G15 - GPR4 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
GPR4 76.4
subunit alpha-15 85.7
Gβ1 92.1
Gγ2 83.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 225 6x36 G.H5 L 373 G.H5.25
Polar ICL3 S 213 - G.H5 D 361 G.H5.13
Hydrophobic ICL3 S 213 - G.H5 D 361 G.H5.13
Hydrophobic ICL2 L 123 34x51 G.H5 F 356 G.H5.08
Van-der-waals ICL2 L 123 34x51 G.H5 F 356 G.H5.08
Hydrophobic C-term Q 352 - G.H5 R 353 G.H5.05
Hydrophobic C-term L 358 - G.S3 N 203 G.S3.02
Van-der-waals C-term L 358 - G.S3 N 203 G.S3.02
Hydrophobic ICL2 P 122 34x50 G.H5 V 363 G.H5.15
Hydrophobic ICL2 L 123 34x51 G.S3 T 202 G.S3.01
Polar H8 G 292 8x49 G.H5 N 372 G.H5.24
Hydrophobic H8 G 292 8x49 G.H5 N 372 G.H5.24
Van-der-waals H8 G 292 8x49 G.H5 N 372 G.H5.24
Polar ICL2 R 129 34x57 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 R 129 34x57 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 R 129 34x57 G.H5 Y 367 G.H5.19
Polar C-term M 357 - G.S2 S 198 G.S2.07
Hydrophobic C-term M 357 - G.S2 S 198 G.S2.07
Hydrophobic ICL2 L 123 34x51 G.H5 R 360 G.H5.12
Hydrophobic C-term M 357 - G.S2 F 197 G.S2.06
Van-der-waals C-term M 357 - G.S2 F 197 G.S2.06
Hydrophobic ICL3 S 213 - G.H5 A 365 G.H5.17
Ionic TM6 E 218 6x29 G.h4s6 R 338 G.h4s6.20
Polar C-term Q 354 - G.s2s3 Q 200 G.s2s3.01
Hydrophobic C-term Q 354 - G.s2s3 Q 200 G.s2s3.01
Van-der-waals C-term Q 354 - G.s2s3 Q 200 G.s2s3.01
Ionic H8 E 291 8x48 G.h4s6 R 335 G.h4s6.17
Polar H8 E 291 8x48 G.h4s6 R 335 G.h4s6.17
Van-der-waals H8 E 291 8x48 G.h4s6 R 335 G.h4s6.17
Polar C-term V 353 - G.H5 R 353 G.H5.05
Hydrophobic C-term V 353 - G.H5 R 353 G.H5.05
Van-der-waals C-term V 353 - G.H5 R 353 G.H5.05
Polar ICL3 S 213 - G.h4s6 R 338 G.h4s6.20
Hydrophobic ICL3 S 213 - G.h4s6 R 338 G.h4s6.20
Van-der-waals ICL3 S 213 - G.h4s6 R 338 G.h4s6.20
Hydrophobic ICL2 P 122 34x50 G.H5 R 360 G.H5.12
Van-der-waals ICL2 P 122 34x50 G.H5 R 360 G.H5.12
Hydrophobic TM3 V 119 3x54 G.H5 Y 367 G.H5.19
Hydrophobic ICL3 V 212 - G.H5 K 357 G.H5.09
Hydrophobic C-term L 358 - G.S2 S 198 G.S2.07
Van-der-waals C-term L 358 - G.S2 S 198 G.S2.07
Polar TM6 K 221 6x32 G.H5 N 372 G.H5.24
Van-der-waals TM6 K 221 6x32 G.H5 N 372 G.H5.24
Hydrophobic C-term V 353 - G.s2s3 Q 200 G.s2s3.01
Van-der-waals C-term V 353 - G.s2s3 Q 200 G.s2s3.01
Polar TM3 D 114 3x49 G.H5 Y 367 G.H5.19
Hydrophobic TM3 V 119 3x54 G.H5 L 368 G.H5.20
Van-der-waals C-term W 342 - G.H4 D 314 G.H4.13
Hydrophobic ICL3 T 214 - G.H5 L 368 G.H5.20
