Gs - kisspeptin receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
kisspeptin 74.0
Gαs 87.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 148 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 148 34x51 G.H5 I 383 G.H5.15
Polar C-term H 369 - G.H3 S 275 G.H3.11
Hydrophobic C-term H 369 - G.H3 S 275 G.H3.11
Van-der-waals C-term H 369 - G.H3 S 275 G.H3.11
Hydrophobic TM3 T 144 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM6 L 264 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 264 6x36 G.H5 L 393 G.H5.25
Hydrophobic ICL2 H 152 34x55 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 H 152 34x55 G.hns1 A 39 G.hns1.03
Polar C-term A 358 - G.H3 R 280 G.H3.16
Hydrophobic C-term L 366 - G.H3 I 276 G.H3.12
Hydrophobic TM6 S 243 6x15 G.H4 Y 339 G.H4.08
Polar ICL3 A 241 - G.H4 Y 339 G.H4.08
Van-der-waals ICL3 A 241 - G.H4 Y 339 G.H4.08
Polar TM6 Q 246 6x18 G.S6 C 359 G.S6.01
Van-der-waals TM6 Q 246 6x18 G.S6 C 359 G.S6.01
Ionic C-term E 362 - G.H3 R 280 G.H3.16
Polar C-term E 362 - G.H3 R 280 G.H3.16
Hydrophobic C-term E 362 - G.H3 R 280 G.H3.16
Van-der-waals C-term E 362 - G.H3 R 280 G.H3.16
Polar ICL2 R 154 34x57 G.H5 Q 390 G.H5.22
Van-der-waals ICL2 R 154 34x57 G.H5 Q 390 G.H5.22
Polar H8 F 330 8x50 G.H5 E 392 G.H5.24
Van-der-waals H8 F 330 8x50 G.H5 E 392 G.H5.24
Hydrophobic ICL2 P 147 34x50 G.H5 Q 384 G.H5.16
Polar TM3 D 139 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 139 3x49 G.H5 Y 391 G.H5.23
Hydrophobic C-term S 380 - H.hahb V 114 H.hahb.01
Hydrophobic TM6 L 250 6x22 G.H5 R 385 G.H5.17
Hydrophobic C-term L 366 - G.H2 W 234 G.H2.07
Hydrophobic TM5 L 231 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 148 34x51 G.H5 C 379 G.H5.11
Polar TM2 T 77 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 T 77 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 T 77 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM4 T 155 4x38 G.HN Q 35 G.HN.52
Polar TM6 A 244 6x16 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM6 A 244 6x16 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM6 A 244 6x16 G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL2 L 151 34x54 G.H5 M 386 G.H5.18
Hydrophobic TM6 S 243 6x15 G.H4 L 346 G.H4.16
Van-der-waals TM6 S 243 6x15 G.H4 L 346 G.H4.16
Polar H8 S 328 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 S 328 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM6 Q 246 6x18 G.H4 L 346 G.H4.16
Van-der-waals TM6 Q 246 6x18 G.H4 L 346 G.H4.16
Ionic C-term K 377 - G.HG D 310 G.HG.17
Polar C-term K 377 - G.HG D 310 G.HG.17
Hydrophobic C-term K 377 - G.HG D 310 G.HG.17
Van-der-waals C-term K 377 - G.HG D 310 G.HG.17
Polar TM6 S 243 6x15 G.H4 R 342 G.H4.12
Hydrophobic TM6 S 243 6x15 G.H4 R 342 G.H4.12
Van-der-waals TM6 S 243 6x15 G.H4 R 342 G.H4.12
Hydrophobic C-term Q 376 - G.s4h3 V 256 G.s4h3.07
Van-der-waals C-term Q 376 - G.s4h3 V 256 G.s4h3.07
Hydrophobic C-term L 366 - G.H3 S 275 G.H3.11
Van-der-waals C-term L 366 - G.H3 S 275 G.H3.11
Hydrophobic ICL2 A 150 34x53 G.H5 H 387 G.H5.19
Polar TM6 K 260 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 260 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 260 6x32 G.H5 L 394 G.H5.26
Polar TM6 K 260 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 K 260 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 260 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 V 257 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 V 257 6x29 G.H5 L 394 G.H5.26
Polar ICL3 A 241 - G.hgh4 T 325 G.hgh4.15
Hydrophobic ICL3 A 241 - G.hgh4 T 325 G.hgh4.15
Van-der-waals ICL3 A 241 - G.hgh4 T 325 G.hgh4.15
Hydrophobic ICL2 L 151 34x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 151 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 151 34x54 G.S1 H 41 G.S1.02
Polar C-term L 366 - G.H2 R 231 G.H2.04
Hydrophobic C-term L 366 - G.H2 R 231 G.H2.04
Van-der-waals C-term L 366 - G.H2 R 231 G.H2.04
Hydrophobic TM6 V 261 6x33 G.H5 L 388 G.H5.20
