G12 - DP2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 22.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM4 T 144 4x38 G.HN R 52 G.HN.52
Polar ICL1 R 62 - G.HN R 51 G.HN.51
Hydrophobic ICL1 R 62 - G.HN R 51 G.HN.51
Van-der-waals ICL1 R 62 - G.HN R 51 G.HN.51
Hydrophobic C-term L 373 - G.H2 R 235 G.H2.04
Hydrophobic ICL2 P 136 34x50 G.H5 Q 372 G.H5.17
Polar TM5 R 236 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 R 236 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 236 5x68 G.H5 D 368 G.H5.13
Polar TM5 R 236 5x68 G.H5 A 365 G.H5.10
Hydrophobic ICL2 V 137 34x51 G.s2s3 K 219 G.s2s3.01
Hydrophobic TM4 T 144 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 T 144 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals H8 K 314 8x53 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 V 137 34x51 G.H5 L 371 G.H5.16
Van-der-waals ICL2 V 137 34x51 G.H5 L 371 G.H5.16
Hydrophobic ICL3 R 239 - G.h4s6 K 344 G.h4s6.19
Hydrophobic ICL3 R 239 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 R 239 - G.S6 F 347 G.S6.02
Hydrophobic TM2 T 64 2x37 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 T 64 2x37 G.hns1 R 55 G.hns1.02
Polar ICL1 Q 63 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 Q 63 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL3 R 238 - G.h4s6 S 343 G.h4s6.12
Polar ICL2 N 141 34x55 G.s2s3 K 219 G.s2s3.01
Van-der-waals ICL2 N 141 34x55 G.s2s3 K 219 G.s2s3.01
Polar ICL2 N 141 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 N 141 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 N 141 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 A 139 34x53 G.H5 L 375 G.H5.20
Polar TM3 Q 132 3x53 G.H5 L 375 G.H5.20
Hydrophobic TM3 Q 132 3x53 G.H5 L 375 G.H5.20
Van-der-waals TM3 Q 132 3x53 G.H5 L 375 G.H5.20
Hydrophobic ICL2 Q 140 34x54 G.S3 I 221 G.S3.01
Van-der-waals ICL2 Q 140 34x54 G.S3 I 221 G.S3.01
Hydrophobic ICL2 V 137 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM3 Q 132 3x53 G.H5 M 379 G.H5.24
Van-der-waals TM3 Q 132 3x53 G.H5 M 379 G.H5.24
Ionic TM5 R 232 5x64 G.H5 D 368 G.H5.13
Polar TM5 R 232 5x64 G.H5 D 368 G.H5.13
Hydrophobic ICL3 R 239 - G.h4s6 P 345 G.h4s6.20
Polar TM3 V 133 3x54 G.H5 Q 372 G.H5.17
Hydrophobic TM3 V 133 3x54 G.H5 Q 372 G.H5.17
Van-der-waals TM3 V 133 3x54 G.H5 Q 372 G.H5.17
Hydrophobic TM5 R 236 5x68 G.S6 F 347 G.S6.02
Van-der-waals TM5 R 236 5x68 G.S6 F 347 G.S6.02
Van-der-waals TM2 T 64 2x37 G.H5 Q 381 G.H5.26
Hydrophobic TM5 L 233 5x65 G.H5 Q 372 G.H5.17
Ionic ICL3 R 239 - G.H5 E 373 G.H5.18
Polar ICL3 R 239 - G.H5 E 373 G.H5.18
Hydrophobic ICL3 R 239 - G.H5 E 373 G.H5.18
Van-der-waals ICL3 R 239 - G.H5 E 373 G.H5.18
Hydrophobic ICL2 P 136 34x50 G.H5 L 375 G.H5.20
Van-der-waals ICL2 P 136 34x50 G.H5 L 375 G.H5.20
Hydrophobic ICL2 Q 140 34x54 G.S1 V 58 G.S1.02
Van-der-waals ICL2 Q 140 34x54 G.S1 V 58 G.S1.02
Hydrophobic ICL2 R 143 34x57 G.H5 M 379 G.H5.24
Van-der-waals ICL2 R 143 34x57 G.H5 M 379 G.H5.24
Hydrophobic ICL2 Q 140 34x54 G.H5 L 371 G.H5.16
Van-der-waals ICL2 Q 140 34x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 P 136 34x50 G.H5 D 368 G.H5.13
Hydrophobic ICL2 P 136 34x50 G.H5 L 371 G.H5.16
Polar TM5 R 236 5x68 G.H5 Q 372 G.H5.17
Hydrophobic TM5 R 236 5x68 G.H5 Q 372 G.H5.17
Van-der-waals TM5 R 236 5x68 G.H5 Q 372 G.H5.17
Hydrophobic ICL1 R 62 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 R 62 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 N 141 34x55 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 N 141 34x55 G.s2s3 K 220 G.s2s3.02
Polar TM5 R 236 5x68 G.H5 T 369 G.H5.14
Hydrophobic TM5 R 236 5x68 G.H5 T 369 G.H5.14
Van-der-waals TM5 R 236 5x68 G.H5 T 369 G.H5.14
Hydrophobic ICL3 G 237 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 Q 140 34x54 G.H5 L 375 G.H5.20
Hydrophobic TM5 R 236 5x68 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM5 R 236 5x68 G.h4s6 P 345 G.h4s6.20
Polar ICL2 Q 140 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 Q 140 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 Q 140 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 F 244 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 F 244 6x33 G.H5 M 379 G.H5.24
Polar ICL2 N 141 34x55 G.S3 I 221 G.S3.01
Hydrophobic ICL2 N 141 34x55 G.S3 I 221 G.S3.01
Van-der-waals ICL2 N 141 34x55 G.S3 I 221 G.S3.01
Hydrophobic TM6 R 243 6x32 G.H5 L 380 G.H5.25
Hydrophobic ICL2 V 137 34x51 G.H5 K 367 G.H5.12
Van-der-waals ICL2 V 137 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM2 V 66 2x39 G.H5 M 379 G.H5.24
Van-der-waals TM2 V 66 2x39 G.H5 M 379 G.H5.24