Gt1 - P2RY8 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 81.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 15.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 129 34x51 G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 L 129 34x51 G.hns1 R 28 G.hns1.03
Hydrophobic C-term L 318 - G.H4 E 305 G.H4.17
Van-der-waals C-term L 318 - G.H4 E 305 G.H4.17
Van-der-waals C-term R 329 - G.s4h3 V 236 G.s4h3.14
Polar C-term R 322 - G.h4s6 L 306 G.h4s6.01
Hydrophobic H8 E 299 8x49 G.H5 K 345 G.H5.21
Hydrophobic TM3 Y 127 3x56 G.hns1 A 27 G.hns1.02
Van-der-waals TM3 Y 127 3x56 G.hns1 A 27 G.hns1.02
Ionic C-term R 321 - G.hgh4 D 285 G.hgh4.04
Polar C-term R 321 - G.hgh4 D 285 G.hgh4.04
Hydrophobic TM6 Q 231 6x30 G.H5 F 350 G.H5.26
Van-der-waals TM6 Q 231 6x30 G.H5 F 350 G.H5.26
Polar ICL2 R 135 34x57 G.H5 N 343 G.H5.19
Van-der-waals ICL2 R 135 34x57 G.H5 N 343 G.H5.19
Aromatic C-term F 359 - G.h2s4 F 211 G.h2s4.01
Hydrophobic C-term F 359 - G.h2s4 F 211 G.h2s4.01
Polar ICL2 S 130 34x52 G.hns1 A 27 G.hns1.02
Hydrophobic ICL2 S 130 34x52 G.hns1 A 27 G.hns1.02
Van-der-waals ICL2 S 130 34x52 G.hns1 A 27 G.hns1.02
Polar ICL2 S 130 34x52 G.HN A 23 G.HN.51
Polar ICL2 K 132 34x54 G.h2s4 V 214 G.h2s4.04
Ionic ICL2 R 135 34x57 G.H5 D 346 G.H5.22
Polar ICL3 H 227 - G.H5 K 341 G.H5.17
Hydrophobic ICL3 H 227 - G.H5 K 341 G.H5.17
Hydrophobic C-term F 359 - G.H3 I 249 G.H3.12
Van-der-waals C-term F 359 - G.H3 I 249 G.H3.12
Hydrophobic ICL3 H 227 - G.H5 I 340 G.H5.16
Van-der-waals ICL3 H 227 - G.H5 I 340 G.H5.16
Hydrophobic TM5 L 220 5x65 G.H5 L 344 G.H5.20
Polar ICL2 L 129 34x51 G.hns1 A 27 G.hns1.02
Hydrophobic ICL2 L 129 34x51 G.hns1 A 27 G.hns1.02
Van-der-waals ICL2 L 129 34x51 G.hns1 A 27 G.hns1.02
Ionic TM5 K 219 5x64 G.s2s3 D 189 G.s2s3.02
Polar TM5 K 219 5x64 G.s2s3 D 189 G.s2s3.02
Van-der-waals TM5 K 219 5x64 G.s2s3 D 189 G.s2s3.02
Hydrophobic C-term F 326 - G.H3 H 244 G.H3.07
Hydrophobic C-term R 322 - G.h4s6 M 308 G.h4s6.03
Van-der-waals C-term R 322 - G.h4s6 M 308 G.h4s6.03
Hydrophobic TM3 G 124 3x53 G.H5 C 347 G.H5.23
Van-der-waals TM3 G 124 3x53 G.H5 C 347 G.H5.23
Hydrophobic ICL3 A 226 - G.H5 D 337 G.H5.13
Van-der-waals ICL3 A 226 - G.H5 D 337 G.H5.13
Hydrophobic C-term F 359 - G.H3 L 245 G.H3.08
Hydrophobic C-term L 325 - G.hgh4 F 283 G.hgh4.02
Hydrophobic C-term F 359 - G.H2 W 207 G.H2.07
Van-der-waals C-term F 359 - G.H2 W 207 G.H2.07
Polar C-term S 324 - G.hgh4 D 285 G.hgh4.04
Van-der-waals C-term S 324 - G.hgh4 D 285 G.hgh4.04
Hydrophobic C-term V 358 - G.H2 R 204 G.H2.04
Polar TM2 S 56 2x37 G.H5 D 346 G.H5.22
Polar ICL2 S 130 34x52 G.hns1 D 26 G.hns1.01
Hydrophobic ICL2 S 130 34x52 G.hns1 D 26 G.hns1.01
Van-der-waals ICL2 S 130 34x52 G.hns1 D 26 G.hns1.01
Polar C-term R 322 - G.H4 E 305 G.H4.17
Polar TM3 E 120 3x49 G.H5 C 347 G.H5.23
Hydrophobic TM3 E 120 3x49 G.H5 C 347 G.H5.23
