Gt1 - GPBA receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 121 - G.hns1 A 27 G.hns1.02
Hydrophobic TM5 A 192 5x65 G.H5 L 344 G.H5.20
Van-der-waals TM5 A 192 5x65 G.H5 L 344 G.H5.20
Hydrophobic TM5 V 206 5x79 G.H5 F 330 G.H5.06
Van-der-waals TM5 V 206 5x79 G.H5 F 330 G.H5.06
Hydrophobic TM3 V 114 3x54 G.H5 C 347 G.H5.23
Van-der-waals TM3 V 114 3x54 G.H5 C 347 G.H5.23
Hydrophobic ICL2 P 120 - G.HN E 24 G.HN.52
Van-der-waals ICL2 P 120 - G.HN E 24 G.HN.52
Hydrophobic TM5 L 202 5x75 G.H5 A 334 G.H5.10
Polar ICL2 L 118 - G.S1 T 29 G.S1.01
Hydrophobic ICL2 L 118 - G.S1 T 29 G.S1.01
Van-der-waals ICL2 L 118 - G.S1 T 29 G.S1.01
Polar TM3 R 110 3x50 G.H5 G 348 G.H5.24
Hydrophobic TM3 R 110 3x50 G.H5 G 348 G.H5.24
Polar ICL2 Q 119 - G.HN E 24 G.HN.52
Hydrophobic TM5 I 199 5x72 G.H5 D 337 G.H5.13
Hydrophobic C-term L 329 - G.H2 W 207 G.H2.07
Hydrophobic ICL2 L 118 - G.S3 N 191 G.S3.02
Van-der-waals ICL2 L 118 - G.S3 N 191 G.S3.02
Polar ICL2 L 118 - G.hns1 R 28 G.hns1.03
Hydrophobic ICL2 L 118 - G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 L 118 - G.hns1 R 28 G.hns1.03
Polar TM3 R 110 3x50 G.H5 C 347 G.H5.23
Hydrophobic TM3 R 110 3x50 G.H5 C 347 G.H5.23
Van-der-waals TM3 R 110 3x50 G.H5 C 347 G.H5.23
Van-der-waals TM5 Q 195 5x68 G.H5 L 344 G.H5.20
Hydrophobic C-term L 327 - G.H3 H 252 G.H3.15
Van-der-waals C-term L 327 - G.H3 H 252 G.H3.15
Polar H8 R 286 8x49 G.H5 K 345 G.H5.21
Hydrophobic H8 R 286 8x49 G.H5 K 345 G.H5.21
Van-der-waals H8 R 286 8x49 G.H5 K 345 G.H5.21
Polar ICL2 Q 119 - G.hns1 A 27 G.hns1.02
Hydrophobic ICL2 Q 119 - G.hns1 A 27 G.hns1.02
Van-der-waals ICL2 Q 119 - G.hns1 A 27 G.hns1.02
Ionic ICL3 R 208 - G.H4 E 293 G.H4.04
Hydrophobic C-term L 329 - G.H3 L 245 G.H3.08
Van-der-waals C-term L 329 - G.H3 L 245 G.H3.08
Hydrophobic TM6 L 218 6x29 G.H5 F 350 G.H5.26
Hydrophobic ICL2 P 120 - G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 P 120 - G.hns1 R 28 G.hns1.03
Hydrophobic TM3 V 114 3x54 G.H5 L 344 G.H5.20
Van-der-waals TM3 V 114 3x54 G.H5 L 344 G.H5.20
Hydrophobic TM3 A 113 3x53 G.H5 C 347 G.H5.23
Van-der-waals TM3 A 113 3x53 G.H5 C 347 G.H5.23
Hydrophobic ICL2 P 117 - G.H5 I 340 G.H5.16
Hydrophobic H8 D 284 8x47 G.H5 G 348 G.H5.24
