Go - GPR143 complex model

GPCR CLASS (FAMILY)

Unclassified

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR143 66.1
Gαo 86.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 20.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar C-term I 380 - G.hfs2 K 181 G.hfs2.04
Hydrophobic TM2 L 71 2x43 G.H5 L 353 G.H5.25
Hydrophobic TM6 E 235 6x26 G.H5 I 344 G.H5.16
Hydrophobic TM6 I 242 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 I 242 6x33 G.H5 L 348 G.H5.20
Hydrophobic C-term A 377 - G.s4h3 H 236 G.s4h3.09
Polar C-term T 379 - G.hfs2 K 181 G.hfs2.04
Hydrophobic C-term T 379 - G.hfs2 K 181 G.hfs2.04
Van-der-waals C-term T 379 - G.hfs2 K 181 G.hfs2.04
Hydrophobic C-term S 372 - G.H2 K 210 G.H2.05
Polar TM2 V 68 2x40 G.H5 C 351 G.H5.23
Hydrophobic TM2 V 68 2x40 G.H5 C 351 G.H5.23
Van-der-waals TM2 V 68 2x40 G.H5 C 351 G.H5.23
Hydrophobic C-term S 372 - G.H2 R 206 G.H2.01
Hydrophobic TM2 P 65 2x37 G.H5 G 352 G.H5.24
Van-der-waals TM2 P 65 2x37 G.H5 G 352 G.H5.24
Hydrophobic TM3 V 144 3x53 G.H5 L 348 G.H5.20
Hydrophobic TM6 N 234 6x25 G.H5 D 341 G.H5.13
Van-der-waals TM6 N 234 6x25 G.H5 D 341 G.H5.13
Polar TM6 R 245 6x36 G.H5 G 352 G.H5.24
Polar TM3 D 140 3x49 G.H5 C 351 G.H5.23
Hydrophobic ICL2 A 149 - G.hns1 K 32 G.hns1.03
Polar TM2 P 65 2x37 G.H5 G 350 G.H5.22
Hydrophobic TM2 P 65 2x37 G.H5 G 350 G.H5.22
Van-der-waals TM2 P 65 2x37 G.H5 G 350 G.H5.22
Hydrophobic TM2 S 67 2x39 G.H5 L 353 G.H5.25
Van-der-waals TM2 S 67 2x39 G.H5 L 353 G.H5.25
Hydrophobic TM6 M 238 6x29 G.H5 A 345 G.H5.17
Van-der-waals TM6 M 238 6x29 G.H5 A 345 G.H5.17
Ionic C-term D 376 - G.hfs2 K 181 G.hfs2.04
Polar C-term D 376 - G.hfs2 K 181 G.hfs2.04
Hydrophobic C-term I 382 - H.HA V 72 H.HA.10
Van-der-waals C-term I 382 - H.HA V 72 H.HA.10
Polar TM2 A 66 2x38 G.H5 G 350 G.H5.22
Hydrophobic ICL2 S 148 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 S 148 - G.S3 L 195 G.S3.01
Hydrophobic C-term I 382 - G.hfs2 V 180 G.hfs2.03
Van-der-waals C-term I 382 - G.hfs2 V 180 G.hfs2.03
Hydrophobic C-term I 382 - H.HA Y 69 H.HA.07
Hydrophobic ICL3 T 232 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 T 232 - G.H5 D 337 G.H5.09
Polar TM6 N 234 6x25 G.S6 Y 320 G.S6.02
Hydrophobic TM6 N 234 6x25 G.S6 Y 320 G.S6.02
Van-der-waals TM6 N 234 6x25 G.S6 Y 320 G.S6.02
Van-der-waals TM6 E 235 6x26 G.H5 T 340 G.H5.12
Polar C-term S 369 - G.H2 K 210 G.H2.05
Hydrophobic C-term S 369 - G.H2 K 210 G.H2.05
Van-der-waals C-term S 369 - G.H2 K 210 G.H2.05
Hydrophobic C-term I 380 - G.hfs2 V 180 G.hfs2.03
Van-der-waals C-term I 380 - G.hfs2 V 180 G.hfs2.03
Hydrophobic ICL2 L 151 - G.HN I 28 G.HN.52
Van-der-waals ICL2 L 151 - G.HN I 28 G.HN.52
Hydrophobic TM3 A 141 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM2 P 65 2x37 G.H5 C 351 G.H5.23
Van-der-waals TM2 P 65 2x37 G.H5 C 351 G.H5.23
Hydrophobic C-term I 380 - H.HA V 72 H.HA.10
Hydrophobic TM2 V 68 2x40 G.H5 G 352 G.H5.24
Van-der-waals TM2 V 68 2x40 G.H5 G 352 G.H5.24
Polar ICL2 S 148 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 S 148 - G.H5 N 347 G.H5.19
