Gq - Olfactory receptor 51I2 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Van-der-waals TM2 M 59 2x39 G.H5 Y 356 G.H5.23
Polar TM6 C 241 6x37 G.H5 L 358 G.H5.25
Hydrophobic TM6 C 241 6x37 G.H5 L 358 G.H5.25
Van-der-waals TM6 C 241 6x37 G.H5 L 358 G.H5.25
Polar TM6 T 240 6x36 G.H5 N 357 G.H5.24
Hydrophobic TM6 T 240 6x36 G.H5 N 357 G.H5.24
Van-der-waals TM6 T 240 6x36 G.H5 N 357 G.H5.24
Polar ICL2 Y 132 34x53 G.hns1 R 37 G.hns1.02
Hydrophobic TM3 I 126 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 I 126 3x54 G.H5 L 353 G.H5.20
Polar ICL2 L 130 34x51 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 L 130 34x51 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 L 130 34x51 G.hns1 R 38 G.hns1.03
Polar ICL2 R 131 34x52 G.s2s3 Q 197 G.s2s3.01
Van-der-waals ICL2 R 131 34x52 G.s2s3 Q 197 G.s2s3.01
Polar ICL2 L 136 34x57 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 L 136 34x57 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 L 136 34x57 G.hns1 R 37 G.hns1.02
Polar TM6 C 241 6x37 G.H5 N 357 G.H5.24
Polar H8 E 298 8x49 G.H5 N 357 G.H5.24
Polar TM2 Y 60 2x40 G.H5 N 357 G.H5.24
Van-der-waals TM2 Y 60 2x40 G.H5 N 357 G.H5.24
Hydrophobic ICL2 T 134 34x55 G.HN R 34 G.HN.52
Van-der-waals ICL2 T 134 34x55 G.HN R 34 G.HN.52
Hydrophobic ICL2 R 131 34x52 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 R 131 34x52 G.hns1 R 38 G.hns1.03
Hydrophobic TM6 E 233 6x29 G.H5 Q 350 G.H5.17
Van-der-waals TM6 E 233 6x29 G.H5 Q 350 G.H5.17
Van-der-waals TM3 D 128 3x56 G.s2s3 S 198 G.s2s3.02
Polar TM6 T 240 6x36 G.H5 V 359 G.H5.26
Hydrophobic TM6 T 240 6x36 G.H5 V 359 G.H5.26
Van-der-waals TM6 T 240 6x36 G.H5 V 359 G.H5.26
Hydrophobic TM6 K 236 6x32 G.H5 K 354 G.H5.21
Van-der-waals TM6 K 236 6x32 G.H5 K 354 G.H5.21
Hydrophobic ICL2 R 131 34x52 G.S3 V 199 G.S3.01
Polar TM6 T 240 6x36 G.H5 L 358 G.H5.25
Hydrophobic TM6 T 240 6x36 G.H5 L 358 G.H5.25
Van-der-waals TM6 T 240 6x36 G.H5 L 358 G.H5.25
Hydrophobic ICL2 T 134 34x55 G.HN D 35 G.HN.53
Van-der-waals ICL2 T 134 34x55 G.HN D 35 G.HN.53
Hydrophobic ICL2 R 131 34x52 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 R 131 34x52 G.hns1 R 37 G.hns1.02
Van-der-waals TM4 T 138 4x39 G.hns1 R 37 G.hns1.02
Hydrophobic TM3 I 126 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 I 126 3x54 G.H5 L 358 G.H5.25
Hydrophobic TM2 M 59 2x39 G.H5 N 357 G.H5.24
Van-der-waals TM2 M 59 2x39 G.H5 N 357 G.H5.24
Hydrophobic ICL2 P 129 34x50 G.H5 L 349 G.H5.16
Van-der-waals ICL2 P 129 34x50 G.H5 L 349 G.H5.16
Polar ICL2 T 134 34x55 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 T 134 34x55 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 T 134 34x55 G.hns1 R 37 G.hns1.02
Hydrophobic TM3 D 121 3x49 G.H5 L 358 G.H5.25
Aromatic ICL2 Y 132 34x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 Y 132 34x53 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 Y 132 34x53 G.H5 Y 356 G.H5.23
Hydrophobic TM3 A 125 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 125 3x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 P 129 34x50 G.S1 L 40 G.S1.02
Hydrophobic ICL2 L 130 34x51 G.S3 F 201 G.S3.03
Van-der-waals ICL2 L 130 34x51 G.S3 F 201 G.S3.03
