Ggust - Olfactory receptor 51J1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 70.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 23.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 L 130 3x55 G.hns1 A 31 G.hns1.02
Van-der-waals TM3 L 130 3x55 G.hns1 A 31 G.hns1.02
Polar ICL2 L 135 34x53 G.h2s4 E 216 G.h2s4.02
Hydrophobic ICL2 L 135 34x53 G.h2s4 E 216 G.h2s4.02
Van-der-waals ICL2 L 135 34x53 G.h2s4 E 216 G.h2s4.02
Polar TM3 H 129 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM3 H 129 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 H 129 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM5 I 230 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 I 230 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM3 L 130 3x55 G.HN E 28 G.HN.52
Van-der-waals TM3 L 130 3x55 G.HN E 28 G.HN.52
Polar TM6 H 246 6x40 G.H5 G 352 G.H5.24
Hydrophobic TM6 H 246 6x40 G.H5 G 352 G.H5.24
Van-der-waals TM6 H 246 6x40 G.H5 G 352 G.H5.24
Hydrophobic ICL2 L 135 34x53 G.H3 Y 258 G.H3.17
Hydrophobic TM2 M 62 2x39 G.H5 G 352 G.H5.24
Van-der-waals TM2 M 62 2x39 G.H5 G 352 G.H5.24
Hydrophobic TM5 I 223 5x61 G.H5 L 348 G.H5.20
Van-der-waals TM5 I 223 5x61 G.H5 L 348 G.H5.20
Hydrophobic TM3 L 130 3x55 G.HN D 26 G.HN.50
Van-der-waals TM3 L 130 3x55 G.HN D 26 G.HN.50
Hydrophobic TM2 M 62 2x39 G.H5 K 349 G.H5.21
Van-der-waals TM2 M 62 2x39 G.H5 K 349 G.H5.21
Ionic TM6 K 238 6x32 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 238 6x32 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 T 242 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 242 6x36 G.H5 L 353 G.H5.25
Polar TM3 H 129 3x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM3 H 129 3x54 G.hns1 A 31 G.hns1.02
Van-der-waals TM3 H 129 3x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM3 L 130 3x55 G.HN R 29 G.HN.53
Van-der-waals TM3 L 130 3x55 G.HN R 29 G.HN.53
Hydrophobic TM6 A 239 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 239 6x33 G.H5 F 354 G.H5.26
Ionic H8 K 299 8x48 G.h4s6 E 315 G.h4s6.09
Polar H8 K 299 8x48 G.h4s6 E 315 G.h4s6.09
Van-der-waals H8 K 299 8x48 G.h4s6 E 315 G.h4s6.09
Hydrophobic TM5 Y 220 5x58 G.H5 L 353 G.H5.25
Van-der-waals TM5 Y 220 5x58 G.H5 L 353 G.H5.25
Hydrophobic TM3 Y 127 3x52 G.HN A 27 G.HN.51
Van-der-waals TM3 Y 127 3x52 G.HN A 27 G.HN.51
Polar TM3 L 130 3x55 G.hns1 D 30 G.hns1.01
Hydrophobic TM3 L 130 3x55 G.hns1 D 30 G.hns1.01
Van-der-waals TM3 L 130 3x55 G.hns1 D 30 G.hns1.01
Hydrophobic ICL3 A 231 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 A 231 - G.H5 D 337 G.H5.09
Hydrophobic TM6 K 238 6x32 G.H5 K 345 G.H5.17
Polar TM3 Y 127 3x52 G.HN E 28 G.HN.52
Hydrophobic TM3 Y 127 3x52 G.HN E 28 G.HN.52
Van-der-waals TM3 Y 127 3x52 G.HN E 28 G.HN.52
Polar TM6 H 246 6x40 G.H5 L 353 G.H5.25
Hydrophobic TM6 H 246 6x40 G.H5 L 353 G.H5.25
Van-der-waals TM6 H 246 6x40 G.H5 L 353 G.H5.25
Hydrophobic TM3 L 126 3x51 G.hns1 A 31 G.hns1.02
Van-der-waals TM3 L 126 3x51 G.hns1 A 31 G.hns1.02
Hydrophobic TM2 M 62 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 M 62 2x39 G.H5 C 351 G.H5.23
Polar ICL3 A 231 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 A 231 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 A 231 - G.H5 D 341 G.H5.13
Hydrophobic TM5 T 226 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 T 226 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM5 V 227 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 V 227 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 T 242 6x36 G.H5 F 354 G.H5.26
Van-der-waals TM6 T 242 6x36 G.H5 F 354 G.H5.26
Polar TM2 M 62 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 M 62 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 M 62 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM3 P 125 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 P 125 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 122 3x47 G.H5 L 353 G.H5.25
Polar TM3 H 121 3x46 G.H5 C 351 G.H5.23
Van-der-waals TM3 H 121 3x46 G.H5 C 351 G.H5.23
Van-der-waals ICL2 T 133 34x51 G.h2s4 E 216 G.h2s4.02
Hydrophobic TM3 L 130 3x55 G.HN A 27 G.HN.51
Van-der-waals TM3 L 130 3x55 G.HN A 27 G.HN.51
Hydrophobic TM3 Y 127 3x52 G.hns1 A 31 G.hns1.02
Van-der-waals TM3 Y 127 3x52 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 K 238 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 238 6x32 G.H5 F 354 G.H5.26
Polar TM6 C 243 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 C 243 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 H 129 3x54 G.hns1 D 30 G.hns1.01
Van-der-waals TM3 H 129 3x54 G.hns1 D 30 G.hns1.01
Hydrophobic TM5 I 223 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 223 5x61 G.H5 L 353 G.H5.25
Polar TM5 G 229 5x67 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM5 G 229 5x67 G.s2s3 K 192 G.s2s3.01
Van-der-waals TM5 G 229 5x67 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM6 T 232 6x26 G.H5 A 338 G.H5.10
Ionic H8 K 299 8x48 G.h4s6 D 316 G.h4s6.10
Polar TM2 Q 60 2x37 G.h3s5 T 261 G.h3s5.02
Hydrophobic TM2 Q 60 2x37 G.h3s5 T 261 G.h3s5.02
Van-der-waals TM2 Q 60 2x37 G.h3s5 T 261 G.h3s5.02
Polar TM6 T 232 6x26 G.H5 D 341 G.H5.13