrowski DW, Price DA, Ruggeri RB, Tess DA. | 10.1021/acs.jmedchem.1c01856 | 2022-06-08 | Yes | |
DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7F24 | - | 4.2 | F | Active | 100 | 62 | Gs | αs | - | 57 | - | - |
dopamine
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, 5-hydroxytryptamine, dopamine | small-molecule | No | No | Teng X, Chen S, Wang Q, Chen Z, Wang X, Huang N, Zheng S | 10.1126/SCIADV.ABO4158 | 2022-06-15 | Yes | |
5HT7R | 5-HT7 | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7XTC | 7XTC_refined | 3.2 | R | Active | 100 | 57 | Gs | αs | - | 61 | BRIL | Nanobody-35 |
5-CT
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Huang S, Xu P, Shen DD, Simon IA, Mao C, Tan Y, Zhang H, Harpsoe K, Li H, Zhang Y, You C, Yu X, Jiang Y, Zhang Y, Gloriam DE, Xu HE | 10.1016/J.MOLCEL.2022.05.031 | 2022-07-27 | Yes | |
5HT2C | 5-HT2C | 5-Hydroxytryptamine | A | Human | Cryo-EM | 8DPH | - | 3.2 | A | Active | 100 | 58 | Gq/11 | αq | Gi2-mini-Gq chimera | 57 | - | scFv16 |
lorcaserin
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Gumpper RH, Fay JF, Roth BL | 10.1016/J.CELREP.2022.111211 | 2022-08-24 | Yes | |
PE2R3 | EP3 | Prostanoid | A | Human | Cryo-EM | 7WU9 | 7WU9_refined | 3.4 | R | Active | 100 | 70 | Gi/o | αi1 | - | 38 | - | scFv16 | - | - | - | PGE2, PGF2α, thromboxane A2, PGI2, PGE1, PGD2 | small-molecule | No | No | Suno R, Sugita Y, Morimoto K, Takazaki H, Tsujimoto H, Hirose M, Suno-Ikeda C, Nomura N, Hino T, Inoue A, Iwasaki K, Kato T, Iwata S, Kobayashi T | 10.1016/J.CELREP.2022.111323 | 2022-08-17 | Yes | |
TSHR | TSH | Glycoprotein hormone | A | Human | Cryo-EM | 7T9I | - | 2.9 | R | Active | 100 | 78 | Gs | αs | Mini-Gs | 56 | - | Nanobody-35 |
Thyrotropin subunit beta
Glycoprotein hormones alpha chain |
protein protein |
Agonist | TSH | peptide | No | No | Faust B, Billesbolle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A | 10.1038/S41586-022-05159-1 | 2022-08-03 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 5OLH | 5OLH_refined | 2.6 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
vipadenant
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Rucktooa P, Cheng RKY, Segala E, Geng T, Errey JC, Brown GA, Cooke RM, Marshall FH, Dore AS | 10.1038/S41598-017-18570-W | 2018-01-17 | Yes | |
Q98SW5 | SMO | Frizzled | F | African clawed frog | X-ray | 6D32 | 6D32_refined | 3.8 | A | Active | 78 | 58 | - | - | - | - | BRIL | - |
cyclopamine
|
small-molecule | Agonist (partial) | - | - | No | No | Huang P, Zheng S, Wierbowski BM, Kim Y, Nedelcu D, Aravena L, Liu J, Kruse AC, Salic A | 10.1016/J.CELL.2018.04.029 | 2018-05-23 | Yes | |
CCR5 | CCR5 | Chemokine | A | Human | X-ray | 6AKY | 6AKY_refined | 2.8 | A | Inactive | 16 | 81 | - | - | - | - | Rubredoxin | - |
CCR5 antagonist 34
|
small-molecule | Antagonist | CCL2, CCL8, CCL11, CCL13, CCL14, CCL7, CCL5, CCL4, CCL16, CCL3 | peptide | No | No | Peng P, Chen H, Zhu Y, Wang Z, Li J, Luo RH, Wang J, Chen L, Yang LM, Jiang H, Xie X, Wu B, Zheng YT, Liu H. | 10.1021/acs.jmedchem.8b01077 | 2018-10-24 | Yes | |
NK1R | NK1 | Tachykinin | A | Human | X-ray | 6HLP | 6HLP_refined | 2.2 | A | Inactive | 1 | 71 | - | - | - | - | GlgA glycogen synthase | - |
netupitant
|
small-molecule | Antagonist | neurokinin B, neuropeptide-γ, hemokinin 1, substance P, neurokinin A, neuropeptide K | peptide | No | No | - | - | 2019-01-16 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 6N48 | 6N48_refined | 3.2 | A | Active | 99 | 70 | - | - | - | - | T4-Lysozyme | Camelid Antibody Fragment |
CHEMBL1615159
2-[[(3R)-4-(4-Tert-butylphenyl)-3-[[2-(4-methoxyphenyl)sulfanyl-5-[methyl(propan-2-yl)sulfamoyl]benzoyl]amino]butanoyl]amino]acetic acid |
small-molecule small-molecule |
Agonist PAM |
noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | - | 10.1126/SCIENCE.AAW8981 | 2019-06-26 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 6PS7 | 6PS7_refined | 1.9 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | - | 10.1107/S2052252519013137 | 2019-11-13 | Yes | |
OX1R | OX1 | Orexin | A | Human | X-ray | 6TOS | 6TOS_refined | 2.1 | B | Inactive | 1 | 72 | - | - | - | - | - | - |
CHEMBL2413522
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-15 | Yes | |
OPRK | κ | Opioid | A | Human | X-ray | 6VI4 | 6VI4_refined | 3.3 | B | Inactive | 4 | 73 | - | - | - | - | - | Nanobody-6 |
JDTic
|
small-molecule | Antagonist | dynorphin A-(1-8), β-neoendorphin, big dynorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, β-endorphin, dynorphin A-(1-13), dynorphin B, α-neoendorphin | peptide | No | No | Che T, English J, Krumm BE, Kim K, Pardon E, Olsen RHJ, Wang S, Zhang S, Diberto JF, Sciaky N, Carroll FI, Steyaert J, Wacker D, Roth BL | 10.1038/S41467-020-14889-7 | 2020-03-18 | Yes | |
GABR2 | GABAB2 | GABAB | C | Human | Cryo-EM | 6W2X | - | 3.6 | B | Inactive | - | 71 | - | - | - | - | - | - |
CGP55845
1-Stearoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine |
small-molecule small-molecule |
Inverse agonist NAM |
- | - | No | No | Papasergi-Scott MM, Robertson MJ, Seven AB, Panova O, Mathiesen JM, Skiniotis G | 10.1038/S41586-020-2469-4 | 2020-07-01 | Yes | |
SMO | SMO | Frizzled | F | Human | Cryo-EM | 6XBK | - | 3.2 | R | Active | 100 | 59 | Gi/o | αi1 | - | 61 | - | scFv16 |
Cholesterol
|
small-molecule | Agonist | - | - | No | No | Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X | 10.1038/S41589-020-0646-2 | 2020-09-30 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7LCI | 7LCI_refined | 2.9 | R | Active | 100 | 85 | Gs | αs | - | 62 | - | - |
danuglipron
|
small-molecule | Agonist | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Zhang X, Johnson RM, Drulyte I, Yu L, Kotecha A, Danev R, Wootten D, Sexton PM, Belousoff MJ | 10.1016/J.STR.2021.04.008 | 2021-01-20 | Yes | |
DRD3 | D3 | Dopamine | A | Human | Cryo-EM | 7CMU | - | 3.0 | R | Active | 100 | 68 | Gi/o | αi1 | - | 64 | BRIL | scFv16 |
pramipexole
|
small-molecule | Agonist | dopamine | small-molecule | No | No | Xu P, Huang S, Mao C, Krumm BE, Zhou XE, Tan Y, Huang XP, Liu Y, Shen DD, Jiang Y, Yu X, Jiang H, Melcher K, Roth BL, Cheng X, Zhang Y, Xu HE | 10.1016/J.MOLCEL.2021.01.003 | 2021-03-10 | Yes | |
GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 7EPB | 7EPB_refined | 3.1 | B | Active | - | 89 | - | - | - | - | - | Anti-RON nanobody |
eglumegad
|
small-molecule | Agonist | L-glutamic acid | small-molecule | No | No | Du J, Wang D, Fan H, Xu C, Tai L, Lin S, Han S, Tan Q, Wang X, Xu T, Zhang H, Chu X, Yi C, Liu P, Wang X, Zhou Y, Pin JP, Rondard P, Liu H, Liu J, Sun F, Wu B, Zhao Q | 10.1038/S41586-021-03641-W | 2021-06-23 | Yes | |
5HT1F | 5-HT1F | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7EXD | 7EXD_refined | 3.4 | R | Active | 100 | 74 | Gi/o | αi1 | - | 62 | BRIL | scFv16 |
lasmiditan
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Huang S, Xu P, Tan Y, You C, Zhang Y, Jiang Y, Xu HE | 10.1038/S41422-021-00527-4 | 2021-08-04 | Yes | |
LSHR | LH | Glycoprotein hormone | A | Human | Cryo-EM | 7FIG | - | 3.9 | R | Active | 100 | 79 | Gs | αs | - | 91 | - | Nanobody-35 |
Choriogonadotropin beta
Glycoprotein alpha |
protein protein |
Agonist | hCG, LH | peptide | No | No | Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE | 10.1038/S41586-021-03924-2 | 2021-09-29 | Yes | |
AGRG2 | ADGRG2 | ADGRG | B2 | Mouse | Cryo-EM | 7WUQ | - | 2.9 | R | Active | - | 28 | Gs | αs | - | 55 | - | Nanobody-35 | - | - | - | - | - | No | No | Xiao P, Guo S, Wen X, He QT, Lin H, Huang SM, Gou L, Zhang C, Yang Z, Zhong YN, Yang CC, Li Y, Gong Z, Tao XN, Yang ZS, Lu Y, Li SL, He JY, Wang C, Zhang L, Kong L, Sun JP, Yu X | 10.1038/S41586-022-04590-8 | 2022-04-27 | Yes | |
SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7WIG | 7WIG_refined | 2.7 | R | Active | 100 | 77 | Gi/o | αi1 | - | 64 | - | scFv16 |
~{N}-[(2~{R})-1-[[(1~{R},3~{S})-3-(aminomethyl)cyclohexyl]methylamino]-3-(1~{H}-indol-3-yl)-1-oxidanylidene-propan-2-yl]spiro[indene-1,4'-piperidine]-1'-carboxamide
|
small-molecule | Agonist | SRIF-14, CST-17, cortistatin-14, SRIF-28 | peptide | No | No | Chen LN, Wang WW, Dong YJ, Shen DD, Guo J, Yu X, Qin J, Ji SY, Zhang H, Shen Q, He Q, Yang B, Zhang Y, Li Q, Mao C | 10.1038/S41422-022-00669-Z | 2022-06-01 | Yes | |
5HT5A | 5-HT5A | 5-Hydroxytryptamine | A | Human | X-ray | 7UM4 | 7UM4_refined | 2.8 | A | Inactive | 35 | 71 | - | - | - | - | PGS | - |
CHEMBL3654198
|
small-molecule | Antagonist | 5-hydroxytryptamine | small-molecule | No | No | Zhang S, Chen H, Zhang C, Yang Y, Popov P, Liu J, Krumm BE, Cao C, Kim K, Xiong Y, Katritch V, Shoichet BK, Jin J, Fay JF, Roth BL | 10.1038/S41594-022-00796-6 | 2022-07-20 | Yes | |
GALR2 | GAL2 | Galanin | A | Human | Cryo-EM | 7XBD | 7XBD_refined | 3.1 | A | Active | 100 | 72 | Gq/11 | αq | - | 60 | - | scFv16 |
Galanin, Human
|
peptide | Agonist | galanin-like peptide, spexin-1, galanin | peptide | No | No | Heo Y, Ishimoto N, Jeon YE, Yun JH, Ohki M, Anraku Y, Sasaki M, Kita S, Fukuhara H, Ikuta T, Kawakami K, Inoue A, Maenaka K, Tame JRH, Lee W, Park SY | 10.1371/JOURNAL.PBIO.3001714 | 2022-07-13 | Yes | |
CCR2 | CCR2 | Chemokine | A | Human | Cryo-EM | 7XA3 | 7XA3_refined | 2.9 | R | Active | 100 | 79 | Gi/o | αi1 | - | 65 | - | scFv16 |
C-C motif chemokine 2
|
peptide | Agonist | CCL2, CCL8, CCL11, CCL13, CCL24, CCL7, CCL26, CCL16 | peptide | No | No | Shao Z, Tan Y, Shen Q, Hou L, Yao B, Qin J, Xu P, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Chen ZH, Jiang Y, Xu HE, Ying S, Ma H, Zhang Y, Shen H | 10.1038/S41421-022-00403-4 | 2022-08-24 | Yes | |
GP119 | GPR119 | GPR18, GPR55 and GPR119 | A | Human | Cryo-EM | 7WCM | 7WCM_refined | 2.3 | R | Active | 100 | 86 | Gs | αs | - | 60 | - | Nanobody-35 |
MBX-2982
|
small-molecule | Agonist | N-oleoylethanolamide, SEA, anandamide, N-palmitoylethanolamine | small-molecule | No | No | Qian Y, Wang J, Yang L, Liu Y, Wang L, Liu W, Lin Y, Yang H, Ma L, Ye S, Wu S, Qiao A | 10.1038/S41467-022-34696-6 | 2022-12-21 | Yes | |
T2R46 | TAS2R46 | Taste 2 | T | Human | Cryo-EM | 7XP5 | - | 3.1 | R | Active | - | 97 | Gi/o | αgust | - | 63 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Xu W, Wu L, Liu S, Liu X, Cao X, Zhou C, Zhang J, Fu Y, Guo Y, Wu Y, Tan Q, Wang L, Liu J, Jiang L, Fan Z, Pei Y, Yu J, Cheng J, Zhao S, Hao X, Liu ZJ, Hua T | 10.1126/SCIENCE.ABO1633 | 2022-10-12 | Yes | |
PACR | PAC1 | VIP and PACAP | B1 | Human | Cryo-EM | 8E3X | 8E3X_refined | 2.3 | R | Active | 100 | 77 | Gs | αs | - | 59 | - | Nanobody-35 |
[Ac-His1]PACAP-27
|
peptide | Agonist | VIP, PHV, PACAP-27, PHI, PHM, PACAP-38 | peptide | No | No | - | - | 2022-11-23 | Yes | |
O51E2 | Olfactory 51E2 | Olfactory | A | Human | Cryo-EM | 8F76 | 8F76_refined | 3.1 | A | Active | 100 | 94 | Gs | αs | Mini-Gs | 55 | - | Nanobody-35 |
propanoic acid
|
small-molecule | Agonist | - | - | No | No | - | 10.1038/S41586-023-05798-Y | 2023-03-22 | Yes | |
GPR20 | GPR20 | A orphans | A | Human | Cryo-EM | 8HSC | - | 3.2 | R | Active | 100 | 76 | Gi/o | αi1 | - | 62 | BRIL | Antibody fab fragment light chain Antibody fab fragment heavy chain scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | - | 2023-03-08 | Yes | |
TAAR9 | TAAR9 | A orphans | A | Mouse | Cryo-EM | 8IW9 | - | 3.1 | R | Active | 100 | 89 | Gs | αs | Mini-Gs | 59 | - | scFv16 Nanobody-35 |
Cadaverine
|
small-molecule | Agonist | - | - | No | No | Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP | 10.1038/S41586-023-06106-4 | 2023-05-31 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 8CIC | - | 2.1 | A | Inactive | 1 | 71 | - | - | - | - | BRIL | - |
AB928
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | Claff T, Schlegel JG, Voss JH, Vaassen VJ, Weisse RH, Cheng RKY, Markovic-Mueller S, Bucher D, Strater N, Muller CE | 10.1038/S42004-023-00894-6 | 2023-05-31 | Yes | |
FFAR1 | FFA1 | Free fatty acid | A | Human | Cryo-EM | 8EJK | - | 3.4 | R | Active | 100 | 89 | Gq/11 | αq | - | 60 | - | scFv16 |
fasiglifam
|
small-molecule | Agonist | oleic acid, docosahexaenoic acid, α-linolenic acid, myristic acid | small-molecule | No | No | Kumari P, Inoue A, Chapman K, Lian P, Rosenbaum DM | 10.1073/PNAS.2219569120 | 2023-05-24 | Yes | |
AA2BR | A2B | Adenosine | A | Human | Cryo-EM | 7XY6 | - | 3.0 | R | Active | 100 | 86 | Gs | αs | - | 57 | BRIL | - |
BAY 60-6583
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Chen Y, Zhang J, Weng Y, Xu Y, Lu W, Liu W, Liu M, Hua T, Song G | 10.1126/SCIADV.ADD3709 | 2023-05-03 | Yes | |
FFAR4 | FFA4 | Free fatty acid | A | Human | Cryo-EM | 8H4I | - | 3.1 | R | Active | 100 | 78 | Gs | αs | - | 59 | - | Nanobody-35 |
docosahexaenoic acid
|
small-molecule | Agonist | linoleic acid, oleic acid, α-linolenic acid, myristic acid | small-molecule | No | No | Yin H, Inoue A, Ma Z, Zhu X, Xia R, Xu Z, Wang N, Duan Y, Zhang A, Guo C, He Y | 10.1038/S41422-023-00835-X | 2023-06-21 | Yes | |
GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 8JCX | - | 3.0 | 2 | Inactive | - | 87 | - | - | - | - | - | - |
LY341495
|
small-molecule | Antagonist | L-glutamic acid | small-molecule | No | No | Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B | 10.1038/S41422-023-00830-2 | 2023-06-21 | Yes | |
GLR | glucagon | Glucagon | B1 | Human | X-ray | 5YQZ | 5YQZ_refined | 3.0 | R | Inactive | 2 | 83 | - | - | - | - | T4-Lysozyme | - |
NNC1702
|
peptide | Agonist (partial) | glucagon | peptide | No | No | Zhang H, Qiao A, Yang L, Van Eps N, Frederiksen KS, Yang D, Dai A, Cai X, Zhang H, Yi C, Cao C, He L, Yang H, Lau J, Ernst OP, Hanson MA, Stevens RC, Wang MW, Reedtz-Runge S, Jiang H, Zhao Q, Wu B | 10.1038/NATURE25153 | 2018-01-17 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 6H7N | 6H7N_refined | 2.5 | A | Active | 99 | 60 | - | - | - | - | Thioredoxin 1 | Camelid antibody fragment Nb6B9 |
(S)-Xamoterol
|
small-molecule | Agonist | - | - | No | No | Miller RH, Bell EM, Russell Esposito E | 10.1101/436212 | 2018-10-17 | Yes | |
NK1R | NK1 | Tachykinin | A | Human | X-ray | 6J21 | 6J21_refined | 3.2 | A | Inactive | 1 | 71 | - | - | - | - | T4-Lysozyme | - |
aprepitant
|
small-molecule | Antagonist | neurokinin B, neuropeptide-γ, hemokinin 1, substance P, neurokinin A, neuropeptide K | peptide | No | No | - | - | 2019-03-06 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 6GT3 | 6GT3_refined | 2.0 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
imaradenant
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | - | - | 2019-06-26 | Yes | |
CLTR1 | CysLT1 | Leukotriene | A | Human | X-ray | 6RZ4 | 6RZ4_refined | 2.7 | A | Intermediate | 44 | 85 | - | - | - | - | BRIL | - |
pranlukast
|
small-molecule | Antagonist | LTE4, LTD4, LTC4 | small-molecule | No | Yes | - | 10.1126/SCIADV.AAX2518 | 2019-10-30 | Yes | |
CLTR2 | CysLT2 | Leukotriene | A | Human | X-ray | 6RZ7 | 6RZ7_refined | 2.4 | A | Intermediate | 44 | 79 | - | - | - | - | BRIL | - |
ONO-2570366
|
small-molecule | Antagonist | LTE4, LTD4, LTC4 | small-molecule | No | No | Gusach A, Luginina A, Marin E, Brouillette RL, Besserer-Offroy E, Longpre JM, Ishchenko A, Popov P, Patel N, Fujimoto T, Maruyama T, Stauch B, Ergasheva M, Romanovskaia D, Stepko A, Kovalev K, Shevtsov M, Gordeliy V, Han GW, Katritch V, Borshchevskiy V, Sarret P, Mishin A, Cherezov V | 10.1038/S41467-019-13348-2 | 2019-12-11 | Yes | |
CRFR2 | CRF2 | Corticotropin-releasing factor | B1 | Human | Cryo-EM | 6PB1 | 6PB1_refined | 2.8 | P | Active | 100 | 68 | Gs | αs | - | 58 | - | Nanobody-35 |
Urocortin
|
peptide | Agonist | urocortin 2, corticotrophin-releasing hormone, urocortin 3, urocortin 1 | peptide | No | No | Ma S, Shen Q, Zhao LH, Mao C, Zhou XE, Shen DD, de Waal PW, Bi P, Li C, Jiang Y, Wang MW, Sexton PM, Wootten D, Melcher K, Zhang Y, Xu HE | 10.1016/J.MOLCEL.2020.01.013 | 2020-02-12 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 6S0L | 6S0L_refined | 2.7 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | - | - | 2020-07-15 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 6X1A | - | 2.5 | R | Active | 100 | 84 | Gs | αs | - | 89 | - | Nanobody-35 |
danuglipron
|
small-molecule | Agonist | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Senel P, Stewart GD, Liang YL, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D | 10.1016/J.MOLCEL.2020.09.020 | 2020-09-09 | Yes | |
GLP2R | GLP-2 | Glucagon | B1 | Human | Cryo-EM | 7D68 | - | 3.0 | R | Active | 100 | 53 | Gs | αs | - | 57 | - | Nanobody-35 |
glucagon
|
peptide | Agonist | glucagon-like peptide 2, glucagon-like peptide 2-(3-33) | peptide | No | No | Sun W, Chen LN, Zhou Q, Zhao LH, Yang D, Zhang H, Cong Z, Shen DD, Zhao F, Zhou F, Cai X, Chen Y, Zhou Y, Gadgaard S, van der Velden WJC, Zhao S, Jiang Y, Rosenkilde MM, Xu HE, Zhang Y, Wang MW | 10.1038/S41422-020-00442-0 | 2020-12-16 | Yes | |
HRH1 | H1 | Histamine | A | Human | Cryo-EM | 7DFL | - | 3.3 | R | Active | 100 | 56 | Gq/11 | αq | - | 63 | - | scFv16 |
histamine
|
small-molecule | Agonist | histamine | small-molecule | No | No | Xia R, Wang N, Xu Z, Lu Y, Song J, Zhang A, Guo C, He Y | 10.1038/S41467-021-22427-2 | 2021-03-31 | Yes | |
GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 7EPA | 7EPA_refined | 3.6 | A | Intermediate | - | 90 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | L-glutamic acid | small-molecule | No | No | Du J, Wang D, Fan H, Xu C, Tai L, Lin S, Han S, Tan Q, Wang X, Xu T, Zhang H, Chu X, Yi C, Liu P, Wang X, Zhou Y, Pin JP, Rondard P, Liu H, Liu J, Sun F, Wu B, Zhao Q | 10.1038/S41586-021-03641-W | 2021-06-23 | Yes | |
GIPR | GIP | Glucagon | B1 | Human | Cryo-EM | 7DTY | - | 3.0 | R | Active | 100 | 79 | Gs | αs | - | 59 | - | Nanobody-35 |
GIP
|
small-molecule | Agonist | gastric inhibitory polypeptide | peptide | No | No | Zhao F, Zhang C, Zhou Q, Hang K, Zou X, Chen Y, Wu F, Rao Q, Dai A, Yin W, Shen DD, Zhang Y, Xia T, Stevens RC, Xu HE, Yang D, Zhao L, Wang MW | 10.7554/ELIFE.68719 | 2021-08-04 | Yes | |
