G12 - HCA1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 L 209 - G.H5 L 371 G.H5.16
Ionic ICL3 R 206 - G.H5 D 368 G.H5.13
Polar ICL3 R 206 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 R 206 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 R 206 - G.H5 D 368 G.H5.13
Ionic C-term E 344 - G.s4h3 R 265 G.s4h3.12
Polar C-term E 344 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term E 344 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term E 344 - G.s4h3 R 265 G.s4h3.12
Hydrophobic ICL2 T 126 34x56 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 T 126 34x56 G.hns1 R 56 G.hns1.03
Polar ICL2 T 126 34x56 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 T 126 34x56 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 T 126 34x56 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 V 117 3x54 G.H5 L 375 G.H5.20
Polar H8 S 284 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 S 284 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 S 284 8x49 G.H5 L 380 G.H5.25
Polar C-term P 340 - H.HA R 106 H.HA.20
Van-der-waals C-term P 340 - H.HA R 106 H.HA.20
Hydrophobic C-term V 343 - H.HA A 111 H.HA.25
Hydrophobic H8 S 284 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 S 284 8x49 G.H5 Q 381 G.H5.26
Polar H8 S 282 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 S 282 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 S 282 8x47 G.H5 M 379 G.H5.24
Polar TM3 K 116 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 K 116 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 K 116 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM6 K 217 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 K 217 6x32 G.H5 M 379 G.H5.24
Hydrophobic C-term V 343 - H.hdhe F 173 H.hdhe.01
Hydrophobic ICL2 H 121 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 H 121 34x51 G.S1 V 58 G.S1.02
Hydrophobic ICL2 P 120 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 120 34x50 G.H5 K 367 G.H5.12
Polar TM6 R 214 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 R 214 6x29 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 H 121 34x51 G.H5 V 366 G.H5.11
Hydrophobic ICL3 L 209 - G.S6 F 347 G.S6.02
Polar C-term V 343 - H.HA D 110 H.HA.24
Hydrophobic C-term V 343 - H.HA D 110 H.HA.24
Van-der-waals C-term V 343 - H.HA D 110 H.HA.24
Hydrophobic TM7 Y 278 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 278 7x53 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 120 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 120 34x50 G.H5 I 370 G.H5.15
Hydrophobic C-term I 342 - H.HA K 114 H.HA.28
Van-der-waals C-term I 342 - H.HA K 114 H.HA.28
Hydrophobic TM3 V 117 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 117 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 H 121 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL2 A 123 34x53 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 A 123 34x53 G.hns1 R 56 G.hns1.03
Polar C-term W 345 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term W 345 - G.s4h3 R 265 G.s4h3.12
Hydrophobic H8 P 283 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 P 283 8x48 G.H5 Q 381 G.H5.26
Hydrophobic C-term H 346 - G.s4h3 V 260 G.s4h3.07
Van-der-waals C-term H 346 - G.s4h3 V 260 G.s4h3.07
Hydrophobic C-term I 342 - H.HA D 110 H.HA.24
Van-der-waals C-term I 342 - H.HA D 110 H.HA.24
Polar TM3 R 113 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 113 3x50 G.H5 I 378 G.H5.23
Aromatic ICL2 H 122 34x52 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 H 122 34x52 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 H 121 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 H 121 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL3 R 206 - G.H5 L 371 G.H5.16
Van-der-waals ICL3 R 206 - G.H5 L 371 G.H5.16
Hydrophobic TM5 L 203 5x65 G.H5 L 371 G.H5.16
Hydrophobic TM6 R 214 6x29 G.H5 K 376 G.H5.21
Polar ICL2 H 121 34x51 G.hns1 R 56 G.hns1.03
Polar TM3 V 118 3x55 G.H5 K 367 G.H5.12
Van-der-waals TM3 V 118 3x55 G.H5 K 367 G.H5.12
Hydrophobic TM6 M 215 6x30 G.H5 Q 372 G.H5.17
Hydrophobic TM3 K 116 3x53 G.H5 I 378 G.H5.23
Hydrophobic C-term H 346 - H.hdhe F 173 H.hdhe.01
Hydrophobic TM6 M 215 6x30 G.H5 L 375 G.H5.20
Van-der-waals TM6 M 215 6x30 G.H5 L 375 G.H5.20
Hydrophobic TM6 A 218 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 A 218 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM6 Q 212 6x27 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 Q 212 6x27 G.h4s6 P 345 G.h4s6.20
Polar C-term H 346 - H.hdhe Q 174 H.hdhe.02
Hydrophobic C-term H 346 - H.hdhe Q 174 H.hdhe.02
Van-der-waals C-term H 346 - H.hdhe Q 174 H.hdhe.02
Hydrophobic ICL1 M 44 - G.H5 L 380 G.H5.25
Hydrophobic TM5 L 203 5x65 G.H5 L 375 G.H5.20
Hydrophobic C-term V 343 - H.HA V 107 H.HA.21
Van-der-waals C-term V 343 - H.HA V 107 H.HA.21
Polar C-term H 346 - G.s4h3 R 265 G.s4h3.12
Aromatic C-term H 346 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term H 346 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term H 346 - G.s4h3 R 265 G.s4h3.12
Polar TM6 Q 212 6x27 G.H5 Q 372 G.H5.17
Polar C-term V 343 - H.HA K 114 H.HA.28
Hydrophobic C-term V 343 - H.HA K 114 H.HA.28
Van-der-waals C-term V 343 - H.HA K 114 H.HA.28
Polar C-term W 345 - H.HA K 114 H.HA.28
Hydrophobic C-term W 345 - H.HA K 114 H.HA.28
Van-der-waals C-term W 345 - H.HA K 114 H.HA.28
Hydrophobic TM6 A 218 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 218 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM7 Y 279 7x54 G.H5 L 380 G.H5.25
Hydrophobic TM6 F 221 6x36 G.H5 I 378 G.H5.23
Hydrophobic C-term H 346 - H.HD E 172 H.HD.12
Van-der-waals C-term H 346 - H.HD E 172 H.HD.12
Hydrophobic TM2 L 54 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 L 54 2x43 G.H5 L 380 G.H5.25
Hydrophobic TM6 M 215 6x30 G.H5 L 371 G.H5.16
Van-der-waals TM6 M 215 6x30 G.H5 L 371 G.H5.16
Hydrophobic TM1 F 40 1x57 G.H5 L 380 G.H5.25
Hydrophobic C-term W 345 - H.HA L 115 H.HA.29
Van-der-waals C-term W 345 - H.HA L 115 H.HA.29
Hydrophobic TM6 F 221 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 F 221 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM4 S 128 4x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 S 128 4x38 G.hns1 R 55 G.hns1.02
Polar ICL2 I 127 34x57 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 I 127 34x57 G.hns1 R 55 G.hns1.02
Polar H8 S 282 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 S 282 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 S 282 8x47 G.H5 L 380 G.H5.25
Ionic TM2 K 48 2x37 G.H5 D 377 G.H5.22
Polar TM2 K 48 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 K 48 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 K 48 2x37 G.H5 D 377 G.H5.22
Hydrophobic ICL3 L 209 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 L 209 - G.H5 Q 372 G.H5.17
Hydrophobic ICL2 H 121 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 H 121 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL3 L 209 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 L 209 - G.H5 D 368 G.H5.13
Hydrophobic TM3 V 117 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 117 3x54 G.H5 I 378 G.H5.23
Polar ICL3 R 206 - G.H5 K 367 G.H5.12
Hydrophobic ICL3 R 206 - G.H5 K 367 G.H5.12
Van-der-waals ICL3 R 206 - G.H5 K 367 G.H5.12