G13 - FPR2/ALX complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 16.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 V 131 34x51 G.H5 F 359 G.H5.08
Hydrophobic H8 Q 307 8x48 G.H5 Q 377 G.H5.26
Hydrophobic TM5 K 231 5x68 G.H5 L 367 G.H5.16
Van-der-waals TM5 K 231 5x68 G.H5 L 367 G.H5.16
Hydrophobic TM3 D 106 3x33 G.HN A 2 G.HN.02
Van-der-waals TM3 D 106 3x33 G.HN A 2 G.HN.02
Polar ICL2 P 130 34x50 G.H5 N 370 G.H5.19
Hydrophobic TM2 Y 64 2x43 G.H5 L 376 G.H5.25
Van-der-waals TM2 Y 64 2x43 G.H5 L 376 G.H5.25
Hydrophobic TM3 W 95 3x22 G.HN P 6 G.HN.06
Hydrophobic TM3 I 103 3x30 G.HN L 5 G.HN.05
Van-der-waals TM3 I 103 3x30 G.HN L 5 G.HN.05
Hydrophobic ECL2 T 177 45x51 G.HN F 4 G.HN.04
Van-der-waals ECL2 T 177 45x51 G.HN F 4 G.HN.04
Hydrophobic TM7 Y 302 7x53 G.H5 L 376 G.H5.25
Van-der-waals TM7 Y 302 7x53 G.H5 L 376 G.H5.25
Hydrophobic TM7 F 292 7x42 G.HN M 1 G.HN.01
Van-der-waals TM7 F 292 7x42 G.HN M 1 G.HN.01
Polar TM3 H 102 3x29 G.HN M 1 G.HN.01
Hydrophobic TM3 H 102 3x29 G.HN M 1 G.HN.01
Van-der-waals TM3 H 102 3x29 G.HN M 1 G.HN.01
Hydrophobic ICL2 V 131 34x51 G.H5 K 363 G.H5.12
Hydrophobic TM3 H 102 3x29 G.HN A 2 G.HN.02
Van-der-waals TM3 H 102 3x29 G.HN A 2 G.HN.02
Ionic TM5 R 205 5x43 G.HN D 3 G.HN.03
Hydrophobic TM4 L 164 4x65 G.HN D 3 G.HN.03
Van-der-waals TM4 L 164 4x65 G.HN D 3 G.HN.03
Hydrophobic ECL2 F 178 45x52 G.HN D 3 G.HN.03
Van-der-waals ECL2 F 178 45x52 G.HN D 3 G.HN.03
Polar TM3 K 99 3x26 G.HN L 5 G.HN.05
Hydrophobic TM3 K 99 3x26 G.HN L 5 G.HN.05
Van-der-waals TM3 K 99 3x26 G.HN L 5 G.HN.05
Hydrophobic ECL2 C 176 45x50 G.HN F 4 G.HN.04
Van-der-waals ECL2 C 176 45x50 G.HN F 4 G.HN.04
Polar ICL2 N 135 34x55 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 N 135 34x55 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 N 135 34x55 G.hns1 R 47 G.hns1.03
Hydrophobic ECL2 T 165 - G.HN F 4 G.HN.04
Van-der-waals ECL2 T 165 - G.HN F 4 G.HN.04
Hydrophobic TM4 L 164 4x65 G.HN F 4 G.HN.04
Van-der-waals TM4 L 164 4x65 G.HN F 4 G.HN.04
Polar ICL2 H 136 34x56 G.hns1 R 47 G.hns1.03
Aromatic ICL2 H 136 34x56 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 H 136 34x56 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 H 136 34x56 G.hns1 R 47 G.hns1.03