BKRB1 | B1 | Bradykinin | A | Human | Cryo-EM | 7EIB | - | 3.0 | A | Active | 100 | 84 | Gq/11 | αq | Gq-Gi1 chimera | 61 | - | - |
[des-Arg10]kallidin
|
peptide | Agonist | [Hyp3]bradykinin, [des-Arg10]kallidin, bradykinin, Lys-[Hyp3]-bradykinin, kallidin, [des-Arg9]bradykinin, T-kinin | peptide | No | No | Yin YL, Ye C, Zhou F, Wang J, Yang D, Yin W, Wang MW, Xu HE, Jiang Y | 10.1038/S41594-021-00645-Y | 2021-10-13 | Yes | |
MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7VDM | 7VDM_refined | 3.0 | R | Active | 100 | 77 | Gi/o | αi1 | - | 61 | - | scFv16 |
substance P
|
peptide | Agonist | PAMP-20 | peptide | No | No | Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP | 10.1038/S41586-021-04077-Y | 2021-12-01 | Yes | |
5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | X-ray | 7WC8 | 7WC8_refined | 2.5 | A | Inactive | 1 | 59 | - | - | - | - | BRIL | - |
LUMATEPERONE
|
small-molecule | Agonist | 5-hydroxytryptamine, tryptamine | small-molecule | No | No | Cao D, Yu J, Wang H, Luo Z, Liu X, He L, Qi J, Fan L, Tang L, Chen Z, Li J, Cheng J, Wang S | 10.1126/SCIENCE.ABL8615 | 2022-01-26 | Yes | |
FPR1 | FPR1 | Formylpeptide | A | Human | Cryo-EM | 7T6T | 7T6T_refined | 3.2 | R | Active | 100 | 85 | Gi/o | αi1 | - | 61 | - | - |
synthetic peptide
|
peptide | Agonist | cathepsin G, spinorphin, annexin I, fMet-Leu-Phe | peptide | No | No | Zhuang Y, Wang L, Guo J, Sun D, Wang Y, Liu W, Xu HE, Zhang C | 10.1038/S41467-022-28586-0 | 2022-03-30 | Yes | |
CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 7TYH | - | 3.3 | R | Active | 100 | 78 | Gs | αs | - | 58 | - | Nanobody-35 |
Calcitonin human
|
peptide | Agonist | β-CGRP, α-CGRP, calcitonin, calcitonin (salmon), amylin, adrenomedullin, adrenomedullin 2/intermedin | peptide | No | No | Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | Yes | |
OPRM | μ | Opioid | A | Mouse | Cryo-EM | 7SBF | - | 2.9 | R | Active | 100 | 71 | Gi/o | αi1 | - | 61 | BRIL | scFv16 |
N-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-N'-[(2S)-1-(thiophen-3-yl)propan-2-yl]urea
|
small-molecule | Agonist | - | - | No | No | Wang H, Hetzer F, Huang W, Qu Q, Meyerowitz J, Kaindl J, Hubner H, Skiniotis G, Kobilka BK, Gmeiner P | 10.1002/ANIE.202200269 | 2022-04-20 | Yes | |
NPY2R | Y2 | Neuropeptide Y | A | Human | Cryo-EM | 7X9B | 7X9B_refined | 3.4 | R | Active | 100 | 79 | Gi/o | αi1 | - | 62 | - | - |
neuropeptide Y
|
peptide | Agonist | neuropeptide Y, neuropeptide Y-(3-36), peptide YY, pancreatic polypeptide, PYY-(3-36) | peptide | No | No | Tang T, Tan Q, Han S, Diemar A, Lobner K, Wang H, Schuss C, Behr V, Morl K, Wang M, Chu X, Yi C, Keller M, Kofoed J, Reedtz-Runge S, Kaiser A, Beck-Sickinger AG, Zhao Q, Wu B | 10.1126/SCIADV.ABM1232 | 2022-05-18 | Yes | |
APJ | apelin | Apelin | A | Human | Cryo-EM | 7W0L | 7W0L_refined | 3.6 | R | Active | 100 | 78 | Gi/o | αi1 | - | 64 | BRIL | scFv16 |
(1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide
|
small-molecule | Agonist | apelin-13, apelin-17, apelin-36, Elabela/Toddler-21, [Pyr1]apelin-13, Elabela/Toddler-11, apelin receptor early endogenous ligand, Elabela/Toddler-32 | peptide | No | No | Yue Y, Liu L, Wu LJ, Wu Y, Wang L, Li F, Liu J, Han GW, Chen B, Lin X, Brouillette RL, Breault E, Longpre JM, Shi S, Lei H, Sarret P, Stevens RC, Hanson MA, Xu F | 10.1038/S41594-022-00797-5 | 2022-07-27 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | Cryo-EM | 8DCS | - | 2.5 | R | Active | 100 | 57 | Gs | αs | - | 51 | T4-Lysozyme | Nanobody-35 |
4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile
|
small-molecule | Agonist | - | - | No | No | Su M, Paknejad N, Zhu L, Wang J, Do HN, Miao Y, Liu W, Hite RK, Huang XY | 10.1038/S41467-022-31823-1 | 2022-07-27 | Yes | |
PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 7VVJ | 7VVJ_refined | 3.2 | R | Active | 100 | 62 | Gs | αs | - | 59 | - | Nanobody-35 |
PTHrP[1-36]
|
peptide | Agonist | PTH, PTHrP-(1-36), TIP39, PTHrP | peptide | No | No | Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O | 10.1016/J.MOLCEL.2022.07.003 | 2022-08-03 | Yes | |
ADA2A | α2A | Adrenoceptors | A | Human | Cryo-EM | 7W6P | - | 3.5 | R | Active | 100 | 55 | Gi/o | αo | - | 58 | - | scFv16 |
N-pyridin-4-ylisoquinolin-4-amine
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | - | - | 2022-09-28 | Yes | |
OX2R | OX2 | Orexin | A | Human | X-ray | 7XRR | 7XRR_refined | 2.9 | A | Inactive | 1 | 70 | - | - | - | - | - | - |
lemborexant
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Asada H, Im D, Hotta Y, Yasuda S, Murata T, Suno R, Iwata S | 10.1016/J.STR.2022.11.001 | 2022-11-23 | Yes | |
MRGX1 | MRGPRX1 | A orphans | A | Human | Cryo-EM | 8DWH | 8DWH_refined | 3.3 | R | Active | 100 | 77 | Gq/11 | αq | Gs-mini-Gq chimera | 57 | - | - |
compound 16 [PMID: 31498617]
|
small-molecule | Agonist | bovine adrenal medulla peptide 8-22 | peptide | No | No | Liu Y, Cao C, Huang XP, Gumpper RH, Rachman MM, Shih SL, Krumm BE, Zhang S, Shoichet BK, Fay JF, Roth BL | 10.1038/S41589-022-01173-6 | 2022-11-02 | Yes | |
OPRK | κ | Opioid | A | Human | Cryo-EM | 8F7W | 8F7W_refined | 3.2 | R | Active | 100 | 75 | Gi/o | αi1 | - | 64 | - | scFv16 |
dynorphin A-(1-8)
|
peptide | Agonist | dynorphin A-(1-8), β-neoendorphin, big dynorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, β-endorphin, dynorphin A-(1-13), dynorphin B, α-neoendorphin | peptide | No | No | Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE | 10.1016/J.CELL.2022.12.026 | 2022-12-14 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 8A6D | 8A6D_refined | 1.8 | A | Inactive | 22 | 87 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Agonist | - | - | No | No | Gruhl T, Weinert T, Rodrigues MJ, Milne CJ, Ortolani G, Nass K, Nango E, Sen S, Johnson PJM, Cirelli C, Furrer A, Mous S, Skopintsev P, James D, Dworkowski F, Bath P, Kekilli D, Ozerov D, Tanaka R, Glover H, Bacellar C, Brunle S, Casadei CM, Diethelm AD, Gashi D, Gotthard G, Guixa-Gonzalez R, Joti Y, Kabanova V, Knopp G, Lesca E, Ma P, Martiel I, Muhle J, Owada S, Pamula F, Sarabi D, Tejero O, Tsai CJ, Varma N, Wach A, Boutet S, Tono K, Nogly P, Deupi X, Iwata S, Neutze R, Standfuss J, Schertler G, Panneels V | 10.1038/S41586-023-05863-6 | 2023-03-29 | Yes | |
GPR21 | GPR21 | A orphans | A | Human | Cryo-EM | 8HJ0 | - | 3.1 | R | Active | 100 | 81 | Gs | αs | Mini-Gs | 61 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | - | 2023-03-15 | Yes | |
ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 7T94 | - | 3.2 | A | Active | 100 | 57 | Gi/o | αo | - | 62 | - | Antibody fragment |
acetylcholine
LY2119620 |
small-molecule small-molecule |
Agonist PAM |
acetylcholine | small-molecule | No | No | - | - | 2023-01-25 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 7XK9 | - | 3.4 | A | Active | 99 | 69 | - | - | - | - | T4-Lysozyme | Camelid Antibody Fragment |
CHEMBL6913
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | - | - | 2023-04-26 | Yes | |
CNR2 | CB2 | Cannabinoid | A | Human | Cryo-EM | 8GUT | 8GUT_refined | 3.0 | R | Active | 100 | 81 | Gi/o | αi1 | - | 62 | - | scFv16 |
1-[[4-[5-Fluoro-6-[(oxan-4-ylamino)methyl]pyridin-2-yl]phenyl]methyl]-3-(2-methylpropyl)imidazolidine-2,4-dione
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Li X, Chang H, Bouma J, de Paus LV, Mukhopadhyay P, Paloczi J, Mustafa M, van der Horst C, Kumar SS, Wu L, Yu Y, van den Berg RJBHN, Janssen APA, Lichtman A, Liu ZJ, Pacher P, van der Stelt M, Heitman LH, Hua T | 10.1038/S41467-023-37112-9 | 2023-05-10 | Yes | |
AGRE5 | ADGRE5 | ADGRE | B2 | Human | Cryo-EM | 7YDH | - | 3.1 | R | Active | - | 33 | G12/13 | α13 | Gi2-mini-G13 chimera | 57 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Wang N, Qian Y, Xia R, Zhu X, Xiong Y, Zhang A, Guo C, He Y | 10.1016/J.CHEMBIOL.2023.08.003 | 2023-07-12 | Yes | |
CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 8F0K | - | 1.9 | R | Active | 100 | 78 | Gs | αs | - | 58 | - | Nanobody-35 RAMP3 |
San385
|
peptide | Agonist | β-CGRP, α-CGRP, calcitonin, calcitonin (salmon), amylin, adrenomedullin, adrenomedullin 2/intermedin | peptide | No | No | Cao J, Belousoff MJ, Gerrard E, Danev R, Fletcher MM, Dal Maso E, Schreuder H, Lorenz K, Evers A, Tiwari G, Besenius M, Li Z, Johnson RM, Wootten D, Sexton PM | 10.1038/S41589-023-01393-4 | 2023-08-02 | Yes | |
GRM4 | mGlu4 | Metabotropic glutamate | C | Human | Cryo-EM | 8JD6 | - | 3.4 | S | Active | - | 83 | Gi/o | αi3 | - | 63 | - | scFv16 |
VU0364770
|
small-molecule | Agonist | L-glutamic acid, L-serine-O-phosphate | small-molecule | No | No | Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B | 10.1038/S41422-023-00830-2 | 2023-06-21 | Yes | |
5HT1B | 5-HT1B | 5-Hydroxytryptamine | A | Human | X-ray | 5V54 | 5V54_refined | 3.9 | A | Inactive | 15 | 71 | - | - | - | - | BRIL | - |
CHEMBL428892
|
small-molecule | Antagonist | 5-hydroxytryptamine, 5-HT-moduline, tryptamine | small-molecule | No | No | - | - | 2018-02-07 | Yes | |
CALRL | calcitonin-like | Calcitonin | B1 | Human | Cryo-EM | 6E3Y | 6E3Y_refined | 3.3 | R | Active | 100 | 75 | Gs | αs | - | 48 | - | Nanobody-35 RAMP1 |
Calcitonin gene-related peptide 1
|
peptide | Agonist | - | - | No | No | Liang YL, Khoshouei M, Deganutti G, Glukhova A, Koole C, Peat TS, Radjainia M, Plitzko JM, Baumeister W, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Wootten D, Sexton PM | 10.1038/S41586-018-0535-Y | 2018-09-19 | Yes | |
MTR1A | MT1 | Melatonin | A | Human | X-ray | 6ME5 | 6ME5_refined | 3.2 | A | Inactive | 1 | 83 | - | - | - | - | GlgA glycogen synthase | - |
agomelatine
|
small-molecule | Agonist | melatonin | small-molecule | No | No | - | - | 2019-04-24 | Yes | |
CLTR1 | CysLT1 | Leukotriene | A | Human | X-ray | 6RZ5 | 6RZ5_refined | 2.5 | B | Intermediate | 44 | 84 | - | - | - | - | BRIL | - |
zafirlukast
|
small-molecule | Antagonist | LTE4, LTD4, LTC4 | small-molecule | No | Yes | - | - | 2019-10-30 | Yes | |
OX2R | OX2 | Orexin | A | Human | X-ray | 6TPJ | 6TPJ_refined | 2.7 | A | Inactive | 1 | 68 | - | - | - | - | GlgA glycogen synthase | - |
suvorexant
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | Yes | |
CALRL | calcitonin-like | Calcitonin | B1 | Human | Cryo-EM | 6UUN | 6UUN_refined | 3.0 | R | Active | 100 | 77 | Gs | αs | - | 48 | - | Nanobody-35 RAMP2 |
Adrenomedullin
|
peptide | Agonist | - | - | No | No | Liang YL, Belousoff MJ, Fletcher MM, Zhang X, Khoshouei M, Deganutti G, Koole C, Furness SGB, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Danev R, Wootten D, Sexton PM | 10.1021/ACSPTSCI.9B00080 | 2020-03-25 | Yes | |
CXCR2 | CXCR2 | Chemokine | A | Human | Cryo-EM | 6LFM | 6LFM_refined | 3.5 | R | Active | 100 | 85 | Gi/o | αi1 | - | 65 | - | scFv16 |
Interleukin-8
|
protein | Agonist | CXCL3, CXCL1, CXCL6, CXCL2, CXCL7, CXCL5, CXCL8 | peptide | No | No | Liu K, Wu L, Yuan S, Wu M, Xu Y, Sun Q, Li S, Zhao S, Hua T, Liu ZJ | 10.1038/S41586-020-2492-5 | 2020-09-02 | Yes | |
DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7LJD | - | 3.2 | R | Active | 100 | 64 | Gs | αs | Engineered G alpha | 60 | - | Nanobody-35 |
dopamine
mevidalen |
small-molecule small-molecule |
Agonist PAM |
noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, 5-hydroxytryptamine, dopamine | small-molecule | No | No | - | - | 2021-03-03 | Yes | |
CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7DD7 | - | 3.2 | B | Active | - | 73 | - | - | - | - | - | - |
Calcium
L-tryptophan evocalcet |
small-molecule small-molecule small-molecule |
Agonist PAM PAM |
spermine, L-tryptophan, Ca2+, Mg2+ | small-molecule | No | No | Wen T, Wang Z, Chen X, Ren Y, Lu X, Xing Y, Lu J, Chang S, Zhang X, Shen Y, Yang X | 10.1126/SCIADV.ABG1483 | 2021-06-16 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7DUR | - | 3.3 | R | Active | 100 | 80 | Gs | αs | - | 60 | - | Nanobody-35 |
N-Tert-butyl-6,7-dichloroquinoxalin-2-amine
|
small-molecule | Ago-PAM | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | - | 10.1038/S41467-021-24058-Z | 2021-08-11 | Yes | |
S1PR3 | S1P3 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7EW2 | - | 3.1 | R | Active | 100 | 77 | Gi/o | αi1 | - | 64 | - | scFv16 |
(S)-FTY720-phosphate
|
small-molecule | Agonist | sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate, sphingosine 1-phosphate | small-molecule | No | No | Zhao C, Cheng L, Wang W, Wang H, Luo Y, Feng Y, Wang X, Fu H, Cai Y, Yang S, Fu P, Yan W, Shao Z | 10.1038/S41422-021-00567-W | 2021-09-29 | Yes | |
MC4R | MC4 | Melanocortin | A | Human | Cryo-EM | 7PIV | 7PIV_refined | 2.9 | R | Active | 100 | 78 | Gs | αs | - | 46 | - | Nanobody-35 |
afamelanotide
|
peptide | Agonist | agouti-related protein, β-MSH, α-MSH, γ-MSH, ACTH | peptide | No | No | Heyder NA, Kleinau G, Speck D, Schmidt A, Paisdzior S, Szczepek M, Bauer B, Koch A, Gallandi M, Kwiatkowski D, Burger J, Mielke T, Beck-Sickinger AG, Hildebrand PW, Spahn CMT, Hilger D, Schacherl M, Biebermann H, Hilal T, Kuhnen P, Kobilka BK, Scheerer P | 10.1038/S41422-021-00569-8 | 2021-11-17 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7S3I | - | 2.5 | R | Active | 100 | 57 | Gs | αs | - | 59 | - | Nanobody-35 |
exendin-4
|
peptide | Agonist | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | - | - | 2022-01-05 | Yes | |
CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7SIN | 7SIN_refined | 5.9 | A | Inactive | - | 74 | - | - | - | - | - | - |
NPS 2143
|
small-molecule | Antagonist | spermine, L-tryptophan, Ca2+, Mg2+ | small-molecule | No | No | Park J, Zuo H, Frangaj A, Fu Z, Yen LY, Zhang Z, Mosyak L, Slavkovich VN, Liu J, Ray KM, Cao B, Vallese F, Geng Y, Chen S, Grassucci R, Dandey VP, Tan YZ, Eng E, Lee Y, Kloss B, Liu Z, Hendrickson WA, Potter CS, Carragher B, Graziano J, Conigrave AD, Frank J, Clarke OB, Fan QR | 10.1073/PNAS.2115849118 | 2022-01-19 | Yes | |
MTR1A | MT1 | Melatonin | A | Human | Cryo-EM | 7VGY | - | 3.1 | A | Active | 100 | 80 | Gi/o | αi1 | - | 62 | - | scFv16 |
2-iodo-melatonin
|
small-molecule | Agonist | melatonin | small-molecule | No | No | Wang Q, Lu Q, Guo Q, Teng M, Gong Q, Li X, Du Y, Liu Z, Tao Y | 10.1038/S41467-022-28111-3 | 2022-03-02 | Yes | |
ADA2A | α2A | Adrenoceptors | A | Human | Cryo-EM | 7EJ0 | - | 3.2 | R | Active | 100 | 56 | Gi/o | αo | - | 61 | - | scFv16 |
(-)-noradrenaline
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Xu J, Cao S, Hubner H, Weikert D, Chen G, Lu Q, Yuan D, Gmeiner P, Liu Z, Du Y | 10.1126/SCIADV.ABJ5347 | 2022-04-13 | Yes | |
FPR2 | FPR2/ALX | Formylpeptide | A | Human | Cryo-EM | 7WVY | 7WVY_refined | 3.0 | R | Active | 100 | 85 | Gi/o | αi2 | - | 63 | BRIL | - |
Amyloid beta-Peptide (1-42)
|
peptide | Agonist | resolvin D1, serum amyloid A, 15-deoxy-LXA4, LTC4, LL-37, humanin, LTD4, aspirin triggered lipoxin A4, annexin I, aspirin-triggered resolvin D1, fMet-Leu-Phe, PrP106-126, LXA4 | peptide | No | No | Zhu Y, Lin X, Zong X, Han S, Wang M, Su Y, Ma L, Chu X, Yi C, Zhao Q, Wu B | 10.1038/S41467-022-29361-X | 2022-04-13 | Yes | |
NPY1R | Y1 | Neuropeptide Y | A | Human | Cryo-EM | 7X9A | 7X9A_refined | 3.2 | R | Active | 100 | 80 | Gi/o | αi1 | - | 61 | - | - |
neuropeptide Y
|
peptide | Agonist | pancreatic polypeptide, neuropeptide Y, peptide YY | peptide | No | No | Tang T, Tan Q, Han S, Diemar A, Lobner K, Wang H, Schuss C, Behr V, Morl K, Wang M, Chu X, Yi C, Keller M, Kofoed J, Reedtz-Runge S, Kaiser A, Beck-Sickinger AG, Zhao Q, Wu B | 10.1126/SCIADV.ABM1232 | 2022-05-18 | Yes | |
APJ | apelin | Apelin | A | Human | Cryo-EM | 7W0N | - | 4.2 | R | Active | 100 | 78 | Gi/o | αi1 | - | 64 | BRIL | scFv16 |
apelin receptor early endogenous ligand
|
peptide | Agonist | apelin-13, apelin-17, apelin-36, Elabela/Toddler-21, [Pyr1]apelin-13, Elabela/Toddler-11, apelin receptor early endogenous ligand, Elabela/Toddler-32 | peptide | No | No | Yue Y, Liu L, Wu LJ, Wu Y, Wang L, Li F, Liu J, Han GW, Chen B, Lin X, Brouillette RL, Breault E, Longpre JM, Shi S, Lei H, Sarret P, Stevens RC, Hanson MA, Xu F | 10.1038/S41594-022-00797-5 | 2022-07-27 | Yes | |
TRFR | TRH1 | Thyrotropin-releasing hormone | A | Human | Cryo-EM | 7X1U | 7X1U_refined | 3.2 | A | Active | 100 | 68 | Gq/11 | αq | - | 57 | - | scFv16 |
TRH
|
peptide | Agonist | TRH | peptide | No | No | Yang F, Zhang H, Meng X, Li Y, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C | 10.1038/S41422-022-00646-6 | 2022-08-31 | Yes | |
PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 7VVL | 7VVL_refined | 2.8 | R | Active | 100 | 58 | Gs | αs | - | 58 | - | Nanobody-35 |
teriparatide
|
peptide | Agonist | PTH, PTHrP-(1-36), TIP39, PTHrP | peptide | No | No | Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O | 10.1016/J.MOLCEL.2022.07.003 | 2022-08-03 | Yes | |
GP119 | GPR119 | GPR18, GPR55 and GPR119 | A | Human | Cryo-EM | 7WCN | 7WCN_refined | 2.9 | R | Active | 100 | 86 | Gs | αs | - | 60 | - | Nanobody-35 |
AR231453
|
small-molecule | Agonist | N-oleoylethanolamide, SEA, anandamide, N-palmitoylethanolamine | small-molecule | No | No | Qian Y, Wang J, Yang L, Liu Y, Wang L, Liu W, Lin Y, Yang H, Ma L, Ye S, Wu S, Qiao A | 10.1038/S41467-022-34696-6 | 2022-12-21 | Yes | |
SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7Y27 | 7Y27_refined | 3.5 | E | Active | 100 | 74 | Gq/11 | αq | Mini-Gq | 60 | - | scFv16 |
SOMATOSTATIN
|
protein | Agonist | SRIF-14, CST-17, cortistatin-14, SRIF-28 | peptide | No | No | Chen S, Teng X, Zheng S | 10.1038/S41589-022-01130-3 | 2022-10-19 | Yes | |
OPRM | μ | Opioid | A | Human | Cryo-EM | 8EFB | 8EFB_refined | 3.2 | R | Active | 100 | 71 | Gi/o | αi1 | - | 64 | - | scFv16 |
OLICERIDINE
|
small-molecule | Agonist | dynorphin A-(1-8), [Met]enkephalin, endomorphin-1, dynorphin A, [Leu]enkephalin, β-endorphin, dynorphin A-(1-13), dynorphin B, endomorphin-2 | peptide | No | No | Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE | 10.1016/J.CELL.2022.09.041 | 2022-11-09 | Yes | |
