Gz - Olfactory receptor 1G1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 16.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 H 131 34x52 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 L 130 34x51 G.H5 T 341 G.H5.12
Van-der-waals ICL2 L 130 34x51 G.H5 T 341 G.H5.12
Hydrophobic TM2 Y 60 2x40 G.H5 G 353 G.H5.24
Van-der-waals TM2 Y 60 2x40 G.H5 G 353 G.H5.24
Hydrophobic TM3 C 122 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 C 122 3x50 G.H5 L 354 G.H5.25
Hydrophobic ICL2 L 130 34x51 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 L 130 34x51 G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL2 P 129 34x50 G.H5 T 341 G.H5.12
Van-der-waals ICL2 P 129 34x50 G.H5 T 341 G.H5.12
Hydrophobic TM2 M 59 2x39 G.H5 I 352 G.H5.23
Van-der-waals TM2 M 59 2x39 G.H5 I 352 G.H5.23
Hydrophobic ICL2 I 133 34x54 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 I 133 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic TM6 Q 232 6x28 G.h4s6 E 319 G.h4s6.12
Polar TM2 T 57 2x37 G.H5 Y 351 G.H5.22
Hydrophobic TM2 T 57 2x37 G.H5 Y 351 G.H5.22
Van-der-waals TM2 T 57 2x37 G.H5 Y 351 G.H5.22
Hydrophobic ICL2 L 130 34x51 G.S3 F 197 G.S3.03
Van-der-waals ICL2 L 130 34x51 G.S3 F 197 G.S3.03
Polar ICL2 H 131 34x52 G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL2 H 131 34x52 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 H 131 34x52 G.s2s3 K 193 G.s2s3.01
Polar TM3 A 125 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 125 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM2 M 59 2x39 G.H5 L 354 G.H5.25
Hydrophobic ICL2 L 134 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 134 34x55 G.hns1 R 32 G.hns1.03
Polar H8 Q 295 8x48 G.H5 C 355 G.H5.26
Hydrophobic H8 Q 295 8x48 G.H5 C 355 G.H5.26
Van-der-waals H8 Q 295 8x48 G.H5 C 355 G.H5.26
Hydrophobic ICL2 P 129 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 129 34x50 G.H5 I 345 G.H5.16
Polar H8 N 294 8x47 G.H5 G 353 G.H5.24
Hydrophobic H8 N 294 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 N 294 8x47 G.H5 G 353 G.H5.24
Polar TM6 T 240 6x36 G.H5 C 355 G.H5.26
Hydrophobic TM6 T 240 6x36 G.H5 C 355 G.H5.26
Van-der-waals TM6 T 240 6x36 G.H5 C 355 G.H5.26
Hydrophobic ICL2 P 129 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 129 34x50 G.H5 I 344 G.H5.15
Hydrophobic ICL2 H 131 34x52 G.S3 L 195 G.S3.01
Hydrophobic H8 E 296 8x49 G.H5 K 350 G.H5.21
Hydrophobic TM6 C 241 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM2 M 59 2x39 G.H5 G 353 G.H5.24
Van-der-waals TM2 M 59 2x39 G.H5 G 353 G.H5.24
Hydrophobic TM3 I 126 3x54 G.H5 I 345 G.H5.16
Polar ICL2 P 129 34x50 G.H5 N 348 G.H5.19
Hydrophobic ICL2 P 129 34x50 G.H5 N 348 G.H5.19
Van-der-waals ICL2 P 129 34x50 G.H5 N 348 G.H5.19
Polar TM6 S 230 6x26 G.h4s6 E 319 G.h4s6.12
Polar TM6 T 240 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM6 T 240 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 T 240 6x36 G.H5 L 354 G.H5.25
Hydrophobic ICL2 L 134 34x55 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 134 34x55 G.S3 L 195 G.S3.01
Hydrophobic ICL2 Y 132 34x53 G.H5 Y 351 G.H5.22
Hydrophobic TM6 K 236 6x32 G.H5 C 355 G.H5.26
Van-der-waals TM6 K 236 6x32 G.H5 C 355 G.H5.26
Hydrophobic TM6 A 237 6x33 G.H5 L 349 G.H5.20
Ionic TM6 K 236 6x32 G.h4s6 E 319 G.h4s6.12
Polar TM6 K 236 6x32 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM3 I 126 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 126 3x54 G.H5 L 349 G.H5.20
Polar TM6 K 236 6x32 G.H5 Q 346 G.H5.17
Hydrophobic TM6 K 236 6x32 G.H5 Q 346 G.H5.17
Van-der-waals TM6 K 236 6x32 G.H5 Q 346 G.H5.17
Polar TM6 G 233 6x29 G.H5 Q 346 G.H5.17
Hydrophobic TM6 T 240 6x36 G.H5 L 349 G.H5.20
Van-der-waals TM6 T 240 6x36 G.H5 L 349 G.H5.20
Hydrophobic ICL2 L 130 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 L 130 34x51 G.H5 I 344 G.H5.15
Hydrophobic ICL2 Y 132 34x53 G.H5 N 348 G.H5.19
Van-der-waals ICL2 Y 132 34x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 125 3x53 G.H5 I 352 G.H5.23
Van-der-waals TM3 A 125 3x53 G.H5 I 352 G.H5.23
Polar TM6 G 233 6x29 G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL2 L 130 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 130 34x51 G.S3 L 195 G.S3.01
Hydrophobic ICL2 L 130 34x51 G.S1 I 34 G.S1.02
Van-der-waals ICL2 L 130 34x51 G.S1 I 34 G.S1.02
Hydrophobic TM3 D 121 3x49 G.H5 I 352 G.H5.23
Van-der-waals TM3 D 121 3x49 G.H5 I 352 G.H5.23
Hydrophobic TM3 C 122 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM6 S 243 6x39 G.H5 L 354 G.H5.25
Van-der-waals TM6 S 243 6x39 G.H5 L 354 G.H5.25
Hydrophobic ICL2 L 130 34x51 G.S2 F 192 G.S2.08