G14 - GPR4 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR4 78.6
subunit alpha-14 89.3
Gβ1 91.7
Gγ2 82.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 11.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 A 118 3x53 G.H5 F 352 G.H5.23
Polar ICL2 R 127 34x55 G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 R 127 34x55 G.s2s3 N 194 G.s2s3.02
Hydrophobic TM2 E 51 2x38 G.H5 F 352 G.H5.23
Van-der-waals TM2 E 51 2x38 G.H5 F 352 G.H5.23
Polar TM6 K 221 6x32 G.H5 V 355 G.H5.26
Hydrophobic TM6 K 221 6x32 G.H5 V 355 G.H5.26
Van-der-waals TM6 K 221 6x32 G.H5 V 355 G.H5.26
Polar TM7 Y 286 7x53 G.H5 N 353 G.H5.24
Polar TM1 Q 45 1x60 G.H5 N 353 G.H5.24
Van-der-waals TM1 Q 45 1x60 G.H5 N 353 G.H5.24
Hydrophobic ICL3 S 211 - G.H5 L 345 G.H5.16
Ionic TM6 E 218 6x29 G.H5 R 350 G.H5.21
Hydrophobic TM2 L 52 2x39 G.H5 N 353 G.H5.24
Polar H8 N 290 8x47 G.H5 N 353 G.H5.24
Hydrophobic H8 N 290 8x47 G.H5 N 353 G.H5.24
Van-der-waals H8 N 290 8x47 G.H5 N 353 G.H5.24
Hydrophobic C-term M 357 - G.H5 D 331 G.H5.02
Polar TM3 R 115 3x50 G.H5 N 353 G.H5.24
Van-der-waals TM3 R 115 3x50 G.H5 N 353 G.H5.24
Polar ICL3 S 213 - G.H5 D 342 G.H5.13
Hydrophobic ICL3 S 213 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 S 213 - G.H5 D 342 G.H5.13
Ionic ICL2 R 124 34x52 G.s2s3 E 193 G.s2s3.01
Polar ICL2 R 124 34x52 G.s2s3 E 193 G.s2s3.01
Van-der-waals ICL2 R 124 34x52 G.s2s3 E 193 G.s2s3.01
Polar ICL3 T 214 - G.H5 Q 346 G.H5.17
Hydrophobic ICL3 T 214 - G.H5 Q 346 G.H5.17
Van-der-waals ICL3 T 214 - G.H5 Q 346 G.H5.17
Van-der-waals TM4 R 130 4x38 G.hns1 R 34 G.hns1.03
Polar TM2 N 50 2x37 G.H5 E 351 G.H5.22
Van-der-waals TM2 N 50 2x37 G.H5 E 351 G.H5.22
Hydrophobic ICL2 R 129 34x57 G.H5 F 352 G.H5.23
Van-der-waals ICL2 R 129 34x57 G.H5 F 352 G.H5.23
Polar ICL3 S 211 - G.H5 D 342 G.H5.13
Hydrophobic ICL3 S 211 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 S 211 - G.H5 D 342 G.H5.13
Hydrophobic ICL2 P 122 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 122 34x50 G.H5 I 344 G.H5.15
Polar ICL3 V 212 - G.H5 D 342 G.H5.13
Polar ICL3 S 213 - G.H5 Q 346 G.H5.17
Hydrophobic ICL3 S 213 - G.H5 Q 346 G.H5.17
Van-der-waals ICL3 S 213 - G.H5 Q 346 G.H5.17
Polar ICL3 S 213 - G.S6 Y 321 G.S6.02
Hydrophobic TM6 L 225 6x36 G.H5 L 354 G.H5.25
Polar TM3 A 118 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 118 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 118 3x53 G.H5 N 348 G.H5.19
Hydrophobic ICL2 P 122 34x50 G.H5 K 341 G.H5.12
Hydrophobic ICL3 S 213 - G.h4s6 V 319 G.h4s6.20
Hydrophobic ICL3 T 214 - G.H5 L 349 G.H5.20
Van-der-waals ICL3 T 214 - G.H5 L 349 G.H5.20
Hydrophobic TM3 R 115 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM3 V 119 3x54 G.H5 L 345 G.H5.16
Van-der-waals TM3 V 119 3x54 G.H5 L 345 G.H5.16
Polar TM3 R 115 3x50 G.H5 F 352 G.H5.23
Hydrophobic TM3 R 115 3x50 G.H5 F 352 G.H5.23
Van-der-waals TM3 R 115 3x50 G.H5 F 352 G.H5.23
Hydrophobic ICL2 L 123 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 L 123 34x51 G.H5 I 344 G.H5.15
Hydrophobic TM2 L 52 2x39 G.H5 F 352 G.H5.23
Van-der-waals TM2 L 52 2x39 G.H5 F 352 G.H5.23
Van-der-waals H8 N 290 8x47 G.H5 V 355 G.H5.26
Hydrophobic TM5 A 207 5x64 G.H5 L 345 G.H5.16
Van-der-waals ICL2 P 122 34x50 G.H5 N 348 G.H5.19
Hydrophobic TM6 E 218 6x29 G.H5 V 355 G.H5.26
Van-der-waals TM6 E 218 6x29 G.H5 V 355 G.H5.26
Hydrophobic TM3 V 119 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 119 3x54 G.H5 L 349 G.H5.20
Hydrophobic ICL2 L 123 34x51 G.S1 L 36 G.S1.02
Van-der-waals ICL2 L 123 34x51 G.S1 L 36 G.S1.02
Hydrophobic TM6 I 222 6x33 G.H5 L 354 G.H5.25
Polar TM3 A 120 3x55 G.H5 K 341 G.H5.12
Hydrophobic TM3 A 120 3x55 G.H5 K 341 G.H5.12
Van-der-waals TM3 A 120 3x55 G.H5 K 341 G.H5.12
Hydrophobic ICL2 L 123 34x51 G.S3 I 195 G.S3.01
Van-der-waals ICL2 L 123 34x51 G.S3 I 195 G.S3.01
Hydrophobic ICL2 R 127 34x55 G.hns1 R 34 G.hns1.03
Hydrophobic TM3 V 119 3x54 G.H5 L 354 G.H5.25
Van-der-waals TM3 V 119 3x54 G.H5 L 354 G.H5.25
Hydrophobic TM6 I 222 6x33 G.H5 L 349 G.H5.20
Van-der-waals TM6 I 222 6x33 G.H5 L 349 G.H5.20
Hydrophobic TM5 V 208 5x65 G.H5 L 349 G.H5.20
Hydrophobic C-term L 355 - G.S6 Y 321 G.S6.02
Van-der-waals C-term L 355 - G.S6 Y 321 G.S6.02
Hydrophobic TM3 D 114 3x49 G.H5 F 352 G.H5.23
Van-der-waals TM3 D 114 3x49 G.H5 F 352 G.H5.23
Polar ICL2 R 129 34x57 G.H5 N 348 G.H5.19
Van-der-waals ICL2 R 129 34x57 G.H5 N 348 G.H5.19
Hydrophobic ICL2 L 123 34x51 G.H5 K 341 G.H5.12
Hydrophobic ICL2 L 123 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 L 123 34x51 G.H5 F 337 G.H5.08
Polar TM6 E 218 6x29 G.H5 Q 346 G.H5.17
Hydrophobic TM6 E 218 6x29 G.H5 Q 346 G.H5.17
Van-der-waals TM6 E 218 6x29 G.H5 Q 346 G.H5.17