G13 - GPR34 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR34 69.8
subunit alpha-13 84.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 N 257 - G.H5 H 368 G.H5.17
Hydrophobic ICL3 N 257 - G.H5 H 368 G.H5.17
Van-der-waals ICL3 N 257 - G.H5 H 368 G.H5.17
Van-der-waals TM7 L 329 7x55 G.H5 M 375 G.H5.24
Polar ICL3 N 257 - G.H5 D 364 G.H5.13
Van-der-waals ICL3 N 257 - G.H5 D 364 G.H5.13
Polar ICL2 Q 161 - G.s2s3 K 214 G.s2s3.01
Van-der-waals ICL2 Q 161 - G.s2s3 K 214 G.s2s3.01
Hydrophobic ICL3 N 257 - G.h4s6 P 341 G.h4s6.20
Van-der-waals ICL3 N 257 - G.h4s6 P 341 G.h4s6.20
Hydrophobic ICL2 Q 161 - G.S3 V 216 G.S3.01
Van-der-waals ICL2 Q 161 - G.S3 V 216 G.S3.01
Polar TM3 R 158 3x56 G.H5 N 370 G.H5.19
Hydrophobic TM6 K 260 6x30 G.H5 H 368 G.H5.17
Van-der-waals TM6 K 260 6x30 G.H5 H 368 G.H5.17
Hydrophobic TM3 I 156 3x54 G.H5 L 374 G.H5.23
Van-der-waals TM3 I 156 3x54 G.H5 L 374 G.H5.23
Polar TM3 S 159 3x57 G.H5 K 363 G.H5.12
Polar TM6 K 260 6x30 G.h4s6 Q 338 G.h4s6.12
Van-der-waals TM6 K 260 6x30 G.h4s6 Q 338 G.h4s6.12
Hydrophobic TM7 M 330 7x56 G.H5 M 375 G.H5.24
Van-der-waals TM7 M 330 7x56 G.H5 M 375 G.H5.24
Hydrophobic TM6 Y 261 6x31 G.H5 L 371 G.H5.20
Van-der-waals TM6 Y 261 6x31 G.H5 L 371 G.H5.20
Hydrophobic ICL2 R 163 - G.H5 I 366 G.H5.15
Polar ICL2 R 163 - G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 R 163 - G.hns1 R 47 G.hns1.03
Hydrophobic TM3 D 151 3x49 G.H5 L 374 G.H5.23
Hydrophobic TM6 N 267 6x37 G.H5 M 375 G.H5.24
Hydrophobic TM2 I 89 2x39 G.H5 L 376 G.H5.25
Polar TM2 N 87 2x37 G.H5 Q 373 G.H5.22
Hydrophobic TM2 N 87 2x37 G.H5 Q 373 G.H5.22
Polar ICL2 R 163 - G.h2s4 T 241 G.h2s4.05
Van-der-waals ICL2 R 163 - G.h2s4 T 241 G.h2s4.05
Hydrophobic TM5 I 248 5x68 G.H5 L 367 G.H5.16
Van-der-waals TM5 I 248 5x68 G.H5 L 367 G.H5.16
Hydrophobic H8 N 333 8x49 G.H5 Q 377 G.H5.26
Van-der-waals H8 N 333 8x49 G.H5 Q 377 G.H5.26
Polar TM6 Y 261 6x31 G.H5 D 364 G.H5.13
Hydrophobic TM6 Y 261 6x31 G.H5 D 364 G.H5.13
Van-der-waals TM6 Y 261 6x31 G.H5 D 364 G.H5.13
Polar TM3 K 155 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM3 K 155 3x53 G.H5 N 370 G.H5.19
Van-der-waals TM3 K 155 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM3 I 156 3x54 G.H5 L 371 G.H5.20
Van-der-waals TM3 I 156 3x54 G.H5 L 371 G.H5.20
Hydrophobic TM2 I 89 2x39 G.H5 L 374 G.H5.23
Van-der-waals TM2 I 89 2x39 G.H5 L 374 G.H5.23
Hydrophobic ICL2 I 160 - G.H5 I 366 G.H5.15
Hydrophobic TM3 I 156 3x54 G.H5 L 367 G.H5.16
Van-der-waals TM3 I 156 3x54 G.H5 L 367 G.H5.16
Hydrophobic ICL2 I 160 - G.S1 V 49 G.S1.02
Van-der-waals ICL2 I 160 - G.S1 V 49 G.S1.02
Hydrophobic ICL3 P 256 - G.h4s6 P 341 G.h4s6.20
Van-der-waals ICL3 P 256 - G.h4s6 P 341 G.h4s6.20
Polar H8 S 331 8x47 G.H5 L 376 G.H5.25
Hydrophobic H8 S 331 8x47 G.H5 L 376 G.H5.25
