Gs - LPA3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 R 135 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 R 135 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM6 T 233 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 T 233 6x29 G.H5 L 394 G.H5.26
Polar ICL3 H 223 - G.H4 Y 339 G.H4.08
Hydrophobic ICL3 H 223 - G.H4 Y 339 G.H4.08
Van-der-waals ICL3 H 223 - G.H4 Y 339 G.H4.08
Hydrophobic ICL2 M 134 34x50 G.H5 I 383 G.H5.15
Polar TM3 S 130 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 S 130 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 S 130 3x53 G.H5 H 387 G.H5.19
Hydrophobic H8 D 297 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 M 134 34x50 G.S3 V 217 G.S3.01
Ionic ICL2 H 137 34x53 G.h2s4 D 240 G.h2s4.03
Hydrophobic ICL2 H 137 34x53 G.h2s4 D 240 G.h2s4.03
Polar ICL2 V 136 34x52 G.H5 H 387 G.H5.19
Hydrophobic ICL2 V 136 34x52 G.H5 M 386 G.H5.18
Van-der-waals ICL2 V 136 34x52 G.H5 M 386 G.H5.18
Hydrophobic TM5 V 213 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM7 K 296 7x56 G.H5 E 392 G.H5.24
Hydrophobic ICL2 M 134 34x50 G.S3 F 219 G.S3.03
Hydrophobic TM6 R 230 6x26 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM3 I 131 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 I 131 3x54 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 220 5x72 G.S6 Y 360 G.S6.02
Polar ICL2 R 135 34x51 G.H5 H 387 G.H5.19
Hydrophobic ICL2 R 135 34x51 G.H5 H 387 G.H5.19
Van-der-waals ICL2 R 135 34x51 G.H5 H 387 G.H5.19
Polar TM5 S 221 5x73 G.S6 H 362 G.S6.04
Hydrophobic TM5 S 221 5x73 G.S6 H 362 G.S6.04
Van-der-waals TM5 S 221 5x73 G.S6 H 362 G.S6.04
Aromatic TM2 F 65 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 F 65 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 F 65 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM6 K 236 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 236 6x32 G.H5 L 394 G.H5.26
Polar TM5 T 217 5x69 G.H5 D 381 G.H5.13
Hydrophobic TM5 L 220 5x72 G.H5 N 377 G.H5.09
Hydrophobic TM2 F 63 2x37 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 T 224 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 T 224 - G.S6 Y 360 G.S6.02
Hydrophobic TM3 I 131 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM5 Y 206 5x58 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 220 5x72 G.H5 D 378 G.H5.10
Van-der-waals TM5 L 220 5x72 G.H5 D 378 G.H5.10
Hydrophobic TM5 K 216 5x68 G.H5 R 380 G.H5.12
Van-der-waals TM5 K 216 5x68 G.H5 R 380 G.H5.12
Polar ICL2 S 138 34x54 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 S 138 34x54 G.H5 Y 391 G.H5.23
Polar TM6 L 237 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 L 237 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 237 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM5 V 219 5x71 G.H5 N 377 G.H5.09
Hydrophobic ICL3 T 224 - G.S6 H 362 G.S6.04
Hydrophobic ICL2 M 134 34x50 G.H5 C 379 G.H5.11
Hydrophobic TM2 F 65 2x39 G.H5 E 392 G.H5.24
Hydrophobic TM5 K 216 5x68 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 M 134 34x50 G.H5 F 376 G.H5.08
Van-der-waals ICL2 M 134 34x50 G.H5 F 376 G.H5.08
Polar TM5 S 221 5x73 G.S6 P 361 G.S6.03
Polar ICL2 R 135 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 R 135 34x51 G.S1 H 41 G.S1.02
Polar TM6 T 240 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM6 T 240 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 240 6x36 G.H5 L 393 G.H5.25
