G15 - GPR52 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR52 74.1
subunit alpha-15 84.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 139 3x50 G.H5 I 371 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 I 371 G.H5.23
Hydrophobic TM6 L 267 6x37 G.H5 I 371 G.H5.23
Van-der-waals TM6 L 267 6x37 G.H5 I 371 G.H5.23
Polar TM7 S 320 7x56 G.H5 N 372 G.H5.24
Hydrophobic TM7 S 320 7x56 G.H5 N 372 G.H5.24
Van-der-waals TM7 S 320 7x56 G.H5 N 372 G.H5.24
Hydrophobic ICL2 P 146 34x50 G.H5 V 363 G.H5.15
Van-der-waals ICL2 P 146 34x50 G.H5 V 363 G.H5.15
Hydrophobic TM6 D 260 6x30 G.H5 L 374 G.H5.26
Hydrophobic TM3 I 143 3x54 G.H5 L 364 G.H5.16
Hydrophobic TM3 I 143 3x54 G.H5 L 368 G.H5.20
Polar TM6 Y 263 6x33 G.H5 L 374 G.H5.26
Hydrophobic TM6 Y 263 6x33 G.H5 L 374 G.H5.26
Van-der-waals TM6 Y 263 6x33 G.H5 L 374 G.H5.26
Hydrophobic H8 N 321 8x47 G.H5 N 372 G.H5.24
Hydrophobic ICL2 L 147 34x51 G.H5 F 356 G.H5.08
Van-der-waals ICL2 L 147 34x51 G.H5 F 356 G.H5.08
Hydrophobic TM3 A 142 3x53 G.H5 I 371 G.H5.23
Hydrophobic ICL2 N 150 34x54 G.hns1 R 40 G.hns1.02
Van-der-waals ICL2 N 150 34x54 G.hns1 R 40 G.hns1.02
Ionic TM5 R 240 5x76 G.H5 D 358 G.H5.10
Polar TM5 R 240 5x76 G.H5 D 358 G.H5.10
Hydrophobic TM5 F 244 5x80 G.H4 L 313 G.H4.12
Polar ICL2 P 146 34x50 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 P 146 34x50 G.H5 Y 367 G.H5.19
Polar TM5 H 233 5x69 G.h4s6 R 338 G.h4s6.20
Hydrophobic TM5 H 233 5x69 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM5 H 233 5x69 G.h4s6 R 338 G.h4s6.20
Hydrophobic TM5 I 237 5x73 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM5 I 237 5x73 G.h4s6 R 338 G.h4s6.20
Hydrophobic ICL2 P 146 34x50 G.H5 L 364 G.H5.16
Hydrophobic TM3 I 143 3x54 G.H5 L 373 G.H5.25
Van-der-waals TM3 I 143 3x54 G.H5 L 373 G.H5.25
Hydrophobic TM6 D 260 6x30 G.H5 L 373 G.H5.25
Van-der-waals TM6 D 260 6x30 G.H5 L 373 G.H5.25
Aromatic ICL2 Y 149 34x53 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 Y 149 34x53 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 Y 149 34x53 G.H5 Y 367 G.H5.19
Hydrophobic TM6 A 264 6x34 G.H5 L 373 G.H5.25
Van-der-waals TM6 A 264 6x34 G.H5 L 373 G.H5.25
Hydrophobic ICL2 L 147 34x51 G.H5 V 363 G.H5.15
Hydrophobic TM4 P 155 4x39 G.hns1 R 40 G.hns1.02
Van-der-waals TM4 P 155 4x39 G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 L 147 34x51 G.H5 V 359 G.H5.11
Hydrophobic TM6 L 267 6x37 G.H5 L 373 G.H5.25
Hydrophobic TM6 Y 263 6x33 G.H5 N 372 G.H5.24
Van-der-waals TM6 Y 263 6x33 G.H5 N 372 G.H5.24
Polar ICL2 Q 151 34x55 G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 Q 151 34x55 G.hns1 R 40 G.hns1.02
Hydrophobic TM3 A 142 3x53 G.H5 Y 367 G.H5.19
Van-der-waals TM3 A 142 3x53 G.H5 Y 367 G.H5.19
Polar TM2 Y 74 2x37 G.H5 E 370 G.H5.22
Hydrophobic TM2 Y 74 2x37 G.H5 E 370 G.H5.22
Van-der-waals TM2 Y 74 2x37 G.H5 E 370 G.H5.22
Polar ICL2 N 150 34x54 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 N 150 34x54 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 P 146 34x50 G.H5 R 360 G.H5.12
Hydrophobic TM5 H 233 5x69 G.H5 L 364 G.H5.16
Hydrophobic TM3 I 143 3x54 G.H5 I 371 G.H5.23
Hydrophobic ICL2 L 147 34x51 G.S3 T 202 G.S3.01
Hydrophobic ICL2 L 147 34x51 G.H5 R 360 G.H5.12
Hydrophobic ICL2 L 147 34x51 G.S1 L 43 G.S1.02
Van-der-waals ICL2 L 147 34x51 G.S1 L 43 G.S1.02
Van-der-waals TM5 R 240 5x76 G.S6 F 340 G.S6.02
Hydrophobic TM6 Y 263 6x33 G.H5 L 373 G.H5.25
Van-der-waals TM6 Y 263 6x33 G.H5 L 373 G.H5.25
Hydrophobic TM5 I 226 5x62 G.H5 L 373 G.H5.25
Polar ICL2 Q 151 34x55 G.hns1 G 41 G.hns1.03
Hydrophobic ICL2 Q 151 34x55 G.hns1 G 41 G.hns1.03
Van-der-waals ICL2 Q 151 34x55 G.hns1 G 41 G.hns1.03
Hydrophobic TM5 R 240 5x76 G.H5 K 357 G.H5.09
Van-der-waals TM5 R 240 5x76 G.H5 K 357 G.H5.09
Polar TM6 Y 263 6x33 G.h4s6 R 335 G.h4s6.17
Hydrophobic TM6 Y 263 6x33 G.h4s6 R 335 G.h4s6.17
Van-der-waals TM6 Y 263 6x33 G.h4s6 R 335 G.h4s6.17
Hydrophobic TM5 H 233 5x69 G.H5 L 368 G.H5.20
Ionic TM5 R 240 5x76 G.H5 D 361 G.H5.13
Polar TM5 R 240 5x76 G.H5 D 361 G.H5.13
Van-der-waals TM5 R 240 5x76 G.H5 D 361 G.H5.13