Gt2 - GPR25 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 83.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 144 34x50 G.S3 L 194 G.S3.01
Hydrophobic C-term F 347 - G.H2 W 211 G.H2.07
Hydrophobic ICL3 V 235 - G.H5 L 348 G.H5.20
Hydrophobic C-term F 347 - G.H2 R 208 G.H2.04
Van-der-waals C-term F 347 - G.H2 R 208 G.H2.04
Hydrophobic C-term F 347 - G.H3 I 253 G.H3.12
Polar C-term C 349 - G.H2 K 209 G.H2.05
Hydrophobic C-term C 349 - G.H2 K 209 G.H2.05
Van-der-waals C-term C 349 - G.H2 K 209 G.H2.05
Hydrophobic TM6 A 238 6x29 G.H5 L 348 G.H5.20
Hydrophobic TM3 A 140 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 141 3x54 G.H5 C 351 G.H5.23
Hydrophobic ICL2 E 146 34x52 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 E 146 34x52 G.s2s3 D 193 G.s2s3.02
Polar TM6 S 242 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 S 242 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 S 242 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM2 V 74 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 V 74 2x39 G.H5 D 350 G.H5.22
Polar ICL2 R 148 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 R 148 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 148 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM3 R 137 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 137 3x50 G.H5 L 353 G.H5.25
Hydrophobic C-term V 346 - G.H2 R 208 G.H2.04
Polar TM3 R 137 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 137 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 137 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 145 34x51 G.H5 I 343 G.H5.15
Polar ICL3 P 233 - G.H5 D 341 G.H5.13
Hydrophobic TM6 I 245 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 245 6x36 G.H5 L 353 G.H5.25
Hydrophobic C-term V 346 - G.H3 S 252 G.H3.11
Ionic ICL2 R 151 34x57 G.H5 D 350 G.H5.22
Polar ICL2 R 151 34x57 G.H5 D 350 G.H5.22
Hydrophobic ICL2 R 151 34x57 G.H5 D 350 G.H5.22
Van-der-waals ICL2 R 151 34x57 G.H5 D 350 G.H5.22
Van-der-waals C-term F 347 - G.H2 K 209 G.H2.05
Hydrophobic TM2 R 72 2x37 G.H5 G 352 G.H5.24
Van-der-waals TM2 R 72 2x37 G.H5 G 352 G.H5.24
Hydrophobic ICL2 L 144 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 L 144 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM5 L 229 5x65 G.H5 I 344 G.H5.16
Van-der-waals TM5 L 229 5x65 G.H5 I 344 G.H5.16
Polar TM2 R 72 2x37 G.H5 K 349 G.H5.21
Hydrophobic TM2 R 72 2x37 G.H5 K 349 G.H5.21
Van-der-waals TM2 R 72 2x37 G.H5 K 349 G.H5.21
Hydrophobic TM6 A 238 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM6 I 246 6x37 G.H5 L 353 G.H5.25
Hydrophobic H8 D 311 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL2 P 149 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic C-term F 347 - G.h2s4 F 215 G.h2s4.01
Polar TM6 N 241 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 N 241 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 N 241 6x32 G.H5 F 354 G.H5.26
Polar TM3 R 137 3x50 G.H5 G 352 G.H5.24
Hydrophobic TM2 V 74 2x39 G.H5 G 352 G.H5.24
Hydrophobic TM5 L 229 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL3 H 234 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 L 145 34x51 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 L 145 34x51 G.hns1 K 32 G.hns1.03
Hydrophobic C-term V 346 - G.H3 L 249 G.H3.08
Van-der-waals C-term V 346 - G.H3 L 249 G.H3.08
Hydrophobic C-term V 346 - G.H3 H 248 G.H3.07
Van-der-waals C-term V 346 - G.H3 H 248 G.H3.07
Polar H8 R 312 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 R 312 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 R 312 8x48 G.H5 F 354 G.H5.26
Hydrophobic ICL3 P 232 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 P 232 - G.H5 D 341 G.H5.13
Hydrophobic C-term F 347 - G.H3 H 256 G.H3.15
Polar ICL3 V 235 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 V 235 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 V 235 - G.H5 D 341 G.H5.13
Polar TM2 R 72 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 R 72 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 72 2x37 G.H5 D 350 G.H5.22
Hydrophobic ICL3 P 232 - G.H5 I 344 G.H5.16
Hydrophobic TM6 A 238 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 238 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 L 145 34x51 G.S1 V 34 G.S1.02
Van-der-waals ICL2 L 145 34x51 G.S1 V 34 G.S1.02
Polar TM3 A 140 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 140 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 140 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 V 141 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 141 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM2 V 74 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 E 146 34x52 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 E 146 34x52 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 L 144 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 P 149 34x55 G.HN D 28 G.HN.52
Hydrophobic ICL3 V 235 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 145 34x51 G.S1 T 33 G.S1.01
Polar ICL3 H 234 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 H 234 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 H 234 - G.H5 D 341 G.H5.13
Hydrophobic TM6 S 242 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 S 242 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 145 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 145 34x51 G.S3 L 194 G.S3.01