NPY2R | Y2 | Neuropeptide Y | A | Human | Cryo-EM | 7YOO | 7YOO_refined | 3.1 | R | Active | 98 | 79 | - | - | - | - | - | - |
neuropeptide Y
|
peptide | Agonist | neuropeptide Y, neuropeptide Y-(3-36), peptide YY, pancreatic polypeptide, PYY-(3-36) | peptide | No | No | Kang H, Park C, Choi YK, Bae J, Kwon S, Kim J, Choi C, Seok C, Im W, Choi HJ | 10.1016/J.STR.2022.11.010 | 2023-03-22 | Yes | |
FSHR | FSH | Glycoprotein hormone | A | Human | Cryo-EM | 8I2H | 8I2H_refined | 6.0 | A | Inactive | 15 | 82 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | FSH | peptide | No | No | - | 10.1038/S41467-023-36170-3 | 2023-03-22 | Yes | |
GLR | glucagon | Glucagon | B1 | Human | Cryo-EM | 8FU6 | 8FU6_refined | 2.9 | R | Active | 100 | 72 | Gs | αs | - | 54 | - | Nanobody-35 |
Glucagon derivative ZP3780
|
peptide | Agonist | glucagon | peptide | No | No | Krishna Kumar K, O'Brien ES, Habrian CH, Latorraca NR, Wang H, Tuneew I, Montabana E, Marqusee S, Hilger D, Isacoff EY, Mathiesen JM, Kobilka BK | 10.1016/J.CELL.2023.02.028 | 2023-04-12 | Yes | |
ACM4 | M4 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 7TRK | - | 2.8 | R | Active | 100 | 57 | Gi/o | αi1 | - | 64 | - | scFv16 |
iperoxo
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | - | - | 2023-05-17 | Yes | |
PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 7Y35 | - | 2.9 | R | Active | 100 | 63 | Gs | αs | - | 57 | - | Nanobody-35 |
abaloparatide
|
small-molecule | Agonist | PTH, PTHrP-(1-36), TIP39, PTHrP | peptide | No | No | - | - | 2023-07-05 | Yes | |
EDNRB | ETB | Endothelin | A | Human | Cryo-EM | 8IY5 | - | 2.8 | R | Active | 100 | 71 | Gi/o | αi1 | - | 62 | - | scFv16 |
ENDOTHELIN
|
protein | Agonist | endothelin-1, endothelin-2, endothelin-3 | peptide | No | No | Sano FK, Akasaka H, Shihoya W, Nureki O | 10.7554/ELIFE.85821 | 2023-08-16 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 8JWZ | - | 2.4 | A | Inactive | 1 | 71 | - | - | - | - | T4-Lysozyme | - |
AB928
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | - | - | 2023-08-16 | Yes | |
5HT2C | 5-HT2C | 5-Hydroxytryptamine | A | Human | X-ray | 6BQG | 6BQG_refined | 3.0 | A | Active | 87 | 62 | - | - | - | - | BRIL | - |
ergotamine
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Peng Y, McCorvy JD, Harpsoe K, Lansu K, Yuan S, Popov P, Qu L, Pu M, Che T, Nikolajsen LF, Huang XP, Wu Y, Shen L, Bjorn-Yoshimoto WE, Ding K, Wacker D, Han GW, Cheng J, Katritch V, Jensen AA, Hanson MA, Zhao S, Gloriam DE, Roth BL, Stevens RC, Liu ZJ | 10.1016/j.cell.2018.01.001 | 2018-02-14 | Yes | |
PTAFR | PAF | Platelet-activating factor | A | Human | X-ray | 5ZKP | 5ZKP_refined | 2.8 | A | Other | - | 85 | - | - | - | - | Flavodoxin | - |
foropafant
|
small-molecule | Antagonist | PAF | small-molecule | No | No | Cao C, Tan Q, Xu C, He L, Yang L, Zhou Y, Zhou Y, Qiao A, Lu M, Yi C, Han GW, Wang X, Li X, Yang H, Rao Z, Jiang H, Zhao Y, Liu J, Stevens RC, Zhao Q, Zhang XC, Wu B | 10.1038/S41594-018-0068-Y | 2018-06-20 | Yes | |
ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | X-ray | 5ZK8 | 5ZK8_refined | 3.0 | A | Inactive | 2 | 59 | - | - | - | - | BRIL | - |
N-methyl scopolamine
|
small-molecule | Antagonist | acetylcholine | small-molecule | No | No | Suno R, Lee S, Maeda S, Yasuda S, Yamashita K, Hirata K, Horita S, Tawaramoto MS, Tsujimoto H, Murata T, Kinoshita M, Yamamoto M, Kobilka BK, Vaidehi N, Iwata S, Kobayashi T | 10.1038/S41589-018-0152-Y | 2018-11-21 | Yes | |
CNR1 | CB1 | Cannabinoid | A | Human | Cryo-EM | 6N4B | 6N4B_refined | 3.0 | R | Active | 100 | 58 | Gi/o | αi1 | - | 62 | - | scFv16 |
MDMB-Fubinaca
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | - | 10.1016/J.CELL.2018.11.040 | 2019-01-30 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | X-ray | 6KJV | 6KJV_refined | 2.8 | B | Inactive | 0 | 57 | - | - | - | - | T4-Lysozyme | - |
PF-06372222
|
small-molecule | NAM | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | - | 10.1107/S2052252519013496 | 2019-11-13 | Yes | |
OX1R | OX1 | Orexin | A | Human | X-ray | 6TP3 | 6TP3_refined | 3.0 | A | Inactive | 1 | 74 | - | - | - | - | - | - |
daridorexant
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | Yes | |
PACR | PAC1 | VIP and PACAP | B1 | Human | Cryo-EM | 6LPB | 6LPB_refined | 3.9 | R | Active | 100 | 71 | Gs | αs | - | 57 | - | Nanobody-35 |
[Ac-His1]PACAP-27
|
peptide | Agonist | VIP, PHV, PACAP-27, PHI, PHM, PACAP-38 | peptide | No | No | Kobayashi K, Shihoya W, Nishizawa T, Kadji FMN, Aoki J, Inoue A, Nureki O | 10.1038/S41594-020-0386-8 | 2020-03-11 | Yes | |
ACM1 | M1 | Acetylcholine (muscarinic) | A | Human | X-ray | 6WJC | - | 2.6 | A | Inactive | 2 | 62 | - | - | - | - | T4-Lysozyme | - |
ENDO-ATROPINE
muscarinic toxin 7 |
small-molecule peptide |
Antagonist NAM |
acetylcholine | small-molecule | No | No | - | 10.1126/SCIENCE.AAX2517 | 2020-07-08 | Yes | |
PE2R4 | EP4 | Prostanoid | A | Human | Cryo-EM | 7D7M | 7D7M_refined | 3.3 | A | Active | 100 | 58 | Gs | αs | - | 58 | - | Nanobody-35 |
PGE2
|
small-molecule | Agonist | PGE2, PGF2α, thromboxane A2, PGI2, PGE1, PGD2 | small-molecule | No | No | Nojima S, Fujita Y, Kimura KT, Nomura N, Suno R, Morimoto K, Yamamoto M, Noda T, Iwata S, Shigematsu H, Kobayashi T | 10.1016/J.STR.2020.11.007 | 2020-11-18 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 6ZA8 | 6ZA8_refined | 2.7 | A | Intermediate | 15 | 78 | - | - | - | - | DARPin D12 | - |
CHEMBL508044
|
small-molecule | Agonist (partial) | neuromedin N, neurotensin | peptide | No | No | Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PRE, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Pluckthun A | 10.1126/sciadv.abe5504 | 2021-02-10 | Yes | |
DRD1 | D1 | Dopamine | A | Human | X-ray | 7JOZ | 7JOZ_refined | 3.8 | R | Active | 100 | 64 | Gs | αs | - | 86 | - | Nanobody-35 |
CHEMBL4453318
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, 5-hydroxytryptamine, dopamine | small-molecule | No | No | Sun B, Feng D, Chu ML, Fish I, Lovera S, Sands ZA, Kelm S, Valade A, Wood M, Ceska T, Kobilka TS, Lebon F, Kobilka BK | 10.1038/S41467-021-23519-9 | 2021-04-14 | Yes | |
GRM2 | mGlu2 | Metabotropic glutamate | C | Human | X-ray | 7EPE | 7EPE_refined | 2.5 | A | Inactive | - | 28 | - | - | - | - | Flavodoxin | - |
CHEMBL3894759
|
small-molecule | NAM | L-glutamic acid | small-molecule | No | No | Du J, Wang D, Fan H, Xu C, Tai L, Lin S, Han S, Tan Q, Wang X, Xu T, Zhang H, Chu X, Yi C, Liu P, Wang X, Zhou Y, Pin JP, Rondard P, Liu H, Liu J, Sun F, Wu B, Zhao Q | 10.1038/S41586-021-03641-W | 2021-06-23 | Yes | |
V2R | V2 | Vasopressin and oxytocin | A | Human | Cryo-EM | 7DW9 | - | 2.6 | R | Active | 100 | 75 | Gs | αs | - | 60 | - | Nanobody-35 scFv16 |
vasopressin
|
peptide | Agonist | oxytocin, vasopressin | peptide | No | No | Zhou F, Ye C, Ma X, Yin W, Croll TI, Zhou Q, He X, Zhang X, Yang D, Wang P, Xu HE, Wang MW, Jiang Y | 10.1038/S41422-021-00480-2 | 2021-07-21 | Yes | |
CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7E6T | 7E6T_refined | 3.0 | A | Active | - | 74 | - | - | - | - | - | - |
Calcium
Cyclomethyltryptophan |
small-molecule small-molecule |
Agonist PAM |
spermine, L-tryptophan, Ca2+, Mg2+ | small-molecule | No | No | Chen X, Wang L, Cui Q, Ding Z, Han L, Kou Y, Zhang W, Wang H, Jia X, Dai M, Shi Z, Li Y, Li X, Geng Y | 10.7554/ELIFE.68578 | 2021-09-22 | Yes | |
GP158 | GPR158 | C Orphans | C | Human | Cryo-EM | 7EWL | 7EWL_refined | 3.5 | A | Inactive | - | 41 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Jeong E, Kim Y, Jeong J, Cho Y | 10.1038/S41467-021-27147-1 | 2021-12-01 | Yes | |
5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | X-ray | 7VOD | 7VOD_refined | 3.3 | A | Inactive | 1 | 58 | - | - | - | - | BRIL | - |
cariprazine
|
small-molecule | Agonist (partial) | 5-hydroxytryptamine, tryptamine | small-molecule | No | No | Chen Z, Fan L, Wang H, Yu J, Lu D, Qi J, Nie F, Luo Z, Liu Z, Cheng J, Wang S | 10.1038/S41593-021-00971-W | 2021-12-22 | Yes | |
GHSR | ghrelin | Ghrelin | A | Human | X-ray | 7F83 | 7F83_refined | 2.9 | A | Inactive | 13 | 78 | - | - | - | - | BRIL | - |
PF-05190457
|
small-molecule | Inverse agonist | [des-Gln14]ghrelin, ghrelin | peptide | No | No | Qin J, Cai Y, Xu Z, Ming Q, Ji SY, Wu C, Zhang H, Mao C, Shen DD, Hirata K, Ma Y, Yan W, Zhang Y, Shao Z | 10.1038/S41467-022-27975-9 | 2022-01-19 | Yes | |
OXYR | OT | Vasopressin and oxytocin | A | Human | Cryo-EM | 7RYC | - | 2.9 | O | Active | 100 | 73 | Gq/11 | αq | Gamma subunit fused to alpha subunit | 55 | - | scFv16 |
oxytocin
|
peptide | Agonist | oxytocin, vasopressin | peptide | No | No | Meyerowitz JG, Robertson MJ, Barros-Alvarez X, Panova O, Nwokonko RM, Gao Y, Skiniotis G | 10.1038/S41594-022-00728-4 | 2022-03-09 | Yes | |
CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 7TYI | - | 3.3 | R | Active | 100 | 77 | Gs | αs | - | 58 | - | Nanobody-35 |
Amylin rat
|
peptide | Agonist | β-CGRP, α-CGRP, calcitonin, calcitonin (salmon), amylin, adrenomedullin, adrenomedullin 2/intermedin | peptide | No | No | Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM | 10.1126/SCIENCE.ABM9609 | 2022-03-30 | Yes | |
OPRM | μ | Opioid | A | Mouse | Cryo-EM | 7SCG | - | 3.0 | D | Active | 100 | 71 | Gi/o | αi1 | - | 61 | - | scFv16 |
(2E)-N-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-3-(naphthalen-1-yl)prop-2-enamide
|
small-molecule | Agonist | - | - | No | No | Wang H, Hetzer F, Huang W, Qu Q, Meyerowitz J, Kaindl J, Hubner H, Skiniotis G, Kobilka BK, Gmeiner P | 10.1002/ANIE.202200269 | 2022-04-20 | Yes | |
NPY4R | Y4 | Neuropeptide Y | A | Human | Cryo-EM | 7X9C | 7X9C_refined | 3.0 | R | Active | 100 | 81 | Gi/o | αi1 | - | 61 | - | - |
Pancreatic polypeptide
|
peptide | Agonist | pancreatic polypeptide, neuropeptide Y, PYY-(3-36), peptide YY | peptide | No | No | Tang T, Tan Q, Han S, Diemar A, Lobner K, Wang H, Schuss C, Behr V, Morl K, Wang M, Chu X, Yi C, Keller M, Kofoed J, Reedtz-Runge S, Kaiser A, Beck-Sickinger AG, Zhao Q, Wu B | 10.1126/SCIADV.ABM1232 | 2022-05-18 | Yes | |
APJ | apelin | Apelin | A | Human | Cryo-EM | 7W0M | 7W0M_refined | 3.7 | R | Active | 100 | 76 | Gi/o | αi1 | - | 62 | BRIL | scFv16 |
(1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide
|
small-molecule | Agonist | apelin-13, apelin-17, apelin-36, Elabela/Toddler-21, [Pyr1]apelin-13, Elabela/Toddler-11, apelin receptor early endogenous ligand, Elabela/Toddler-32 | peptide | No | No | Yue Y, Liu L, Wu LJ, Wu Y, Wang L, Li F, Liu J, Han GW, Chen B, Lin X, Brouillette RL, Breault E, Longpre JM, Shi S, Lei H, Sarret P, Stevens RC, Hanson MA, Xu F | 10.1038/S41594-022-00797-5 | 2022-07-27 | Yes | |
5HT2C | 5-HT2C | 5-Hydroxytryptamine | A | Human | Cryo-EM | 8DPG | - | 3.6 | A | Active | 100 | 58 | Gq/11 | αq | Gi2-mini-Gq chimera | 57 | - | scFv16 |
psilocin
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | - | - | 2022-08-24 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 8CU6 | 8CU6_refined | 2.8 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
LJ-4517
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Shiriaeva A, Park D, Kim G, Lee Y, Hou X, Jarhad DB, Kim G, Yu J, Hyun YE, Kim W, Gao ZG, Jacobson KA, Han GW, Stevens RC, Jeong LS, Choi S, Cherezov V. | 10.1021/acs.jmedchem.2c00462 | 2022-08-31 | Yes | |
TSHR | TSH | Glycoprotein hormone | A | Human | Cryo-EM | 7T9M | - | 3.1 | R | Inactive | 28 | 74 | - | - | - | - | - | - |
CS-17 heavy chain
CS-17 light chain |
protein protein |
Inverse agonist | TSH | peptide | No | No | Faust B, Billesbolle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A | 10.1038/S41586-022-05159-1 | 2022-08-10 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 6B3J | - | 3.3 | R | Active | 100 | 82 | Gs | αs | - | 49 | - | - |
Exendin-P5
|
peptide | Agonist | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Liang YL, Khoshouei M, Glukhova A, Furness SGB, Zhao P, Clydesdale L, Koole C, Truong TT, Thal DM, Lei S, Radjainia M, Danev R, Baumeister W, Wang MW, Miller LJ, Christopoulos A, Sexton PM, Wootten D | 10.1038/NATURE25773 | 2018-02-21 | Yes | |
PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 6NBF | - | 3.0 | R | Active | 100 | 62 | Gs | αs | - | 58 | - | Nanobody-35 |
Long-acting parathyroid hormone analog
|
peptide | Agonist | PTH, PTHrP-(1-36), TIP39, PTHrP | peptide | No | No | - | 10.1126/SCIENCE.AAV7942 | 2019-04-17 | Yes | |
MTR1A | MT1 | Melatonin | A | Human | X-ray | 6PS8 | 6PS8_refined | 3.3 | A | Inactive | 1 | 83 | - | - | - | - | GlgA glycogen synthase | - |
CHEMBL15060
|
small-molecule | Agonist | melatonin | small-molecule | No | No | - | 10.1107/S2052252519013137 | 2019-11-13 | Yes | |
OX1R | OX1 | Orexin | A | Human | X-ray | 6TQ6 | 6TQ6_refined | 2.6 | B | Inactive | 1 | 71 | - | - | - | - | - | - |
CHEMBL4592653
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | Yes | |
ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 6U1N | 6U1N_refined | 4.0 | R | Active | 100 | 57 | Beta | Beta-arrestin-1 | - | 86 | - | Fab30 light chain Fab30 heavy chain |
LY2119620
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | Staus DP, Hu H, Robertson MJ, Kleinhenz ALW, Wingler LM, Capel WD, Latorraca NR, Lefkowitz RJ, Skiniotis G | 10.1038/S41586-020-1954-0 | 2020-02-26 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 6PEL | 6PEL_refined | 3.2 | A | Active | 100 | 93 | Gi/o | αt1 | Only H5 | 3 | - | - |
Citronellol
|
small-molecule | unknown | - | - | No | No | - | - | 2020-06-24 | Yes | |
OX1R | OX1 | Orexin | A | Human | X-ray | 6V9S | 6V9S_refined | 3.5 | A | Inactive | 1 | 72 | - | - | - | - | GlgA glycogen synthase | - |
JH112
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Hellmann J, Drabek M, Yin J, Gunera J, Proll T, Kraus F, Langmead CJ, Hubner H, Weikert D, Kolb P, Rosenbaum DM, Gmeiner P | 10.1073/PNAS.2002704117 | 2020-07-15 | Yes | |
GPBAR | GPBA | Bile acid | A | Human | Cryo-EM | 7CFM | - | 3.0 | R | Active | 100 | 83 | Gs | αs | - | 58 | - | Nanobody-35 |
CHEMBL2331646
|
small-molecule | Agonist | deoxycholic acid, chenodeoxycholic acid, lithocholic acid, cholic acid | small-molecule | No | No | Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen DD, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun JP, Xie X, Yu X, Zhang Y | 10.1038/S41586-020-2569-1 | 2020-09-09 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Human | X-ray | 7BTS | 7BTS_refined | 3.1 | A | Active | 99 | 58 | - | - | - | - | T4-Lysozyme | Camelid antibody fragment Nb6B9 |
(-)-adrenaline
|
small-molecule | Agonist | noradrenaline, (-)-adrenaline, L-NOREPINEPHRINE, (-)-noradrenaline | small-molecule | No | No | - | - | 2020-12-02 | Yes | |
NPY2R | Y2 | Neuropeptide Y | A | Human | X-ray | 7DDZ | 7DDZ_refined | 2.8 | A | Inactive | 1 | 76 | - | - | - | - | Flavodoxin | - |
CHEMBL1823578
|
small-molecule | Antagonist | neuropeptide Y, neuropeptide Y-(3-36), peptide YY, pancreatic polypeptide, PYY-(3-36) | peptide | No | No | Tang T, Hartig C, Chen Q, Zhao W, Kaiser A, Zhang X, Zhang H, Qu H, Yi C, Ma L, Han S, Zhao Q, Beck-Sickinger AG, Wu B | 10.1038/S41467-021-21030-9 | 2021-01-27 | Yes | |
DRD3 | D3 | Dopamine | A | Human | Cryo-EM | 7CMV | - | 2.7 | R | Active | 100 | 68 | Gi/o | αi1 | - | 64 | BRIL | scFv16 |
CHEMBL70565
|
small-molecule | Agonist | dopamine | small-molecule | No | No | Xu P, Huang S, Mao C, Krumm BE, Zhou XE, Tan Y, Huang XP, Liu Y, Shen DD, Jiang Y, Yu X, Jiang H, Melcher K, Roth BL, Cheng X, Zhang Y, Xu HE | 10.1016/J.MOLCEL.2021.01.003 | 2021-03-10 | Yes | |
GRM7 | mGlu7 | Metabotropic glutamate | C | Human | Cryo-EM | 7EPC | 7EPC_refined | 4.0 | B | Inactive | - | 85 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | L-glutamic acid, L-serine-O-phosphate | small-molecule | No | No | Du J, Wang D, Fan H, Xu C, Tai L, Lin S, Han S, Tan Q, Wang X, Xu T, Zhang H, Chu X, Yi C, Liu P, Wang X, Zhou Y, Pin JP, Rondard P, Liu H, Liu J, Sun F, Wu B, Zhao Q | 10.1038/S41586-021-03641-W | 2021-06-23 | Yes | |
FZD7 | FZD7 | Frizzled | F | Human | Cryo-EM | 7EVW | - | 3.2 | R | Active | 100 | 59 | Gs | αs | - | 59 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Xu L, Chen B, Schihada H, Wright SC, Turku A, Wu Y, Han GW, Kowalski-Jahn M, Kozielewicz P, Bowin CF, Zhang X, Li C, Bouvier M, Schulte G, Xu F | 10.1038/S41422-021-00525-6 | 2021-08-04 | Yes | |
GRM1 | mGlu1 | Metabotropic glutamate | C | Human | Cryo-EM | 7DGD | 7DGD_refined | 4.0 | A | Inactive | - | 66 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | L-glutamic acid | small-molecule | No | No | Zhang J, Qu L, Wu L, Tang X, Luo F, Xu W, Xu Y, Liu ZJ, Hua T | 10.1007/S13238-020-00808-5 | 2021-09-22 | Yes | |
MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7S8L | - | 2.5 | R | Active | 100 | 76 | Gq/11 | αq | Gq-Gs chimera | 57 | - | scFv16 |
Cortistatin 14
|
peptide | Agonist | PAMP-20 | peptide | No | No | Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL | 10.1038/S41586-021-04126-6 | 2021-11-17 | Yes | |
MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7VUZ | 7VUZ_refined | 2.9 | R | Active | 100 | 76 | Gi/o | αi1 | - | 62 | - | scFv16 |
PAMP-12
|
peptide | Agonist | PAMP-20 | peptide | No | No | Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP | 10.1038/S41586-021-04077-Y | 2021-12-01 | Yes | |
GHSR | ghrelin | Ghrelin | A | Human | Cryo-EM | 7W2Z | 7W2Z_refined | 2.8 | R | Active | 100 | 82 | Gi/o | αo | - | 60 | - | scFv16 |
Ghrelin
|
peptide | Agonist | [des-Gln14]ghrelin, ghrelin | peptide | No | No | - | - | 2022-01-19 | Yes | |
CCR1 | CCR1 | Chemokine | A | Human | Cryo-EM | 7VLA | 7VLA_refined | 2.7 | R | Active | 100 | 85 | Gi/o | αi1 | - | 64 | - | scFv16 |
CCL15(27-92)
|
