Gi1 - AT2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 T 250 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 T 250 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 V 254 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 F 150 34x51 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 F 150 34x51 G.s2s3 K 192 G.s2s3.01
Ionic ICL1 K 77 - G.H5 D 350 G.H5.22
Polar ICL1 K 77 - G.H5 D 350 G.H5.22
Hydrophobic ICL1 K 77 - G.H5 D 350 G.H5.22
Van-der-waals ICL1 K 77 - G.H5 D 350 G.H5.22
Hydrophobic C-term F 361 - G.H3 S 252 G.H3.11
Van-der-waals C-term F 361 - G.H3 S 252 G.H3.11
Polar ICL2 R 154 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 154 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 154 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 154 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 154 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic C-term M 358 - G.H2 I 212 G.H2.08
Van-der-waals C-term M 358 - G.H2 I 212 G.H2.08
Polar TM3 D 141 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 D 141 3x49 G.H5 C 351 G.H5.23
Van-der-waals TM3 D 141 3x49 G.H5 C 351 G.H5.23
Hydrophobic C-term F 361 - G.H2 W 211 G.H2.07
Hydrophobic TM6 N 247 6x26 G.S6 Y 320 G.S6.02
Hydrophobic ICL2 Q 153 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 Q 153 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM3 R 142 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 142 3x50 G.H5 L 353 G.H5.25
Polar TM2 S 79 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 S 79 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 S 79 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL2 F 150 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 F 150 34x51 G.H5 T 340 G.H5.12
Ionic TM6 K 246 6x25 G.H4 E 308 G.H4.16
Hydrophobic ICL2 F 150 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 150 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM6 V 254 6x33 G.H5 L 348 G.H5.20
Polar TM3 R 142 3x50 G.H5 G 352 G.H5.24
Hydrophobic TM3 R 142 3x50 G.H5 G 352 G.H5.24
Van-der-waals TM3 R 142 3x50 G.H5 G 352 G.H5.24
Hydrophobic TM2 S 79 2x39 G.H5 C 351 G.H5.23
Ionic H8 R 324 8x49 G.h3s5 D 261 G.h3s5.02
Polar H8 R 324 8x49 G.h3s5 D 261 G.h3s5.02
Hydrophobic H8 R 324 8x49 G.h3s5 D 261 G.h3s5.02
Van-der-waals H8 R 324 8x49 G.h3s5 D 261 G.h3s5.02
Polar TM6 N 247 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 N 247 6x26 G.H5 D 341 G.H5.13
Polar ICL2 P 149 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 149 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 149 34x50 G.H5 N 347 G.H5.19
Polar ICL2 R 154 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 R 154 34x55 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 154 34x55 G.hns1 A 31 G.hns1.02
Ionic H8 R 324 8x49 G.H5 D 350 G.H5.22
Polar H8 R 324 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 R 324 8x49 G.H5 D 350 G.H5.22
Polar TM4 N 156 4x38 G.HN R 24 G.HN.48
Hydrophobic TM4 N 156 4x38 G.HN R 24 G.HN.48
Van-der-waals TM4 N 156 4x38 G.HN R 24 G.HN.48
Hydrophobic C-term F 361 - G.H3 N 256 G.H3.15
Van-der-waals C-term F 361 - G.H3 N 256 G.H3.15
Polar TM4 Y 162 4x44 G.HN R 24 G.HN.48
Hydrophobic TM4 Y 162 4x44 G.HN R 24 G.HN.48
Hydrophobic ICL2 P 149 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 149 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 149 34x50 G.H5 I 343 G.H5.15
Polar TM6 T 250 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM6 T 250 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 T 250 6x29 G.H5 K 345 G.H5.17
Polar ICL2 S 152 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 S 152 34x53 G.H5 N 347 G.H5.19
Polar TM3 R 142 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 142 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 142 3x50 G.H5 C 351 G.H5.23
Polar H8 N 323 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 N 323 8x48 G.H5 F 354 G.H5.26
Polar TM3 S 145 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 145 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM4 W 158 4x40 G.HN D 20 G.HN.44
Hydrophobic TM6 Q 253 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 Q 253 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM3 V 146 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 146 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 M 257 6x36 G.H5 L 353 G.H5.25
Polar TM3 S 145 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 S 145 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 S 145 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM4 W 158 4x40 G.HN R 24 G.HN.48
Van-der-waals TM4 W 158 4x40 G.HN R 24 G.HN.48
Hydrophobic H8 G 322 8x47 G.H5 F 354 G.H5.26
Van-der-waals H8 G 322 8x47 G.H5 F 354 G.H5.26
Hydrophobic C-term V 362 - G.H2 K 209 G.H2.05
Hydrophobic C-term F 361 - G.H3 I 253 G.H3.12
Van-der-waals C-term F 361 - G.H3 I 253 G.H3.12
Hydrophobic ICL2 Q 153 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 Q 153 34x54 G.hns1 A 31 G.hns1.02
Ionic C-term E 357 - G.H3 K 257 G.H3.16
Polar C-term E 357 - G.H3 K 257 G.H3.16
Hydrophobic C-term E 357 - G.H3 K 257 G.H3.16
Van-der-waals C-term E 357 - G.H3 K 257 G.H3.16
Polar TM4 N 156 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 N 156 4x38 G.HN E 28 G.HN.52
Hydrophobic ICL2 F 150 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 F 150 34x51 G.H5 I 343 G.H5.15