Ggust - OPN1MW complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 T 259 6x26 G.H5 K 345 G.H5.17
Hydrophobic TM6 T 259 6x26 G.H5 K 345 G.H5.17
Van-der-waals TM6 T 259 6x26 G.H5 K 345 G.H5.17
Hydrophobic TM3 V 155 3x54 G.H5 C 351 G.H5.23
Hydrophobic C-term S 345 - G.h3s5 T 261 G.h3s5.02
Polar H8 R 327 8x48 G.H5 G 352 G.H5.24
Hydrophobic TM6 M 269 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 269 6x36 G.H5 L 353 G.H5.25
Polar TM3 V 154 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 V 154 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 V 249 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 V 249 5x68 G.H5 D 341 G.H5.13
Polar ICL2 N 161 34x53 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 N 161 34x53 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 N 161 34x53 G.hns1 R 32 G.hns1.03
Polar TM6 S 256 6x23 G.H5 K 345 G.H5.17
Van-der-waals TM6 S 256 6x23 G.H5 K 345 G.H5.17
Hydrophobic H8 N 326 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 326 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM3 V 155 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 155 3x54 G.H5 L 348 G.H5.20
Polar TM5 Q 253 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM5 Q 253 5x72 G.H5 D 337 G.H5.09
Van-der-waals TM5 Q 253 5x72 G.H5 D 337 G.H5.09
Polar C-term T 353 - G.H3 Y 258 G.H3.17
Polar C-term G 344 - G.h4s6 D 316 G.h4s6.10
Hydrophobic C-term G 344 - G.h4s6 D 316 G.h4s6.10
Van-der-waals C-term G 344 - G.h4s6 D 316 G.h4s6.10
Polar TM3 R 151 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 151 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 155 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM6 V 266 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM6 E 265 6x32 G.H5 F 354 G.H5.26
Hydrophobic C-term L 347 - G.h4s6 K 313 G.h4s6.04
Van-der-waals C-term L 347 - G.h4s6 K 313 G.h4s6.04
Hydrophobic TM5 V 249 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 V 249 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL2 V 162 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 V 162 34x54 G.hns1 R 32 G.hns1.03
Polar TM5 Q 253 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM5 Q 253 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 Q 253 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM3 K 157 3x56 G.H5 N 347 G.H5.19
Van-der-waals TM3 K 157 3x56 G.H5 N 347 G.H5.19
Polar TM6 T 259 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 T 259 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 T 259 6x26 G.H5 D 341 G.H5.13
Polar TM5 Q 252 5x71 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM5 Q 253 5x72 G.H5 A 338 G.H5.10
Van-der-waals TM5 Q 253 5x72 G.H5 A 338 G.H5.10
Polar C-term S 351 - G.H3 K 257 G.H3.16
Hydrophobic C-term S 351 - G.H3 K 257 G.H3.16
Van-der-waals C-term S 351 - G.H3 K 257 G.H3.16
Hydrophobic ICL2 R 163 34x55 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 163 34x55 G.hns1 A 31 G.hns1.02
Polar ICL2 N 161 34x53 G.S3 H 195 G.S3.02
Hydrophobic ICL2 N 161 34x53 G.S3 H 195 G.S3.02
Van-der-waals ICL2 N 161 34x53 G.S3 H 195 G.S3.02
Polar C-term G 344 - G.h4s6 K 313 G.h4s6.04
Polar TM6 S 258 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 S 258 6x25 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 S 258 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 A 262 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 262 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM5 I 246 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 I 246 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM3 K 157 3x56 G.S3 L 194 G.S3.01
Van-der-waals TM3 K 157 3x56 G.S3 L 194 G.S3.01
Hydrophobic TM6 V 266 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 G 160 34x52 G.s2s3 D 193 G.s2s3.02
Polar TM4 K 167 4x40 G.HN Q 24 G.HN.48
Hydrophobic TM4 K 167 4x40 G.HN Q 24 G.HN.48
Van-der-waals TM4 K 167 4x40 G.HN Q 24 G.HN.48
Hydrophobic TM2 L 88 2x39 G.H5 D 350 G.H5.22
Polar C-term T 353 - G.H3 K 257 G.H3.16
Hydrophobic C-term T 353 - G.H3 K 257 G.H3.16
Van-der-waals C-term T 353 - G.H3 K 257 G.H3.16
Polar TM6 S 258 6x25 G.H5 K 345 G.H5.17
Hydrophobic TM6 S 258 6x25 G.H5 K 345 G.H5.17
Van-der-waals TM6 S 258 6x25 G.H5 K 345 G.H5.17
Polar TM6 S 256 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 R 151 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 151 3x50 G.H5 L 353 G.H5.25
Aromatic H8 R 327 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 R 327 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 R 327 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM3 V 154 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 V 154 3x53 G.H5 C 351 G.H5.23
Hydrophobic C-term G 344 - G.h3s5 T 261 G.h3s5.02