G12 - ADGRL4 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.8
PAE mean: 15.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 R 459 2x46 G.H5 I 378 G.H5.23
Hydrophobic ICL2 I 523 - G.S1 V 58 G.S1.02
Hydrophobic TM6 L 623 6x45 G.H5 I 378 G.H5.23
Hydrophobic ICL2 V 522 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 V 522 - G.H5 I 370 G.H5.15
Polar TM6 S 615 6x37 G.H5 Q 381 G.H5.26
Hydrophobic TM6 S 615 6x37 G.H5 Q 381 G.H5.26
Van-der-waals TM6 S 615 6x37 G.H5 Q 381 G.H5.26
Hydrophobic TM2 S 457 2x44 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 V 519 3x58 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 519 3x58 G.H5 L 371 G.H5.16
Hydrophobic TM5 V 596 5x61 G.H5 M 379 G.H5.24
Van-der-waals TM5 V 596 5x61 G.H5 M 379 G.H5.24
Van-der-waals ICL2 F 528 - G.hns1 R 56 G.hns1.03
Hydrophobic TM5 L 603 5x68 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM5 L 603 5x68 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 I 523 - G.H5 I 370 G.H5.15
Hydrophobic TM3 V 519 3x58 G.H5 L 375 G.H5.20
Hydrophobic ICL2 G 527 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 G 527 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 I 523 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 I 523 - G.S3 I 221 G.S3.01
Hydrophobic TM5 I 592 5x57 G.H5 I 378 G.H5.23
Hydrophobic TM6 G 619 6x41 G.H5 M 379 G.H5.24
Van-der-waals TM6 G 619 6x41 G.H5 M 379 G.H5.24
Hydrophobic TM5 K 595 5x60 G.H5 L 375 G.H5.20
Hydrophobic TM5 H 599 5x64 G.H5 Q 372 G.H5.17
Van-der-waals TM5 H 599 5x64 G.H5 Q 372 G.H5.17
Ionic TM2 R 459 2x46 G.H5 D 377 G.H5.22
Polar TM2 R 459 2x46 G.H5 D 377 G.H5.22
Hydrophobic TM2 R 459 2x46 G.H5 D 377 G.H5.22
Van-der-waals TM2 R 459 2x46 G.H5 D 377 G.H5.22
Hydrophobic TM3 L 515 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 515 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM6 A 620 6x42 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 620 6x42 G.H5 M 379 G.H5.24
Polar ICL2 N 525 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 N 525 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 N 525 - G.hns1 R 56 G.hns1.03
Hydrophobic TM7 F 663 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 663 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM6 C 616 6x38 G.H5 M 379 G.H5.24
Van-der-waals TM6 C 616 6x38 G.H5 M 379 G.H5.24
Hydrophobic TM5 H 599 5x64 G.H5 L 371 G.H5.16
Hydrophobic ICL3 E 606 - G.h4s6 R 342 G.h4s6.11
Van-der-waals ICL3 E 606 - G.h4s6 R 342 G.h4s6.11
Ionic H8 K 670 8x49 G.H5 D 377 G.H5.22
Polar H8 K 670 8x49 G.H5 D 377 G.H5.22
Hydrophobic H8 K 670 8x49 G.H5 D 377 G.H5.22
Van-der-waals H8 K 670 8x49 G.H5 D 377 G.H5.22
Hydrophobic TM5 H 599 5x64 G.H5 L 375 G.H5.20
Polar TM5 H 599 5x64 G.H5 D 368 G.H5.13
Hydrophobic TM5 L 603 5x68 G.H5 Q 372 G.H5.17
Van-der-waals TM5 L 603 5x68 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 V 522 - G.H5 L 371 G.H5.16
Polar ICL1 Q 456 12x51 G.hns1 R 55 G.hns1.02
Hydrophobic ICL1 Q 456 12x51 G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 Q 456 12x51 G.hns1 R 55 G.hns1.02
Hydrophobic TM7 L 667 7x60 G.H5 L 380 G.H5.25
Hydrophobic H8 S 668 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 R 669 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 R 669 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM5 V 596 5x61 G.H5 L 375 G.H5.20
Van-der-waals TM5 V 596 5x61 G.H5 L 375 G.H5.20
Hydrophobic ICL2 K 526 - G.hns1 R 55 G.hns1.02
Hydrophobic TM3 V 519 3x58 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 519 3x58 G.H5 I 378 G.H5.23
Hydrophobic ICL2 I 523 - G.H5 F 363 G.H5.08
Hydrophobic TM6 A 622 6x44 G.H5 L 380 G.H5.25
Polar TM3 I 518 3x57 G.H5 N 374 G.H5.19
Hydrophobic TM3 I 518 3x57 G.H5 N 374 G.H5.19
Van-der-waals TM3 I 518 3x57 G.H5 N 374 G.H5.19
Hydrophobic ICL2 V 522 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 V 522 - G.H5 K 367 G.H5.12
Hydrophobic TM6 L 623 6x45 G.H5 M 379 G.H5.24