Polar TM6 R 230 6x26 G.H5 R 385 G.H5.17
Hydrophobic TM6 R 230 6x26 G.H5 R 385 G.H5.17
Hydrophobic ICL2 M 134 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 M 134 34x50 G.H5 R 380 G.H5.12
Polar TM6 G 226 6x22 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM6 G 226 6x22 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM6 G 226 6x22 G.hgh4 D 323 G.hgh4.13
Polar ICL2 V 136 34x52 G.S1 H 41 G.S1.02
Hydrophobic ICL2 V 136 34x52 G.S1 H 41 G.S1.02
Van-der-waals ICL2 V 136 34x52 G.S1 H 41 G.S1.02
Polar ICL2 M 134 34x50 G.S1 H 41 G.S1.02
Hydrophobic ICL2 M 134 34x50 G.S1 H 41 G.S1.02
Van-der-waals ICL2 M 134 34x50 G.S1 H 41 G.S1.02
Polar TM5 Y 212 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 Y 212 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Y 212 5x64 G.H5 Q 384 G.H5.16
Ionic TM6 R 230 6x26 G.H5 D 381 G.H5.13
Polar TM6 R 230 6x26 G.H5 D 381 G.H5.13
Van-der-waals TM6 R 230 6x26 G.H5 D 381 G.H5.13
Hydrophobic TM7 Y 293 7x53 G.H5 E 392 G.H5.24
Van-der-waals TM7 Y 293 7x53 G.H5 E 392 G.H5.24
Ionic H8 E 298 8x48 G.H5 R 389 G.H5.21
Hydrophobic ICL2 V 136 34x52 G.H5 I 383 G.H5.15
Hydrophobic TM3 I 131 3x54 G.H5 H 387 G.H5.19
Polar TM6 R 230 6x26 G.S6 C 359 G.S6.01
Van-der-waals TM6 R 230 6x26 G.S6 C 359 G.S6.01
Hydrophobic TM3 E 126 3x49 G.H5 Y 391 G.H5.23
Polar TM3 R 127 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 127 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 127 3x50 G.H5 Y 391 G.H5.23
Polar ICL3 H 223 - G.hgh4 T 325 G.hgh4.15
Hydrophobic ICL3 H 223 - G.hgh4 T 325 G.hgh4.15
Van-der-waals ICL3 H 223 - G.hgh4 T 325 G.hgh4.15
Polar ICL3 H 223 - G.H4 R 342 G.H4.12
Hydrophobic ICL3 H 223 - G.S6 P 361 G.S6.03
Hydrophobic TM5 L 220 5x72 G.H5 D 381 G.H5.13
Van-der-waals TM5 L 220 5x72 G.H5 D 381 G.H5.13
Polar TM6 R 230 6x26 G.S6 Y 360 G.S6.02
Aromatic TM6 R 230 6x26 G.S6 Y 360 G.S6.02
Hydrophobic TM6 R 230 6x26 G.S6 Y 360 G.S6.02
Van-der-waals TM6 R 230 6x26 G.S6 Y 360 G.S6.02
Polar TM3 S 130 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 S 130 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 S 130 3x53 G.H5 Y 391 G.H5.23
Aromatic ICL3 H 223 - G.S6 F 363 G.S6.05
Hydrophobic ICL3 H 223 - G.S6 F 363 G.S6.05
Van-der-waals ICL3 H 223 - G.S6 F 363 G.S6.05
Hydrophobic ICL3 P 222 - G.hgh4 T 325 G.hgh4.15
Van-der-waals ICL3 P 222 - G.hgh4 T 325 G.hgh4.15
Polar ICL2 S 138 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic TM2 L 69 2x43 G.H5 E 392 G.H5.24
Van-der-waals TM2 L 69 2x43 G.H5 E 392 G.H5.24
Hydrophobic TM2 F 63 2x37 G.H5 Q 390 G.H5.22
Van-der-waals TM2 F 63 2x37 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 H 137 34x53 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 H 137 34x53 G.hns1 R 38 G.hns1.02
Hydrophobic TM6 L 237 6x33 G.H5 L 388 G.H5.20
Ionic TM3 R 127 3x50 G.H5 E 392 G.H5.24
Polar TM3 R 127 3x50 G.H5 E 392 G.H5.24
Polar TM6 T 233 6x29 G.H5 R 385 G.H5.17
Hydrophobic TM6 T 233 6x29 G.H5 R 385 G.H5.17
Van-der-waals TM6 T 233 6x29 G.H5 R 385 G.H5.17
Hydrophobic TM3 R 127 3x50 G.H5 L 393 G.H5.25
Van-der-waals TM3 R 127 3x50 G.H5 L 393 G.H5.25
Polar ICL3 T 224 - G.S6 P 361 G.S6.03
Hydrophobic ICL3 T 224 - G.S6 P 361 G.S6.03
Hydrophobic ICL2 V 136 34x52 G.h2s4 T 242 G.h2s4.05
Van-der-waals ICL2 V 136 34x52 G.h2s4 T 242 G.h2s4.05