peptide | Agonist | CCL8, CCL13, CCL14, CCL16, CCL5, CCL7, CCL4, CCL23, CCL15, CCL3 | peptide | No | No | Shao Z, Shen Q, Yao B, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Ma H, Chen ZH, Xu HE, Ying S, Zhang Y, Shen H | 10.1038/S41589-021-00918-Z | 2022-03-23 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7VBH | 7VBH_refined | 3.0 | R | Active | 100 | 83 | Gs | αs | - | 53 | - | Nanobody-35 |
Peptide 20
|
peptide | Agonist | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW | 10.1038/S41467-022-28683-0 | 2022-04-06 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Human | Cryo-EM | 7UL2 | 7UL2_refined | 2.4 | R | Inactive | 4 | 69 | - | - | - | - | - | Nanobody-6 |
meclinertant
|
small-molecule | Inverse agonist | neuromedin N, large neurotensin, neurotensin, large neuromedin N | peptide | No | No | - | - | 2022-06-29 | Yes | |
5HT5A | 5-HT5A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7UM5 | 7UM5_refined | 2.7 | A | Active | 100 | 75 | Gi/o | αo | Mini-Go | 60 | - | scFv16 |
5-CT
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Zhang S, Chen H, Zhang C, Yang Y, Popov P, Liu J, Krumm BE, Cao C, Kim K, Xiong Y, Katritch V, Shoichet BK, Jin J, Fay JF, Roth BL | 10.1038/S41594-022-00796-6 | 2022-07-20 | Yes | |
ACKR3 | ACKR3 | Chemokine | A | Human | Cryo-EM | 7SK8 | 7SK8_refined | 3.3 | A | Active | 95 | 85 | - | - | - | - | - | CID25 Fab light chain CID25 Fab heavy chain CID24 Fab light chain CID24 Fab heavy chain |
Stromal cell-derived factor 1
(1R)-4-[7-(3-carboxypropoxy)-6-methylquinolin-8-yl]-1-{[2-(4-hydroxypiperidin-1-yl)-1,3-thiazol-4-yl]methyl}-1,4-diazepan-1-ium |
peptide small-molecule |
Agonist Agonist (partial) |
CXCL12α, CXCL11 | peptide | No | No | Yen YC, Schafer CT, Gustavsson M, Eberle SA, Dominik PK, Deneka D, Zhang P, Schall TJ, Kossiakoff AA, Tesmer JJG, Handel TM | 10.1126/SCIADV.ABN8063 | 2022-07-27 | Yes | |
MRGX1 | MRGPRX1 | A orphans | A | Human | Cryo-EM | 8DWC | - | 2.9 | R | Active | 100 | 78 | Gq/11 | αq | Gs-mini-Gq chimera | 57 | - | scFv16 |
Proenkephalin-A
|
peptide | Agonist | bovine adrenal medulla peptide 8-22 | peptide | No | No | - | - | 2022-11-02 | Yes | |
C5AR1 | C5a1 | Complement peptide | A | Human | Cryo-EM | 7Y65 | - | 3.2 | D | Active | 100 | 81 | Gi/o | αi1 | - | 64 | - | scFv16 |
C5a
|
peptide | Agonist | C3a, C5a, ribosomal protein S19, C5a des-Arg | peptide | No | No | Feng Y, Zhao C, Deng Y, Wang H, Ma L, Liu S, Tian X, Wang B, Bin Y, Chen P, Yan W, Fu P, Shao Z | 10.1038/S41422-023-00779-2 | 2023-03-01 | Yes | |
EDNRB | ETB | Endothelin | A | Human | Cryo-EM | 8HBD | 8HBD_refined | 3.0 | R | Active | 100 | 68 | Gi/o | αi1 | - | 61 | - | scFv16 |
sovateltide
|
peptide | Agonist | endothelin-1, endothelin-2, endothelin-3 | peptide | No | No | - | - | 2023-03-22 | Yes | |
FFAR1 | FFA1 | Free fatty acid | A | Human | Cryo-EM | 8EIT | - | 2.8 | R | Active | 100 | 89 | Gq/11 | αq | - | 59 | - | scFv16 |
docosahexaenoic acid
|
small-molecule | Agonist | oleic acid, docosahexaenoic acid, α-linolenic acid, myristic acid | small-molecule | No | No | Kumari P, Inoue A, Chapman K, Lian P, Rosenbaum DM | 10.1073/PNAS.2219569120 | 2023-05-24 | Yes | |
ACM4 | M4 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 7TRS | - | 2.8 | R | Active | 100 | 56 | Gi/o | αi1 | - | 63 | - | scFv16 |
acetylcholine
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | - | - | 2023-05-17 | Yes | |
CNR2 | CB2 | Cannabinoid | A | Human | Cryo-EM | 8GUQ | 8GUQ_refined | 3.1 | R | Active | 100 | 81 | Gi/o | αi1 | - | 62 | - | scFv16 |
olorinab
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Li X, Chang H, Bouma J, de Paus LV, Mukhopadhyay P, Paloczi J, Mustafa M, van der Horst C, Kumar SS, Wu L, Yu Y, van den Berg RJBHN, Janssen APA, Lichtman A, Liu ZJ, Pacher P, van der Stelt M, Heitman LH, Hua T | 10.1038/S41467-023-37112-9 | 2023-05-10 | Yes | |
AGRE5 | ADGRE5 | ADGRE | B2 | Human | Cryo-EM | 7YDP | - | 3.1 | R | Active | - | 32 | Gs | αs | Mini-Gs | 59 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Wang N, Qian Y, Xia R, Zhu X, Xiong Y, Zhang A, Guo C, He Y | 10.1016/J.CHEMBIOL.2023.08.003 | 2023-07-12 | Yes | |
CXCR1 | CXCR1 | Chemokine | A | Human | Cryo-EM | 8IC0 | - | 3.4 | A | Active | 100 | 86 | Gi/o | αi1 | - | 65 | - | scFv16 |
Interleukin-8
|
protein | Agonist | CXCL8, cytokine domain of tyrosyl tRNA synthetase, CXCL6 | peptide | No | No | Ishimoto N, Park JH, Kawakami K, Tajiri M, Mizutani K, Akashi S, Tame JRH, Inoue A, Park SY | 10.1038/S41467-023-39799-2 | 2023-07-19 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 8JWY | - | 2.3 | A | Inactive | 1 | 70 | - | - | - | - | T4-Lysozyme | - |
3-[2-Azanyl-6-[2-oxidanylidene-1-[[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]methyl]pyridin-4-yl]pyrimidin-4-yl]-2-methyl-benzenecarbonitrile
|
small-molecule | Antagonist | adenosine | small-molecule | No | Yes | - | - | 2023-08-16 | Yes | |
GRM5 | mGlu5 | Metabotropic glutamate | C | Human | X-ray | 6FFH | 6FFH_refined | 2.7 | A | Inactive | - | 21 | - | - | - | - | T4-Lysozyme | - |
fenobam
|
small-molecule | NAM | L-glutamic acid | small-molecule | No | No | Christopher JA, Orgovan Z, Congreve M, Dore AS, Errey JC, Marshall FH, Mason JS, Okrasa K, Rucktooa P, Serrano-Vega MJ, Ferenczy GG, Keseru GM | 10.1021/ACS.JMEDCHEM.7B01722 | 2018-03-07 | Yes | |
5HT1B | 5-HT1B | 5-Hydroxytryptamine | A | Human | Cryo-EM | 6G79 | - | 3.8 | S | Active | 100 | 67 | Gi/o | αo | - | 59 | - | - |
donitriptan
|
small-molecule | Agonist | 5-hydroxytryptamine, 5-HT-moduline, tryptamine | small-molecule | No | No | Garcia-Nafria J, Nehme R, Edwards PC, Tate CG | 10.1038/S41586-018-0241-9 | 2018-06-20 | Yes | |
TA2R | TP | Prostanoid | A | Human | X-ray | 6IIU | 6IIU_refined | 2.5 | A | Inactive | 35 | 87 | - | - | - | - | Rubredoxin | - |
ramatroban
|
small-molecule | Antagonist | PGE2, PGF2α, thromboxane A2, PGH2, PGI2, PGD2 | small-molecule | No | No | - | 10.1038/S41589-018-0170-9 | 2018-12-19 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 6MH8 | 6MH8_refined | 4.2 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | - | 10.1107/S205225251900263X | 2019-04-24 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 6PS2 | 6PS2_refined | 2.4 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
CHEMBL1160734
|
small-molecule | Antagonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | - | - | 2019-11-13 | Yes | |
OX1R | OX1 | Orexin | A | Human | X-ray | 6TQ7 | 6TQ7_refined | 2.7 | A | Inactive | 1 | 71 | - | - | - | - | - | - |
SB-334867
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Human | Cryo-EM | 6UP7 | 6UP7_refined | 4.2 | R | Active | 100 | 77 | Beta | Beta-arrestin-1 | - | 83 | - | - |
JMV431
|
peptide | Agonist | neuromedin N, large neurotensin, neurotensin, large neuromedin N | peptide | No | No | Huang W, Masureel M, Qu Q, Janetzko J, Inoue A, Kato HE, Robertson MJ, Nguyen KC, Glenn JS, Skiniotis G, Kobilka BK | 10.1038/S41586-020-1953-1 | 2020-02-26 | Yes | |
GABR2 | GABAB2 | GABAB | C | Human | Cryo-EM | 6UO8 | - | 3.6 | B | Active | - | 74 | - | - | - | - | - | - |
CHEMBL112710
GS39783 |
small-molecule small-molecule |
Agonist PAM |
- | - | No | No | Shaye H, Ishchenko A, Lam JH, Han GW, Xue L, Rondard P, Pin JP, Katritch V, Gati C, Cherezov V | 10.1038/S41586-020-2408-4 | 2020-06-10 | Yes | |
CXCR2 | CXCR2 | Chemokine | A | Human | X-ray | 6LFL | 6LFL_refined | 3.2 | A | Inactive | 5 | 76 | - | - | - | - | GlgA glycogen synthase | - |
4-[[3,4-Dioxo-2-[[(1R)-1-(4-propan-2-ylfuran-2-yl)propyl]amino]cyclobuten-1-yl]amino]-3-hydroxy-N,N-dimethylpyridine-2-carboxamide
|
small-molecule | Allosteric antagonist | CXCL3, CXCL1, CXCL6, CXCL2, CXCL7, CXCL5, CXCL8 | peptide | No | No | Liu K, Wu L, Yuan S, Wu M, Xu Y, Sun Q, Li S, Zhao S, Hua T, Liu ZJ | 10.1038/S41586-020-2492-5 | 2020-09-02 | Yes | |
SCTR | secretin | Glucagon | B1 | Human | Cryo-EM | 7D3S | 7D3S_refined | 2.9 | R | Active | 100 | 60 | Gs | αs | - | 58 | - | Nanobody-35 |
SECRETIN
|
protein | Agonist | secretin, VIP | peptide | No | No | Fukuhara S, Kobayashi K, Kusakizako T, Iida W, Kato M, Shihoya W, Nureki O | 10.1016/J.BBRC.2020.08.042 | 2020-11-04 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 6Z66 | 6Z66_refined | 3.2 | A | Intermediate | 15 | 80 | - | - | - | - | DARPin D12 | - |
Apo (no ligand)
|
none | Apo (no ligand) | neuromedin N, neurotensin | peptide | No | No | Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PRE, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Pluckthun A | 10.1126/sciadv.abe5504 | 2021-02-10 | Yes | |
DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7CRH | 7CRH_refined | 3.3 | R | Active | 100 | 61 | Gs | αs | - | 60 | - | Nanobody-35 |
CHEMBL1416789
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, 5-hydroxytryptamine, dopamine | small-molecule | No | No | Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z | 10.1016/J.CELL.2021.01.028 | 2021-03-03 | Yes | |
CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7DD6 | - | 3.2 | B | Active | - | 73 | - | - | - | - | - | - |
Calcium
L-tryptophan |
small-molecule small-molecule |
Agonist PAM |
spermine, L-tryptophan, Ca2+, Mg2+ | small-molecule | No | No | - | - | 2021-06-16 | Yes | |
ADRB3 | β3 | Adrenoceptors | A | Dog | Cryo-EM | 7DH5 | - | 3.2 | R | Active | 100 | 68 | Gs | αs | - | 59 | - | Nanobody-35 |
mirabegron
|
small-molecule | Agonist | - | - | No | No | Nagiri C, Kobayashi K, Tomita A, Kato M, Kobayashi K, Yamashita K, Nishizawa T, Inoue A, Shihoya W, Nureki O | 10.1016/J.MOLCEL.2021.06.024 | 2021-08-04 | Yes | |
PD2R2 | DP2 | Prostanoid | A | Human | X-ray | 7M8W | 7M8W_refined | 2.6 | A | Inactive | 25 | 83 | - | - | - | - | T4-Lysozyme | - |
15(R)-15-methyl-PGD2
|
small-molecule | Antagonist | PGE2, PGD3, PGF2α, thromboxane A2, PGJ2, PGI2, PGD2 | small-molecule | No | Yes | Liu H, Deepak RNVK, Shiriaeva A, Gati C, Batyuk A, Hu H, Weierstall U, Liu W, Wang L, Cherezov V, Fan H, Zhang C | 10.1073/PNAS.2102813118 | 2021-08-25 | Yes | |
LSHR | LH | Glycoprotein hormone | A | Human | Cryo-EM | 7FIJ | 7FIJ_refined | 3.8 | R | Inactive | 9 | 80 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | hCG, LH | peptide | No | No | Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE | 10.1038/S41586-021-03924-2 | 2021-09-29 | Yes | |
MC4R | MC4 | Melanocortin | A | Human | Cryo-EM | 7PIU | - | 2.6 | R | Active | 100 | 78 | Gs | αs | - | 48 | - | Nanobody-35 |
setmelanotide
|
peptide | Agonist | agouti-related protein, β-MSH, α-MSH, γ-MSH, ACTH | peptide | No | No | Heyder NA, Kleinau G, Speck D, Schmidt A, Paisdzior S, Szczepek M, Bauer B, Koch A, Gallandi M, Kwiatkowski D, Burger J, Mielke T, Beck-Sickinger AG, Hildebrand PW, Spahn CMT, Hilger D, Schacherl M, Biebermann H, Hilal T, Kuhnen P, Kobilka BK, Scheerer P | 10.1038/S41422-021-00569-8 | 2021-11-17 | Yes | |
GHSR | ghrelin | Ghrelin | A | Human | Cryo-EM | 7NA7 | 7NA7_refined | 2.7 | R | Active | 100 | 80 | Gi/o | αi1 | - | 61 | - | Antibody fragment |
Ghrelin-27
|
peptide | Agonist | [des-Gln14]ghrelin, ghrelin | peptide | No | No | Liu H, Sun D, Myasnikov A, Damian M, Baneres JL, Sun J, Zhang C | 10.1038/S41467-021-26735-5 | 2021-12-15 | Yes | |
FPR2 | FPR2/ALX | Formylpeptide | A | Human | Cryo-EM | 7T6U | - | 2.9 | R | Active | 100 | 85 | Gi/o | αi1 | - | 62 | - | - |
synthetic peptide
|
peptide | Agonist | resolvin D1, serum amyloid A, 15-deoxy-LXA4, LTC4, LL-37, humanin, LTD4, aspirin triggered lipoxin A4, annexin I, aspirin-triggered resolvin D1, fMet-Leu-Phe, PrP106-126, LXA4 | peptide | No | No | Zhuang Y, Wang L, Guo J, Sun D, Wang Y, Liu W, Xu HE, Zhang C | 10.1038/S41467-022-28586-0 | 2022-03-30 | Yes | |
CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 7TYX | - | 2.6 | R | Active | 100 | 77 | Gs | αs | - | 59 | - | Nanobody-35 |
Amylin rat
|
peptide | Agonist | β-CGRP, α-CGRP, calcitonin, calcitonin (salmon), amylin, adrenomedullin, adrenomedullin 2/intermedin | peptide | No | No | Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM | 10.1126/SCIENCE.ABM9609 | 2022-03-30 | Yes | |
AGRF1 | ADGRF1 | ADGRF | B2 | Human | Cryo-EM | 7WU3 | - | 3.1 | R | Active | - | 31 | Gs | αs | Mini-Gs | 54 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Qu X, Qiu N, Wang M, Zhang B, Du J, Zhong Z, Xu W, Chu X, Ma L, Yi C, Han S, Shui W, Zhao Q, Wu B | 10.1038/S41586-022-04580-W | 2022-04-27 | Yes | |
VIPR2 | VPAC2 | VIP and PACAP | B1 | Human | Cryo-EM | 7VQX | - | 2.7 | R | Active | 100 | 82 | Gs | αs | - | 60 | - | Nanobody-35 |
PACAP-27
|
peptide | Agonist | VIP, PACAP-27, secretin, PHI, GHRH, PACAP-38 | peptide | No | No | Xu Y, Feng W, Zhou Q, Liang A, Li J, Dai A, Zhao F, Yan J, Chen CW, Li H, Zhao LH, Xia T, Jiang Y, Xu HE, Yang D, Wang MW | 10.1038/S41467-022-30041-Z | 2022-05-18 | Yes | |
5HT5A | 5-HT5A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7UM6 | - | 2.8 | A | Active | 100 | 72 | Gi/o | αo | Mini-Go | 60 | - | scFv16 |
lisuride
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Zhang S, Chen H, Zhang C, Yang Y, Popov P, Liu J, Krumm BE, Cao C, Kim K, Xiong Y, Katritch V, Shoichet BK, Jin J, Fay JF, Roth BL | 10.1038/S41594-022-00796-6 | 2022-07-20 | Yes | |
ACKR3 | ACKR3 | Chemokine | A | Human | Cryo-EM | 7SK6 | 7SK6_refined | 4.0 | A | Active | 95 | 83 | - | - | - | - | - | CID24 Fab light chain CID24 Fab heavy chain |
Stromal cell-derived factor 1
|
peptide | Agonist | CXCL12α, CXCL11 | peptide | No | No | Yen YC, Schafer CT, Gustavsson M, Eberle SA, Dominik PK, Deneka D, Zhang P, Schall TJ, Kossiakoff AA, Tesmer JJG, Handel TM | 10.1126/SCIADV.ABN8063 | 2022-07-27 | Yes | |
AGRL3 | ADGRL3 | ADGRL | B2 | Mouse | Cryo-EM | 7WY5 | - | 2.8 | R | Active | - | 17 | Gq/11 | αq | Mini-Gq | 59 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Qian Y, Ma Z, Liu C, Li X, Zhu X, Wang N, Xu Z, Xia R, Liang J, Duan Y, Yin H, Xiong Y, Zhang A, Guo C, Chen Z, Huang Z, He Y | 10.1016/J.MOLCEL.2022.10.009 | 2022-10-26 | Yes | |
LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | Cryo-EM | 7YU4 | 7YU4_refined | 3.3 | A | Active | 99 | 73 | - | - | - | - | - | - |
[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate
|
small-molecule | Agonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | Akasaka H, Tanaka T, Sano FK, Matsuzaki Y, Shihoya W, Nureki O | 10.1038/S41467-022-33121-2 | 2022-10-05 | Yes | |
ACM3 | M3 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 8E9Z | - | 2.7 | A | Active | 100 | 47 | Gq/11 | αq | Mini-Gq | 57 | - | scFv16 |
iperoxo
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | - | - | 2022-11-30 | Yes | |
AGTR1 | AT1 | Angiotensin | A | Human | Cryo-EM | 7F6G | 7F6G_refined | 2.9 | A | Active | 100 | 86 | Gq/11 | αq | - | 97 | - | - |
SAR1-AngII
|
peptide | Agonist | angiotensin A, angiotensin III, angiotensin IV, angiotensin II | peptide | No | No | - | - | 2023-03-29 | Yes | |
EDNRA | ETA | Endothelin | A | Human | Cryo-EM | 8HCQ | 8HCQ_refined | 3.0 | R | Active | 100 | 71 | Gq/11 | αq | - | 57 | - | scFv16 |
ENDOTHELIN
|
protein | Agonist | endothelin-1, endothelin-2, endothelin-3 | peptide | No | No | - | - | 2023-03-22 | Yes | |
GRPR | BB2 | Bombesin | A | Human | Cryo-EM | 7W40 | 7W40_refined | 3.0 | A | Active | 100 | 78 | Gq/11 | αq | - | 79 | - | scFv16 |
Bombesin
|
peptide | Agonist | neuromedin B, gastrin releasing peptide(14-27) (human), gastrin-releasing peptide, neuromedin C, GRP-(18-27) | peptide | No | No | Peng S, Zhan Y, Zhang D, Ren L, Chen A, Chen ZF, Zhang H | 10.1073/PNAS.2216230120 | 2023-02-22 | Yes | |
S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 8G94 | 8G94_refined | 3.2 | A | Active | 100 | 75 | Gi/o | αi1 | - | 62 | - | scFv16 |
Early activation antigen CD69
|
peptide | Agonist | sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate, sphingosine 1-phosphate | small-molecule | No | No | Chen H, Qin Y, Chou M, Cyster JG, Li X | 10.7554/ELIFE.88204 | 2023-04-19 | Yes | |
ACM4 | M4 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 7TRP | - | 2.4 | R | Active | 100 | 56 | Gi/o | αi1 | - | 64 | - | scFv16 |
iperoxo
LY2033298 |
small-molecule small-molecule |
Agonist PAM |
acetylcholine | small-molecule | No | No | - | - | 2023-05-17 | Yes | |
PF2R | FP | Prostanoid | A | Human | Cryo-EM | 8IUM | - | 3.1 | R | Active | 100 | 82 | Gq/11 | αq | - | 60 | - | scFv16 Nanobody-35 |
tafluprost acid
|
small-molecule | Agonist | PGE2, PGF2α, thromboxane A2, PGI2, PGD2 | small-molecule | No | No | Wu C, Xu Y, He Q, Li D, Duan J, Li C, You C, Chen H, Fan W, Jiang Y, Eric Xu H | 10.1038/S41467-023-38411-X | 2023-07-12 | Yes | |
GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 8JD5 | - | 3.6 | 2 | Active | - | 90 | Gi/o | αi1 | - | 63 | - | scFv16 |
ADX88178
L-glutamic acid JNJ-40411813 |
small-molecule small-molecule small-molecule |
Agonist | L-glutamic acid | small-molecule | No | No | Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B | 10.1038/S41422-023-00830-2 | 2023-06-21 | Yes | |
GRM5 | mGlu5 | Metabotropic glutamate | C | Human | X-ray | 6FFI | 6FFI_refined | 2.2 | A | Inactive | - | 20 | - | - | - | - | T4-Lysozyme | - |
methoxy-MPEP
|
small-molecule | NAM | L-glutamic acid | small-molecule | No | No | Christopher JA, Orgovan Z, Congreve M, Dore AS, Errey JC, Marshall FH, Mason JS, Okrasa K, Rucktooa P, Serrano-Vega MJ, Ferenczy GG, Keseru GM | 10.1021/ACS.JMEDCHEM.7B01722 | 2018-03-07 | Yes | |
AA1R | A1 | Adenosine | A | Human | Cryo-EM | 6D9H | 6D9H_refined | 3.6 | R | Active | 100 | 88 | Gi/o | αi2 | - | 59 | - | - |
adenosine
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Draper-Joyce CJ, Khoshouei M, Thal DM, Liang YL, Nguyen ATN, Furness SGB, Venugopal H, Baltos JA, Plitzko JM, Danev R, Baumeister W, May LT, Wootten D, Sexton PM, Glukhova A, Christopoulos A | 10.1038/S41586-018-0236-6 | 2018-06-20 | Yes | |
CCR2 | CCR2 | Chemokine | A | Human | X-ray | 6GPS | 6GPS_refined | 3.3 | A | Inactive | 16 | 74 | - | - | - | - | Rubredoxin | - |
MK-0812
|
small-molecule | Antagonist | CCL2, CCL8, CCL11, CCL13, CCL24, CCL7, CCL26, CCL16 | peptide | No | No | - | 10.1016/J.STR.2018.10.027 | 2019-01-02 | Yes | |
