G12 - BB2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 75.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 R 259 6x30 G.H5 L 371 G.H5.16
Van-der-waals TM6 R 259 6x30 G.H5 L 371 G.H5.16
Polar ICL1 R 72 12x51 G.HN R 52 G.HN.52
Van-der-waals ICL1 R 72 12x51 G.HN R 52 G.HN.52
Hydrophobic ICL2 P 145 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 145 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 M 146 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM3 I 142 3x54 G.H5 L 375 G.H5.20
Polar TM3 R 138 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 138 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM6 R 261 6x32 G.H5 M 379 G.H5.24
Hydrophobic ICL2 M 146 34x51 G.S1 V 58 G.S1.02
Polar TM2 N 73 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 N 73 2x37 G.H5 D 377 G.H5.22
Hydrophobic ICL3 V 246 - G.S6 L 346 G.S6.01
Hydrophobic TM5 L 244 5x72 G.S6 F 347 G.S6.02
Polar H8 S 326 8x47 G.H5 M 379 G.H5.24
Hydrophobic ICL3 P 245 - G.H5 F 361 G.H5.06
Van-der-waals ICL3 P 245 - G.H5 F 361 G.H5.06
Van-der-waals ICL2 Q 149 34x54 G.hns1 V 54 G.hns1.01
Hydrophobic TM6 L 262 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 L 262 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM6 R 259 6x30 G.H5 L 375 G.H5.20
Van-der-waals TM6 R 259 6x30 G.H5 L 375 G.H5.20
Hydrophobic ICL3 V 246 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 V 246 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM2 P 75 2x39 G.H5 I 378 G.H5.23
Polar H8 S 326 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 S 326 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 S 326 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM5 L 237 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM5 L 244 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 L 244 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM6 L 262 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 L 262 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL3 P 245 - G.S6 F 347 G.S6.02
Hydrophobic ICL2 M 146 34x51 G.H5 K 367 G.H5.12
Van-der-waals ICL2 M 146 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL3 V 246 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 V 246 - G.S6 F 347 G.S6.02
Polar TM3 A 141 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 141 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 141 3x53 G.H5 N 374 G.H5.19
Polar TM6 H 251 6x22 G.h4s6 R 342 G.h4s6.11
Hydrophobic TM6 H 251 6x22 G.h4s6 R 342 G.h4s6.11
Van-der-waals TM6 H 251 6x22 G.h4s6 R 342 G.h4s6.11
Hydrophobic ICL2 M 146 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 M 146 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL2 A 150 34x55 G.HN A 53 G.HN.53
Van-der-waals ICL2 A 150 34x55 G.HN A 53 G.HN.53
Hydrophobic TM6 L 262 6x33 G.H5 I 378 G.H5.23
Van-der-waals TM6 L 262 6x33 G.H5 I 378 G.H5.23
Hydrophobic ICL2 I 148 34x53 G.S3 P 222 G.S3.02
Hydrophobic ICL2 P 145 34x50 G.H5 L 371 G.H5.16
Hydrophobic ICL2 M 146 34x51 G.S3 F 223 G.S3.03
Van-der-waals ICL2 M 146 34x51 G.S3 F 223 G.S3.03
Hydrophobic TM3 I 142 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 145 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 145 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM1 F 65 1x57 G.H5 L 380 G.H5.25
Hydrophobic TM6 H 251 6x22 G.h4s6 K 344 G.h4s6.19
Hydrophobic ICL2 M 146 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 M 146 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM5 S 240 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 S 240 5x68 G.H5 L 371 G.H5.16
Polar TM6 Q 255 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 Q 255 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 Q 255 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM5 L 237 5x65 G.H5 L 371 G.H5.16
Polar ICL2 P 145 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 145 34x50 G.H5 N 374 G.H5.19
Polar ICL2 S 151 34x56 G.HN A 53 G.HN.53
Hydrophobic ICL2 S 151 34x56 G.HN A 53 G.HN.53
Van-der-waals ICL2 S 151 34x56 G.HN A 53 G.HN.53
Ionic ICL3 E 247 - G.S6 H 348 G.S6.03
Polar ICL3 E 247 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 E 247 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 E 247 - G.S6 H 348 G.S6.03
Hydrophobic TM6 S 258 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 S 258 6x29 G.H5 M 379 G.H5.24
Ionic TM6 R 259 6x30 G.H5 D 368 G.H5.13
Polar TM6 R 259 6x30 G.H5 D 368 G.H5.13
Hydrophobic TM6 R 259 6x30 G.H5 D 368 G.H5.13
Van-der-waals TM6 R 259 6x30 G.H5 D 368 G.H5.13
Hydrophobic TM6 Q 255 6x26 G.h4s6 P 345 G.h4s6.20
Polar TM6 H 251 6x22 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM6 H 251 6x22 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 H 251 6x22 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM3 A 141 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 141 3x53 G.H5 I 378 G.H5.23
Polar TM5 N 236 5x64 G.H5 K 367 G.H5.12
Hydrophobic TM6 R 259 6x30 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 259 6x30 G.H5 Q 372 G.H5.17
Hydrophobic TM2 N 73 2x37 G.H5 L 380 G.H5.25
Van-der-waals TM2 N 73 2x37 G.H5 L 380 G.H5.25
Van-der-waals ICL2 Q 149 34x54 G.HN R 52 G.HN.52
Hydrophobic ICL3 P 245 - G.H5 H 364 G.H5.09
Hydrophobic TM2 N 76 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 N 76 2x40 G.H5 L 380 G.H5.25
Polar H8 S 328 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 S 328 8x49 G.H5 Q 381 G.H5.26
Polar TM5 N 243 5x71 G.H5 H 364 G.H5.09
Hydrophobic TM5 N 243 5x71 G.H5 H 364 G.H5.09
Van-der-waals TM5 N 243 5x71 G.H5 H 364 G.H5.09
Polar TM5 S 240 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 S 240 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM3 I 142 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 M 146 34x51 G.H5 F 363 G.H5.08
Polar H8 S 328 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 S 328 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 S 328 8x49 G.H5 L 380 G.H5.25
Hydrophobic TM4 L 154 4x39 G.HN R 49 G.HN.49
Van-der-waals TM4 L 154 4x39 G.HN R 49 G.HN.49
Hydrophobic ICL2 I 148 34x53 G.hns1 R 55 G.hns1.02
Hydrophobic TM6 H 251 6x22 G.h4s6 P 345 G.h4s6.20