Gt2 - GPR75 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR75 56.9
Gαt2 88.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 17.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 I 309 - G.H5 A 338 G.H5.10
Van-der-waals ICL3 I 309 - G.H5 A 338 G.H5.10
Hydrophobic ICL3 I 309 - G.H5 I 342 G.H5.14
Hydrophobic TM3 M 146 3x53 G.H5 L 348 G.H5.20
Van-der-waals TM3 M 146 3x53 G.H5 L 348 G.H5.20
Hydrophobic TM4 F 158 4x39 G.HN D 28 G.HN.52
Van-der-waals TM4 F 158 4x39 G.HN D 28 G.HN.52
Polar TM6 S 312 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 S 312 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 S 312 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM6 T 322 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 322 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 322 6x36 G.H5 L 353 G.H5.25
Polar ICL2 T 155 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 T 155 - G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 T 155 - G.hns1 K 32 G.hns1.03
Hydrophobic TM6 L 311 6x25 G.S6 Y 320 G.S6.02
Van-der-waals TM6 L 311 6x25 G.S6 Y 320 G.S6.02
Hydrophobic ICL1 F 75 12x50 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 A 319 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 319 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL3 I 309 - G.S6 H 322 G.S6.04
Van-der-waals TM6 D 316 6x30 G.H5 F 354 G.H5.26
Ionic TM6 K 315 6x29 G.H5 E 346 G.H5.18
Polar TM6 K 315 6x29 G.H5 E 346 G.H5.18
Van-der-waals TM6 K 315 6x29 G.H5 E 346 G.H5.18
Hydrophobic TM5 L 229 5x65 G.H5 K 345 G.H5.17
Van-der-waals TM5 L 229 5x65 G.H5 K 345 G.H5.17
Ionic TM6 K 315 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 315 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 K 315 6x29 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 315 6x29 G.h4s6 E 318 G.h4s6.12
Ionic TM6 D 316 6x30 G.H5 K 345 G.H5.17
Polar TM6 D 316 6x30 G.H5 K 345 G.H5.17
Hydrophobic TM6 D 316 6x30 G.H5 K 345 G.H5.17
Van-der-waals TM6 D 316 6x30 G.H5 K 345 G.H5.17
Polar TM7 R 378 7x55 G.H5 C 351 G.H5.23
Hydrophobic TM7 R 378 7x55 G.H5 C 351 G.H5.23
Van-der-waals TM7 R 378 7x55 G.H5 C 351 G.H5.23
Hydrophobic TM7 S 377 7x54 G.H5 G 352 G.H5.24
Van-der-waals TM7 S 377 7x54 G.H5 G 352 G.H5.24
Hydrophobic TM5 L 229 5x65 G.H5 F 354 G.H5.26
Ionic ICL1 K 74 12x49 G.hns1 E 30 G.hns1.01
Polar ICL1 K 74 12x49 G.hns1 E 30 G.hns1.01
Hydrophobic ICL1 K 74 12x49 G.hns1 E 30 G.hns1.01
Van-der-waals ICL1 K 74 12x49 G.hns1 E 30 G.hns1.01
Polar C-term Y 486 - G.H3 H 248 G.H3.07
Aromatic C-term Y 486 - G.H3 H 248 G.H3.07
Hydrophobic C-term Y 486 - G.H3 H 248 G.H3.07
Van-der-waals C-term Y 486 - G.H3 H 248 G.H3.07
Polar TM3 R 143 3x50 G.H5 G 352 G.H5.24
Hydrophobic TM3 R 143 3x50 G.H5 G 352 G.H5.24
Van-der-waals TM3 R 143 3x50 G.H5 G 352 G.H5.24
Hydrophobic ICL3 L 305 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 L 305 - G.H5 F 334 G.H5.06
Van-der-waals TM7 I 375 7x52 G.H5 G 352 G.H5.24
Hydrophobic TM3 R 143 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 143 3x50 G.H5 L 353 G.H5.25
Ionic TM7 R 378 7x55 G.H5 D 350 G.H5.22
Polar TM7 R 378 7x55 G.H5 D 350 G.H5.22
Hydrophobic TM7 R 378 7x55 G.H5 D 350 G.H5.22
Van-der-waals TM7 R 378 7x55 G.H5 D 350 G.H5.22
Hydrophobic ICL2 Q 151 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 Q 151 - G.H5 I 344 G.H5.16
Hydrophobic TM6 L 311 6x25 G.H5 K 345 G.H5.17
Hydrophobic TM5 I 225 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL1 R 76 12x51 G.hns1 A 31 G.hns1.02
Van-der-waals ICL1 R 76 12x51 G.hns1 A 31 G.hns1.02
Hydrophobic C-term I 485 - G.h2s4 F 215 G.h2s4.01
Hydrophobic ICL3 V 306 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 V 306 - G.H5 F 334 G.H5.06
Hydrophobic TM2 F 79 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 F 79 2x39 G.H5 C 351 G.H5.23
Polar ICL1 R 73 12x48 G.HN Q 24 G.HN.48
Polar ICL2 R 154 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 154 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 154 - G.s2s3 D 193 G.s2s3.02
Polar ICL2 Q 151 - G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 Q 151 - G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 Q 151 - G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL3 L 305 - G.H5 N 331 G.H5.03
Ionic ICL1 K 74 12x49 G.h2s4 E 216 G.h2s4.02
Polar ICL1 K 74 12x49 G.h2s4 E 216 G.h2s4.02
Van-der-waals ICL1 K 74 12x49 G.h2s4 E 216 G.h2s4.02
Hydrophobic C-term I 485 - G.H3 I 253 G.H3.12
Hydrophobic TM6 K 315 6x29 G.H5 K 349 G.H5.21
Van-der-waals TM6 K 315 6x29 G.H5 K 349 G.H5.21
Polar TM3 R 143 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 143 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL3 L 305 - G.H5 V 335 G.H5.07
Polar C-term I 485 - G.H3 S 252 G.H3.11
Hydrophobic C-term I 485 - G.H3 S 252 G.H3.11
Van-der-waals C-term I 485 - G.H3 S 252 G.H3.11
Hydrophobic ICL1 K 74 12x49 G.hns1 A 31 G.hns1.02
Van-der-waals ICL1 K 74 12x49 G.hns1 A 31 G.hns1.02
Polar ICL2 T 155 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 T 155 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 T 155 - G.s2s3 D 193 G.s2s3.02
Hydrophobic TM6 L 311 6x25 G.H5 K 349 G.H5.21
Polar ICL2 N 153 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 N 153 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 N 153 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL3 A 308 - G.S6 H 322 G.S6.04
Polar C-term Y 482 - G.H2 K 209 G.H2.05
Hydrophobic C-term Y 482 - G.H2 K 209 G.H2.05
Van-der-waals C-term Y 482 - G.H2 K 209 G.H2.05
Hydrophobic TM7 R 378 7x55 G.H5 G 352 G.H5.24
Hydrophobic TM6 C 323 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 C 323 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 311 6x25 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 L 311 6x25 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 318 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 318 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 318 6x32 G.H5 F 354 G.H5.26
Polar TM7 R 378 7x55 G.H5 N 347 G.H5.19
Hydrophobic C-term I 485 - G.H3 H 256 G.H3.15
Van-der-waals C-term I 485 - G.H3 H 256 G.H3.15
Hydrophobic TM5 Y 222 5x58 G.H5 L 353 G.H5.25
Polar ICL2 P 152 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 P 152 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 P 152 - G.s2s3 D 193 G.s2s3.02