Polar TM3 V 143 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 V 143 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 V 143 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 151 34x54 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 151 34x54 G.H5 I 383 G.H5.15
Hydrophobic TM6 V 257 6x29 G.H5 L 388 G.H5.20
Hydrophobic C-term L 363 - G.H2 I 235 G.H2.08
Van-der-waals C-term L 363 - G.H2 I 235 G.H2.08
Hydrophobic ICL2 P 147 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 147 34x50 G.H5 R 380 G.H5.12
Hydrophobic TM6 R 253 6x25 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 R 253 6x25 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 L 148 34x51 G.H5 R 380 G.H5.12
Polar TM5 H 230 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 230 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 230 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM6 V 261 6x33 G.H5 L 393 G.H5.25
Polar ICL3 D 242 - G.H4 Y 339 G.H4.08
Hydrophobic ICL3 D 242 - G.H4 Y 339 G.H4.08
Polar H8 H 329 8x49 G.H5 R 389 G.H5.21
Hydrophobic C-term P 359 - G.H2 I 235 G.H2.08
Hydrophobic C-term L 366 - G.H3 L 272 G.H3.08
Van-der-waals C-term L 366 - G.H3 L 272 G.H3.08
Hydrophobic TM5 M 227 5x61 G.H5 L 393 G.H5.25
Hydrophobic ICL3 P 240 - G.S6 H 362 G.S6.04
Hydrophobic ICL2 L 148 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 148 34x51 G.H5 F 376 G.H5.08
Hydrophobic C-term L 363 - G.H2 R 232 G.H2.05
Ionic ICL3 D 242 - G.H4 R 342 G.H4.12
Hydrophobic ICL3 D 242 - G.H4 R 342 G.H4.12
Van-der-waals ICL3 D 242 - G.H4 R 342 G.H4.12
Hydrophobic C-term R 374 - G.hgh4 P 313 G.hgh4.03
Van-der-waals C-term R 374 - G.hgh4 P 313 G.hgh4.03
Polar ICL2 R 154 34x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 R 154 34x57 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 R 154 34x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 148 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL2 P 147 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM6 Q 246 6x18 G.S6 P 361 G.S6.03
Van-der-waals TM6 Q 246 6x18 G.S6 P 361 G.S6.03
Polar TM3 T 144 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 T 144 3x54 G.H5 Q 384 G.H5.16
Ionic C-term R 374 - G.hgh4 E 314 G.hgh4.04
Polar C-term R 374 - G.hgh4 E 314 G.hgh4.04
Hydrophobic C-term R 374 - G.hgh4 E 314 G.hgh4.04
Van-der-waals C-term R 374 - G.hgh4 E 314 G.hgh4.04
Polar TM6 K 260 6x32 G.H5 L 393 G.H5.25
Hydrophobic TM6 K 260 6x32 G.H5 L 393 G.H5.25
Van-der-waals TM6 K 260 6x32 G.H5 L 393 G.H5.25
Polar C-term G 367 - G.H2 R 228 G.H2.01
Hydrophobic C-term G 367 - G.H2 R 228 G.H2.01
Van-der-waals C-term G 367 - G.H2 R 228 G.H2.01
Polar H8 H 329 8x49 G.H5 E 392 G.H5.24
Hydrophobic H8 H 329 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 H 329 8x49 G.H5 E 392 G.H5.24
Polar TM4 R 157 4x40 G.HN Q 31 G.HN.48
Hydrophobic TM4 R 157 4x40 G.HN Q 31 G.HN.48
Van-der-waals TM4 R 157 4x40 G.HN Q 31 G.HN.48
Hydrophobic ICL2 L 148 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 148 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 P 147 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 147 34x50 G.H5 H 387 G.H5.19
Hydrophobic TM3 R 140 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 140 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 V 143 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 V 143 3x53 G.H5 Y 391 G.H5.23
Polar TM6 R 253 6x25 G.h4s6 G 353 G.h4s6.09
Hydrophobic TM5 L 231 5x65 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 D 242 - G.S6 F 363 G.S6.05
Van-der-waals ICL3 D 242 - G.S6 F 363 G.S6.05
Hydrophobic TM6 S 243 6x15 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM6 S 243 6x15 G.hgh4 D 323 G.hgh4.13
Hydrophobic C-term A 371 - G.H3 N 271 G.H3.07
Van-der-waals C-term A 371 - G.H3 N 271 G.H3.07
Polar TM6 L 245 6x17 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM6 L 245 6x17 G.hgh4 D 323 G.hgh4.13
Polar H8 G 327 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 G 327 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 G 327 8x47 G.H5 E 392 G.H5.24