EDNRB | ETB | Endothelin | A | Human | X-ray | 6K1Q | 6K1Q_refined | 2.7 | A | Inactive | 4 | 68 | - | - | - | - | T4-Lysozyme | - |
IRL 2500
|
peptide | Inverse agonist | endothelin-1, endothelin-2, endothelin-3 | peptide | No | No | - | 10.1038/S42003-019-0482-7 | 2019-07-17 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 6NI3 | 6NI3_refined | 3.8 | R | Active | 100 | 69 | Gs | αs | - | 59 | - | Nanobody-35 |
CHEMBL1615159
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | Nguyen AH, Thomsen ARB, Cahill TJ 3rd, Huang R, Huang LY, Marcink T, Clarke OB, Heissel S, Masoudi A, Ben-Hail D, Samaan F, Dandey VP, Tan YZ, Hong C, Mahoney JP, Triest S, Little J 4th, Chen X, Sunahara R, Steyaert J, Molina H, Yu Z, des Georges A, Lefkowitz RJ | 10.1038/S41594-019-0330-Y | 2019-11-20 | Yes | |
PACR | PAC1 | VIP and PACAP | B1 | Human | Cryo-EM | 6M1I | - | 3.5 | A | Active | 100 | 75 | Gs | αs | - | 57 | - | Nanobody-35 |
[Ac-His1]PACAP-27
|
peptide | Agonist | VIP, PHV, PACAP-27, PHI, PHM, PACAP-38 | peptide | No | No | - | - | 2020-03-11 | Yes | |
GLR | glucagon | Glucagon | B1 | Human | Cryo-EM | 6WPW | 6WPW_refined | 3.1 | R | Active | 100 | 83 | Gs | αs | - | 56 | - | Nanobody-35 |
Glucagon derivative ZP3780
|
peptide | Agonist | glucagon | peptide | No | No | Hilger D, Kumar KK, Hu H, Pedersen MF, O'Brien ES, Giehm L, Jennings C, Eskici G, Inoue A, Lerch M, Mathiesen JM, Skiniotis G, Kobilka BK | 10.1126/SCIENCE.ABA3373 | 2020-08-12 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Rat | Cryo-EM | 7L0R | - | 4.2 | C | Active | 100 | 73 | Gi/o | αi1 | Non-canonical conformation | 63 | - | - |
neurotensin
|
peptide | Agonist | neuromedin N, neurotensin | peptide | No | No | Zhang M, Gui M, Wang ZF, Gorgulla C, Yu JJ, Wu H, Sun ZJ, Klenk C, Merklinger L, Morstein L, Hagn F, Pluckthun A, Brown A, Nasr ML, Wagner G | 10.1038/S41594-020-00554-6 | 2021-01-06 | Yes | |
DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7LJC | - | 3.0 | R | Active | 100 | 63 | Gs | αs | Engineered G alpha | 60 | - | Nanobody-35 |
CHEMBL1160787
mevidalen |
small-molecule small-molecule |
Agonist PAM |
noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, 5-hydroxytryptamine, dopamine | small-molecule | No | No | Zhuang Y, Krumm B, Zhang H, Zhou XE, Wang Y, Huang XP, Liu Y, Cheng X, Jiang Y, Jiang H, Zhang C, Yi W, Roth BL, Zhang Y, Xu HE | 10.1038/S41422-021-00482-0 | 2021-03-03 | Yes | |
GRM4 | mGlu4 | Metabotropic glutamate | C | Human | Cryo-EM | 7E9H | - | 4.0 | R | Intermediate | - | 84 | Gi/o | αi3 | - | 63 | - | scFv16 |
L-serine-O-phosphate
|
small-molecule | Agonist | L-glutamic acid, L-serine-O-phosphate | small-molecule | No | No | Lin S, Han S, Cai X, Tan Q, Zhou K, Wang D, Wang X, Du J, Yi C, Chu X, Dai A, Zhou Y, Chen Y, Zhou Y, Liu H, Liu J, Yang D, Wang MW, Zhao Q, Wu B | 10.1038/S41586-021-03495-2 | 2021-06-23 | Yes | |
MTR1A | MT1 | Melatonin | A | Human | Cryo-EM | 7DB6 | 7DB6_refined | 3.3 | D | Active | 100 | 79 | Gi/o | αi1 | - | 62 | - | scFv16 |
ramelteon
|
small-molecule | Agonist | melatonin | small-molecule | No | No | Okamoto HH, Miyauchi H, Inoue A, Raimondi F, Tsujimoto H, Kusakizako T, Shihoya W, Yamashita K, Suno R, Nomura N, Kobayashi T, Iwata S, Nishizawa T, Nureki O | 10.1038/S41594-021-00634-1 | 2021-08-18 | Yes | |
LSHR | LH | Glycoprotein hormone | A | Human | Cryo-EM | 7FIH | - | 3.2 | R | Active | 100 | 79 | Gs | αs | - | 60 | - | - |
Choriogonadotropin beta
Glycoprotein alpha 5-Amino-N-(1,1-dimethylethyl)-2-(methylthio)-4-[3-[[2-(4-morpholinyl)acetyl]amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide |
protein protein small-molecule |
Agonist | hCG, LH | peptide | No | No | Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE | 10.1038/S41586-021-03924-2 | 2021-09-29 | Yes | |
GP183 | GPR183 | A orphans | A | Human | Cryo-EM | 7TUY | 7TUY_refined | 3.0 | R | Active | 65 | 73 | - | - | - | - | BRIL | anti-BRIL Fab heavy chain anti-BRIL Fab light chain anti-Fab Nanobody |
8-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]-3-[(3,4-dichlorophenyl)methyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one
|
small-molecule | Inverse agonist | 7α,25-dihydroxycholesterol, 7α,27-dihydroxycholesterol, 7β, 27-dihydroxycholesterol, 7β, 25-dihydroxycholesterol, 7α-hydroxycholesterol, 25-hydroxycholesterol, 27-hydroxycholesterol, 7β-hydroxycholesterol | small-molecule | No | No | Chen H, Huang W, Li X | 10.1016/J.STR.2022.04.006 | 2022-04-13 | Yes | |
NMUR1 | NMU1 | Neuromedin U | A | Human | Cryo-EM | 7W56 | - | 2.9 | R | Active | 100 | 65 | Gq/11 | αq | - | 59 | - | scFv16 |
Neuromedin-S
|
peptide | Agonist | neuromedin U-25, neuromedin U-23, neuromedin S-33, neuromedin S-36 | peptide | No | No | You C, Zhang Y, Xu P, Huang S, Yin W, Eric Xu H, Jiang Y | 10.1038/S41467-022-29683-W | 2022-04-20 | Yes | |
APJ | apelin | Apelin | A | Human | Cryo-EM | 7W0P | 7W0P_refined | 3.2 | R | Active | 100 | 77 | Gi/o | αi1 | - | 64 | BRIL | scFv16 |
apelin receptor early endogenous ligand
|
peptide | Agonist | apelin-13, apelin-17, apelin-36, Elabela/Toddler-21, [Pyr1]apelin-13, Elabela/Toddler-11, apelin receptor early endogenous ligand, Elabela/Toddler-32 | peptide | No | No | Yue Y, Liu L, Wu LJ, Wu Y, Wang L, Li F, Liu J, Han GW, Chen B, Lin X, Brouillette RL, Breault E, Longpre JM, Shi S, Lei H, Sarret P, Stevens RC, Hanson MA, Xu F | 10.1038/S41594-022-00797-5 | 2022-07-27 | Yes | |
SSR4 | SST4 | Somatostatin | A | Human | Cryo-EM | 7XMT | 7XMT_refined | 2.8 | R | Active | 100 | 68 | Gi/o | αi1 | - | 63 | - | scFv16 |
J-2156
|
small-molecule | Agonist | SRIF-14, CST-17, cortistatin-14, SRIF-28 | peptide | No | No | Zhao W, Han S, Qiu N, Feng W, Lu M, Zhang W, Wang M, Zhou Q, Chen S, Xu W, Du J, Chu X, Yi C, Dai A, Hu L, Shen MY, Sun Y, Zhang Q, Ma Y, Zhong W, Yang D, Wang MW, Wu B, Zhao Q | 10.1038/S41422-022-00679-X | 2022-08-03 | Yes | |
AGRG2 | ADGRG2 | ADGRG | B2 | Mouse | Cryo-EM | 7XKE | - | 2.9 | R | Active | - | 25 | Gs | αs | Mini-Gs | 60 | - | Nanobody-35 |
PRASTERONE
|
small-molecule | Agonist | - | - | No | No | - | - | 2022-08-10 | Yes | |
P2Y12 | P2Y12 | P2Y | A | Human | X-ray | 7PP1 | - | 2.8 | A | Intermediate | 44 | 78 | - | - | - | - | BRIL | - |
selatogrel
|
small-molecule | Antagonist | ADP, ATP | small-molecule | No | No | Pons V, Garcia C, Tidten-Luksch N, Mac Sweeney A, Caroff E, Gales C, Riederer MA | 10.1016/j.bcp.2022.115291 | 2022-11-02 | Yes | |
S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7VIF | 7VIF_refined | 2.8 | F | Active | 100 | 73 | Gi/o | αi1 | - | 64 | - | scFv16 |
(S)-FTY720-phosphate
|
small-molecule | Agonist | sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate, sphingosine 1-phosphate | small-molecule | No | No | Yu L, He L, Gan B, Ti R, Xiao Q, Hu H, Zhu L, Wang S, Ren R | 10.1073/PNAS.2117716119 | 2022-09-28 | Yes | |
LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | Cryo-EM | 7YU3 | 7YU3_refined | 3.4 | R | Active | 100 | 80 | Gi/o | αi1 | - | 63 | - | scFv16 |
[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate
|
small-molecule | Agonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | Akasaka H, Tanaka T, Sano FK, Matsuzaki Y, Shihoya W, Nureki O | 10.1038/S41467-022-33121-2 | 2022-10-05 | Yes | |
OPRM | μ | Opioid | A | Human | Cryo-EM | 8F7R | - | 3.3 | R | Active | 100 | 72 | Gi/o | αi1 | - | 63 | - | scFv16 |
endomorphin-1
|
peptide | Agonist | dynorphin A-(1-8), [Met]enkephalin, endomorphin-1, dynorphin A, [Leu]enkephalin, β-endorphin, dynorphin A-(1-13), dynorphin B, endomorphin-2 | peptide | No | No | Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE | 10.1016/J.CELL.2022.12.026 | 2022-12-14 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Rat | Cryo-EM | 8FMZ | - | 2.6 | A | Active | 100 | 66 | Gq/11 | αq | Mini-Gq | 57 | - | scFv16 |
neurotensin
|
peptide | Agonist | neuromedin N, neurotensin | peptide | No | No | - | 10.1021/ACS.BIOCHEM.3C00029 | 2023-03-29 | Yes | |
FFAR4 | FFA4 | Free fatty acid | A | Human | Cryo-EM | 8ID3 | 8ID3_refined | 3.1 | R | Active | 100 | 81 | Gi/o | αi1 | - | 64 | - | scFv16 |
9-Hydroxyoctadecanoic acid
|
small-molecule | Agonist | linoleic acid, oleic acid, α-linolenic acid, myristic acid | small-molecule | No | No | - | 10.1126/SCIENCE.ADD6220 | 2023-03-15 | Yes | |
TAAR9 | TAAR9 | A orphans | A | Mouse | Cryo-EM | 8IW7 | - | 3.0 | R | Active | 100 | 78 | Gs | αs | - | 59 | - | scFv16 |
2-Phenylethanaminium
|
small-molecule | Agonist | - | - | No | No | Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP | 10.1038/S41586-023-06106-4 | 2023-05-31 | Yes | |
PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 8FLS | - | 3.1 | R | Active | 100 | 61 | Gs | αs | - | 59 | - | Nanobody-35 |
abaloparatide
|
small-molecule | Agonist | PTH, PTHrP-(1-36), TIP39, PTHrP | peptide | No | No | Cary BP, Gerrard EJ, Belousoff MJ, Fletcher MM, Jiang Y, Russell IC, Piper SJ, Wootten D, Sexton PM | 10.1016/J.STR.2023.04.002 | 2023-04-26 | Yes | |
PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 8FLR | - | 2.9 | R | Active | 100 | 61 | Gs | αs | - | 59 | - | Nanobody-35 |
PTHrP[1-36]
|
peptide | Agonist | PTH, PTHrP-(1-36), TIP39, PTHrP | peptide | No | No | Cary BP, Gerrard EJ, Belousoff MJ, Fletcher MM, Jiang Y, Russell IC, Piper SJ, Wootten D, Sexton PM | 10.1016/J.STR.2023.04.002 | 2023-04-26 | Yes | |
GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 8JCU | - | 2.8 | 2 | Inactive | - | 87 | - | - | - | - | - | - |
LY341495
|
small-molecule | Antagonist | L-glutamic acid | small-molecule | No | No | Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B | 10.1038/S41422-023-00830-2 | 2023-06-21 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 6FK7 | 6FK7_refined | 2.6 | A | Active | 98 | 94 | - | - | - | - | - | - |
(2~{S})-2-(4-chlorophenyl)-3-methyl-1-spiro[1,3-benzodioxole-2,4'-piperidine]-1'-yl-butan-1-one
|
small-molecule | Agonist | - | - | No | No | - | - | 2018-04-04 | Yes | |
5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | Human | X-ray | 6DRY | 6DRY_refined | 2.9 | A | Intermediate | 44 | 60 | - | - | - | - | BRIL | - |
methylergonovine
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | McCorvy JD, Wacker D, Wang S, Agegnehu B, Liu J, Lansu K, Tribo AR, Olsen RHJ, Che T, Jin J, Roth BL | 10.1038/s41594-018-0116-7 | 2018-08-29 | Yes | |
EDNRB | ETB | Endothelin | A | Human | X-ray | 6IGL | - | 2.7 | A | Inactive | 4 | 70 | - | - | - | - | T4-Lysozyme | - |
sovateltide
|
peptide | Agonist (partial) | endothelin-1, endothelin-2, endothelin-3 | peptide | No | No | - | - | 2018-11-21 | Yes | |
PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 6NBI | - | 4.0 | R | Active | 100 | 62 | Gs | αs | - | 56 | - | Nanobody-35 |
Long-acting parathyroid hormone analog
|
peptide | Agonist | PTH, PTHrP-(1-36), TIP39, PTHrP | peptide | No | No | - | - | 2019-04-17 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 6PS6 | 6PS6_refined | 2.7 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
timolol
|
small-molecule | Antagonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | - | 10.1107/S2052252519013137 | 2019-11-13 | Yes | |
AGTR2 | AT2 | Angiotensin | A | Human | X-ray | 6JOD | 6JOD_refined | 3.2 | A | Active | 100 | 84 | - | - | - | - | BRIL | Heavy chain of 4A03Fab Light chain of 4A03Fab |
angiotensin II
|
peptide | Agonist | angiotensin-(1-7), angiotensin II, angiotensin III | peptide | No | No | Asada H, Inoue A, Ngako Kadji FM, Hirata K, Shiimura Y, Im D, Shimamura T, Nomura N, Iwanari H, Hamakubo T, Kusano-Arai O, Hisano H, Uemura T, Suno C, Aoki J, Iwata S | 10.1016/J.STR.2019.12.003 | 2020-01-15 | Yes | |
PACR | PAC1 | VIP and PACAP | B1 | Human | Cryo-EM | 6M1H | - | 3.6 | A | Active | 100 | 73 | Gs | αs | - | 55 | - | Nanobody-35 |
maxadilan
|
peptide | Agonist | VIP, PHV, PACAP-27, PHI, PHM, PACAP-38 | peptide | No | No | Wang J, Song X, Zhang D, Chen X, Li X, Sun Y, Li C, Song Y, Ding Y, Ren R, Harrington EH, Hu LA, Zhong W, Xu C, Huang X, Wang HW, Ma Y | 10.1038/S41422-020-0280-2 | 2020-03-11 | Yes | |
SUCR1 | succinate | Succinate | A | Rat | X-ray | 6Z10 | 6Z10_refined | 2.3 | A | Active | 65 | 90 | - | - | - | - | - | Nanobody-6 |
CHEMBL4751488
|
small-molecule | Antagonist | - | - | No | No | Velcicky J,Wilcken R,Cotesta S,Janser P,Schlapbach A,Wagner T,Piechon P,Villard F,Bouhelal R,Piller F,Harlfinger S,Stringer R,Fehlmann D,Kaupmann K,Littlewood-Evans A,Haffke M,Gommermann N | 10.1021/acs.jmedchem.0c01020 | 2020-09-16 | Yes | |
GHRHR | GHRH | Glucagon | B1 | Human | Cryo-EM | 7CZ5 | 7CZ5_refined | 2.6 | R | Active | 100 | 64 | Gs | αs | - | 58 | - | Nanobody-35 |
Somatoliberin
|
peptide | Agonist | GHRH | peptide | No | No | Zhou F, Zhang H, Cong Z, Zhao LH, Zhou Q, Mao C, Cheng X, Shen DD, Cai X, Ma C, Wang Y, Dai A, Zhou Y, Sun W, Zhao F, Zhao S, Jiang H, Jiang Y, Yang D, Eric Xu H, Zhang Y, Wang MW | 10.1038/S41467-020-18945-0 | 2020-11-18 | Yes | |
CALRL | calcitonin-like | Calcitonin | B1 | Human | Cryo-EM | 7KNU | 7KNU_refined | 3.5 | R | Inactive | 10 | 74 | - | - | - | - | - | RAMP1 |
Calcitonin gene-related peptide 1
|
peptide | Agonist | - | - | No | No | Josephs TM, Belousoff MJ, Liang YL, Piper SJ, Cao J, Garama DJ, Leach K, Gregory KJ, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM | 10.1126/SCIENCE.ABF7258 | 2021-02-24 | Yes | |
GABR2 | GABAB2 | GABAB | C | Human | Cryo-EM | 7EB2 | - | 3.5 | D | Active | - | 72 | Gi/o | αi1 | - | 99 | - | scFv16 |
(-)-baclofen
BHFF |
small-molecule small-molecule |
Agonist PAM |
- | - | No | No | Shen C, Mao C, Xu C, Jin N, Zhang H, Shen DD, Shen Q, Wang X, Hou T, Chen Z, Rondard P, Pin JP, Zhang Y, Liu J | 10.1038/S41586-021-03507-1 | 2021-05-05 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7KI1 | - | 2.5 | R | Active | 100 | 83 | Gs | αs | - | 89 | - | Nanobody-35 |
Taspoglutide
|
peptide | Agonist | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Zhang X, Belousoff MJ, Liang YL, Danev R, Sexton PM, Wootten D | 10.1016/J.CELREP.2021.109374 | 2021-08-04 | Yes | |
NK1R | NK1 | Tachykinin | A | Human | Cryo-EM | 7RMG | - | 3.0 | R | Active | 100 | 71 | Gs | αs | Gs-Gq chimera | 49 | - | Nanobody-35 |
substance P
|
peptide | Agonist | neurokinin B, neuropeptide-γ, hemokinin 1, substance P, neurokinin A, neuropeptide K | peptide | No | No | Harris JA, Faust B, Gondin AB, Damgen MA, Suomivuori CM, Veldhuis NA, Cheng Y, Dror RO, Thal DM, Manglik A | 10.1038/S41589-021-00890-8 | 2021-11-03 | Yes | |
GP139 | GPR139 | A orphans | A | Human | Cryo-EM | 7VUH | 7VUH_refined | 3.2 | R | Active | 100 | 80 | Gs | αs | - | 61 | - | Nanobody-35 |
JNJ-63533054
|
small-molecule | Agonist | L-tryptophan, L-phenylalanine | small-molecule | No | No | Zhou Y, Daver H, Trapkov B, Wu L, Wu M, Harpsoe K, Gentry PR, Liu K, Larionova M, Liu J, Chen N, Brauner-Osborne H, Gloriam DE, Hua T, Liu ZJ | 10.1038/S41422-021-00591-W | 2021-12-29 | Yes | |
US28 | US28 | Unclassified | A | strain AD169 | Cryo-EM | 7RKN | - | 3.6 | R | Active | 100 | 83 | Gi/o | αi1 | - | 61 | - | scFv16 |
Fractalkine
|
peptide | Agonist | - | - | No | No | Tsutsumi N, Maeda S, Qu Q, Vogele M, Jude KM, Suomivuori CM, Panova O, Waghray D, Kato HE, Velasco A, Dror RO, Skiniotis G, Kobilka BK, Garcia KC | 10.1126/SCIADV.ABL5442 | 2022-01-26 | Yes | |
ADA2A | α2A | Adrenoceptors | A | Human | Cryo-EM | 7EJK | - | 3.4 | R | Active | 100 | 55 | Gi/o | αo | - | 61 | - | scFv16 |
oxymetazoline
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Xu J, Cao S, Hubner H, Weikert D, Chen G, Lu Q, Yuan D, Gmeiner P, Liu Z, Du Y | 10.1126/SCIADV.ABJ5347 | 2022-04-13 | Yes | |
GALR2 | GAL2 | Galanin | A | Human | Cryo-EM | 7WQ4 | 7WQ4_refined | 2.6 | R | Active | 100 | 73 | Gq/11 | αq | - | 60 | - | Nanobody-35 |
galanin
|
peptide | Agonist | galanin-like peptide, spexin-1, galanin | peptide | No | No | - | - | 2022-04-20 | Yes | |
AGRG5 | ADGRG5 | ADGRG | B2 | Human | Cryo-EM | 7EQ1 | - | 3.3 | R | Active | - | 54 | Gs | αs | - | 60 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Ping YQ, Xiao P, Yang F, Zhao RJ, Guo SC, Yan X, Wu X, Zhang C, Lu Y, Zhao F, Zhou F, Xi YT, Yin W, Liu FZ, He DF, Zhang DL, Zhu ZL, Jiang Y, Du L, Feng SQ, Schoneberg T, Liebscher I, Xu HE, Sun JP | 10.1038/S41586-022-04619-Y | 2022-05-11 | Yes | |
SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7WIC | - | 2.8 | R | Active | 100 | 78 | Gi/o | αi1 | - | 64 | - | scFv16 |
SOMATOSTATIN
|
protein | Agonist | SRIF-14, CST-17, cortistatin-14, SRIF-28 | peptide | No | No | Chen LN, Wang WW, Dong YJ, Shen DD, Guo J, Yu X, Qin J, Ji SY, Zhang H, Shen Q, He Q, Yang B, Zhang Y, Li Q, Mao C | 10.1038/S41422-022-00669-Z | 2022-06-01 | Yes | |
CCKAR | CCK1 | Cholecystokinin | A | Human | Cryo-EM | 7XOU | - | 3.2 | R | Active | 100 | 67 | Gs | αs | - | 58 | - | Nanobody-35 |
CCK-8
|
peptide | Agonist | desulfated cholecystokinin-8, CCK-33, CCK-8, CCK-58, CCK-4, CCK-39, gastrin-17 | peptide | No | No | Ding Y, Zhang H, Liao YY, Chen LN, Ji SY, Qin J, Mao C, Shen DD, Lin L, Wang H, Zhang Y, Li XM | 10.1038/S41421-022-00420-3 | 2022-07-20 | Yes | |
5HT2C | 5-HT2C | 5-Hydroxytryptamine | A | Human | Cryo-EM | 8DPI | - | 3.4 | A | Active | 100 | 58 | Gq/11 | αq | Gi2-mini-Gq chimera | 57 | - | scFv16 |
lorcaserin
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Gumpper RH, Fay JF, Roth BL | 10.1016/J.CELREP.2022.111211 | 2022-08-24 | Yes | |
AA2AR | A2A | Adenosine | A | Human | Cryo-EM | 7T32 | 7T32_refined | 3.4 | A | Inactive | 1 | 69 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Zhang K, Wu H, Hoppe N, Manglik A, Cheng Y | 10.1038/S41467-022-32125-2 | 2022-08-10 | Yes | |
GP119 | GPR119 | GPR18, GPR55 and GPR119 | A | Human | Cryo-EM | 7XZ6 | - | 2.8 | R | Active | 100 | 87 | Gs | αs | - | 60 | BRIL | Nanobody-35 |
APD668
|
