Gz - Olfactory receptor 2T11 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 R 128 34x52 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 R 128 34x52 G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL2 L 127 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 L 127 34x51 G.H5 I 344 G.H5.15
Hydrophobic ICL2 L 127 34x51 G.S1 I 34 G.S1.02
Van-der-waals ICL2 L 127 34x51 G.S1 I 34 G.S1.02
Van-der-waals TM3 D 118 3x49 G.H5 I 352 G.H5.23
Polar TM2 Y 57 2x40 G.H5 G 353 G.H5.24
Hydrophobic TM2 Y 57 2x40 G.H5 G 353 G.H5.24
Van-der-waals TM2 Y 57 2x40 G.H5 G 353 G.H5.24
Hydrophobic TM6 K 233 6x32 G.H5 K 350 G.H5.21
Van-der-waals TM6 K 233 6x32 G.H5 K 350 G.H5.21
Ionic ICL2 R 128 34x52 G.s2s3 E 194 G.s2s3.02
Polar ICL2 R 128 34x52 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 R 128 34x52 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 R 128 34x52 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 V 131 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 V 131 34x55 G.hns1 R 32 G.hns1.03
Polar H8 N 291 8x47 G.H5 G 353 G.H5.24
Hydrophobic H8 N 291 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 N 291 8x47 G.H5 G 353 G.H5.24
Polar TM6 K 233 6x32 G.S6 Y 321 G.S6.02
Hydrophobic ICL2 P 126 34x50 G.H5 Q 346 G.H5.17
Van-der-waals ICL2 P 126 34x50 G.H5 Q 346 G.H5.17
Hydrophobic ICL3 M 225 - G.H5 Q 346 G.H5.17
Van-der-waals ICL3 M 225 - G.H5 Q 346 G.H5.17
Hydrophobic TM6 K 233 6x32 G.H5 C 355 G.H5.26
Van-der-waals TM6 K 233 6x32 G.H5 C 355 G.H5.26
Hydrophobic TM7 Y 287 7x53 G.H5 L 354 G.H5.25
Hydrophobic TM2 Y 57 2x40 G.H5 I 352 G.H5.23
Hydrophobic ICL2 V 131 34x55 G.S3 L 195 G.S3.01
Van-der-waals ICL2 V 131 34x55 G.S3 L 195 G.S3.01
Hydrophobic TM3 A 122 3x53 G.H5 L 349 G.H5.20
Van-der-waals TM3 A 122 3x53 G.H5 L 349 G.H5.20
Hydrophobic ICL2 Y 129 34x53 G.H5 L 349 G.H5.20
Van-der-waals ICL2 Y 129 34x53 G.H5 L 349 G.H5.20
Hydrophobic ICL2 P 126 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 126 34x50 G.H5 I 345 G.H5.16
Hydrophobic ICL2 L 127 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 127 34x51 G.S3 L 195 G.S3.01
Hydrophobic ICL2 Y 129 34x53 G.H5 N 348 G.H5.19
Van-der-waals ICL2 Y 129 34x53 G.H5 N 348 G.H5.19
Hydrophobic TM6 S 240 6x39 G.H5 L 354 G.H5.25
Van-der-waals TM6 S 240 6x39 G.H5 L 354 G.H5.25
Hydrophobic TM3 V 123 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM2 M 56 2x39 G.H5 L 354 G.H5.25
Van-der-waals TM2 M 56 2x39 G.H5 L 354 G.H5.25
Hydrophobic ICL2 P 130 34x54 G.H5 N 348 G.H5.19
Van-der-waals ICL2 P 130 34x54 G.H5 N 348 G.H5.19
Polar ICL2 L 127 34x51 G.H5 I 345 G.H5.16
Hydrophobic ICL2 L 127 34x51 G.H5 I 345 G.H5.16
Van-der-waals ICL2 L 127 34x51 G.H5 I 345 G.H5.16
Polar TM6 T 237 6x36 G.H5 C 355 G.H5.26
Van-der-waals TM6 T 237 6x36 G.H5 C 355 G.H5.26
Hydrophobic ICL2 P 126 34x50 G.H5 L 349 G.H5.20
Van-der-waals ICL2 P 126 34x50 G.H5 L 349 G.H5.20
Hydrophobic ICL2 R 128 34x52 G.S3 L 195 G.S3.01
Van-der-waals ICL2 R 128 34x52 G.S3 L 195 G.S3.01
Polar H8 K 292 8x48 G.H5 C 355 G.H5.26
Hydrophobic TM2 M 56 2x39 G.H5 I 352 G.H5.23
Van-der-waals TM2 M 56 2x39 G.H5 I 352 G.H5.23
Ionic TM6 K 233 6x32 G.h4s6 E 319 G.h4s6.12
Polar TM6 K 233 6x32 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 K 233 6x32 G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL2 L 127 34x51 G.H5 T 341 G.H5.12
Van-der-waals ICL2 L 127 34x51 G.H5 T 341 G.H5.12
Polar TM6 T 237 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM6 T 237 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 T 237 6x36 G.H5 L 354 G.H5.25
Polar ICL2 V 131 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 V 131 34x55 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 V 131 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic TM3 A 122 3x53 G.H5 I 352 G.H5.23
Van-der-waals TM3 A 122 3x53 G.H5 I 352 G.H5.23
Hydrophobic TM3 N 125 3x56 G.H5 I 345 G.H5.16
Polar TM2 T 54 2x37 G.H5 Y 351 G.H5.22
Hydrophobic TM2 T 54 2x37 G.H5 Y 351 G.H5.22
Van-der-waals TM2 T 54 2x37 G.H5 Y 351 G.H5.22
Hydrophobic ICL2 L 127 34x51 G.S3 F 197 G.S3.03
Hydrophobic ICL2 Y 129 34x53 G.H5 I 352 G.H5.23
Van-der-waals ICL2 Y 129 34x53 G.H5 I 352 G.H5.23