Golf - FFA1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 87.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 14.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 104 3x50 G.H5 L 380 G.H5.25
Hydrophobic ICL2 Q 115 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 Q 115 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM5 L 209 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM6 V 225 6x37 G.H5 L 380 G.H5.25
Hydrophobic TM6 V 225 6x37 G.H5 E 379 G.H5.24
Hydrophobic ICL2 L 112 34x51 G.H5 R 367 G.H5.12
Polar TM3 G 103 3x49 G.H5 Y 378 G.H5.23
Hydrophobic TM3 G 103 3x49 G.H5 Y 378 G.H5.23
Van-der-waals TM3 G 103 3x49 G.H5 Y 378 G.H5.23
Hydrophobic ICL3 L 214 - G.H5 L 381 G.H5.26
Polar ICL2 Q 115 34x54 G.H5 H 374 G.H5.19
Hydrophobic ICL2 Q 115 34x54 G.H5 H 374 G.H5.19
Hydrophobic ICL2 R 118 34x57 G.H5 M 373 G.H5.18
Van-der-waals ICL2 R 118 34x57 G.H5 M 373 G.H5.18
Hydrophobic ICL2 P 111 34x50 G.H5 R 367 G.H5.12
Van-der-waals ICL2 P 111 34x50 G.H5 R 367 G.H5.12
Hydrophobic ICL2 Q 115 34x54 G.S1 H 43 G.S1.02
Van-der-waals ICL2 Q 115 34x54 G.S1 H 43 G.S1.02
Hydrophobic TM3 G 107 3x53 G.H5 H 374 G.H5.19
Van-der-waals TM3 G 107 3x53 G.H5 H 374 G.H5.19
Polar ICL2 R 118 34x57 G.H5 Q 377 G.H5.22
Hydrophobic ICL2 R 118 34x57 G.H5 Q 377 G.H5.22
Van-der-waals ICL2 R 118 34x57 G.H5 Q 377 G.H5.22
Hydrophobic ICL3 L 214 - G.H5 L 375 G.H5.20
Van-der-waals ICL3 L 214 - G.H5 L 375 G.H5.20
Hydrophobic TM4 R 119 4x38 G.HN L 37 G.HN.52
Van-der-waals TM4 R 119 4x38 G.HN L 37 G.HN.52
Hydrophobic TM3 L 100 3x46 G.H5 Y 378 G.H5.23
Hydrophobic TM7 Y 278 7x55 G.H5 E 379 G.H5.24
Hydrophobic ICL2 P 111 34x50 G.H5 Q 371 G.H5.16
Van-der-waals ICL2 P 111 34x50 G.H5 Q 371 G.H5.16
Polar ICL2 Y 114 34x53 G.H5 Y 378 G.H5.23
Hydrophobic ICL2 Y 114 34x53 G.H5 Y 378 G.H5.23
Van-der-waals ICL2 Y 114 34x53 G.H5 Y 378 G.H5.23
Polar ICL2 P 111 34x50 G.H5 H 374 G.H5.19
Hydrophobic ICL2 P 111 34x50 G.H5 H 374 G.H5.19
Van-der-waals ICL2 P 111 34x50 G.H5 H 374 G.H5.19
Polar TM2 S 41 2x39 G.H5 Q 377 G.H5.22
Hydrophobic TM2 S 41 2x39 G.H5 Q 377 G.H5.22
Van-der-waals TM2 S 41 2x39 G.H5 Q 377 G.H5.22
Hydrophobic ICL2 Q 115 34x54 G.H5 M 373 G.H5.18
Van-der-waals ICL2 Q 115 34x54 G.H5 M 373 G.H5.18
Hydrophobic ICL2 P 111 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 111 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 L 112 34x51 G.S1 H 43 G.S1.02
Van-der-waals ICL2 L 112 34x51 G.S1 H 43 G.S1.02
Polar TM7 Y 278 7x55 G.H5 Q 377 G.H5.22
Ionic H8 R 281 8x48 G.H5 E 379 G.H5.24
Polar H8 R 281 8x48 G.H5 E 379 G.H5.24
Van-der-waals H8 R 281 8x48 G.H5 E 379 G.H5.24
Polar TM3 A 108 3x54 G.H5 Q 371 G.H5.16
Hydrophobic TM3 A 108 3x54 G.H5 Q 371 G.H5.16
Van-der-waals TM3 A 108 3x54 G.H5 Q 371 G.H5.16
Hydrophobic ICL3 L 214 - G.H5 R 372 G.H5.17
Polar ICL2 R 118 34x57 G.H5 H 374 G.H5.19
Hydrophobic ICL2 R 118 34x57 G.H5 H 374 G.H5.19
Van-der-waals ICL2 R 118 34x57 G.H5 H 374 G.H5.19
Aromatic ICL2 Y 114 34x53 G.H5 H 374 G.H5.19
Hydrophobic ICL2 Y 114 34x53 G.H5 H 374 G.H5.19
Van-der-waals ICL2 Y 114 34x53 G.H5 H 374 G.H5.19
Hydrophobic TM3 A 108 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM6 A 226 6x38 G.H5 L 380 G.H5.25
Hydrophobic TM7 G 277 7x54 G.H5 E 379 G.H5.24
Hydrophobic ICL2 L 112 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 112 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL2 L 112 34x51 G.S3 V 204 G.S3.01
Hydrophobic ICL3 S 212 - G.H5 Q 371 G.H5.16
Van-der-waals ICL3 S 212 - G.H5 Q 371 G.H5.16
Hydrophobic TM2 T 39 2x37 G.H5 Q 377 G.H5.22
Polar TM5 A 208 5x64 G.H5 Q 371 G.H5.16
Polar TM6 A 222 6x34 G.H5 L 380 G.H5.25
Hydrophobic TM6 A 222 6x34 G.H5 L 380 G.H5.25
Van-der-waals TM6 A 222 6x34 G.H5 L 380 G.H5.25
Polar TM3 R 104 3x50 G.H5 Y 378 G.H5.23
Hydrophobic TM3 R 104 3x50 G.H5 Y 378 G.H5.23
Van-der-waals TM3 R 104 3x50 G.H5 Y 378 G.H5.23
Hydrophobic ICL2 A 116 34x55 G.hns1 A 41 G.hns1.03
Polar TM6 R 218 6x30 G.h4s6 Y 345 G.h4s6.20
Hydrophobic TM6 R 218 6x30 G.h4s6 Y 345 G.h4s6.20
Van-der-waals TM6 R 218 6x30 G.h4s6 Y 345 G.h4s6.20
Polar ICL3 G 213 - G.H5 D 368 G.H5.13
Polar H8 R 281 8x48 G.H5 L 381 G.H5.26
Hydrophobic H8 R 281 8x48 G.H5 L 381 G.H5.26
Van-der-waals H8 R 281 8x48 G.H5 L 381 G.H5.26
Hydrophobic ICL2 L 112 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 112 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM6 R 218 6x30 G.H5 L 381 G.H5.26
Polar ICL3 G 213 - G.H5 R 372 G.H5.17
Van-der-waals ICL3 G 213 - G.H5 R 372 G.H5.17
Hydrophobic TM2 S 41 2x39 G.H5 Y 378 G.H5.23
Van-der-waals TM2 S 41 2x39 G.H5 Y 378 G.H5.23