G15 - ADGRG2 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRG2 70.1
subunit alpha-15 85.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 P 661 2x46 G.H5 I 371 G.H5.23
Van-der-waals TM2 P 661 2x46 G.H5 I 371 G.H5.23
Hydrophobic ICL2 F 727 - G.S1 L 43 G.S1.02
Van-der-waals ICL2 F 727 - G.S1 L 43 G.S1.02
Hydrophobic ICL2 N 728 - G.S3 T 202 G.S3.01
Hydrophobic C-term L 977 - G.H2 I 220 G.H2.08
Van-der-waals C-term L 977 - G.H2 I 220 G.H2.08
Hydrophobic ICL2 Y 730 - G.HN K 37 G.HN.52
Van-der-waals ICL2 Y 730 - G.HN K 37 G.HN.52
Polar TM6 R 833 6x40 G.H5 N 372 G.H5.24
Hydrophobic TM6 R 833 6x40 G.H5 N 372 G.H5.24
Van-der-waals TM6 R 833 6x40 G.H5 N 372 G.H5.24
Polar TM7 A 882 7x60 G.H5 N 372 G.H5.24
Van-der-waals TM7 A 882 7x60 G.H5 N 372 G.H5.24
Polar TM3 H 718 3x53 G.H5 Y 367 G.H5.19
Aromatic TM3 H 718 3x53 G.H5 Y 367 G.H5.19
Hydrophobic TM3 H 718 3x53 G.H5 Y 367 G.H5.19
Van-der-waals TM3 H 718 3x53 G.H5 Y 367 G.H5.19
Polar ICL2 N 728 - G.s2s3 K 201 G.s2s3.02
Van-der-waals ICL2 N 728 - G.s2s3 K 201 G.s2s3.02
Hydrophobic TM5 K 819 5x68 G.h4s6 R 338 G.h4s6.20
Hydrophobic TM3 L 723 3x58 G.H5 L 368 G.H5.20
Hydrophobic ICL2 V 726 - G.H5 R 360 G.H5.12
Ionic C-term D 979 - G.H2 K 217 G.H2.05
Polar C-term D 979 - G.H2 K 217 G.H2.05
Hydrophobic C-term D 979 - G.H2 K 217 G.H2.05
Van-der-waals C-term D 979 - G.H2 K 217 G.H2.05
Polar TM3 M 719 3x54 G.H5 Y 367 G.H5.19
Hydrophobic TM3 M 719 3x54 G.H5 Y 367 G.H5.19
Hydrophobic TM5 L 812 5x61 G.H5 L 373 G.H5.25
Van-der-waals TM5 L 812 5x61 G.H5 L 373 G.H5.25
Hydrophobic TM3 M 719 3x54 G.H5 I 371 G.H5.23
Aromatic ICL2 F 727 - G.H5 F 356 G.H5.08
Hydrophobic ICL2 F 727 - G.H5 F 356 G.H5.08
Van-der-waals ICL2 F 727 - G.H5 F 356 G.H5.08
Hydrophobic TM5 I 815 5x64 G.H5 L 364 G.H5.16
Hydrophobic TM2 P 661 2x46 G.H5 Y 367 G.H5.19
Van-der-waals TM2 P 661 2x46 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 F 727 - G.H5 V 359 G.H5.11
Polar TM2 Y 660 2x45 G.hns1 R 40 G.hns1.02
Van-der-waals TM2 Y 660 2x45 G.hns1 R 40 G.hns1.02
Hydrophobic TM5 V 808 5x57 G.H5 L 368 G.H5.20
Hydrophobic ICL2 V 726 - G.H5 V 363 G.H5.15
Van-der-waals ICL2 V 726 - G.H5 V 363 G.H5.15
Hydrophobic TM6 L 838 6x45 G.H5 L 373 G.H5.25
Hydrophobic ICL2 F 727 - G.S3 T 202 G.S3.01
Van-der-waals ICL2 F 727 - G.S3 T 202 G.S3.01
Hydrophobic TM5 Q 811 5x60 G.H5 L 364 G.H5.16
Hydrophobic ICL2 F 727 - G.H5 V 363 G.H5.15
Hydrophobic ICL2 Y 730 - G.hns1 R 40 G.hns1.02
Van-der-waals ICL2 Y 730 - G.hns1 R 40 G.hns1.02
Polar TM6 Q 830 6x37 G.h4s6 R 335 G.h4s6.17
Hydrophobic TM6 Q 830 6x37 G.h4s6 R 335 G.h4s6.17
Van-der-waals TM6 Q 830 6x37 G.h4s6 R 335 G.h4s6.17
Hydrophobic ICL2 F 727 - G.H5 R 360 G.H5.12
Van-der-waals ICL2 F 727 - G.H5 R 360 G.H5.12
Hydrophobic ICL2 V 726 - G.H5 L 364 G.H5.16
Van-der-waals ICL2 V 726 - G.H5 L 364 G.H5.16
Polar C-term G 973 - G.H2 H 221 G.H2.09
Polar TM6 Q 830 6x37 G.H5 L 374 G.H5.26
Hydrophobic TM6 Q 830 6x37 G.H5 L 374 G.H5.26
Van-der-waals TM6 Q 830 6x37 G.H5 L 374 G.H5.26
Hydrophobic TM5 V 808 5x57 G.H5 L 373 G.H5.25
Ionic TM5 K 818 5x67 G.H5 D 361 G.H5.13
Polar TM5 K 818 5x67 G.H5 D 361 G.H5.13
Van-der-waals TM5 K 818 5x67 G.H5 D 361 G.H5.13
Hydrophobic C-term V 975 - G.H2 H 221 G.H2.09
Hydrophobic C-term F 980 - G.H3 L 264 G.H3.15
Polar TM6 S 834 6x41 G.H5 L 373 G.H5.25
Hydrophobic TM6 S 834 6x41 G.H5 L 373 G.H5.25
Van-der-waals TM6 S 834 6x41 G.H5 L 373 G.H5.25
Polar TM7 F 878 7x56 G.H5 N 372 G.H5.24
Hydrophobic TM3 A 722 3x57 G.H5 Y 367 G.H5.19
Van-der-waals TM3 A 722 3x57 G.H5 Y 367 G.H5.19
Hydrophobic TM5 I 815 5x64 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM5 I 815 5x64 G.h4s6 R 338 G.h4s6.20
Hydrophobic TM5 L 812 5x61 G.H5 L 368 G.H5.20
Hydrophobic TM5 I 815 5x64 G.H5 L 374 G.H5.26
Hydrophobic H8 K 883 8x47 G.H5 N 372 G.H5.24
Polar TM5 K 816 5x65 G.H5 L 373 G.H5.25
Hydrophobic TM5 I 815 5x64 G.H5 L 368 G.H5.20
Van-der-waals TM5 I 815 5x64 G.H5 L 368 G.H5.20
Hydrophobic TM3 L 723 3x58 G.H5 Y 367 G.H5.19
Van-der-waals TM3 L 723 3x58 G.H5 Y 367 G.H5.19
Polar TM5 K 819 5x68 G.h4s6 R 335 G.h4s6.17
Van-der-waals TM5 K 819 5x68 G.h4s6 R 335 G.h4s6.17
Polar H8 K 883 8x47 G.H5 E 370 G.H5.22
Hydrophobic C-term F 980 - G.H3 T 260 G.H3.11
Hydrophobic TM3 L 723 3x58 G.H5 L 364 G.H5.16
Van-der-waals TM3 L 723 3x58 G.H5 L 364 G.H5.16