G12 - ADGRE3 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 17.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 T 389 2x47 G.H5 L 380 G.H5.25
Hydrophobic C-term Q 603 - G.H5 Q 381 G.H5.26
Van-der-waals C-term Q 603 - G.H5 Q 381 G.H5.26
Hydrophobic TM5 L 537 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 L 537 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM3 L 444 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 444 3x54 G.H5 I 378 G.H5.23
Polar ICL2 S 457 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 S 457 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 S 457 - G.hns1 R 55 G.hns1.02
Hydrophobic TM3 A 448 3x58 G.H5 I 378 G.H5.23
Hydrophobic ICL3 T 543 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 T 543 - G.S6 F 347 G.S6.02
Hydrophobic TM6 L 550 6x38 G.H5 L 375 G.H5.20
Polar TM2 N 386 2x44 G.H5 D 377 G.H5.22
Hydrophobic ICL2 L 451 - G.H5 I 370 G.H5.15
Polar ICL2 N 455 - G.hns1 V 54 G.hns1.01
Van-der-waals ICL2 N 455 - G.hns1 V 54 G.hns1.01
Polar TM6 K 553 6x41 G.H5 M 379 G.H5.24
Hydrophobic TM6 K 553 6x41 G.H5 M 379 G.H5.24
Van-der-waals TM6 K 553 6x41 G.H5 M 379 G.H5.24
Hydrophobic ICL1 I 384 12x50 G.H5 L 380 G.H5.25
Polar ICL2 N 455 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 N 455 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 N 455 - G.hns1 R 55 G.hns1.02
Polar ICL3 T 543 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 T 543 - G.H5 Q 372 G.H5.17
Hydrophobic TM2 H 392 2x50 G.H5 L 380 G.H5.25
Van-der-waals TM2 H 392 2x50 G.H5 L 380 G.H5.25
Hydrophobic TM6 L 550 6x38 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 V 454 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 V 454 - G.H5 I 370 G.H5.15
Polar TM2 S 388 2x46 G.H5 D 377 G.H5.22
Polar C-term S 602 - G.H5 L 380 G.H5.25
Hydrophobic C-term S 602 - G.H5 L 380 G.H5.25
Van-der-waals C-term S 602 - G.H5 L 380 G.H5.25
Polar C-term Q 604 - G.H5 Q 381 G.H5.26
Hydrophobic C-term Q 604 - G.H5 Q 381 G.H5.26
Van-der-waals C-term Q 604 - G.H5 Q 381 G.H5.26
Polar ICL2 V 453 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 V 453 - G.H5 N 374 G.H5.19
Polar TM5 S 536 5x67 G.H5 K 367 G.H5.12
Hydrophobic ICL2 V 453 - G.H5 I 370 G.H5.15
Hydrophobic ICL3 T 543 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 T 543 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 V 453 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 L 451 - G.H5 L 375 G.H5.20
Van-der-waals ICL2 L 451 - G.H5 L 375 G.H5.20
Hydrophobic ICL2 V 454 - G.h2s4 T 246 G.h2s4.05
Hydrophobic TM5 L 530 5x61 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 530 5x61 G.H5 L 375 G.H5.20
Hydrophobic ICL2 V 454 - G.S1 V 58 G.S1.02
Van-der-waals ICL2 V 454 - G.S1 V 58 G.S1.02
Hydrophobic ICL3 V 541 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 V 541 - G.S6 F 347 G.S6.02
Hydrophobic TM5 L 537 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 L 537 5x68 G.H5 D 368 G.H5.13
Polar ICL2 L 451 - G.H5 L 371 G.H5.16
Hydrophobic ICL2 L 451 - G.H5 L 371 G.H5.16
Van-der-waals ICL2 L 451 - G.H5 L 371 G.H5.16
Hydrophobic ICL3 I 544 - G.H5 L 375 G.H5.20
Van-der-waals ICL3 I 544 - G.H5 L 375 G.H5.20
Polar ICL2 L 451 - G.H5 N 374 G.H5.19
Hydrophobic ICL2 L 451 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 L 451 - G.H5 N 374 G.H5.19
Hydrophobic TM1 F 378 1x61 G.H5 L 380 G.H5.25
Hydrophobic TM5 L 530 5x61 G.H5 M 379 G.H5.24
Polar ICL3 S 542 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 I 544 - G.H5 L 371 G.H5.16
Polar TM6 K 553 6x41 G.H5 L 380 G.H5.25
Van-der-waals TM6 K 553 6x41 G.H5 L 380 G.H5.25
Hydrophobic ICL3 V 541 - G.H5 A 365 G.H5.10
Hydrophobic TM3 T 447 3x57 G.H5 I 378 G.H5.23
Van-der-waals TM3 T 447 3x57 G.H5 I 378 G.H5.23
Hydrophobic TM7 Y 598 7x57 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 598 7x57 G.H5 L 380 G.H5.25
Hydrophobic TM5 K 533 5x64 G.H5 L 371 G.H5.16
Hydrophobic ICL2 T 452 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 T 452 - G.H5 K 367 G.H5.12
Hydrophobic ICL2 S 458 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 S 458 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL3 V 541 - G.H5 F 361 G.H5.06
Van-der-waals ICL3 V 541 - G.H5 F 361 G.H5.06
Hydrophobic ICL2 L 451 - G.H5 I 378 G.H5.23
Hydrophobic ICL2 T 452 - G.H5 I 370 G.H5.15
Hydrophobic ICL2 T 452 - G.H5 L 371 G.H5.16
Hydrophobic ICL2 V 454 - G.S1 L 57 G.S1.01
Hydrophobic ICL3 I 544 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 I 544 - G.H5 Q 372 G.H5.17
Hydrophobic TM6 L 550 6x38 G.H5 M 379 G.H5.24
Van-der-waals TM6 L 550 6x38 G.H5 M 379 G.H5.24
Polar TM3 N 450 3x60 G.H5 N 374 G.H5.19
Hydrophobic TM6 A 554 6x42 G.H5 M 379 G.H5.24