G12 - LPA6 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 K 221 6x27 G.h4s6 S 343 G.h4s6.12
Polar ICL3 L 217 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 L 217 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 L 217 - G.H5 D 368 G.H5.13
Polar TM6 S 218 6x24 G.H5 D 368 G.H5.13
Polar TM6 K 221 6x27 G.h4s6 R 342 G.h4s6.11
Van-der-waals TM6 K 221 6x27 G.h4s6 R 342 G.h4s6.11
Hydrophobic ICL2 F 122 34x51 G.H5 K 367 G.H5.12
Van-der-waals ICL2 F 122 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM4 T 129 4x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 T 129 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic ICL3 T 216 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 T 216 - G.H5 L 371 G.H5.16
Van-der-waals ICL3 T 216 - G.H5 L 371 G.H5.16
Hydrophobic TM6 R 219 6x25 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 R 219 6x25 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 F 122 34x51 G.S3 F 223 G.S3.03
Hydrophobic TM7 T 294 7x56 G.H5 I 378 G.H5.23
Van-der-waals TM7 T 294 7x56 G.H5 I 378 G.H5.23
Hydrophobic TM2 N 50 2x37 G.H5 L 380 G.H5.25
Van-der-waals TM2 N 50 2x37 G.H5 L 380 G.H5.25
Aromatic ICL2 F 122 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 122 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 122 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM6 S 220 6x26 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL3 L 217 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 L 217 - G.H5 Q 372 G.H5.17
Hydrophobic TM3 R 114 3x50 G.H5 I 378 G.H5.23
Polar ICL2 R 128 34x57 G.H5 N 374 G.H5.19
Polar ICL2 P 121 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 121 34x50 G.H5 N 374 G.H5.19
Hydrophobic TM6 I 222 6x28 G.H5 M 379 G.H5.24
Van-der-waals C-term I 326 - G.H3 K 284 G.H3.16
Hydrophobic ICL2 T 126 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 T 126 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL1 L 46 12x48 G.H5 L 380 G.H5.25
Polar TM6 S 220 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 S 220 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 S 220 6x26 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 F 122 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 122 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 T 126 34x55 G.hns1 R 55 G.hns1.02
Polar H8 D 296 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 D 296 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 D 296 8x48 G.H5 Q 381 G.H5.26
Polar TM6 R 219 6x25 G.S6 H 348 G.S6.03
Aromatic TM6 R 219 6x25 G.S6 H 348 G.S6.03
Hydrophobic TM6 R 219 6x25 G.S6 H 348 G.S6.03
Van-der-waals TM6 R 219 6x25 G.S6 H 348 G.S6.03
Hydrophobic ICL3 L 217 - G.H5 L 375 G.H5.20
Van-der-waals ICL3 L 217 - G.H5 L 375 G.H5.20
Hydrophobic TM3 I 118 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 118 3x54 G.H5 L 375 G.H5.20
Polar TM3 A 117 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 117 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 117 3x53 G.H5 N 374 G.H5.19
Polar TM2 N 50 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 N 50 2x37 G.H5 D 377 G.H5.22
Hydrophobic ICL2 K 125 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 K 125 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL3 V 215 - G.H5 H 364 G.H5.09
Hydrophobic ICL2 P 121 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 121 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL3 L 217 - G.H5 L 371 G.H5.16
Hydrophobic TM6 R 219 6x25 G.H5 F 361 G.H5.06
Van-der-waals TM6 R 219 6x25 G.H5 F 361 G.H5.06
Hydrophobic TM3 I 118 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 118 3x54 G.H5 L 371 G.H5.16
Polar H8 T 297 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 T 297 8x49 G.H5 L 380 G.H5.25
Hydrophobic ICL2 R 128 34x57 G.H5 I 378 G.H5.23
Hydrophobic TM2 M 56 2x43 G.H5 L 380 G.H5.25
Hydrophobic C-term L 333 - G.H3 T 279 G.H3.11
Hydrophobic TM6 V 227 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM6 I 222 6x28 G.H5 L 375 G.H5.20
Ionic ICL2 K 125 34x54 G.H5 E 373 G.H5.18
Polar ICL2 K 125 34x54 G.H5 E 373 G.H5.18
Hydrophobic ICL2 T 126 34x55 G.HN R 52 G.HN.52
Van-der-waals ICL2 T 126 34x55 G.HN R 52 G.HN.52
Hydrophobic TM6 V 227 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 V 227 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM6 M 230 6x36 G.H5 I 378 G.H5.23
Hydrophobic ICL2 F 122 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 F 122 34x51 G.S1 V 58 G.S1.02
Hydrophobic ICL2 P 121 34x50 G.H5 L 371 G.H5.16
Hydrophobic ICL2 K 125 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 K 125 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM3 I 118 3x54 G.H5 I 378 G.H5.23
Polar ICL2 S 124 34x53 G.H5 N 374 G.H5.19
Van-der-waals ICL2 S 124 34x53 G.H5 N 374 G.H5.19
Van-der-waals TM2 T 53 2x40 G.H5 L 380 G.H5.25
Hydrophobic TM6 R 219 6x25 G.S6 F 347 G.S6.02
Van-der-waals TM6 R 219 6x25 G.S6 F 347 G.S6.02
Hydrophobic TM7 T 294 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM7 T 294 7x56 G.H5 M 379 G.H5.24
Hydrophobic TM1 F 42 1x57 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 121 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 121 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 F 122 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 122 34x51 G.H5 I 370 G.H5.15
Hydrophobic H8 S 295 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 S 295 8x47 G.H5 M 379 G.H5.24
Hydrophobic TM6 I 222 6x28 G.H5 Q 372 G.H5.17
Van-der-waals TM6 I 222 6x28 G.H5 Q 372 G.H5.17
Hydrophobic TM3 A 117 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 117 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 F 122 34x51 G.H5 V 366 G.H5.11
Polar H8 D 296 8x48 G.H5 M 379 G.H5.24
Van-der-waals H8 D 296 8x48 G.H5 M 379 G.H5.24
Polar H8 S 295 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 S 295 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 S 295 8x47 G.H5 L 380 G.H5.25