Hydrophobic TM6 M 238 6x29 G.H5 L 348 G.H5.20
Van-der-waals TM6 M 238 6x29 G.H5 L 348 G.H5.20
Polar TM6 E 235 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 E 235 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 E 235 6x26 G.H5 D 341 G.H5.13
Polar ICL2 G 150 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 G 150 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 G 150 - G.H5 N 347 G.H5.19
Hydrophobic C-term G 374 - G.s4h3 E 237 G.s4h3.10
Hydrophobic C-term I 380 - H.HA S 75 H.HA.13
Van-der-waals C-term I 380 - H.HA S 75 H.HA.13
Hydrophobic ICL2 A 149 - G.hns1 A 31 G.hns1.02
Hydrophobic TM6 M 238 6x29 G.H5 I 344 G.H5.16
Van-der-waals TM6 M 238 6x29 G.H5 I 344 G.H5.16
Hydrophobic TM3 V 144 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 V 144 3x53 G.H5 N 347 G.H5.19
Hydrophobic C-term L 371 - G.H2 R 206 G.H2.01
Van-der-waals C-term L 371 - G.H2 R 206 G.H2.01
Hydrophobic C-term S 375 - G.s4h3 E 237 G.s4h3.10
Polar TM2 S 67 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 S 67 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 S 67 2x39 G.H5 C 351 G.H5.23
Polar TM6 R 245 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 245 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 245 6x36 G.H5 L 353 G.H5.25
Polar ICL1 S 59 - G.h3s5 D 262 G.h3s5.02
Van-der-waals ICL1 S 59 - G.h3s5 D 262 G.h3s5.02
Hydrophobic TM2 A 66 2x38 G.H5 C 351 G.H5.23
Hydrophobic C-term I 380 - H.hbhc T 117 H.hbhc.05
Polar C-term S 372 - G.H2 S 207 G.H2.02
Hydrophobic C-term S 372 - G.H2 S 207 G.H2.02
Van-der-waals C-term S 372 - G.H2 S 207 G.H2.02
Polar ICL3 T 232 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 T 232 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 T 232 - G.H5 D 341 G.H5.13
Hydrophobic TM3 I 145 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM3 V 144 3x53 G.H5 C 351 G.H5.23
Hydrophobic C-term T 379 - G.hfs2 R 179 G.hfs2.02
Hydrophobic ICL2 S 148 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 S 148 - G.H5 I 343 G.H5.15
Hydrophobic TM3 V 144 3x53 G.H5 I 344 G.H5.16
Polar C-term S 375 - G.s4h3 H 236 G.s4h3.09
Hydrophobic C-term S 375 - G.s4h3 H 236 G.s4h3.09
Van-der-waals C-term S 375 - G.s4h3 H 236 G.s4h3.09
Hydrophobic TM6 M 238 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM3 Y 137 3x46 G.H5 L 353 G.H5.25
Van-der-waals TM3 Y 137 3x46 G.H5 L 353 G.H5.25
Polar C-term S 378 - H.HA Q 79 H.HA.17
Hydrophobic C-term S 378 - H.HA Q 79 H.HA.17
Van-der-waals C-term S 378 - H.HA Q 79 H.HA.17
Polar TM6 N 234 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 N 234 6x25 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 N 234 6x25 G.h4s6 E 318 G.h4s6.12
Polar C-term S 375 - G.s3h2 Q 205 G.s3h2.03
Hydrophobic TM2 P 65 2x37 G.H5 R 349 G.H5.21
Van-der-waals TM2 P 65 2x37 G.H5 R 349 G.H5.21
Hydrophobic C-term G 374 - G.H2 S 207 G.H2.02
Polar C-term E 381 - G.hfs2 T 183 G.hfs2.06
Hydrophobic C-term E 381 - G.hfs2 T 183 G.hfs2.06
Van-der-waals C-term E 381 - G.hfs2 T 183 G.hfs2.06