Gi3 - A2B receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 T 216 5x72 G.S6 I 319 G.S6.01
Hydrophobic TM5 Q 212 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL2 K 114 34x54 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 K 114 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic TM3 I 107 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 107 3x54 G.H5 L 348 G.H5.20
Polar TM5 T 216 5x72 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 T 216 5x72 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 T 216 5x72 G.h4s6 E 318 G.h4s6.12
Ionic TM5 R 215 5x71 G.H5 D 341 G.H5.13
Polar TM5 R 215 5x71 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 215 5x71 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 215 5x71 G.H5 D 341 G.H5.13
Polar TM4 G 119 4x39 G.HN R 24 G.HN.48
Hydrophobic TM4 G 119 4x39 G.HN R 24 G.HN.48
Van-der-waals TM4 G 119 4x39 G.HN R 24 G.HN.48
Hydrophobic ICL3 M 219 - G.H4 E 308 G.H4.16
Van-der-waals ICL3 M 219 - G.H4 E 308 G.H4.16
Hydrophobic TM5 A 209 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 107 3x54 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 110 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 110 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL3 M 219 - G.H4 Q 304 G.H4.12
Van-der-waals ICL3 M 219 - G.H4 Q 304 G.H4.12
Hydrophobic ICL2 P 110 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM4 R 123 4x43 G.HN R 24 G.HN.48
Hydrophobic TM5 I 205 5x61 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 111 34x51 G.S2 F 191 G.S2.08
Polar TM5 Q 212 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 Q 212 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 Q 212 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL2 L 111 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 L 111 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM3 I 107 3x54 G.H5 L 353 G.H5.25
Ionic ICL2 R 112 34x52 G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 112 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 112 34x52 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 112 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 K 114 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 K 114 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 L 236 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 236 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 I 239 6x40 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 111 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 111 34x51 G.S3 L 194 G.S3.01
Polar TM3 R 103 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 103 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 103 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 S 115 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 S 115 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 P 110 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM7 R 293 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM5 I 205 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 205 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL3 M 219 - G.H4 C 305 G.H4.13
Van-der-waals ICL3 M 219 - G.H4 C 305 G.H4.13
Hydrophobic ICL2 L 111 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 111 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL2 L 111 34x51 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 L 111 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM5 L 213 5x69 G.H5 Y 354 G.H5.26
Van-der-waals TM5 L 213 5x69 G.H5 Y 354 G.H5.26
Hydrophobic ICL3 M 219 - G.H4 A 301 G.H4.08
Van-der-waals ICL3 M 219 - G.H4 A 301 G.H4.08
Polar TM3 A 106 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 106 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 106 3x53 G.H5 N 347 G.H5.19
Polar TM6 R 228 6x29 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM5 T 216 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 T 216 5x72 G.S6 Y 320 G.S6.02
Polar TM4 G 119 4x39 G.HN E 28 G.HN.52
Hydrophobic TM4 G 119 4x39 G.HN E 28 G.HN.52
Van-der-waals TM4 G 119 4x39 G.HN E 28 G.HN.52
Polar TM2 Y 44 2x41 G.HN R 24 G.HN.48
Hydrophobic TM2 Y 44 2x41 G.HN R 24 G.HN.48
Van-der-waals TM2 Y 44 2x41 G.HN R 24 G.HN.48
Polar H8 N 294 8x47 G.H5 E 350 G.H5.22
Van-der-waals H8 N 294 8x47 G.H5 E 350 G.H5.22
Ionic H8 R 295 8x48 G.h3s5 E 261 G.h3s5.02
Polar H8 R 295 8x48 G.h3s5 E 261 G.h3s5.02
Hydrophobic TM5 V 208 5x64 G.H5 I 344 G.H5.16
Polar ICL2 R 112 34x52 G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 R 112 34x52 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 R 112 34x52 G.s2s3 K 192 G.s2s3.01