Gs - PTH2 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
PTH2 70.0
Gαs 86.9
Gβ1 93.8
Gγ2 85.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 H 180 2x50 G.H5 Y 391 G.H5.23
Polar TM6 K 360 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM6 K 360 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 K 360 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM3 L 261 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 269 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 269 - G.S3 V 217 G.S3.01
Polar TM5 T 347 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 T 347 5x68 G.H5 R 385 G.H5.17
Aromatic ICL2 F 269 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 269 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 269 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 269 - G.S3 F 219 G.S3.03
Polar TM6 K 360 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 360 6x37 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 360 6x37 G.H5 L 394 G.H5.26
Aromatic TM2 R 176 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 176 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 176 2x46 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 A 268 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 A 268 - G.H5 R 380 G.H5.12
Hydrophobic ICL3 V 350 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM3 L 264 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM6 L 368 6x45 G.H5 L 393 G.H5.25
Polar TM6 K 360 6x37 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 360 6x37 G.H5 E 392 G.H5.24
Hydrophobic TM3 I 265 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 265 3x58 G.H5 L 388 G.H5.20
Hydrophobic TM5 L 340 5x61 G.H5 L 394 G.H5.26
Ionic TM5 E 346 5x67 G.H5 R 385 G.H5.17
Polar TM5 E 346 5x67 G.H5 R 385 G.H5.17
Van-der-waals TM5 E 346 5x67 G.H5 R 385 G.H5.17
Polar TM2 R 176 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 176 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 176 2x46 G.H5 Q 390 G.H5.22
Hydrophobic H8 N 417 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 417 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM3 L 261 3x54 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 344 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM5 K 343 5x64 G.H5 L 388 G.H5.20
Polar TM3 I 265 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 265 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 265 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM7 Y 413 7x57 G.H5 Y 391 G.H5.23
Van-der-waals TM7 Y 413 7x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 269 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 269 - G.H5 I 383 G.H5.15
Ionic TM5 K 343 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 343 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 343 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 343 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM3 L 264 3x57 G.H5 Y 391 G.H5.23
Polar TM5 K 343 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 343 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 L 340 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 L 340 5x61 G.H5 L 393 G.H5.25
Polar H8 G 418 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 G 418 8x48 G.H5 E 392 G.H5.24
Polar TM6 S 364 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 364 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 364 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM3 Y 260 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 269 - G.H5 C 379 G.H5.11
Hydrophobic ICL2 F 269 - G.H5 R 380 G.H5.12
Hydrophobic TM5 L 340 5x61 G.H5 L 388 G.H5.20
Aromatic ICL2 F 269 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 269 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 269 - G.S1 H 41 G.S1.02
Hydrophobic TM5 T 347 5x68 G.h4s6 Y 358 G.h4s6.20
Polar TM3 E 257 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 257 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 257 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM6 V 367 6x44 G.H5 L 393 G.H5.25