Hydrophobic TM3 V 127 3x54 G.H5 L 371 G.H5.20
Van-der-waals TM3 V 127 3x54 G.H5 L 371 G.H5.20
Hydrophobic TM2 L 81 2x60 G.HN M 1 G.HN.01
Polar TM4 F 161 4x62 G.HN L 5 G.HN.05
Hydrophobic TM4 F 161 4x62 G.HN L 5 G.HN.05
Van-der-waals TM4 F 161 4x62 G.HN L 5 G.HN.05
Hydrophobic TM5 K 227 5x64 G.H5 L 367 G.H5.16
Hydrophobic ICL2 P 130 34x50 G.H5 K 363 G.H5.12
Hydrophobic TM3 V 127 3x54 G.H5 L 374 G.H5.23
Van-der-waals TM3 V 127 3x54 G.H5 L 374 G.H5.23
Polar TM3 C 126 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM3 C 126 3x53 G.H5 N 370 G.H5.19
Van-der-waals TM3 C 126 3x53 G.H5 N 370 G.H5.19
Hydrophobic ICL2 V 131 34x51 G.S3 V 216 G.S3.01
Van-der-waals ICL2 V 131 34x51 G.S3 V 216 G.S3.01
Hydrophobic TM3 V 105 3x32 G.HN M 1 G.HN.01
Van-der-waals TM3 V 105 3x32 G.HN M 1 G.HN.01
Aromatic TM3 H 102 3x29 G.HN F 4 G.HN.04
Hydrophobic TM3 H 102 3x29 G.HN F 4 G.HN.04
Van-der-waals TM3 H 102 3x29 G.HN F 4 G.HN.04
Hydrophobic TM6 R 238 6x32 G.H5 M 375 G.H5.24
Hydrophobic TM5 I 228 5x65 G.H5 L 371 G.H5.20
Van-der-waals TM5 I 228 5x65 G.H5 L 371 G.H5.20
Hydrophobic TM3 L 100 3x27 G.HN L 5 G.HN.05
Van-der-waals TM3 L 100 3x27 G.HN L 5 G.HN.05
Polar H8 Q 307 8x48 G.H5 L 376 G.H5.25
Van-der-waals H8 Q 307 8x48 G.H5 L 376 G.H5.25
Hydrophobic TM6 R 238 6x32 G.H5 Q 377 G.H5.26
Van-der-waals TM6 R 238 6x32 G.H5 Q 377 G.H5.26
Polar TM5 R 201 5x39 G.HN A 2 G.HN.02
Hydrophobic TM5 R 201 5x39 G.HN A 2 G.HN.02
Van-der-waals TM5 R 201 5x39 G.HN A 2 G.HN.02
Hydrophobic TM6 V 242 6x36 G.H5 M 375 G.H5.24
Van-der-waals TM6 V 242 6x36 G.H5 M 375 G.H5.24
Hydrophobic TM3 C 98 3x25 G.HN F 4 G.HN.04
Van-der-waals TM3 C 98 3x25 G.HN F 4 G.HN.04
Hydrophobic TM6 P 239 6x33 G.H5 M 375 G.H5.24
Van-der-waals TM6 P 239 6x33 G.H5 M 375 G.H5.24
Polar TM4 L 162 4x63 G.HN L 5 G.HN.05
Van-der-waals TM4 L 162 4x63 G.HN L 5 G.HN.05
Polar TM3 K 99 3x26 G.HN F 4 G.HN.04
Hydrophobic TM3 K 99 3x26 G.HN F 4 G.HN.04
Van-der-waals TM3 K 99 3x26 G.HN F 4 G.HN.04
Polar TM4 V 160 4x61 G.HN D 3 G.HN.03
Hydrophobic TM4 V 160 4x61 G.HN D 3 G.HN.03
Van-der-waals TM4 V 160 4x61 G.HN D 3 G.HN.03
Hydrophobic ICL3 M 233 - G.H5 D 364 G.H5.13
Van-der-waals ICL3 M 233 - G.H5 D 364 G.H5.13