Van-der-waals H8 S 331 8x47 G.H5 L 376 G.H5.25
Polar H8 S 332 8x48 G.H5 L 376 G.H5.25
Hydrophobic ICL2 K 164 - G.HN T 43 G.HN.52
Hydrophobic TM6 Y 261 6x31 G.H5 L 367 G.H5.16
Van-der-waals TM6 Y 261 6x31 G.H5 L 367 G.H5.16
Hydrophobic ICL2 I 160 - G.H5 F 359 G.H5.08
Hydrophobic TM3 K 155 3x53 G.H5 L 374 G.H5.23
Van-der-waals TM3 K 155 3x53 G.H5 L 374 G.H5.23
Polar ICL3 N 257 - G.S6 Y 343 G.S6.02
Hydrophobic ICL2 I 160 - G.H5 V 362 G.H5.11
Polar H8 N 333 8x49 G.H5 L 376 G.H5.25
Hydrophobic H8 N 333 8x49 G.H5 L 376 G.H5.25
Van-der-waals H8 N 333 8x49 G.H5 L 376 G.H5.25
Hydrophobic ICL3 F 255 - G.H5 D 361 G.H5.10
Van-der-waals ICL3 F 255 - G.H5 D 361 G.H5.10
Polar ICL2 R 163 - G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 R 163 - G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 R 163 - G.hns1 K 46 G.hns1.02
Polar ICL3 R 252 - G.H5 R 360 G.H5.09
Van-der-waals ICL3 R 252 - G.H5 R 360 G.H5.09
Hydrophobic TM2 N 87 2x37 G.H5 L 376 G.H5.25
Hydrophobic H8 S 331 8x47 G.H5 M 375 G.H5.24
Van-der-waals H8 S 331 8x47 G.H5 M 375 G.H5.24
Hydrophobic TM2 L 93 2x43 G.H5 L 376 G.H5.25
Van-der-waals TM2 L 93 2x43 G.H5 L 376 G.H5.25
Polar H8 S 332 8x48 G.H5 M 375 G.H5.24
Van-der-waals H8 S 332 8x48 G.H5 M 375 G.H5.24
Polar H8 S 332 8x48 G.H5 Q 377 G.H5.26
Hydrophobic H8 S 332 8x48 G.H5 Q 377 G.H5.26
Van-der-waals H8 S 332 8x48 G.H5 Q 377 G.H5.26
Polar TM3 R 152 3x50 G.H5 L 374 G.H5.23
Hydrophobic TM3 R 152 3x50 G.H5 L 374 G.H5.23
Van-der-waals TM3 R 152 3x50 G.H5 L 374 G.H5.23
Polar ICL2 Q 161 - G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 Q 161 - G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 Q 161 - G.hns1 R 47 G.hns1.03
Hydrophobic TM5 L 245 5x65 G.H5 L 371 G.H5.20
Hydrophobic ICL2 I 160 - G.S3 V 216 G.S3.01
Van-der-waals ICL2 I 160 - G.S3 V 216 G.S3.01
Polar ICL2 R 163 - G.S1 L 48 G.S1.01
Hydrophobic ICL2 R 163 - G.S1 L 48 G.S1.01
Van-der-waals ICL2 R 163 - G.S1 L 48 G.S1.01
Hydrophobic ICL2 I 160 - G.H5 K 363 G.H5.12
Van-der-waals ICL2 I 160 - G.H5 K 363 G.H5.12
Hydrophobic ICL2 Q 161 - G.s2s3 N 215 G.s2s3.02
Hydrophobic TM6 T 264 6x34 G.H5 L 371 G.H5.20
Van-der-waals TM6 T 264 6x34 G.H5 L 371 G.H5.20
Hydrophobic TM6 T 264 6x34 G.H5 M 375 G.H5.24
Van-der-waals TM6 T 264 6x34 G.H5 M 375 G.H5.24
Hydrophobic ICL3 F 255 - G.H5 R 360 G.H5.09
Van-der-waals ICL3 F 255 - G.H5 R 360 G.H5.09
Hydrophobic TM2 Q 90 2x40 G.H5 L 376 G.H5.25
Van-der-waals TM2 Q 90 2x40 G.H5 L 376 G.H5.25
Polar ICL3 R 252 - G.H5 K 363 G.H5.12
Hydrophobic ICL3 R 252 - G.H5 K 363 G.H5.12
Van-der-waals ICL3 R 252 - G.H5 K 363 G.H5.12
Ionic ICL3 R 252 - G.H5 D 364 G.H5.13
Polar ICL3 R 252 - G.H5 D 364 G.H5.13
Hydrophobic ICL3 R 252 - G.H5 D 364 G.H5.13
Van-der-waals ICL3 R 252 - G.H5 D 364 G.H5.13
Hydrophobic ICL3 F 255 - G.S6 Y 343 G.S6.02
Van-der-waals ICL3 F 255 - G.S6 Y 343 G.S6.02