small-molecule | Agonist | N-oleoylethanolamide, SEA, anandamide, N-palmitoylethanolamine | small-molecule | No | No | Xu P, Huang S, Guo S, Yun Y, Cheng X, He X, Cai P, Lan Y, Zhou H, Jiang H, Jiang Y, Xie X, Xu HE | 10.1038/S41594-022-00816-5 | 2022-08-24 | Yes | |
AGRF1 | ADGRF1 | ADGRF | B2 | Human | Cryo-EM | 7WXU | - | 2.9 | R | Active | - | 30 | Gq/11 | αq | - | 60 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Zhu X, Qian Y, Li X, Xu Z, Xia R, Wang N, Liang J, Yin H, Zhang A, Guo C, Wang G, He Y | 10.1038/S41467-022-33173-4 | 2022-09-28 | Yes | |
AGRF1 | ADGRF1 | ADGRF | B2 | Human | Cryo-EM | 7X2V | - | 3.1 | R | Active | - | 30 | Gi/o | αi1 | - | 62 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Zhu X, Qian Y, Li X, Xu Z, Xia R, Wang N, Liang J, Yin H, Zhang A, Guo C, Wang G, He Y | 10.1038/S41467-022-33173-4 | 2022-09-28 | Yes | |
OPRM | μ | Opioid | A | Human | Cryo-EM | 8EFL | 8EFL_refined | 3.2 | R | Active | 100 | 72 | Gi/o | αi1 | - | 64 | - | scFv16 |
CHEMBL4452384
|
small-molecule | Agonist | dynorphin A-(1-8), [Met]enkephalin, endomorphin-1, dynorphin A, [Leu]enkephalin, β-endorphin, dynorphin A-(1-13), dynorphin B, endomorphin-2 | peptide | No | No | Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE | 10.1016/J.CELL.2022.09.041 | 2022-11-09 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 8A6C | 8A6C_refined | 1.8 | A | Inactive | 22 | 87 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Agonist | - | - | No | No | Gruhl T, Weinert T, Rodrigues MJ, Milne CJ, Ortolani G, Nass K, Nango E, Sen S, Johnson PJM, Cirelli C, Furrer A, Mous S, Skopintsev P, James D, Dworkowski F, Bath P, Kekilli D, Ozerov D, Tanaka R, Glover H, Bacellar C, Brunle S, Casadei CM, Diethelm AD, Gashi D, Gotthard G, Guixa-Gonzalez R, Joti Y, Kabanova V, Knopp G, Lesca E, Ma P, Martiel I, Muhle J, Owada S, Pamula F, Sarabi D, Tejero O, Tsai CJ, Varma N, Wach A, Boutet S, Tono K, Nogly P, Deupi X, Iwata S, Neutze R, Standfuss J, Schertler G, Panneels V | 10.1038/S41586-023-05863-6 | 2023-03-29 | Yes | |
EDNRB | ETB | Endothelin | A | Human | Cryo-EM | 8HCX | 8HCX_refined | 3.5 | C | Active | 100 | 66 | Gq/11 | αq | - | 61 | - | scFv16 |
ENDOTHELIN
|
protein | Agonist | endothelin-1, endothelin-2, endothelin-3 | peptide | No | No | - | - | 2023-03-22 | Yes | |
DRD2 | D2 | Dopamine | A | Human | Cryo-EM | 8IRS | - | 3.0 | R | Active | 100 | 60 | Gi/o | αi1 | - | 63 | BRIL | scFv16 |
rotigotine
|
small-molecule | Agonist | dopamine | small-molecule | No | No | Xu P, Huang S, Krumm BE, Zhuang Y, Mao C, Zhang Y, Wang Y, Huang XP, Liu YF, He X, Li H, Yin W, Jiang Y, Zhang Y, Roth BL, Xu HE | 10.1038/S41422-023-00808-0 | 2023-06-07 | Yes | |
PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 8FLQ | - | 2.6 | R | Active | 100 | 61 | Gs | αs | - | 59 | - | Nanobody-35 |
Parathyroid hormone
|
peptide | Agonist | PTH, PTHrP-(1-36), TIP39, PTHrP | peptide | No | No | Cary BP, Gerrard EJ, Belousoff MJ, Fletcher MM, Jiang Y, Russell IC, Piper SJ, Wootten D, Sexton PM | 10.1016/J.STR.2023.04.002 | 2023-04-26 | Yes | |
GRPR | BB2 | Bombesin | A | Human | Cryo-EM | 8H0Q | - | 3.3 | R | Active | 100 | 77 | Gq/11 | αq | - | 56 | - | - |
Gastrin-releasing peptide
|
peptide | Agonist | neuromedin B, gastrin releasing peptide(14-27) (human), gastrin-releasing peptide, neuromedin C, GRP-(18-27) | peptide | No | No | Li C, Xu Y, Liu H, Cai H, Jiang Y, Xu HE, Yin W | 10.1038/S41422-022-00743-6 | 2023-08-09 | Yes | |
GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 8JCV | - | 3.4 | 2 | Inactive | - | 88 | - | - | - | - | - | - |
LY341495
|
small-molecule | Antagonist | L-glutamic acid | small-molecule | No | No | Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B | 10.1038/S41422-023-00830-2 | 2023-06-21 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 6FK8 | 6FK8_refined | 2.9 | A | Active | 98 | 94 | - | - | - | - | - | - |
(2~{R},3~{S})-3-azanyl-2-(4-chlorophenyl)-1-spiro[1,3-benzodioxole-2,4'-piperidine]-1'-yl-butan-1-one
|
small-molecule | Agonist | - | - | No | No | Mattle D, Kuhn B, Aebi J, Bedoucha M, Kekilli D, Grozinger N, Alker A, Rudolph MG, Schmid G, Schertler GFX, Hennig M, Standfuss J, Dawson RJP | 10.1073/PNAS.1718084115 | 2018-04-04 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 6FUF | 6FUF_refined | 3.1 | A | Active | 100 | 91 | Gi/o | αo | Mini-Go | 51 | - | - |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | Tsai CJ, Pamula F, Nehme R, Muhle J, Weinert T, Flock T, Nogly P, Edwards PC, Carpenter B, Gruhl T, Ma P, Deupi X, Standfuss J, Tate CG, Schertler GFX | 10.1126/SCIADV.AAT7052 | 2018-10-03 | Yes | |
NK1R | NK1 | Tachykinin | A | Human | X-ray | 6E59 | 6E59_refined | 3.4 | A | Inactive | 1 | 70 | - | - | - | - | GlgA glycogen synthase | - |
L760735
|
small-molecule | Antagonist | neurokinin B, neuropeptide-γ, hemokinin 1, substance P, neurokinin A, neuropeptide K | peptide | No | No | - | 10.1073/PNAS.1812717115 | 2018-12-12 | Yes | |
MTR1A | MT1 | Melatonin | A | Human | X-ray | 6ME3 | 6ME3_refined | 2.9 | A | Inactive | 1 | 82 | - | - | - | - | GlgA glycogen synthase | - |
CHEMBL15060
|
small-molecule | Agonist | melatonin | small-molecule | No | No | - | - | 2019-04-24 | Yes | |
SUCR1 | succinate | Succinate | A | Rat | X-ray | 6IBB | 6IBB_refined | 2.1 | A | Active | 65 | 93 | - | - | - | - | - | Nanobody-6 | - | - | - | - | - | No | No | - | 10.1038/S41586-019-1663-8 | 2019-08-14 | Yes | |
ADA2A | α2A | Adrenoceptors | A | Human | X-ray | 6KUY | 6KUY_refined | 3.2 | A | Inactive | 1 | 56 | - | - | - | - | BRIL | - |
(2~{S})-4-fluoranyl-2-(1~{H}-imidazol-5-yl)-1-propan-2-yl-2,3-dihydroindole
|
small-molecule | Agonist (partial) | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | - | - | 2019-12-04 | Yes | |
APJ | apelin | Apelin | A | Human | X-ray | 6KNM | 6KNM_refined | 3.2 | B | Inactive | 4 | 78 | - | - | - | - | Rubredoxin | - |
Single domain antibody JN241
|
protein | Agonist | apelin-13, apelin-17, apelin-36, Elabela/Toddler-21, [Pyr1]apelin-13, Elabela/Toddler-11, apelin receptor early endogenous ligand, Elabela/Toddler-32 | peptide | No | No | Ma Y, Ding Y, Song X, Ma X, Li X, Zhang N, Song Y, Sun Y, Shen Y, Zhong W, Hu LA, Ma Y, Zhang MY | 10.1126/SCIADV.AAX7379 | 2020-01-29 | Yes | |
VIPR1 | VPAC1 | VIP and PACAP | B1 | Human | Cryo-EM | 6VN7 | 6VN7_refined | 3.2 | R | Active | 100 | 58 | Gs | αs | - | 61 | - | Nanobody-35 |
[Ac-His1]PACAP-27
|
peptide | Agonist | VIP, PACAP-27, secretin, PHI, PHM, GHRH, PACAP-38 | peptide | No | No | Duan J, Shen DD, Zhou XE, Bi P, Liu QF, Tan YX, Zhuang YW, Zhang HB, Xu PY, Huang SJ, Ma SS, He XH, Melcher K, Zhang Y, Xu HE, Jiang Y | 10.1038/S41467-020-17933-8 | 2020-09-02 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Rat | Cryo-EM | 7L0Q | - | 4.3 | C | Active | 100 | 73 | Gi/o | αi1 | - | 95 | - | - |
neurotensin
|
peptide | Agonist | neuromedin N, neurotensin | peptide | No | No | Zhang M, Gui M, Wang ZF, Gorgulla C, Yu JJ, Wu H, Sun ZJ, Klenk C, Merklinger L, Morstein L, Hagn F, Pluckthun A, Brown A, Nasr ML, Wagner G | 10.1038/S41594-020-00554-6 | 2021-01-06 | Yes | |
DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7CKY | - | 3.2 | R | Active | 100 | 62 | Gs | αs | - | 60 | - | Nanobody-35 |
CHEMBL3697578
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, 5-hydroxytryptamine, dopamine | small-molecule | No | No | Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z | 10.1016/J.CELL.2021.01.028 | 2021-03-03 | Yes | |
V2R | V2 | Vasopressin and oxytocin | A | Human | Cryo-EM | 7BB7 | - | 4.4 | A | Active | 100 | 72 | Gs | αs | - | 55 | - | Nanobody-35 |
vasopressin
|
peptide | Agonist | oxytocin, vasopressin | peptide | No | No | Bous J, Orcel H, Floquet N, Leyrat C, Lai-Kee-Him J, Gaibelet G, Ancelin A, Saint-Paul J, Trapani S, Louet M, Sounier R, Demene H, Granier S, Bron P, Mouillac B | 10.1126/SCIADV.ABG5628 | 2021-06-02 | Yes | |
CCR5 | CCR5 | Chemokine | A | Human | Cryo-EM | 7F1R | - | 3.0 | R | Active | 100 | 79 | Gi/o | αi1 | - | 61 | - | - |
CCL5
|
peptide | Agonist | CCL2, CCL8, CCL11, CCL13, CCL14, CCL7, CCL5, CCL4, CCL16, CCL3 | peptide | No | No | - | - | 2021-07-14 | Yes | |
GHSR | ghrelin | Ghrelin | A | Human | Cryo-EM | 7F9Y | - | 2.9 | R | Active | 100 | 78 | Gq/11 | αq | Engineered G alpha | 59 | - | Nanobody-35 |
ghrelin
|
peptide | Agonist | [des-Gln14]ghrelin, ghrelin | peptide | No | No | Wang Y, Guo S, Zhuang Y, Yun Y, Xu P, He X, Guo J, Yin W, Xu HE, Xie X, Jiang Y | 10.1038/S41467-021-25364-2 | 2021-08-18 | Yes | |
BKRB2 | B2 | Bradykinin | A | Human | Cryo-EM | 7F2O | - | 2.9 | R | Active | 100 | 73 | Gq/11 | αq | Gq-Gi1 chimera | 60 | - | scFv16 |
bradykinin
|
peptide | Agonist | [Hyp3]bradykinin, [des-Arg10]kallidin, bradykinin, Lys-[Hyp3]-bradykinin, kallidin, [des-Arg9]bradykinin, T-kinin | peptide | No | No | Yin YL, Ye C, Zhou F, Wang J, Yang D, Yin W, Wang MW, Xu HE, Jiang Y | 10.1038/S41594-021-00645-Y | 2021-10-13 | Yes | |
MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7VUY | - | 2.8 | R | Active | 100 | 78 | Gi/o | αi1 | - | 64 | - | scFv16 |
PAMP-12
|
peptide | Agonist | PAMP-20 | peptide | No | No | Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP | 10.1038/S41586-021-04077-Y | 2021-12-01 | Yes | |
ADA1B | α1B | Adrenoceptors | A | Human | X-ray | 7B6W | - | 2.9 | A | Inactive | 1 | 51 | - | - | - | - | DARPin D12 | - |
(+)-cyclazosin
|
small-molecule | Inverse agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Deluigi M, Morstein L, Schuster M, Klenk C, Merklinger L, Cridge RR, de Zhang LA, Klipp A, Vacca S, Vaid TM, Mittl PRE, Egloff P, Eberle SA, Zerbe O, Chalmers DK, Scott DJ, Pluckthun A | 10.1038/s41467-021-27911-3 | 2022-01-12 | Yes | |
SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7T10 | - | 2.5 | R | Active | 100 | 78 | Gi/o | αi3 | - | 62 | - | scFv16 |
SOMATOSTATIN
|
protein | Agonist | SRIF-14, CST-17, cortistatin-14, SRIF-28 | peptide | No | No | Robertson MJ, Meyerowitz JG, Panova O, Borrelli K, Skiniotis G | 10.1038/S41594-022-00727-5 | 2022-03-09 | Yes | |
CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 7TYY | - | 3.0 | R | Active | 100 | 78 | Gs | αs | - | 58 | - | Nanobody-35 |
calcitonin (salmon synthetic)
|
small-molecule | Agonist | β-CGRP, α-CGRP, calcitonin, calcitonin (salmon), amylin, adrenomedullin, adrenomedullin 2/intermedin | peptide | No | No | Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | Yes | |
AGRL3 | ADGRL3 | ADGRL | B2 | Human | Cryo-EM | 7SF7 | - | 2.9 | A | Active | - | 19 | G12/13 | α13 | Gi2-mini-G13 chimera | 56 | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Barros-Alvarez X, Nwokonko RM, Vizurraga A, Matzov D, He F, Papasergi-Scott MM, Robertson MJ, Panova O, Yardeni EH, Seven AB, Kwarcinski FE, Su H, Peroto MC, Meyerowitz JG, Shalev-Benami M, Tall GG, Skiniotis G | 10.1038/S41586-022-04575-7 | 2022-04-27 | Yes | |
FPR1 | FPR1 | Formylpeptide | A | Human | Cryo-EM | 7EUO | 7EUO_refined | 2.9 | R | Active | 100 | 84 | Gi/o | αi1 | - | 62 | - | scFv16 |
Peptide Agonist fMLF
|
peptide | Agonist | cathepsin G, spinorphin, annexin I, fMet-Leu-Phe | peptide | No | No | Chen G, Wang X, Liao Q, Ge Y, Jiao H, Chen Q, Liu Y, Lyu W, Zhu L, van Zundert GCP, Robertson MJ, Skiniotis G, Du Y, Hu H, Ye RD | 10.1038/S41467-022-32822-Y | 2022-05-25 | Yes | |
DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7X2D | 7X2D_refined | 3.3 | F | Active | 100 | 63 | Gs | αs | - | 58 | - | Nanobody-35 |
TAVAPADON
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, 5-hydroxytryptamine, dopamine | small-molecule | No | No | Teng X, Chen S, Nie Y, Xiao P, Yu X, Shao Z, Zheng S | 10.1038/S41467-022-30929-W | 2022-06-15 | Yes | |
CCKAR | CCK1 | Cholecystokinin | A | Human | Cryo-EM | 7XOV | - | 3.0 | R | Active | 100 | 67 | Gs | αs | - | 58 | - | Nanobody-35 |
SR146131
|
small-molecule | Agonist | desulfated cholecystokinin-8, CCK-33, CCK-8, CCK-58, CCK-4, CCK-39, gastrin-17 | peptide | No | No | Ding Y, Zhang H, Liao YY, Chen LN, Ji SY, Qin J, Mao C, Shen DD, Lin L, Wang H, Zhang Y, Li XM | 10.1038/S41421-022-00420-3 | 2022-07-20 | Yes | |
SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7XAT | 7XAT_refined | 2.9 | A | Active | 100 | 78 | Gi/o | αi1 | - | 63 | - | scFv16 |
SOMATOSTATIN
|
protein | Agonist | SRIF-14, CST-17, cortistatin-14, SRIF-28 | peptide | No | No | Bo Q, Yang F, Li Y, Meng X, Zhang H, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C | 10.1038/S41421-022-00405-2 | 2022-08-31 | Yes | |
AGRG2 | ADGRG2 | ADGRG | B2 | Mouse | Cryo-EM | 7XKD | - | 2.4 | R | Active | - | 26 | Gs | αs | - | 57 | - | Nanobody-35 |
PRASTERONE
|
small-molecule | Agonist | - | - | No | No | Lin H, Xiao P, Bu RQ, Guo S, Yang Z, Yuan D, Zhu ZL, Zhang CX, He QT, Zhang C, Ping YQ, Zhao RJ, Ma CS, Liu CH, Zhang XN, Jiang D, Huang S, Xi YT, Zhang DL, Xue CY, Yang BS, Li JY, Lin HC, Zeng XH, Zhao H, Xu WM, Yi F, Liu Z, Sun JP, Yu X | 10.1038/S41589-022-01084-6 | 2022-08-10 | Yes | |
5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7SRS | - | 3.3 | R | Active | 100 | 60 | Beta | Beta-arrestin-1 | - | 85 | - | Fab light chain Fab heavy chain Fab30 heavy chain Fab30 light chain |
Lysergide
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Cao C, Barros-Alvarez X, Zhang S, Kim K, Damgen MA, Panova O, Suomivuori CM, Fay JF, Zhong X, Krumm BE, Gumpper RH, Seven AB, Robertson MJ, Krogan NJ, Huttenhain R, Nichols DE, Dror RO, Skiniotis G, Roth BL | 10.1016/J.NEURON.2022.08.006 | 2022-09-21 | Yes | |
S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7VIH | 7VIH_refined | 3.0 | F | Active | 100 | 73 | Gi/o | αi1 | - | 64 | - | scFv16 |
icanbelimod
|
small-molecule | Agonist | sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate, sphingosine 1-phosphate | small-molecule | No | No | Yu L, He L, Gan B, Ti R, Xiao Q, Hu H, Zhu L, Wang S, Ren R | 10.1073/PNAS.2117716119 | 2022-09-28 | Yes | |
GPR17 | GPR17 | A orphans | A | Human | Cryo-EM | 7Y89 | - | 3.0 | A | Active | 100 | 78 | Gi/o | αi1 | - | 58 | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | LTE4, UDP-galactose, LTC4, ATP, LTD4, UDP-glucose, UDP | small-molecule | No | No | Ye F, Wong TS, Chen G, Zhang Z, Zhang B, Gan S, Gao W, Li J, Wu Z, Pan X, Du Y | 10.1002/MCO2.159 | 2022-10-12 | Yes | |
OPRM | μ | Opioid | A | Human | Cryo-EM | 8F7Q | - | 3.2 | R | Active | 100 | 72 | Gi/o | αi1 | - | 64 | - | scFv16 |
β-endorphin
|
peptide | Agonist | dynorphin A-(1-8), [Met]enkephalin, endomorphin-1, dynorphin A, [Leu]enkephalin, β-endorphin, dynorphin A-(1-13), dynorphin B, endomorphin-2 | peptide | No | No | Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE | 10.1016/J.CELL.2022.12.026 | 2022-12-14 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 8GNE | - | 2.3 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
Sipagladenant
|
small-molecule | Inverse agonist | adenosine | small-molecule | No | Yes | - | 10.1124/MOLPHARM.122.000633 | 2023-03-22 | Yes | |
FSHR | FSH | Glycoprotein hormone | A | Human | Cryo-EM | 8I2G | - | 2.8 | R | Active | 100 | 86 | Gs | αs | fused Gs | 58 | - | Nanobody-35 |
Glycoprotein alpha
Follitropin subunit beta FSHR agonist 1 |
peptide peptide small-molecule |
Agonist | FSH | peptide | No | No | - | - | 2023-03-29 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 6FKB | 6FKB_refined | 3.0 | A | Active | 98 | 94 | - | - | - | - | - | - |
2-(4-Chlorophenyl)-1-spiro[1,3-benzodioxole-2,4'-piperidine]-1'-yl-ethanone
|
small-molecule | Agonist | - | - | No | No | Mattle D, Kuhn B, Aebi J, Bedoucha M, Kekilli D, Grozinger N, Alker A, Rudolph MG, Schmid G, Schertler GFX, Hennig M, Standfuss J, Dawson RJP | 10.1073/PNAS.1718084115 | 2018-04-04 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 6H7J | 6H7J_refined | 2.8 | A | Active | 99 | 60 | - | - | - | - | Thioredoxin 1 | Camelid antibody fragment Nb80 |
LEVISOPRENALINE
|
small-molecule | Agonist | - | - | No | No | Warne T, Edwards PC, Dore AS, Leslie AGW, Tate CG | 10.1126/SCIENCE.AAU5595 | 2018-10-17 | Yes | |
TA2R | TP | Prostanoid | A | Human | X-ray | 6IIV | 6IIV_refined | 3.0 | A | Inactive | 35 | 87 | - | - | - | - | Rubredoxin | - |
daltroban
|
small-molecule | Antagonist | PGE2, PGF2α, thromboxane A2, PGH2, PGI2, PGD2 | small-molecule | No | No | - | - | 2018-12-19 | Yes | |
ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 6OIK | 6OIK_refined | 3.6 | R | Active | 100 | 60 | Gi/o | αo | - | 61 | - | - |
LY2119620
iperoxo |
small-molecule small-molecule |
Ago-PAM Agonist |
acetylcholine | small-molecule | No | No | - | - | 2019-05-08 | Yes | |
DRD4 | D4 | Dopamine | A | Mouse | X-ray | 6IQL | 6IQL_refined | 3.5 | A | Inactive | 15 | 65 | - | - | - | - | BRIL | - |
L745870
|
small-molecule | Antagonist | - | - | No | No | Zhou Y, Cao C, He L, Wang X, Zhang XC | 10.7554/ELIFE.48822 | 2019-12-04 | Yes | |
CNR2 | CB2 | Cannabinoid | A | Human | Cryo-EM | 6KPF | 6KPF_refined | 2.9 | R | Active | 100 | 81 | Gi/o | αi1 | - | 62 | - | scFv16 |
AM12033
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Hua T, Li X, Wu L, Iliopoulos-Tsoutsouvas C, Wang Y, Wu M, Shen L, Brust CA, Nikas SP, Song F, Song X, Yuan S, Sun Q, Wu Y, Jiang S, Grim TW, Benchama O, Stahl EL, Zvonok N, Zhao S, Bohn LM, Makriyannis A, Liu ZJ | 10.1016/J.CELL.2020.01.008 | 2020-02-12 | Yes | |
GLR | glucagon | Glucagon | B1 | Human | Cryo-EM | 6WHC | 6WHC_refined | 3.4 | R | Active | 100 | 78 | Gs | αs | - | 56 | - | Nanobody-35 |
Dual-agonist peptide P15
|
peptide | Agonist | glucagon | peptide | No | No | Chang R, Zhang X, Qiao A, Dai A, Belousoff MJ, Tan Q, Shao L, Zhong L, Lin G, Liang YL, Ma L, Han S, Yang D, Danev R, Wang MW, Wootten D, Wu B, Sexton PM | 10.1074/JBC.RA120.013793 | 2020-05-27 | Yes | |
GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 6X18 | - | 2.1 | R | Active | 100 | 83 | Gs | αs | - | 90 | - | Nanobody-35 |
CHEMBL410972
|
