Gt2 - ADGRE4P complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 89.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.9
PAE mean: 11.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 A 288 - G.S1 T 33 G.S1.01
Hydrophobic ICL3 V 374 - G.S6 H 322 G.S6.04
Van-der-waals ICL3 V 374 - G.S6 H 322 G.S6.04
Hydrophobic ICL3 V 374 - G.H5 D 337 G.H5.09
Hydrophobic ICL3 I 377 - G.H5 F 354 G.H5.26
Polar ICL2 V 287 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 V 287 - G.H5 N 347 G.H5.19
Hydrophobic ICL3 V 374 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 V 374 - G.H5 F 334 G.H5.06
Hydrophobic ICL3 I 377 - G.H5 D 341 G.H5.13
Polar ICL3 N 371 - G.H5 D 337 G.H5.09
Hydrophobic ICL3 N 371 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 N 371 - G.H5 D 337 G.H5.09
Hydrophobic TM5 L 367 5x65 G.H5 I 344 G.H5.16
Polar TM6 K 386 6x41 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 386 6x41 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 386 6x41 G.H5 F 354 G.H5.26
Hydrophobic TM5 L 370 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM5 L 370 5x68 G.H5 T 340 G.H5.12
Polar ICL2 N 289 - G.S1 T 33 G.S1.01
Hydrophobic ICL2 V 287 - G.S3 L 194 G.S3.01
Polar H8 R 440 8x48 G.h4s6 D 315 G.h4s6.09
Hydrophobic H8 R 440 8x48 G.h4s6 D 315 G.h4s6.09
Van-der-waals H8 R 440 8x48 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM3 L 278 3x54 G.H5 L 353 G.H5.25
Hydrophobic ICL2 A 288 - G.S1 V 34 G.S1.02
Van-der-waals ICL2 A 288 - G.S1 V 34 G.S1.02
Hydrophobic ICL2 A 288 - G.H5 I 343 G.H5.15
Polar ICL3 T 376 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 T 376 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 T 376 - G.h4s6 E 318 G.h4s6.12
Polar H8 R 440 8x48 G.h4s6 K 314 G.h4s6.08
Polar TM3 N 284 3x60 G.H5 N 347 G.H5.19
Polar ICL3 T 376 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 T 376 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 T 376 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 I 377 - G.H5 K 345 G.H5.17
Polar ICL2 T 291 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 T 291 - G.H5 D 350 G.H5.22
Van-der-waals ICL2 T 291 - G.H5 D 350 G.H5.22
Hydrophobic TM2 S 222 2x46 G.H5 C 351 G.H5.23
Hydrophobic TM3 T 281 3x57 G.H5 C 351 G.H5.23
Hydrophobic H8 L 444 8x52 G.h4s6 D 315 G.h4s6.09
Van-der-waals H8 L 444 8x52 G.h4s6 D 315 G.h4s6.09
Polar ICL2 L 285 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 285 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 L 285 - G.H5 N 347 G.H5.19
Hydrophobic ICL3 I 377 - G.H5 L 348 G.H5.20
Hydrophobic H8 L 444 8x52 G.h4s6 V 316 G.h4s6.10
Van-der-waals H8 L 444 8x52 G.h4s6 V 316 G.h4s6.10
Hydrophobic ICL2 V 287 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 V 287 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 V 287 - G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 V 287 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 K 286 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 K 286 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 T 293 - G.hns1 E 30 G.hns1.01
Hydrophobic TM5 L 367 5x65 G.H5 L 348 G.H5.20
Polar ICL2 L 285 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 285 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 L 285 - G.H5 I 344 G.H5.16
Hydrophobic TM6 Q 390 6x45 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 383 6x38 G.H5 L 353 G.H5.25
Hydrophobic ICL2 K 286 - G.H5 T 340 G.H5.12
Hydrophobic ICL2 K 286 - G.H5 I 344 G.H5.16
Polar ICL3 S 375 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 S 375 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 S 375 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 A 288 - G.S3 L 194 G.S3.01
Hydrophobic ICL2 V 287 - G.hns1 A 31 G.hns1.02
Polar ICL2 T 293 - G.HN A 27 G.HN.51
Hydrophobic ICL2 T 293 - G.HN A 27 G.HN.51
Van-der-waals ICL2 T 293 - G.HN A 27 G.HN.51
Hydrophobic TM5 L 370 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM3 T 281 3x57 G.H5 N 347 G.H5.19
Polar ICL2 R 295 - G.HN Q 24 G.HN.48
Hydrophobic ICL2 R 295 - G.HN Q 24 G.HN.48
Van-der-waals ICL2 R 295 - G.HN Q 24 G.HN.48
Polar ICL2 A 288 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 A 288 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 A 288 - G.hns1 A 31 G.hns1.02
Polar ICL3 T 376 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 T 376 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 V 374 - G.H5 A 338 G.H5.10
Van-der-waals ICL3 V 374 - G.H5 A 338 G.H5.10
Hydrophobic ICL2 L 285 - G.H5 L 348 G.H5.20
Van-der-waals ICL2 L 285 - G.H5 L 348 G.H5.20
Hydrophobic TM5 L 363 5x61 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 363 5x61 G.H5 L 348 G.H5.20
Hydrophobic ICL2 K 286 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 K 286 - G.S3 L 194 G.S3.01
Polar TM2 N 220 2x44 G.H5 D 350 G.H5.22
Van-der-waals TM2 N 220 2x44 G.H5 D 350 G.H5.22
Hydrophobic TM3 L 278 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 278 3x54 G.H5 C 351 G.H5.23
Polar TM6 K 386 6x41 G.H5 G 352 G.H5.24
Hydrophobic TM6 K 386 6x41 G.H5 G 352 G.H5.24
Van-der-waals TM6 K 386 6x41 G.H5 G 352 G.H5.24
Hydrophobic TM6 K 386 6x41 G.H5 L 353 G.H5.25
Van-der-waals TM6 K 386 6x41 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 363 5x61 G.H5 L 353 G.H5.25
Polar ICL2 T 293 - G.HN Q 24 G.HN.48
Polar ICL2 R 295 - G.HN E 20 G.HN.44
Hydrophobic ICL2 R 295 - G.HN E 20 G.HN.44
Van-der-waals ICL2 R 295 - G.HN E 20 G.HN.44
Hydrophobic ICL3 I 377 - G.H5 I 344 G.H5.16
Polar TM2 S 222 2x46 G.H5 D 350 G.H5.22
Hydrophobic TM2 S 222 2x46 G.H5 D 350 G.H5.22
Van-der-waals TM2 S 222 2x46 G.H5 D 350 G.H5.22
Van-der-waals ICL3 V 374 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 T 293 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 T 293 - G.hns1 A 31 G.hns1.02
Hydrophobic TM3 V 282 3x58 G.H5 L 353 G.H5.25
Ionic TM4 K 297 4x42 G.HN E 20 G.HN.44
Hydrophobic TM6 M 383 6x38 G.H5 L 348 G.H5.20
Van-der-waals TM6 M 383 6x38 G.H5 L 348 G.H5.20
Hydrophobic TM6 A 387 6x42 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 282 3x58 G.H5 C 351 G.H5.23
Polar ICL2 N 289 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 N 289 - G.hns1 A 31 G.hns1.02