Van-der-waals ICL3 T 214 - G.H5 L 368 G.H5.20
Hydrophobic TM6 K 221 6x32 G.H5 L 373 G.H5.25
Hydrophobic C-term L 355 - G.S2 V 199 G.S2.08
Van-der-waals C-term L 355 - G.S2 V 199 G.S2.08
Polar TM6 K 221 6x32 G.H5 L 374 G.H5.26
Van-der-waals TM6 K 221 6x32 G.H5 L 374 G.H5.26
Polar H8 N 290 8x47 G.H5 N 372 G.H5.24
Hydrophobic H8 N 290 8x47 G.H5 N 372 G.H5.24
Van-der-waals H8 N 290 8x47 G.H5 N 372 G.H5.24
Hydrophobic C-term M 357 - G.h1ha G 67 G.h1ha.01
Van-der-waals C-term M 357 - G.h1ha G 67 G.h1ha.01
Hydrophobic C-term M 357 - G.h1ha A 68 G.h1ha.02
Van-der-waals C-term M 357 - G.h1ha A 68 G.h1ha.02
Hydrophobic ICL2 L 123 34x51 G.S1 L 43 G.S1.02
Van-der-waals ICL2 L 123 34x51 G.S1 L 43 G.S1.02
Polar H8 N 290 8x47 G.H5 I 371 G.H5.23
Van-der-waals H8 N 290 8x47 G.H5 I 371 G.H5.23
Polar ICL2 R 127 34x55 G.hns1 G 41 G.hns1.03
Hydrophobic ICL2 R 127 34x55 G.hns1 G 41 G.hns1.03
Van-der-waals ICL2 R 127 34x55 G.hns1 G 41 G.hns1.03
Hydrophobic C-term L 355 - G.H5 I 352 G.H5.04
Van-der-waals C-term L 355 - G.H5 I 352 G.H5.04
Hydrophobic TM3 V 119 3x54 G.H5 L 364 G.H5.16
Van-der-waals TM3 V 119 3x54 G.H5 L 364 G.H5.16
Polar ICL3 V 212 - G.H5 D 361 G.H5.13
Hydrophobic TM3 A 118 3x53 G.H5 Y 367 G.H5.19
Van-der-waals TM3 A 118 3x53 G.H5 Y 367 G.H5.19
Hydrophobic TM3 R 115 3x50 G.H5 I 371 G.H5.23
Polar ICL2 R 124 34x52 G.s2s3 Q 200 G.s2s3.01
Polar C-term S 333 - G.h4s6 E 328 G.h4s6.10
Hydrophobic C-term S 333 - G.h4s6 E 328 G.h4s6.10
Van-der-waals C-term S 333 - G.h4s6 E 328 G.h4s6.10
Hydrophobic TM6 I 222 6x33 G.H5 L 373 G.H5.25
Hydrophobic TM6 E 218 6x29 G.H5 L 374 G.H5.26
Van-der-waals TM6 E 218 6x29 G.H5 L 374 G.H5.26
Hydrophobic C-term L 355 - G.H1 H 66 G.H1.12
Van-der-waals C-term L 355 - G.H1 H 66 G.H1.12
Polar C-term M 357 - G.H1 H 66 G.H1.12
Hydrophobic C-term M 357 - G.H1 H 66 G.H1.12
Van-der-waals C-term M 357 - G.H1 H 66 G.H1.12
Hydrophobic TM6 I 222 6x33 G.H5 L 368 G.H5.20
Hydrophobic ICL2 L 123 34x51 G.H5 V 363 G.H5.15
Van-der-waals ICL2 L 123 34x51 G.H5 V 363 G.H5.15
Hydrophobic C-term V 353 - G.H5 F 356 G.H5.08
Hydrophobic C-term W 342 - G.H4 T 317 G.H4.16
Van-der-waals C-term W 342 - G.H4 T 317 G.H4.16
Polar C-term K 356 - G.S2 S 198 G.S2.07
Hydrophobic C-term K 356 - G.S2 S 198 G.S2.07
Van-der-waals C-term K 356 - G.S2 S 198 G.S2.07
Hydrophobic TM2 L 52 2x39 G.H5 I 371 G.H5.23
Van-der-waals TM2 L 52 2x39 G.H5 I 371 G.H5.23
Hydrophobic ICL3 S 211 - G.H5 L 364 G.H5.16