protein | Agonist | glucagon, glucagon-like peptide 1-(7-37), glucagon-like peptide 1-(7-36) amide | peptide | No | No | Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Senel P, Stewart GD, Liang YL, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D | 10.1016/J.MOLCEL.2020.09.020 | 2020-09-09 | Yes | |
LT4R1 | BLT1 | Leukotriene | A | Human | X-ray | 7K15 | 7K15_refined | 2.9 | A | Inactive | 5 | 85 | - | - | - | - | Flavodoxin | - |
N-(tert-butylsulfonyl)-4-fluoro-2-{(3S,4R)-4-hydroxy-3-[(pyridin-2-yl)methyl]-3,4-dihydro-2H-1-benzopyran-7-yl}benzamide
|
small-molecule | Antagonist | 12R-HETE, LTB4, 20-hydroxy-LTB4 | small-molecule | No | Yes | Michaelian N, Sadybekov A, Besserer-Offroy E, Han GW, Krishnamurthy H, Zamlynny BA, Fradera X, Siliphaivanh P, Presland J, Spencer KB, Soisson SM, Popov P, Sarret P, Katritch V, Cherezov V | 10.1038/S41467-021-23149-1 | 2021-02-17 | Yes | |
CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7DTW | 7DTW_refined | 4.5 | A | Inactive | - | 72 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | spermine, L-tryptophan, Ca2+, Mg2+ | small-molecule | No | No | Ling S, Shi P, Liu S, Meng X, Zhou Y, Sun W, Chang S, Zhang X, Zhang L, Shi C, Sun D, Liu L, Tian C | 10.1038/S41422-021-00474-0 | 2021-03-10 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | Cryo-EM | 7MT8 | 7MT8_refined | 5.8 | R | Active | 98 | 93 | - | - | - | - | - | GRK1 |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | - | 10.1038/S41586-021-03721-X | 2021-07-07 | Yes | |
CCKAR | CCK1 | Cholecystokinin | A | Human | Cryo-EM | 7EZH | - | 3.2 | D | Active | 100 | 69 | Gi/o | αi1 | - | 61 | - | scFv16 |
CCK-8
|
peptide | Agonist | desulfated cholecystokinin-8, CCK-33, CCK-8, CCK-58, CCK-4, CCK-39, gastrin-17 | peptide | No | No | Liu Q, Yang D, Zhuang Y, Croll TI, Cai X, Dai A, He X, Duan J, Yin W, Ye C, Zhou F, Wu B, Zhao Q, Xu HE, Wang MW, Jiang Y | 10.1038/S41589-021-00841-3 | 2021-08-25 | Yes | |
MC4R | MC4 | Melanocortin | A | Human | Cryo-EM | 7F55 | - | 3.1 | R | Active | 100 | 82 | Gs | αs | - | 58 | - | Nanobody-35 |
bremelanotide
|
peptide | Agonist | agouti-related protein, β-MSH, α-MSH, γ-MSH, ACTH | peptide | No | No | Zhang H, Chen LN, Yang D, Mao C, Shen Q, Feng W, Shen DD, Dai A, Xie S, Zhou Y, Qin J, Sun JP, Scharf DH, Hou T, Zhou T, Wang MW, Zhang Y | 10.1038/S41422-021-00552-3 | 2021-11-03 | Yes | |
NK1R | NK1 | Tachykinin | A | Human | Cryo-EM | 7P00 | - | 2.7 | R | Active | 100 | 71 | Gq/11 | αq | Gq-Gs-Gi1 chimera | 59 | - | scFv16 |
substance P
|
peptide | Agonist | neurokinin B, neuropeptide-γ, hemokinin 1, substance P, neurokinin A, neuropeptide K | peptide | No | No | - | - | 2021-12-15 | Yes | |
MSHR | MC1 | Melanocortin | A | Human | Cryo-EM | 7F4F | - | 2.9 | R | Active | 100 | 85 | Gs | αs | - | 59 | - | scFv16 |
CHEMBL407070
|
protein | Agonist | γ-MSH, ACTH, β-MSH, α-MSH | peptide | No | No | - | - | 2021-09-08 | Yes | |
CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 7TYF | - | 2.2 | R | Active | 100 | 77 | Gs | αs | - | 58 | - | Nanobody-35 RAMP1 |
amylin peptide
|
peptide | Agonist | β-CGRP, α-CGRP, calcitonin, calcitonin (salmon), amylin, adrenomedullin, adrenomedullin 2/intermedin | peptide | No | No | Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | Yes | |
GIPR | GIP | Glucagon | B1 | Human | Cryo-EM | 7RA3 | - | 3.2 | R | Active | 100 | 80 | Gs | αs | Engineered G alpha | 56 | - | scFv16 Nanobody-35 |
gastric inhibitory polypeptide (human) - Incretin
|
peptide | Agonist | gastric inhibitory polypeptide | peptide | No | No | Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW | 10.1073/PNAS.2116506119 | 2022-04-13 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 6FKC | 6FKC_refined | 2.5 | A | Active | 98 | 94 | - | - | - | - | - | - |
3-[1'-[(2~{S})-2-(4-chlorophenyl)-3-methyl-butanoyl]spiro[1,3-benzodioxole-2,4'-piperidine]-5-yl]propanoic acid
|
small-molecule | Agonist | - | - | No | No | Mattle D, Kuhn B, Aebi J, Bedoucha M, Kekilli D, Grozinger N, Alker A, Rudolph MG, Schmid G, Schertler GFX, Hennig M, Standfuss J, Dawson RJP | 10.1073/PNAS.1718084115 | 2018-04-04 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 6H7L | 6H7L_refined | 2.7 | A | Active | 99 | 60 | - | - | - | - | Thioredoxin 1 | Camelid antibody fragment Nb6B9 |
Dobutamine
|
small-molecule | Agonist | - | - | No | No | Warne T, Edwards PC, Dore AS, Leslie AGW, Tate CG | 10.1126/SCIENCE.AAU5595 | 2018-10-17 | Yes | |
NK1R | NK1 | Tachykinin | A | Human | X-ray | 6HLL | 6HLL_refined | 3.3 | A | Inactive | 1 | 67 | - | - | - | - | GlgA glycogen synthase | - |
CP 99994
|
small-molecule | Antagonist | neurokinin B, neuropeptide-γ, hemokinin 1, substance P, neurokinin A, neuropeptide K | peptide | No | No | - | 10.1038/S41467-018-07939-8 | 2019-01-16 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 6E67 | 6E67_refined | 3.7 | B | Active | 100 | 72 | Gs | αs | Fused partial Gs | 44 | T4-Lysozyme | - |
CHEMBL1615159
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | - | 10.1016/J.CELL.2019.04.021 | 2019-06-05 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 6PS3 | 6PS3_refined | 2.5 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
CHEMBL3799125
|
small-molecule | Antagonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | - | - | 2019-11-13 | Yes | |
CRFR1 | CRF1 | Corticotropin-releasing factor | B1 | Human | Cryo-EM | 6P9X | - | 2.9 | R | Active | 100 | 65 | Gs | αs | - | 49 | - | Nanobody-35 |
Corticoliberin
|
peptide | Agonist | urocortin 2, corticotrophin-releasing hormone, urocortin 1 | peptide | No | No | Liang YL, Belousoff MJ, Zhao P, Koole C, Fletcher MM, Truong TT, Julita V, Christopoulos G, Xu HE, Zhang Y, Khoshouei M, Christopoulos A, Danev R, Sexton PM, Wootten D | 10.1016/J.MOLCEL.2020.01.012 | 2020-02-05 | Yes | |
OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 6PGS | 6PGS_refined | 2.9 | A | Active | 100 | 94 | Gi/o | αt2 | Only H5 | 3 | - | - |
Geraniol
|
small-molecule | unknown | - | - | No | No | - | - | 2020-07-01 | Yes | |
OXYR | OT | Vasopressin and oxytocin | A | Human | X-ray | 6TPK | 6TPK_refined | 3.2 | A | Inactive | 15 | 68 | - | - | - | - | GlgA glycogen synthase | - |
retosiban
|
small-molecule | Antagonist | oxytocin, vasopressin | peptide | No | No | Waltenspuhl Y, Schoppe J, Ehrenmann J, Kummer L, Pluckthun A | 10.1126/SCIADV.ABB5419 | 2020-08-05 | Yes | |
5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 6WHA | - | 3.4 | A | Active | 100 | 52 | Gq/11 | αq | Gq-Gi2-Gs chimera | 57 | BRIL | scFv16 |
CHEMBL5184791
|
small-molecule | Agonist | 5-hydroxytryptamine, tryptamine | small-molecule | No | No | Kim K, Che T, Panova O, DiBerto JF, Lyu J, Krumm BE, Wacker D, Robertson MJ, Seven AB, Nichols DE, Shoichet BK, Skiniotis G, Roth BL | 10.1016/J.CELL.2020.08.024 | 2020-09-23 | Yes | |
ADRB1 | β1 | Adrenoceptors | A | Human | X-ray | 7BU7 | 7BU7_refined | 2.6 | A | Active | 99 | 58 | - | - | - | - | T4-Lysozyme | Camelid antibody fragment Nb6B9 |
CHEMBL1615159
|
small-molecule | Agonist | noradrenaline, (-)-adrenaline, L-NOREPINEPHRINE, (-)-noradrenaline | small-molecule | No | No | Xu X, Kaindl J, Clark MJ, Hubner H, Hirata K, Sunahara RK, Gmeiner P, Kobilka BK, Liu X | 10.1038/S41422-020-00424-2 | 2020-12-02 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 6YVR | - | 2.5 | B | Inactive | 3 | 83 | - | - | - | - | DARPin D12 | - |
JMV431
|
peptide | Agonist | neuromedin N, neurotensin | peptide | No | No | Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PRE, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Pluckthun A | 10.1126/sciadv.abe5504 | 2021-02-10 | Yes | |
GRM2 | mGlu2 | Metabotropic glutamate | C | Human | X-ray | 7EPF | 7EPF_refined | 2.7 | A | Inactive | - | 28 | - | - | - | - | Flavodoxin | - |
(8~{R})-4-[2,4-Bis(fluoranyl)phenyl]-8-methyl-7-[(2-methylpyrazol-3-yl)methyl]-6,8-dihydro-5~{H}-1,7-naphthyridine-2-carboxamide
|
small-molecule | NAM | L-glutamic acid | small-molecule | No | No | Du J, Wang D, Fan H, Xu C, Tai L, Lin S, Han S, Tan Q, Wang X, Xu T, Zhang H, Chu X, Yi C, Liu P, Wang X, Zhou Y, Pin JP, Rondard P, Liu H, Liu J, Sun F, Wu B, Zhao Q | 10.1038/S41586-021-03641-W | 2021-06-23 | Yes | |
CCR5 | CCR5 | Chemokine | A | Human | X-ray | 7F1T | - | 2.6 | A | Inactive | 16 | 86 | - | - | - | - | Rubredoxin | - |
CCL3
|
peptide | Agonist | CCL2, CCL8, CCL11, CCL13, CCL14, CCL7, CCL5, CCL4, CCL16, CCL3 | peptide | No | No | - | - | 2021-07-14 | Yes | |
MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7VDL | - | 3.2 | R | Active | 100 | 78 | Gi/o | αi1 | - | 61 | - | scFv16 |
Cortistatin 14
|
peptide | Agonist | PAMP-20 | peptide | No | No | Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP | 10.1038/S41586-021-04077-Y | 2021-12-01 | Yes | |
5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | X-ray | 7WC6 | 7WC6_refined | 2.6 | A | Inactive | 1 | 58 | - | - | - | - | BRIL | - |
Lysergide
|
small-molecule | Agonist | 5-hydroxytryptamine, tryptamine | small-molecule | No | No | Cao D, Yu J, Wang H, Luo Z, Liu X, He L, Qi J, Fan L, Tang L, Chen Z, Li J, Cheng J, Wang S | 10.1126/SCIENCE.ABL8615 | 2022-01-26 | Yes | |
AGTR2 | AT2 | Angiotensin | A | Human | X-ray | 7JNI | 7JNI_refined | 3.0 | A | Active | 99 | 82 | - | - | - | - | BRIL | - |
olodanrigan
|
small-molecule | Antagonist | angiotensin-(1-7), angiotensin II, angiotensin III | peptide | No | No | Perryman R, Renziehausen A, Shaye H, Kostagianni AD, Tsiailanis AD, Thorne T, Chatziathanasiadou MV, Sivolapenko GB, El Mubarak MA, Han GW, Zarzycka B, Katritch V, Lebon G, Lo Nigro C, Lattanzio L, Morse SV, Choi JJ, O'Neill K, Kanaki Z, Klinakis A, Crook T, Cherezov V, Tzakos AG, Syed N | 10.1073/PNAS.2116289119 | 2022-02-09 | Yes | |
CCR1 | CCR1 | Chemokine | A | Human | Cryo-EM | 7VL9 | - | 2.6 | R | Active | 100 | 85 | Gi/o | αi1 | - | 62 | - | scFv16 |
CCL15(26-92)
|
peptide | Agonist | CCL8, CCL13, CCL14, CCL16, CCL5, CCL7, CCL4, CCL23, CCL15, CCL3 | peptide | No | No | Shao Z, Shen Q, Yao B, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Ma H, Chen ZH, Xu HE, Ying S, Zhang Y, Shen H | 10.1038/S41589-021-00918-Z | 2022-03-23 | Yes | |
AGRG2 | ADGRG2 | ADGRG | B2 | Mouse | Cryo-EM | 7WUI | - | 3.1 | R | Active | - | 24 | Gs | αs | Mini-Gs | 58 | - | - |
IP15
|
peptide | Agonist | - | - | No | No | Xiao P, Guo S, Wen X, He QT, Lin H, Huang SM, Gou L, Zhang C, Yang Z, Zhong YN, Yang CC, Li Y, Gong Z, Tao XN, Yang ZS, Lu Y, Li SL, He JY, Wang C, Zhang L, Kong L, Sun JP, Yu X | 10.1038/S41586-022-04590-8 | 2022-04-27 | Yes | |
DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7F23 | - | 3.6 | F | Active | 100 | 62 | Gs | αs | - | 60 | - | Nanobody-35 |
dopamine
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, 5-hydroxytryptamine, dopamine | small-molecule | No | No | Teng X, Chen S, Wang Q, Chen Z, Wang X, Huang N, Zheng S | 10.1126/SCIADV.ABO4158 | 2022-06-15 | Yes | |
5HT4R | 5-HT4 | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7XTA | 7XTA_refined | 3.2 | R | Active | 100 | 73 | Gi/o | αi1 | - | 62 | BRIL | scFv16 |
5-hydroxytryptamine
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Huang S, Xu P, Shen DD, Simon IA, Mao C, Tan Y, Zhang H, Harpsoe K, Li H, Zhang Y, You C, Yu X, Jiang Y, Zhang Y, Gloriam DE, Xu HE | 10.1016/J.MOLCEL.2022.05.031 | 2022-07-27 | Yes | |
SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7XAU | - | 3.0 | A | Active | 100 | 76 | Gi/o | αi1 | - | 63 | - | scFv16 |
Octreotide
|
peptide | Agonist | SRIF-14, CST-17, cortistatin-14, SRIF-28 | peptide | No | No | Bo Q, Yang F, Li Y, Meng X, Zhang H, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C | 10.1038/S41421-022-00405-2 | 2022-08-31 | Yes | |
PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 7VVN | 7VVN_refined | 3.8 | R | Active | 100 | 51 | Gs | αs | - | 58 | - | Nanobody-35 |
teriparatide
|
peptide | Agonist | PTH, PTHrP-(1-36), TIP39, PTHrP | peptide | No | No | Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O | 10.1016/J.MOLCEL.2022.07.003 | 2022-08-03 | Yes | |
OPRM | μ | Opioid | A | Mouse | Cryo-EM | 7T2H | - | 3.2 | D | Active | 100 | 71 | Gi/o | αi1 | - | 61 | - | scFv16 |
LOFENTANIL
|
small-molecule | Agonist | - | - | No | No | Qu Q, Huang W, Aydin D, Paggi JM, Seven AB, Wang H, Chakraborty S, Che T, DiBerto JF, Robertson MJ, Inoue A, Suomivuori CM, Roth BL, Majumdar S, Dror RO, Kobilka BK, Skiniotis G | 10.1038/S41589-022-01208-Y | 2022-12-07 | Yes | |
AGRL3 | ADGRL3 | ADGRL | B2 | Mouse | Cryo-EM | 7WYB | - | 3.0 | R | Active | - | 17 | Gi/o | αi1 | - | 64 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Qian Y, Ma Z, Liu C, Li X, Zhu X, Wang N, Xu Z, Xia R, Liang J, Duan Y, Yin H, Xiong Y, Zhang A, Guo C, Chen Z, Huang Z, He Y | 10.1016/J.MOLCEL.2022.10.009 | 2022-10-26 | Yes | |
LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | Cryo-EM | 7YU7 | - | 3.8 | R | Active | 100 | 80 | Gi/o | αi1 | - | 63 | - | scFv16 |
[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate
|
small-molecule | Agonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | Akasaka H, Tanaka T, Sano FK, Matsuzaki Y, Shihoya W, Nureki O | 10.1038/S41467-022-33121-2 | 2022-10-05 | Yes | |
PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 8HA0 | - | 2.6 | R | Active | 100 | 61 | Gs | αs | - | 60 | - | Nanobody-35 |
teriparatide
|
peptide | Agonist | PTH, PTHrP-(1-36), TIP39, PTHrP | peptide | No | No | Zhao LH, Yuan QN, Dai AT, He XH, Chen CW, Zhang C, Xu YW, Zhou Y, Wang MW, Yang DH, Xu HE | 10.1038/S41401-022-01032-Z | 2022-12-21 | Yes | |
AA2BR | A2B | Adenosine | A | Human | Cryo-EM | 8HDP | - | 3.2 | R | Active | 100 | 84 | Gs | αs | Mini-Gs | 60 | - | Nanobody-35 |
adenosine
|
small-molecule | Agonist | adenosine | small-molecule | No | No | - | - | 2023-01-18 | Yes | |
NMUR2 | NMU2 | Neuromedin U | A | Human | Cryo-EM | 7XK8 | 7XK8_refined | 3.3 | R | Active | 100 | 68 | Gi/o | αi1 | - | 64 | - | - |
Neuromedin U-25 (human)
|
peptide | Agonist | neuromedin U-25, neuromedin U-23, neuromedin S-33, neuromedin S-36 | peptide | No | No | Zhao W, Zhang W, Wang M, Lu M, Chen S, Tang T, Schnapp G, Wagner H, Brennauer A, Yi C, Chu X, Han S, Wu B, Zhao Q | 10.1038/S41467-022-34814-4 | 2023-02-22 | Yes | |
OPRK | κ | Opioid | A | Human | Cryo-EM | 8DZQ | 8DZQ_refined | 2.8 | A | Active | 100 | 72 | Gi/o | αo | - | 61 | - | scFv16 |
SALVINORIN B METHOXYMETHYL ETHER
|
small-molecule | Agonist | dynorphin A-(1-8), β-neoendorphin, big dynorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, β-endorphin, dynorphin A-(1-13), dynorphin B, α-neoendorphin | peptide | No | No | Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T | 10.1038/S41586-023-06030-7 | 2023-05-03 | Yes | |
CNR1 | CB1 | Cannabinoid | A | Human | Cryo-EM | 8GHV | 8GHV_refined | 2.8 | D | Active | 100 | 59 | Gi/o | αi1 | - | 62 | - | scFv16 |
CHEMBL4208628
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Krishna Kumar K, Robertson MJ, Thadhani E, Wang H, Suomivuori CM, Powers AS, Ji L, Nikas SP, Dror RO, Inoue A, Makriyannis A, Skiniotis G, Kobilka B | 10.1038/S41467-023-37864-4 | 2023-05-24 | Yes | |
PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 8GW8 | - | 2.9 | R | Active | 100 | 37 | Gs | αs | - | 58 | - | Nanobody-35 |
PCO371
|
small-molecule | Agonist | PTH, PTHrP-(1-36), TIP39, PTHrP | peptide | No | No | Kobayashi K, Kawakami K, Kusakizako T, Tomita A, Nishimura M, Sawada K, Okamoto HH, Hiratsuka S, Nakamura G, Kuwabara R, Noda H, Muramatsu H, Shimizu M, Taguchi T, Inoue A, Murata T, Nureki O | 10.1038/S41586-023-06169-3 | 2023-06-14 | Yes | |
GPR84 | GPR84 | A orphans | A | Human | Cryo-EM | 8J1A | - | 3.2 | R | Active | 100 | 73 | Gi/o | αi1 | - | 62 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Liu H, Zhang Q, He X, Jiang M, Wang S, Yan X, Cheng X, Liu Y, Nan FJ, Xu HE, Xie X, Yin W | 10.1038/S41467-023-38985-6 | 2023-06-21 | Yes | |
GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 8JD4 | - | 2.9 | 2 | Active | - | 84 | - | - | - | - | - | - |
L-glutamic acid
|
small-molecule | Agonist | L-glutamic acid | small-molecule | No | No | Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B | 10.1038/S41422-023-00830-2 | 2023-06-21 | Yes | |
AA2AR | A2A | Adenosine | A | Human | Cryo-EM | 6GDG | 6GDG_refined | 4.1 | A | Active | 100 | 64 | Gs | αs | - | 57 | TrxA | Nanobody-35 |
NECA
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Garcia-Nafria J, Lee Y, Bai X, Carpenter B, Tate CG | 10.7554/ELIFE.35946 | 2018-05-16 | Yes | |
PE2R3 | EP3 | Prostanoid | A | Human | X-ray | 6M9T | 6M9T_refined | 2.5 | A | Active | 91 | 70 | - | - | - | - | T4-Lysozyme | - |
Misoprostol-FA
|
small-molecule | Agonist | PGE2, PGF2α, thromboxane A2, PGI2, PGE1, PGD2 | small-molecule | No | No | - | 10.1038/S41589-018-0160-Y | 2018-12-05 | Yes | |
MTR1B | MT2 | Melatonin | A | Human | X-ray | 6ME9 | 6ME9_refined | 3.3 | B | Inactive | 1 | 79 | - | - | - | - | Rubredoxin | - |
ramelteon
|
small-molecule | Agonist | melatonin | small-molecule | No | No | - | - | 2019-04-24 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 6PRZ | 6PRZ_refined | 2.8 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
CHEMBL1160734
|
small-molecule | Antagonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | - | 10.1107/S2052252519013137 | 2019-11-13 | Yes | |
CLTR2 | CysLT2 | Leukotriene | A | Human | X-ray | 6RZ9 | 6RZ9_refined | 2.7 | A | Intermediate | 44 | 81 | - | - | - | - | BRIL | - |
ONO-2770372
|
small-molecule | Antagonist | LTE4, LTD4, LTC4 | small-molecule | No | No | Gusach A, Luginina A, Marin E, Brouillette RL, Besserer-Offroy E, Longpre JM, Ishchenko A, Popov P, Patel N, Fujimoto T, Maruyama T, Stauch B, Ergasheva M, Romanovskaia D, Stepko A, Kovalev K, Shevtsov M, Gordeliy V, Han GW, Katritch V, Borshchevskiy V, Sarret P, Mishin A, Cherezov V | 10.1038/S41467-019-13348-2 | 2019-12-11 | Yes | |
AGTR1 | AT1 | Angiotensin | A | Human | X-ray | 6OS1 | - | 2.8 | A | Active | 95 | 85 | - | - | - | - | BRIL | Nanobody-Nb.AT110i1_le |
TRV023
|