Van-der-waals TM3 E 120 3x49 G.H5 C 347 G.H5.23
Polar TM2 S 58 2x39 G.H5 C 347 G.H5.23
Hydrophobic TM2 S 58 2x39 G.H5 C 347 G.H5.23
Van-der-waals TM2 S 58 2x39 G.H5 C 347 G.H5.23
Ionic H8 R 303 8x53 G.h4s6 D 311 G.h4s6.09
Polar H8 R 303 8x53 G.h4s6 D 311 G.h4s6.09
Hydrophobic H8 R 303 8x53 G.h4s6 D 311 G.h4s6.09
Van-der-waals H8 R 303 8x53 G.h4s6 D 311 G.h4s6.09
Polar ICL2 R 135 34x57 G.H5 C 347 G.H5.23
Van-der-waals ICL2 R 135 34x57 G.H5 C 347 G.H5.23
Polar C-term V 358 - G.H3 S 248 G.H3.11
Hydrophobic C-term V 358 - G.H3 S 248 G.H3.11
Van-der-waals C-term V 358 - G.H3 S 248 G.H3.11
Hydrophobic TM5 T 216 5x61 G.H5 L 349 G.H5.25
Hydrophobic H8 S 297 8x47 G.H5 F 350 G.H5.26
Hydrophobic ICL3 A 226 - G.H5 I 340 G.H5.16
Hydrophobic TM3 V 125 3x54 G.H5 L 344 G.H5.20
Van-der-waals TM3 V 125 3x54 G.H5 L 344 G.H5.20
Hydrophobic C-term V 358 - G.H3 L 245 G.H3.08
Van-der-waals C-term V 358 - G.H3 L 245 G.H3.08
Ionic ICL1 R 55 - G.h4s6 D 311 G.h4s6.09
Hydrophobic TM3 R 121 3x50 G.H5 L 349 G.H5.25
Hydrophobic C-term V 358 - G.H3 H 244 G.H3.07
Van-der-waals C-term V 358 - G.H3 H 244 G.H3.07
Hydrophobic ICL2 L 129 34x51 G.S1 T 29 G.S1.01
Van-der-waals ICL2 L 129 34x51 G.S1 T 29 G.S1.01
Polar H8 R 298 8x48 G.H5 F 350 G.H5.26
Hydrophobic H8 R 298 8x48 G.H5 F 350 G.H5.26
Van-der-waals H8 R 298 8x48 G.H5 F 350 G.H5.26
Hydrophobic ICL2 P 128 34x50 G.H5 N 343 G.H5.19
Van-der-waals ICL2 P 128 34x50 G.H5 N 343 G.H5.19
Hydrophobic C-term F 359 - G.H3 S 248 G.H3.11
Van-der-waals C-term F 359 - G.H3 S 248 G.H3.11
Hydrophobic ICL3 A 226 - G.s2s3 K 188 G.s2s3.01
Polar H8 E 299 8x49 G.H5 F 350 G.H5.26
Hydrophobic ICL1 R 55 - G.h4s6 V 312 G.h4s6.10
Van-der-waals ICL1 R 55 - G.h4s6 V 312 G.h4s6.10
Polar TM3 R 121 3x50 G.H5 G 348 G.H5.24
Hydrophobic TM3 R 121 3x50 G.H5 G 348 G.H5.24
Van-der-waals TM3 R 121 3x50 G.H5 G 348 G.H5.24
Hydrophobic ICL3 H 227 - G.H5 L 344 G.H5.20
Van-der-waals ICL3 H 227 - G.H5 L 344 G.H5.20
Polar TM2 S 58 2x39 G.H5 D 346 G.H5.22
Van-der-waals TM2 S 58 2x39 G.H5 D 346 G.H5.22
Polar TM3 R 121 3x50 G.H5 C 347 G.H5.23
Hydrophobic TM3 R 121 3x50 G.H5 C 347 G.H5.23
Van-der-waals TM3 R 121 3x50 G.H5 C 347 G.H5.23
Aromatic C-term F 359 - G.H3 H 252 G.H3.15
Hydrophobic C-term F 359 - G.H3 H 252 G.H3.15
Hydrophobic TM6 L 238 6x37 G.H5 L 349 G.H5.25
Polar TM3 Y 127 3x56 G.HN E 24 G.HN.52
Hydrophobic TM3 Y 127 3x56 G.HN E 24 G.HN.52
Van-der-waals TM3 Y 127 3x56 G.HN E 24 G.HN.52
Hydrophobic ICL2 L 129 34x51 G.S3 L 190 G.S3.01
Hydrophobic C-term L 325 - G.H4 Q 302 G.H4.14
Van-der-waals C-term L 325 - G.H4 Q 302 G.H4.14
Hydrophobic TM3 V 125 3x54 G.H5 L 349 G.H5.25
Hydrophobic ICL2 L 129 34x51 G.S1 V 30 G.S1.02
Van-der-waals ICL2 L 129 34x51 G.S1 V 30 G.S1.02
Hydrophobic TM6 A 239 6x38 G.H5 L 349 G.H5.25
Hydrophobic ICL2 L 129 34x51 G.h2s4 T 215 G.h2s4.05
Van-der-waals ICL2 L 129 34x51 G.h2s4 T 215 G.h2s4.05
Polar ICL2 P 128 34x50 G.hns1 A 27 G.hns1.02