G12 - H4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 T 124 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 T 124 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 V 116 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 T 124 34x55 G.S1 V 58 G.S1.02
Polar ICL3 T 217 - G.H4 R 329 G.H4.09
Hydrophobic ICL3 T 217 - G.H4 R 329 G.H4.09
Van-der-waals ICL3 T 217 - G.H4 R 329 G.H4.09
Hydrophobic TM7 C 361 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 C 361 7x56 G.H5 L 380 G.H5.25
Hydrophobic ICL2 V 120 34x51 G.H5 K 367 G.H5.12
Polar TM3 S 115 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 S 115 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 S 115 3x53 G.H5 N 374 G.H5.19
Polar TM6 R 297 6x29 G.H5 Q 372 G.H5.17
Hydrophobic TM6 R 297 6x29 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 297 6x29 G.H5 Q 372 G.H5.17
Hydrophobic TM6 L 305 6x37 G.H5 I 378 G.H5.23
Van-der-waals TM6 L 305 6x37 G.H5 I 378 G.H5.23
Hydrophobic ICL2 V 120 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM5 R 204 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 R 204 5x68 G.H5 L 371 G.H5.16
Polar TM3 R 112 3x50 G.H5 D 377 G.H5.22
Hydrophobic ICL2 T 124 34x55 G.S3 I 221 G.S3.01
Polar ICL2 H 126 34x57 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 H 126 34x57 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 H 126 34x57 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 V 116 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 116 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM6 I 307 6x39 G.H5 L 380 G.H5.25
Van-der-waals TM6 I 307 6x39 G.H5 L 380 G.H5.25
Hydrophobic ICL2 V 120 34x51 G.S1 V 58 G.S1.02
Hydrophobic ICL2 T 124 34x55 G.S3 P 222 G.S3.02
Hydrophobic ICL3 R 290 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 R 290 - G.S6 F 347 G.S6.02
Hydrophobic TM6 L 301 6x33 G.H5 I 378 G.H5.23
Van-der-waals TM6 L 301 6x33 G.H5 I 378 G.H5.23
Hydrophobic TM5 R 204 5x68 G.H5 K 367 G.H5.12
Hydrophobic TM6 S 304 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 S 304 6x36 G.H5 M 379 G.H5.24
Polar TM6 S 304 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM6 S 304 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 S 304 6x36 G.H5 L 380 G.H5.25
Hydrophobic ICL2 R 123 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM5 L 201 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 201 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL2 R 123 34x54 G.h2s4 T 246 G.h2s4.05
Ionic H8 R 364 8x49 G.H5 D 377 G.H5.22
Hydrophobic TM6 L 301 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM5 L 201 5x65 G.H5 L 371 G.H5.16
Polar ICL2 H 126 34x57 G.HN R 52 G.HN.52
Hydrophobic ICL2 H 126 34x57 G.HN R 52 G.HN.52
Van-der-waals ICL2 H 126 34x57 G.HN R 52 G.HN.52
Ionic H8 H 362 8x47 G.H5 D 377 G.H5.22
Polar H8 H 362 8x47 G.H5 D 377 G.H5.22
Hydrophobic H8 H 362 8x47 G.H5 D 377 G.H5.22
Van-der-waals H8 H 362 8x47 G.H5 D 377 G.H5.22
Polar H8 K 363 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 K 363 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 363 8x48 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 A 119 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM7 L 357 7x52 G.H5 L 380 G.H5.25
Van-der-waals TM7 L 357 7x52 G.H5 L 380 G.H5.25
Ionic ICL2 R 123 34x54 G.H5 E 373 G.H5.18
Polar ICL2 R 123 34x54 G.H5 E 373 G.H5.18
Van-der-waals ICL2 R 123 34x54 G.H5 E 373 G.H5.18
Hydrophobic ICL2 V 120 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 V 120 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM6 R 300 6x32 G.H5 M 379 G.H5.24
Ionic ICL3 R 290 - G.H5 D 368 G.H5.13
Polar ICL3 R 290 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 R 290 - G.H5 D 368 G.H5.13
Hydrophobic TM6 L 301 6x33 G.H5 M 379 G.H5.24
Polar TM2 H 48 2x37 G.hns1 R 55 G.hns1.02
Aromatic TM2 H 48 2x37 G.hns1 R 55 G.hns1.02
Hydrophobic TM2 H 48 2x37 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 H 48 2x37 G.hns1 R 55 G.hns1.02
Ionic H8 R 364 8x49 G.H5 E 373 G.H5.18
Polar H8 R 364 8x49 G.H5 E 373 G.H5.18
Hydrophobic TM6 L 308 6x40 G.H5 L 380 G.H5.25
Hydrophobic ICL2 A 119 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM3 V 116 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 116 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM4 V 129 4x39 G.HN R 52 G.HN.52
Van-der-waals TM4 V 129 4x39 G.HN R 52 G.HN.52
Hydrophobic TM3 R 112 3x50 G.H5 I 378 G.H5.23