Van-der-waals H8 D 284 8x47 G.H5 G 348 G.H5.24
Hydrophobic TM5 L 196 5x69 G.H5 F 350 G.H5.26
Hydrophobic ICL2 L 118 - G.S1 V 30 G.S1.02
Van-der-waals ICL2 L 118 - G.S1 V 30 G.S1.02
Hydrophobic TM5 L 202 5x75 G.H5 F 330 G.H5.06
Van-der-waals TM5 L 202 5x75 G.H5 F 330 G.H5.06
Hydrophobic TM3 A 113 3x53 G.H5 N 343 G.H5.19
Van-der-waals TM3 A 113 3x53 G.H5 N 343 G.H5.19
Ionic H8 R 286 8x49 G.H5 D 346 G.H5.22
Polar H8 R 286 8x49 G.H5 D 346 G.H5.22
Hydrophobic H8 R 286 8x49 G.H5 D 346 G.H5.22
Van-der-waals H8 R 286 8x49 G.H5 D 346 G.H5.22
Hydrophobic TM3 V 114 3x54 G.H5 I 340 G.H5.16
Van-der-waals TM3 V 114 3x54 G.H5 I 340 G.H5.16
Hydrophobic ICL2 P 120 - G.HN A 23 G.HN.51
Van-der-waals ICL2 P 120 - G.HN A 23 G.HN.51
Hydrophobic TM5 Q 195 5x68 G.H5 I 340 G.H5.16
Van-der-waals TM5 Q 195 5x68 G.H5 I 340 G.H5.16
Hydrophobic TM3 V 114 3x54 G.H5 L 349 G.H5.25
Van-der-waals TM3 V 114 3x54 G.H5 L 349 G.H5.25
Van-der-waals C-term N 330 - G.H2 R 201 G.H2.01
Hydrophobic TM3 R 116 3x56 G.hns1 R 28 G.hns1.03
Van-der-waals TM3 R 116 3x56 G.hns1 R 28 G.hns1.03
Hydrophobic TM5 A 205 5x78 G.H5 F 330 G.H5.06
Van-der-waals TM5 A 205 5x78 G.H5 F 330 G.H5.06
Hydrophobic ICL2 P 117 - G.S3 L 190 G.S3.01
Van-der-waals ICL2 P 117 - G.S3 L 190 G.S3.01
Hydrophobic ICL2 L 118 - G.S3 L 190 G.S3.01
Van-der-waals ICL2 L 118 - G.S3 L 190 G.S3.01
Hydrophobic ICL2 L 118 - G.hns1 A 27 G.hns1.02
Van-der-waals ICL2 L 118 - G.hns1 A 27 G.hns1.02
Hydrophobic ICL2 P 117 - G.H5 N 343 G.H5.19
Van-der-waals ICL2 P 117 - G.H5 N 343 G.H5.19
Hydrophobic TM6 Q 222 6x33 G.H5 F 350 G.H5.26
Van-der-waals TM6 Q 222 6x33 G.H5 F 350 G.H5.26
Hydrophobic TM5 V 188 5x61 G.H5 L 349 G.H5.25
Van-der-waals TM5 V 188 5x61 G.H5 L 349 G.H5.25
Polar ICL2 P 120 - G.hns1 A 27 G.hns1.02
Hydrophobic ICL2 P 120 - G.hns1 A 27 G.hns1.02
Van-der-waals ICL2 P 120 - G.hns1 A 27 G.hns1.02
Hydrophobic C-term L 327 - G.h2s4 F 211 G.h2s4.01
Polar ICL2 Q 119 - G.hns1 R 28 G.hns1.03
Hydrophobic ICL2 Q 119 - G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 Q 119 - G.hns1 R 28 G.hns1.03
Hydrophobic TM5 L 202 5x75 G.H5 D 333 G.H5.09
Polar C-term L 329 - G.H2 R 204 G.H2.04
Hydrophobic C-term L 329 - G.H2 R 204 G.H2.04
Van-der-waals C-term L 329 - G.H2 R 204 G.H2.04