Polar ICL2 A 133 34x54 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 A 133 34x54 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 A 133 34x54 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 T 134 34x55 G.hns1 A 36 G.hns1.01
Ionic TM4 E 139 4x40 G.HN R 30 G.HN.48
Polar TM4 E 139 4x40 G.HN R 30 G.HN.48
Hydrophobic TM4 E 139 4x40 G.HN R 30 G.HN.48
Van-der-waals TM4 E 139 4x40 G.HN R 30 G.HN.48
Hydrophobic TM4 V 140 4x41 G.HN R 34 G.HN.52
Hydrophobic TM5 I 221 5x61 G.H5 L 358 G.H5.25
Polar TM3 R 122 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 122 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 122 3x50 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 L 130 34x51 G.H5 I 348 G.H5.15
Polar ICL2 L 130 34x51 G.S1 L 40 G.S1.02
Hydrophobic ICL2 L 130 34x51 G.S1 L 40 G.S1.02
Van-der-waals ICL2 L 130 34x51 G.S1 L 40 G.S1.02
Polar TM4 T 137 4x38 G.hns1 R 37 G.hns1.02
Hydrophobic TM4 T 137 4x38 G.hns1 R 37 G.hns1.02
Van-der-waals TM4 T 137 4x38 G.hns1 R 37 G.hns1.02
Hydrophobic TM6 E 233 6x29 G.H5 K 354 G.H5.21
Van-der-waals TM6 E 233 6x29 G.H5 K 354 G.H5.21
Hydrophobic TM6 A 237 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 A 237 6x33 G.H5 L 358 G.H5.25
Polar ICL2 L 130 34x51 G.S1 E 39 G.S1.01
Van-der-waals ICL2 L 130 34x51 G.S1 E 39 G.S1.01
Polar TM3 R 122 3x50 G.H5 N 357 G.H5.24
Hydrophobic TM3 R 122 3x50 G.H5 N 357 G.H5.24
Van-der-waals TM3 R 122 3x50 G.H5 N 357 G.H5.24
Hydrophobic ICL2 L 130 34x51 G.H5 L 349 G.H5.16
Van-der-waals ICL2 L 130 34x51 G.H5 L 349 G.H5.16
Hydrophobic TM5 T 228 5x68 G.H5 Q 350 G.H5.17
Van-der-waals TM5 T 228 5x68 G.H5 Q 350 G.H5.17
Hydrophobic TM6 K 236 6x32 G.H5 V 359 G.H5.26
Van-der-waals TM6 K 236 6x32 G.H5 V 359 G.H5.26
Polar TM6 A 237 6x33 G.H5 V 359 G.H5.26
Hydrophobic TM6 A 237 6x33 G.H5 V 359 G.H5.26
Van-der-waals TM6 A 237 6x33 G.H5 V 359 G.H5.26
Hydrophobic TM6 N 239 6x35 G.H5 V 359 G.H5.26
Van-der-waals TM6 N 239 6x35 G.H5 V 359 G.H5.26
Ionic H8 K 297 8x48 G.h4s6 D 321 G.h4s6.12
Polar H8 K 297 8x48 G.h4s6 D 321 G.h4s6.12
Hydrophobic TM3 A 125 3x53 G.H5 L 358 G.H5.25
Van-der-waals TM3 A 125 3x53 G.H5 L 358 G.H5.25
Polar ICL2 T 134 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 T 134 34x55 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 T 134 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 P 129 34x50 G.H5 L 353 G.H5.20
Van-der-waals ICL2 P 129 34x50 G.H5 L 353 G.H5.20
Van-der-waals H8 T 296 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 T 296 8x47 G.H5 N 357 G.H5.24
Hydrophobic TM3 R 122 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 R 122 3x50 G.H5 L 358 G.H5.25
Van-der-waals ICL2 L 130 34x51 G.hns1 R 37 G.hns1.02
Polar ICL2 R 131 34x52 G.s2s3 S 198 G.s2s3.02
Hydrophobic ICL2 R 131 34x52 G.s2s3 S 198 G.s2s3.02
Van-der-waals ICL2 R 131 34x52 G.s2s3 S 198 G.s2s3.02
Hydrophobic ICL2 P 129 34x50 G.H5 N 352 G.H5.19
Van-der-waals ICL2 P 129 34x50 G.H5 N 352 G.H5.19
Hydrophobic ICL2 L 130 34x51 G.S3 V 199 G.S3.01
Van-der-waals ICL2 L 130 34x51 G.S3 V 199 G.S3.01
Polar TM3 A 125 3x53 G.H5 L 353 G.H5.20
Hydrophobic TM3 A 125 3x53 G.H5 L 353 G.H5.20
Van-der-waals TM3 A 125 3x53 G.H5 L 353 G.H5.20