peptide | Agonist | angiotensin A, angiotensin III, angiotensin IV, angiotensin II | peptide | No | No | Wingler LM, Skiba MA, McMahon C, Staus DP, Kleinhenz ALW, Suomivuori CM, Latorraca NR, Dror RO, Lefkowitz RJ, Kruse AC | 10.1126/SCIENCE.AAY9813 | 2020-02-19 | Yes | |
GABR2 | GABAB2 | GABAB | C | Human | Cryo-EM | 6UOA | - | 6.3 | B | Intermediate | - | 71 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | - | 2020-06-10 | Yes | |
SCTR | secretin | Glucagon | B1 | Human | Cryo-EM | 6WZG | 6WZG_refined | 2.3 | R | Active | 100 | 86 | Gs | αs | - | 61 | - | Nanobody-35 |
SECRETIN
|
protein | Agonist | secretin, VIP | peptide | No | No | Dong M, Deganutti G, Piper SJ, Liang YL, Khoshouei M, Belousoff MJ, Harikumar KG, Reynolds CA, Glukhova A, Furness SGB, Christopoulos A, Danev R, Wootten D, Sexton PM, Miller LJ | 10.1038/S41467-020-17791-4 | 2020-08-12 | Yes | |
STE2 | STE2 | STE2 | D1 | strain ATCC 204508 / S288c | Cryo-EM | 7AD3 | - | 3.5 | A | Active | - | 69 | GPa1 family | αPa1 | Two alpha subunits bound to STE2 dimer | 46 | - | - |
Alpha-factor mating pheromone
|
peptide | Agonist | - | - | No | No | Velazhahan V, Ma N, Pandy-Szekeres G, Kooistra AJ, Lee Y, Gloriam DE, Vaidehi N, Tate CG | 10.1038/S41586-020-2994-1 | 2020-12-09 | Yes | |
DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7CKZ | - | 3.1 | R | Active | 100 | 62 | Gs | αs | - | 60 | - | Nanobody-35 |
dopamine
mevidalen |
small-molecule small-molecule |
Agonist PAM |
noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, 5-hydroxytryptamine, dopamine | small-molecule | No | No | Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z | 10.1016/J.CELL.2021.01.028 | 2021-03-03 | Yes | |
GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 7E9G | - | 3.5 | R | Intermediate | - | 88 | Gi/o | αi1 | - | 63 | - | scFv16 |
eglumegad
JNJ-40411813 |
small-molecule small-molecule |
Agonist PAM |
L-glutamic acid | small-molecule | No | No | - | - | 2021-06-23 | Yes | |
GRM1 | mGlu1 | Metabotropic glutamate | C | Human | Cryo-EM | 7DGE | 7DGE_refined | 3.7 | A | Intermediate | - | 66 | - | - | - | - | - | Nanobody-43 |
quisqualate
|
small-molecule | Agonist | L-glutamic acid | small-molecule | No | No | Zhang J, Qu L, Wu L, Tang X, Luo F, Xu W, Xu Y, Liu ZJ, Hua T | 10.1007/S13238-020-00808-5 | 2021-09-22 | Yes | |
MRGX4 | MRGPRX4 | A orphans | A | Human | Cryo-EM | 7S8P | 7S8P_refined | 2.6 | R | Active | 100 | 77 | Gq/11 | αq | Gq-Gs chimera | 57 | BRIL | scFv16 |
N-[(1r,3R,5S,7R)-3,5-dimethyltricyclo[3.3.1.1~3,7~]decane-1-carbonyl]-D-phenylalanine
|
small-molecule | Agonist | - | - | No | No | Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL | 10.1038/S41586-021-04126-6 | 2021-11-17 | Yes | |
MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7VV6 | 7VV6_refined | 3.3 | R | Active | 97 | 82 | - | - | - | - | - | - |
compound 48/80
|
small-molecule | Agonist | PAMP-20 | peptide | No | No | Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP | 10.1038/S41586-021-04077-Y | 2021-12-01 | Yes | |
5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | X-ray | 7WC7 | 7WC7_refined | 2.6 | A | Inactive | 1 | 59 | - | - | - | - | BRIL | - |
lisuride
|
small-molecule | Agonist | 5-hydroxytryptamine, tryptamine | small-molecule | No | No | Cao D, Yu J, Wang H, Luo Z, Liu X, He L, Qi J, Fan L, Tang L, Chen Z, Li J, Cheng J, Wang S | 10.1126/SCIENCE.ABL8615 | 2022-01-26 | Yes | |
MSHR | MC1 | Melanocortin | A | Human | Cryo-EM | 7F4H | - | 2.7 | R | Active | 100 | 84 | Gs | αs | - | 59 | - | Nanobody-35 scFv16 |
CHEMBL407070
|
protein | Agonist | γ-MSH, ACTH, β-MSH, α-MSH | peptide | No | No | Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE | 10.1038/S41422-021-00557-Y | 2021-09-08 | Yes | |
CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 7TZF | - | 2.4 | R | Active | 100 | 77 | Gs | αs | - | 59 | - | Nanobody-35 RAMP3 |
amylin peptide
|
peptide | Agonist | β-CGRP, α-CGRP, calcitonin, calcitonin (salmon), amylin, adrenomedullin, adrenomedullin 2/intermedin | peptide | No | No | Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | Yes | |
NMUR1 | NMU1 | Neuromedin U | A | Human | Cryo-EM | 7W53 | - | 3.2 | R | Active | 100 | 62 | Gq/11 | αq | - | 54 | - | scFv16 |
Neuromedin U-25 (human)
|
peptide | Agonist | neuromedin U-25, neuromedin U-23, neuromedin S-33, neuromedin S-36 | peptide | No | No | You C, Zhang Y, Xu P, Huang S, Yin W, Eric Xu H, Jiang Y | 10.1038/S41467-022-29683-W | 2022-04-20 | Yes | |
APJ | apelin | Apelin | A | Human | X-ray | 7SUS | 7SUS_refined | 2.7 | A | Inactive | 4 | 76 | - | - | - | - | Rubredoxin | - |
(1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide
|
small-molecule | Agonist | apelin-13, apelin-17, apelin-36, Elabela/Toddler-21, [Pyr1]apelin-13, Elabela/Toddler-11, apelin receptor early endogenous ligand, Elabela/Toddler-32 | peptide | No | No | Yue Y, Liu L, Wu LJ, Wu Y, Wang L, Li F, Liu J, Han GW, Chen B, Lin X, Brouillette RL, Breault E, Longpre JM, Shi S, Lei H, Sarret P, Stevens RC, Hanson MA, Xu F | 10.1038/S41594-022-00797-5 | 2022-07-27 | Yes | |
ACKR3 | ACKR3 | Chemokine | A | Human | Cryo-EM | 7SK9 | 7SK9_refined | 3.7 | A | Active | 95 | 78 | - | - | - | - | - | CID24 Fab heavy chain CID24 Fab light chain |
(1R)-4-[7-(3-carboxypropoxy)-6-methylquinolin-8-yl]-1-{[2-(4-hydroxypiperidin-1-yl)-1,3-thiazol-4-yl]methyl}-1,4-diazepan-1-ium
|
small-molecule | Agonist (partial) | CXCL12α, CXCL11 | peptide | No | No | Yen YC, Schafer CT, Gustavsson M, Eberle SA, Dominik PK, Deneka D, Zhang P, Schall TJ, Kossiakoff AA, Tesmer JJG, Handel TM | 10.1126/SCIADV.ABN8063 | 2022-07-27 | Yes | |
CCR3 | CCR3 | Chemokine | A | Human | Cryo-EM | 7X9Y | 7X9Y_refined | 3.1 | R | Active | 100 | 83 | Gi/o | αi1 | - | 62 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | CCL2, CCL8, CCL11, CXCL9, CCL13, CCL24, CCL5, CCL7, CXCL10, CXCL11, CCL26, CCL15, CCL28 | peptide | No | No | Shao Z, Tan Y, Shen Q, Hou L, Yao B, Qin J, Xu P, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Chen ZH, Jiang Y, Xu HE, Ying S, Ma H, Zhang Y, Shen H | 10.1038/S41421-022-00403-4 | 2022-08-24 | Yes | |
GP119 | GPR119 | GPR18, GPR55 and GPR119 | A | Human | Cryo-EM | 7XZ5 | - | 3.1 | R | Active | 100 | 87 | Gs | αs | - | 60 | BRIL | Nanobody-35 |
(4R,7R,18E)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide
|
small-molecule | Agonist | N-oleoylethanolamide, SEA, anandamide, N-palmitoylethanolamine | small-molecule | No | No | Xu P, Huang S, Guo S, Yun Y, Cheng X, He X, Cai P, Lan Y, Zhou H, Jiang H, Jiang Y, Xie X, Xu HE | 10.1038/S41594-022-00816-5 | 2022-08-24 | Yes | |
AGRF1 | ADGRF1 | ADGRF | B2 | Human | Cryo-EM | 7WY0 | - | 2.8 | R | Active | - | 30 | G12/13 | α13 | - | 55 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Zhu X, Qian Y, Li X, Xu Z, Xia R, Wang N, Liang J, Yin H, Zhang A, Guo C, Wang G, He Y | 10.1038/S41467-022-33173-4 | 2022-09-28 | Yes | |
TRFR | TRH1 | Thyrotropin-releasing hormone | A | Human | Cryo-EM | 7XW9 | - | 2.7 | R | Active | 100 | 72 | Gq/11 | αq | - | 58 | - | scFv16 |
TRH
|
peptide | Agonist | TRH | peptide | No | No | - | - | 2022-12-28 | Yes | |
ACM3 | M3 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 8E9Y | - | 2.8 | A | Active | 100 | 47 | Gq/11 | αq | Mini-Gq | 56 | - | scFv16 |
Clozapine N-oxide
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | Zhang S, Gumpper RH, Huang XP, Liu Y, Krumm BE, Cao C, Fay JF, Roth BL | 10.1038/S41586-022-05489-0 | 2022-11-30 | Yes | |
RL3R2 | RXFP4 | Relaxin family peptide | A | Human | Cryo-EM | 7YK6 | 7YK6_refined | 3.0 | R | Active | 100 | 76 | Gi/o | αi2 | - | 59 | - | scFv16 |
CHEMBL4522365
|
small-molecule | Agonist | relaxin-3, INSL5, relaxin-3 (B chain) | peptide | No | No | Chen Y, Zhou Q, Wang J, Xu Y, Wang Y, Yan J, Wang Y, Zhu Q, Zhao F, Li C, Chen CW, Cai X, Bathgate RAD, Shen C, Eric Xu H, Yang D, Liu H, Wang MW | 10.1038/S41467-023-36182-Z | 2023-03-01 | Yes | |
FFAR4 | FFA4 | Free fatty acid | A | Human | Cryo-EM | 8G59 | 8G59_refined | 2.6 | R | Active | 100 | 78 | Gq/11 | αq | - | 61 | - | - |
TUG-891
|
small-molecule | Agonist | linoleic acid, oleic acid, α-linolenic acid, myristic acid | small-molecule | No | No | - | 10.1126/SCIENCE.ADD6220 | 2023-03-08 | Yes | |
ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 7T90 | 7T90_refined | 3.3 | A | Active | 100 | 59 | Gi/o | αo | - | 62 | - | scFv16 |
acetylcholine
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | - | - | 2023-01-25 | Yes | |
OPRK | κ | Opioid | A | Human | Cryo-EM | 8DZR | - | 2.6 | A | Active | 100 | 68 | Gi/o | αgust | - | 58 | - | scFv16 |
CHEMBL277863
|
small-molecule | Agonist | dynorphin A-(1-8), β-neoendorphin, big dynorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, β-endorphin, dynorphin A-(1-13), dynorphin B, α-neoendorphin | peptide | No | No | Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T | 10.1038/S41586-023-06030-7 | 2023-05-03 | Yes | |
C5AR1 | C5a1 | Complement peptide | A | Human | Cryo-EM | 7Y64 | - | 2.9 | D | Active | 100 | 84 | Gi/o | αi1 | - | 63 | - | scFv16 |
C5a anaphylatoxin
|
peptide | Agonist | C3a, C5a, ribosomal protein S19, C5a des-Arg | peptide | No | No | Feng Y, Zhao C, Deng Y, Wang H, Ma L, Liu S, Tian X, Wang B, Bin Y, Chen P, Yan W, Fu P, Shao Z | 10.1038/S41422-023-00779-2 | 2023-03-01 | Yes | |
FFAR4 | FFA4 | Free fatty acid | A | Human | Cryo-EM | 8H4L | - | 3.1 | R | Active | 100 | 84 | Gq/11 | αq | - | 60 | - | Nanobody-35 |
docosahexaenoic acid
|
small-molecule | Agonist | linoleic acid, oleic acid, α-linolenic acid, myristic acid | small-molecule | No | No | Yin H, Inoue A, Ma Z, Zhu X, Xia R, Xu Z, Wang N, Duan Y, Zhang A, Guo C, He Y | 10.1038/S41422-023-00835-X | 2023-06-21 | Yes | |
GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 8JD0 | - | 3.3 | 2 | Inactive | - | 88 | - | - | - | - | - | - |
L-glutamic acid
CHEMBL3894759 |
small-molecule small-molecule |
Agonist NAM |
L-glutamic acid | small-molecule | No | No | Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B | 10.1038/S41422-023-00830-2 | 2023-06-21 | Yes | |
OPRK | κ | Opioid | A | Human | X-ray | 7YIT | - | 3.3 | A | Active | 100 | 74 | - | - | - | - | BRIL | Nanobody-39 |
nalfurafine
|
small-molecule | Agonist | dynorphin A-(1-8), β-neoendorphin, big dynorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, β-endorphin, dynorphin A-(1-13), dynorphin B, α-neoendorphin | peptide | No | No | El Daibani A, Paggi JM, Kim K, Laloudakis YD, Popov P, Bernhard SM, Krumm BE, Olsen RHJ, Diberto J, Carroll FI, Katritch V, Wunsch B, Dror RO, Che T | 10.1038/S41467-023-37041-7 | 2023-04-12 | Yes | |
OPRK | κ | Opioid | A | Human | Cryo-EM | 8DZP | - | 2.7 | A | Active | 100 | 74 | Gi/o | αi1 | - | 60 | - | scFv16 |
SALVINORIN B METHOXYMETHYL ETHER
|
small-molecule | Agonist | dynorphin A-(1-8), β-neoendorphin, big dynorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, β-endorphin, dynorphin A-(1-13), dynorphin B, α-neoendorphin | peptide | No | No | - | - | 2023-05-03 | Yes | |
DRD5 | D5 | Dopamine | A | Human | Cryo-EM | 8IRV | 8IRV_refined | 3.1 | R | Active | 100 | 58 | Gs | αs | - | 60 | BRIL | - |
rotigotine
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, 5-hydroxytryptamine, dopamine | small-molecule | No | No | Xu P, Huang S, Krumm BE, Zhuang Y, Mao C, Zhang Y, Wang Y, Huang XP, Liu YF, He X, Li H, Yin W, Jiang Y, Zhang Y, Roth BL, Xu HE | 10.1038/S41422-023-00808-0 | 2023-06-07 | Yes | |
ADA1A | α1A | Adrenoceptors | A | Human | Cryo-EM | 7YMH | 7YMH_refined | 3.5 | A | Active | 100 | 58 | Gq/11 | αq | Mini-Gq | 51 | - | Nanobody-29 |
Noradrenaline
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | - | - | 2023-07-05 | Yes | |
DRD4 | D4 | Dopamine | A | Human | Cryo-EM | 8IRU | - | 3.2 | R | Active | 100 | 64 | Gi/o | αi1 | - | 60 | - | scFv16 |
rotigotine
|
small-molecule | Agonist | dopamine | small-molecule | No | No | Xu P, Huang S, Krumm BE, Zhuang Y, Mao C, Zhang Y, Wang Y, Huang XP, Liu YF, He X, Li H, Yin W, Jiang Y, Zhang Y, Roth BL, Xu HE | 10.1038/S41422-023-00808-0 | 2023-06-21 | Yes | |
5HT6R | 5-HT6 | 5-Hydroxytryptamine | A | Human | Cryo-EM | 8JLZ | - | 3.1 | R | Active | 100 | 61 | Gs | αs | - | 58 | - | Nanobody-35 |
CHEMBL365751
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Pei Y, Wen X, Guo SC, Yang ZS, Zhang R, Xiao P, Sun JP | 10.1016/J.BBRC.2023.05.126 | 2023-06-28 | Yes | |
ADA1A | α1A | Adrenoceptors | A | Human | Cryo-EM | 8THK | - | 2.6 | R | Active | 100 | 52 | Gq/11 | αq | - | 55 | T4-Lysozyme | scFv16 |
CHEMBL133451
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Su M, Wang J, Xiang G, Do HN, Levitz J, Miao Y, Huang XY | 10.1038/S41467-023-40524-2 | 2023-08-16 | Yes | |
GPR20 | GPR20 | A orphans | A | Human | Cryo-EM | 8HS2 | 8HS2_refined | 3.1 | R | Active | 65 | 80 | - | - | - | - | BRIL | Antibody fab fragment heavy chain Antibody fab fragment light chain |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | 10.1038/S41421-023-00520-8 | 2023-03-08 | Yes | |
GRPR | BB2 | Bombesin | A | Human | X-ray | 7W41 | 7W41_refined | 3.0 | A | Inactive | 4 | 75 | - | - | - | - | GlgA glycogen synthase | - |
PD 176252
|
small-molecule | Antagonist | neuromedin B, gastrin releasing peptide(14-27) (human), gastrin-releasing peptide, neuromedin C, GRP-(18-27) | peptide | No | No | Peng S, Zhan Y, Zhang D, Ren L, Chen A, Chen ZF, Zhang H | 10.1073/PNAS.2216230120 | 2023-02-22 | Yes | |
ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 7XKA | - | 3.1 | A | Active | 99 | 69 | - | - | - | - | T4-Lysozyme | Antibody fragment |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline, Zn2+ | small-molecule | No | No | - | - | 2023-04-26 | Yes | |
GPR12 | GPR12 | A orphans | A | Human | Cryo-EM | 7Y3G | 7Y3G_refined | 2.8 | R | Active | 100 | 78 | Gs | αs | - | 56 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | sphingosine 1-phosphate | small-molecule | No | No | Li H, Zhang J, Yu Y, Luo F, Wu L, Liu J, Chen N, Liu Z, Hua T | 10.1016/J.SCIB.2022.12.023 | 2023-06-07 | Yes | |
C3AR | C3a | Complement peptide | A | Human | Cryo-EM | 8IA8 | - | 2.9 | A | Active | 100 | 59 | Gi/o | αi1 | - | 61 | - | scFv16 |
ALA-SER-LYS-LEU-GLY-LEU-ALA-ARG
|
peptide | Agonist | C3a, C5a | peptide | No | No | - | - | 2023-05-24 | Yes | |
ADA1A | α1A | Adrenoceptors | A | Human | Cryo-EM | 7YM8 | 7YM8_refined | 2.9 | A | Active | 100 | 58 | Gq/11 | αq | Mini-Gq | 46 | - | Nanobody-29 |
oxymetazoline
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Toyoda Y, Zhu A, Kong F, Shan S, Zhao J, Wang N, Sun X, Zhang L, Yan C, Kobilka BK, Liu X | 10.1038/S41467-023-39310-X | 2023-07-05 | Yes | |
DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 8IRR | - | 3.2 | R | Active | 100 | 63 | Gs | αs | Mini-Gs | 57 | - | Nanobody-35 |
rotigotine
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, 5-hydroxytryptamine, dopamine | small-molecule | No | No | Xu P, Huang S, Krumm BE, Zhuang Y, Mao C, Zhang Y, Wang Y, Huang XP, Liu YF, He X, Li H, Yin W, Jiang Y, Zhang Y, Roth BL, Xu HE | 10.1038/S41422-023-00808-0 | 2023-06-21 | Yes | |
PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 8JR9 | - | 2.6 | R | Active | 100 | 43 | Gs | αs | - | 59 | - | Nanobody-35 |
PCO371
|
small-molecule | Agonist | PTH, PTHrP-(1-36), TIP39, PTHrP | peptide | No | No | Zhao LH, He Q, Yuan Q, Gu Y, He X, Shan H, Li J, Wang K, Li Y, Hu W, Wu K, Shen J, Xu HE | 10.1038/S41586-023-06467-W | 2023-08-02 | Yes | |
FFAR4 | FFA4 | Free fatty acid | A | Human | Cryo-EM | 8ID8 | - | 3.0 | R | Active | 100 | 81 | Gi/o | αi1 | - | 64 | - | scFv16 |
TUG-891
|
small-molecule | Agonist | linoleic acid, oleic acid, α-linolenic acid, myristic acid | small-molecule | No | No | - | 10.1126/SCIENCE.ADD6220 | 2023-03-15 | Yes | |
P2Y12 | P2Y12 | P2Y | A | Human | Cryo-EM | 7XXI | 7XXI_refined | 3.0 | A | Active | 100 | 86 | Gi/o | αi2 | - | 61 | - | - |
2MeSADP
|
small-molecule | Agonist | ADP, ATP | small-molecule | No | No | - | - | 2023-06-07 | Yes | |
FFAR1 | FFA1 | Free fatty acid | A | Human | Cryo-EM | 8EJC | - | 3.0 | R | Active | 100 | 90 | Gq/11 | αq | - | 60 | - | scFv16 |
fasiglifam
|
small-molecule | Agonist | oleic acid, docosahexaenoic acid, α-linolenic acid, myristic acid | small-molecule | No | No | Kumari P, Inoue A, Chapman K, Lian P, Rosenbaum DM | 10.1073/PNAS.2219569120 | 2023-05-24 | Yes | |
CNR2 | CB2 | Cannabinoid | A | Human | Cryo-EM | 8GUR | 8GUR_refined | 2.8 | R | Active | 100 | 78 | Gi/o | αi1 | - | 64 | - | scFv16 |
CP55940
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Li X, Chang H, Bouma J, de Paus LV, Mukhopadhyay P, Paloczi J, Mustafa M, van der Horst C, Kumar SS, Wu L, Yu Y, van den Berg RJBHN, Janssen APA, Lichtman A, Liu ZJ, Pacher P, van der Stelt M, Heitman LH, Hua T | 10.1038/S41467-023-37112-9 | 2023-05-10 | Yes | |
AA2AR | A2A | Adenosine | A | Human | X-ray | 8C9W | - | 2.1 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
AB928
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Claff T, Schlegel JG, Voss JH, Vaassen VJ, Weisse RH, Cheng RKY, Markovic-Mueller S, Bucher D, Strater N, Muller CE | 10.1038/S42004-023-00894-6 | 2023-07-12 | Yes | |
GPR84 | GPR84 | A orphans | A | Human | Cryo-EM | 8J19 | - | 3.2 | R | Active | 100 | 71 | Gi/o | αi1 | - | 62 | - | scFv16 |
6-nonylpyridine-2,4-diol
|
small-molecule | Agonist | - | - | No | No | Liu H, Zhang Q, He X, Jiang M, Wang S, Yan X, Cheng X, Liu Y, Nan FJ, Xu HE, Xie X, Yin W | 10.1038/S41467-023-38985-6 | 2023-06-21 | Yes | |
NTR1 | NTS1 | Neurotensin | A | Human | Cryo-EM | 8JPC | - | 3.1 | R | Active | 100 | 71 | Gq/11 | αq | GRK2 bound | 88 | - | GRK2 |
JMV431
CHEMBL4576388 |
peptide small-molecule |
Agonist PAM |
neuromedin N, large neurotensin, neurotensin, large neuromedin N | peptide | No | No | Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE | 10.1038/S41586-023-06395-9 | 2023-08-09 | Yes |
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