Van-der-waals TM4 F 161 4x62 G.HN R 8 G.HN.10
Polar TM3 R 123 3x50 G.H5 L 374 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 L 374 G.H5.23
Van-der-waals TM3 R 123 3x50 G.H5 L 374 G.H5.23
Hydrophobic TM3 K 99 3x26 G.HN P 6 G.HN.06
Van-der-waals TM3 K 99 3x26 G.HN P 6 G.HN.06
Hydrophobic ICL2 Q 134 34x54 G.H5 I 366 G.H5.15
Van-der-waals ICL2 Q 134 34x54 G.H5 I 366 G.H5.15
Hydrophobic ICL2 V 131 34x51 G.H5 I 366 G.H5.15
Hydrophobic TM4 V 160 4x61 G.HN A 2 G.HN.02
Van-der-waals TM4 V 160 4x61 G.HN A 2 G.HN.02
Hydrophobic TM2 T 60 2x39 G.H5 L 376 G.H5.25
Polar TM4 F 161 4x62 G.HN S 7 G.HN.09
Hydrophobic TM4 F 161 4x62 G.HN S 7 G.HN.09
Van-der-waals TM4 F 161 4x62 G.HN S 7 G.HN.09
Polar H8 D 308 8x49 G.H5 L 376 G.H5.25
Van-der-waals H8 D 308 8x49 G.H5 L 376 G.H5.25
Hydrophobic TM3 V 127 3x54 G.H5 L 367 G.H5.16
Van-der-waals TM3 V 127 3x54 G.H5 L 367 G.H5.16
Polar TM4 F 161 4x62 G.HN P 6 G.HN.06
Hydrophobic TM4 F 161 4x62 G.HN P 6 G.HN.06
Van-der-waals TM4 F 161 4x62 G.HN P 6 G.HN.06
Polar TM4 V 160 4x61 G.HN L 5 G.HN.05
Hydrophobic TM4 V 160 4x61 G.HN L 5 G.HN.05
Van-der-waals TM4 V 160 4x61 G.HN L 5 G.HN.05
Hydrophobic ICL2 P 130 34x50 G.H5 I 366 G.H5.15
Hydrophobic ICL3 M 233 - G.H5 H 368 G.H5.17
Van-der-waals ICL3 M 233 - G.H5 H 368 G.H5.17
Hydrophobic ICL2 P 130 34x50 G.H5 L 367 G.H5.16
Hydrophobic ICL3 I 234 - G.H5 L 371 G.H5.20
Hydrophobic TM7 V 303 7x54 G.H5 L 376 G.H5.25
Van-der-waals TM7 V 303 7x54 G.H5 L 376 G.H5.25
Hydrophobic H8 G 306 8x47 G.H5 L 376 G.H5.25
Van-der-waals H8 G 306 8x47 G.H5 L 376 G.H5.25
Hydrophobic ICL3 M 233 - G.H5 L 367 G.H5.16
Van-der-waals ICL3 M 233 - G.H5 L 367 G.H5.16
Polar TM4 V 160 4x61 G.HN F 4 G.HN.04
Hydrophobic TM4 V 160 4x61 G.HN F 4 G.HN.04
Van-der-waals TM4 V 160 4x61 G.HN F 4 G.HN.04
Ionic TM5 R 201 5x39 G.HN D 3 G.HN.03
Polar TM5 R 201 5x39 G.HN D 3 G.HN.03
Hydrophobic TM5 R 201 5x39 G.HN D 3 G.HN.03
Van-der-waals TM5 R 201 5x39 G.HN D 3 G.HN.03
Ionic TM5 K 231 5x68 G.H5 D 364 G.H5.13
Polar TM5 K 231 5x68 G.H5 D 364 G.H5.13
Hydrophobic TM5 K 231 5x68 G.H5 D 364 G.H5.13
Van-der-waals TM5 K 231 5x68 G.H5 D 364 G.H5.13
Hydrophobic TM3 I 103 3x30 G.HN A 2 G.HN.02
Hydrophobic ICL3 M 233 - G.H5 L 371 G.H5.20