G12 - LPA2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 V 240 6x37 G.H5 M 379 G.H5.24
Hydrophobic ICL3 H 222 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 H 222 - G.S6 F 347 G.S6.02
Hydrophobic TM6 H 226 6x23 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 H 226 6x23 G.h4s6 P 345 G.h4s6.20
Polar ICL3 V 223 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 V 223 - G.S6 H 348 G.S6.03
Hydrophobic TM5 M 219 5x72 G.H5 A 365 G.H5.10
Van-der-waals TM5 M 219 5x72 G.H5 A 365 G.H5.10
Polar TM3 A 132 3x56 G.H5 N 374 G.H5.19
Hydrophobic TM3 S 129 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 S 129 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 V 133 34x50 G.S3 I 221 G.S3.01
Van-der-waals ICL2 V 133 34x50 G.S3 I 221 G.S3.01
Hydrophobic TM2 L 68 2x43 G.H5 L 380 G.H5.25
Hydrophobic TM3 V 130 3x54 G.H5 L 375 G.H5.20
Ionic TM5 R 215 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 215 5x68 G.H5 D 368 G.H5.13
Polar TM6 H 226 6x23 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM6 H 226 6x23 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 H 226 6x23 G.h4s6 S 343 G.h4s6.12
Polar TM6 T 239 6x36 G.H5 Q 381 G.H5.26
Polar ICL3 S 224 - G.H4 D 336 G.H4.16
Hydrophobic ICL3 S 224 - G.H4 D 336 G.H4.16
Hydrophobic TM5 M 219 5x72 G.H5 D 368 G.H5.13
Hydrophobic ICL2 Q 134 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM5 V 212 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM6 T 232 6x29 G.H5 K 376 G.H5.21
Hydrophobic TM6 T 239 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 239 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM7 R 295 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 R 295 7x56 G.H5 L 380 G.H5.25
Polar ICL3 S 224 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 S 224 - G.S6 H 348 G.S6.03
Hydrophobic TM6 Y 229 6x26 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 R 138 34x55 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 R 138 34x55 G.hns1 R 55 G.hns1.02
Hydrophobic TM7 Y 292 7x53 G.H5 L 380 G.H5.25
Hydrophobic TM6 Y 229 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 Y 229 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 L 236 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 L 236 6x33 G.H5 M 379 G.H5.24
Polar ICL3 S 224 - G.h4s6 R 339 G.h4s6.08
Van-der-waals ICL3 S 224 - G.h4s6 R 339 G.h4s6.08
Van-der-waals TM5 V 216 5x69 G.H5 Q 372 G.H5.17
Hydrophobic TM3 V 130 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 L 135 34x52 G.H5 E 373 G.H5.18
Van-der-waals ICL2 L 135 34x52 G.H5 E 373 G.H5.18
Polar H8 D 296 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 D 296 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 D 296 8x47 G.H5 L 380 G.H5.25
Polar TM6 H 226 6x23 G.h4s6 K 344 G.h4s6.19
Hydrophobic TM6 H 226 6x23 G.h4s6 K 344 G.h4s6.19
Van-der-waals TM6 H 226 6x23 G.h4s6 K 344 G.h4s6.19
Hydrophobic TM5 M 219 5x72 G.H5 F 361 G.H5.06
Van-der-waals TM5 M 219 5x72 G.H5 F 361 G.H5.06
Hydrophobic TM6 L 236 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM5 V 212 5x65 G.H5 L 371 G.H5.16
Polar TM5 R 215 5x68 G.H5 K 367 G.H5.12
Hydrophobic TM5 R 215 5x68 G.H5 K 367 G.H5.12
Van-der-waals TM5 R 215 5x68 G.H5 K 367 G.H5.12
Polar TM3 S 129 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 S 129 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM2 Y 65 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 Y 65 2x40 G.H5 L 380 G.H5.25
Hydrophobic TM3 V 130 3x54 G.H5 I 378 G.H5.23
Polar TM6 H 226 6x23 G.h4s6 R 342 G.h4s6.11
Hydrophobic TM6 H 226 6x23 G.h4s6 R 342 G.h4s6.11
Van-der-waals TM6 H 226 6x23 G.h4s6 R 342 G.h4s6.11
Hydrophobic ICL2 L 135 34x52 G.h2s4 T 246 G.h2s4.05
Polar ICL2 H 136 34x53 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 H 136 34x53 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 H 136 34x53 G.hns1 R 55 G.hns1.02
Polar ICL3 H 222 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 H 222 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 H 222 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 V 223 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 V 223 - G.S6 F 347 G.S6.02
Polar TM6 T 232 6x29 G.H5 Q 372 G.H5.17
Van-der-waals TM6 T 232 6x29 G.H5 Q 372 G.H5.17
Hydrophobic TM5 M 219 5x72 G.S6 F 347 G.S6.02
Hydrophobic ICL2 V 133 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL3 V 223 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 V 223 - G.h4s6 P 345 G.h4s6.20
Polar TM3 R 126 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 126 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 126 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 126 3x50 G.H5 M 379 G.H5.24
Polar ICL3 S 224 - G.S6 L 346 G.S6.01
Hydrophobic ICL3 S 224 - G.S6 L 346 G.S6.01
Van-der-waals ICL3 S 224 - G.S6 L 346 G.S6.01
Polar TM6 Y 229 6x26 G.H5 D 368 G.H5.13
Hydrophobic TM6 Y 229 6x26 G.H5 D 368 G.H5.13
Van-der-waals TM6 Y 229 6x26 G.H5 D 368 G.H5.13
Hydrophobic TM5 Y 211 5x64 G.H5 L 371 G.H5.16
Aromatic ICL3 H 222 - G.H5 F 361 G.H5.06
Hydrophobic ICL3 H 222 - G.H5 F 361 G.H5.06
Van-der-waals ICL3 H 222 - G.H5 F 361 G.H5.06
Polar ICL3 H 222 - G.S6 H 349 G.S6.04
Aromatic ICL3 H 222 - G.S6 H 349 G.S6.04
Hydrophobic ICL3 H 222 - G.S6 H 349 G.S6.04
Van-der-waals ICL3 H 222 - G.S6 H 349 G.S6.04
Hydrophobic TM5 R 215 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 R 215 5x68 G.H5 L 371 G.H5.16
Hydrophobic ICL2 L 135 34x52 G.H5 I 370 G.H5.15
Hydrophobic TM2 I 64 2x39 G.H5 L 380 G.H5.25
Polar TM6 S 235 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM6 S 235 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 S 235 6x32 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 V 133 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 V 133 34x50 G.H5 K 367 G.H5.12
Polar TM2 Q 62 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 Q 62 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 Q 62 2x37 G.H5 D 377 G.H5.22
Polar ICL2 Q 134 34x51 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 Q 134 34x51 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 Q 134 34x51 G.hns1 R 56 G.hns1.03
Hydrophobic TM5 M 219 5x72 G.H5 H 364 G.H5.09
Van-der-waals TM5 M 219 5x72 G.H5 H 364 G.H5.09