Gt2 - kisspeptin receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
kisspeptin 74.1
Gαt2 88.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 11.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 147 34x50 G.H5 I 344 G.H5.16
Ionic ICL3 D 242 - G.H4 K 304 G.H4.12
Polar ICL3 D 242 - G.H4 K 304 G.H4.12
Van-der-waals ICL3 D 242 - G.H4 K 304 G.H4.12
Hydrophobic TM5 L 231 5x65 G.H5 I 344 G.H5.16
Polar TM3 V 143 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 V 143 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 V 143 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 V 234 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 V 234 5x68 G.H5 D 341 G.H5.13
Polar TM2 T 75 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 75 2x37 G.H5 D 350 G.H5.22
Polar TM3 R 140 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 140 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 140 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 148 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 148 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL2 L 151 34x54 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 L 151 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic H8 H 329 8x49 G.H5 K 349 G.H5.21
Hydrophobic TM3 T 144 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM3 R 140 3x50 G.H5 L 353 G.H5.25
Polar TM6 S 243 6x15 G.H4 N 301 G.H4.08
Hydrophobic TM6 S 243 6x15 G.H4 N 301 G.H4.08
Van-der-waals TM6 S 243 6x15 G.H4 N 301 G.H4.08
Polar TM6 K 260 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 260 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 260 6x32 G.H5 F 354 G.H5.26
Hydrophobic C-term L 363 - G.S2 I 184 G.S2.01
Ionic H8 H 329 8x49 G.H5 E 346 G.H5.18
Ionic TM5 R 237 5x71 G.H5 D 337 G.H5.09
Polar TM5 R 237 5x71 G.H5 D 337 G.H5.09
Van-der-waals TM5 R 237 5x71 G.H5 D 337 G.H5.09
Hydrophobic H8 G 327 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM6 Q 246 6x18 G.H4 L 308 G.H4.16
Van-der-waals TM6 Q 246 6x18 G.H4 L 308 G.H4.16
Polar TM6 Q 246 6x18 G.S6 S 321 G.S6.03
Hydrophobic TM6 Q 246 6x18 G.S6 S 321 G.S6.03
Van-der-waals TM6 Q 246 6x18 G.S6 S 321 G.S6.03
Ionic ICL1 K 71 12x48 G.HN E 20 G.HN.44
Polar ICL1 K 71 12x48 G.HN E 20 G.HN.44
Van-der-waals ICL1 K 71 12x48 G.HN E 20 G.HN.44
Polar TM6 Q 246 6x18 G.S6 I 319 G.S6.01
Van-der-waals TM6 Q 246 6x18 G.S6 I 319 G.S6.01
Hydrophobic TM6 L 264 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 264 6x36 G.H5 L 353 G.H5.25
Polar TM2 T 77 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 77 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 77 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 77 2x39 G.H5 C 351 G.H5.23
Polar TM6 S 243 6x15 G.H4 K 304 G.H4.12
Hydrophobic TM6 S 243 6x15 G.H4 K 304 G.H4.12
Van-der-waals TM6 S 243 6x15 G.H4 K 304 G.H4.12
Hydrophobic ICL2 L 151 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 L 151 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 V 261 6x33 G.H5 L 348 G.H5.20
Hydrophobic H8 H 329 8x49 G.H5 D 350 G.H5.22
Polar ICL3 D 242 - G.S6 M 323 G.S6.05
Hydrophobic ICL3 D 242 - G.S6 M 323 G.S6.05
Van-der-waals ICL3 D 242 - G.S6 M 323 G.S6.05
Polar TM6 R 253 6x25 G.h4s6 K 317 G.h4s6.11
Van-der-waals TM6 R 253 6x25 G.h4s6 K 317 G.h4s6.11
Hydrophobic TM5 L 231 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL3 P 240 - G.H5 F 334 G.H5.06
Ionic ICL1 R 74 12x51 G.HN E 20 G.HN.44
Hydrophobic ICL2 L 148 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 148 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM6 V 261 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 261 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 M 227 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 147 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 H 152 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic C-term L 366 - G.S2 I 185 G.S2.02
Hydrophobic TM3 T 144 3x54 G.H5 L 348 G.H5.20
Polar ICL2 H 152 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 H 152 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 H 152 34x55 G.s2s3 D 193 G.s2s3.02
Ionic ICL2 R 154 34x57 G.H5 D 350 G.H5.22
Polar ICL2 R 154 34x57 G.H5 D 350 G.H5.22
Van-der-waals ICL2 R 154 34x57 G.H5 D 350 G.H5.22
Hydrophobic TM6 V 257 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 V 257 6x29 G.H5 F 354 G.H5.26
Polar TM6 R 253 6x25 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 R 253 6x25 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 R 253 6x25 G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL2 L 151 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL2 P 147 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 147 34x50 G.H5 T 340 G.H5.12
Hydrophobic ICL2 L 151 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 151 34x54 G.S3 L 194 G.S3.01
Hydrophobic C-term L 398 - G.H2 K 209 G.H2.05
Hydrophobic TM3 V 143 3x53 G.H5 C 351 G.H5.23
Polar TM6 Q 246 6x18 G.H4 K 304 G.H4.12
Hydrophobic TM6 Q 246 6x18 G.H4 K 304 G.H4.12
Van-der-waals TM6 Q 246 6x18 G.H4 K 304 G.H4.12
Hydrophobic TM6 V 257 6x29 G.H5 L 348 G.H5.20
Hydrophobic C-term A 358 - G.H2 H 213 G.H2.09
Hydrophobic ICL2 L 148 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 L 148 34x51 G.H5 F 336 G.H5.08