Golf - QRFP receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 G 146 3x53 G.H5 Y 378 G.H5.23
Ionic TM5 E 240 5x64 G.H5 R 367 G.H5.12
Polar TM5 E 240 5x64 G.H5 R 367 G.H5.12
Hydrophobic TM5 E 240 5x64 G.H5 R 367 G.H5.12
Van-der-waals TM5 E 240 5x64 G.H5 R 367 G.H5.12
Hydrophobic H8 F 339 8x50 G.H5 E 379 G.H5.24
Van-der-waals H8 F 339 8x50 G.H5 E 379 G.H5.24
Polar TM2 T 80 2x39 G.H5 Q 377 G.H5.22
Hydrophobic ICL2 M 153 34x53 G.H5 H 374 G.H5.19
Hydrophobic TM6 M 275 6x37 G.H5 L 380 G.H5.25
Van-der-waals TM6 M 275 6x37 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 150 34x50 G.H5 H 374 G.H5.19
Van-der-waals ICL2 P 150 34x50 G.H5 H 374 G.H5.19
Hydrophobic TM5 L 241 5x65 G.H5 Q 371 G.H5.16
Hydrophobic TM5 T 255 5x79 G.H4 L 333 G.H4.16
Van-der-waals TM5 T 255 5x79 G.H4 L 333 G.H4.16
Hydrophobic ICL2 F 151 34x51 G.H5 C 366 G.H5.11
Hydrophobic ICL2 F 151 34x51 G.S3 V 204 G.S3.01
Van-der-waals ICL2 F 151 34x51 G.S3 V 204 G.S3.01
Hydrophobic TM6 I 264 6x26 G.h4s6 Y 345 G.h4s6.20
Hydrophobic TM3 L 147 3x54 G.H5 H 374 G.H5.19
Polar ICL2 F 151 34x51 G.S1 H 43 G.S1.02
Aromatic ICL2 F 151 34x51 G.S1 H 43 G.S1.02
Hydrophobic ICL2 F 151 34x51 G.S1 H 43 G.S1.02
Van-der-waals ICL2 F 151 34x51 G.S1 H 43 G.S1.02
Hydrophobic TM6 M 274 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 M 274 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM5 R 254 5x78 G.hgh4 D 310 G.hgh4.13
Hydrophobic TM6 I 264 6x26 G.H5 R 372 G.H5.17
Van-der-waals TM6 I 264 6x26 G.H5 R 372 G.H5.17
Hydrophobic TM3 L 147 3x54 G.H5 L 380 G.H5.25
Hydrophobic ICL2 K 154 34x54 G.hns1 K 40 G.hns1.02
Van-der-waals ICL2 K 154 34x54 G.hns1 K 40 G.hns1.02
Hydrophobic TM2 T 80 2x39 G.H5 Y 378 G.H5.23
Van-der-waals TM2 T 80 2x39 G.H5 Y 378 G.H5.23
Hydrophobic TM5 L 241 5x65 G.H5 L 375 G.H5.20
Aromatic ICL2 F 151 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 151 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 151 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 151 34x51 G.S3 F 206 G.S3.03
Polar TM5 R 246 5x70 G.H5 Q 371 G.H5.16
Hydrophobic TM5 R 246 5x70 G.H5 Q 371 G.H5.16
Van-der-waals TM5 R 246 5x70 G.H5 Q 371 G.H5.16
Polar TM3 E 142 3x49 G.H5 Y 378 G.H5.23
Hydrophobic TM3 E 142 3x49 G.H5 Y 378 G.H5.23
Van-der-waals TM3 E 142 3x49 G.H5 Y 378 G.H5.23
Hydrophobic ICL2 F 151 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 151 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM5 V 252 5x76 G.S6 P 348 G.S6.03
Polar ICL2 W 155 34x55 G.HN R 36 G.HN.51
Hydrophobic ICL2 W 155 34x55 G.HN R 36 G.HN.51
Van-der-waals ICL2 W 155 34x55 G.HN R 36 G.HN.51
Polar TM3 R 143 3x50 G.H5 Y 378 G.H5.23
Hydrophobic TM3 R 143 3x50 G.H5 Y 378 G.H5.23
Van-der-waals TM3 R 143 3x50 G.H5 Y 378 G.H5.23
Hydrophobic TM6 A 271 6x33 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 150 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 150 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM5 V 252 5x76 G.H5 D 365 G.H5.10
Hydrophobic TM5 T 255 5x79 G.H4 R 329 G.H4.12
Van-der-waals TM5 T 255 5x79 G.H4 R 329 G.H4.12
Ionic TM6 K 268 6x30 G.H5 D 368 G.H5.13
Polar TM6 K 268 6x30 G.H5 D 368 G.H5.13
Polar TM2 N 81 2x40 G.H5 E 379 G.H5.24
Hydrophobic TM2 N 81 2x40 G.H5 E 379 G.H5.24
Van-der-waals TM2 N 81 2x40 G.H5 E 379 G.H5.24
Hydrophobic TM6 A 271 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM5 V 252 5x76 G.S6 Y 347 G.S6.02
Van-der-waals TM5 V 252 5x76 G.S6 Y 347 G.S6.02
Hydrophobic C-term F 391 - G.H3 S 262 G.H3.11
Hydrophobic TM3 R 143 3x50 G.H5 L 380 G.H5.25
Hydrophobic ICL3 E 260 - G.h4s6 T 337 G.h4s6.03
Polar TM3 L 147 3x54 G.H5 Q 371 G.H5.16
Hydrophobic TM3 L 147 3x54 G.H5 Q 371 G.H5.16
Van-der-waals TM3 L 147 3x54 G.H5 Q 371 G.H5.16
Hydrophobic TM5 T 255 5x79 G.S6 P 348 G.S6.03
Van-der-waals TM5 T 255 5x79 G.S6 P 348 G.S6.03
Polar TM3 V 148 3x55 G.H5 R 367 G.H5.12
Van-der-waals TM3 V 148 3x55 G.H5 R 367 G.H5.12
Hydrophobic C-term I 396 - G.H2 Q 223 G.H2.09
Van-der-waals C-term I 396 - G.H2 Q 223 G.H2.09
Ionic ICL2 K 154 34x54 G.h2s4 D 227 G.h2s4.03
Polar ICL2 K 154 34x54 G.h2s4 D 227 G.h2s4.03
Van-der-waals ICL2 K 154 34x54 G.h2s4 D 227 G.h2s4.03
Aromatic ICL2 Y 157 34x57 G.H5 H 374 G.H5.19
Hydrophobic ICL2 Y 157 34x57 G.H5 H 374 G.H5.19
Van-der-waals ICL2 Y 157 34x57 G.H5 H 374 G.H5.19
Hydrophobic ICL2 F 151 34x51 G.H5 R 367 G.H5.12
Van-der-waals ICL2 F 151 34x51 G.H5 R 367 G.H5.12
Polar H8 N 336 8x47 G.H5 E 379 G.H5.24
Hydrophobic H8 N 336 8x47 G.H5 E 379 G.H5.24
Van-der-waals H8 N 336 8x47 G.H5 E 379 G.H5.24
Polar TM5 R 246 5x70 G.H5 R 367 G.H5.12
Hydrophobic TM5 R 246 5x70 G.H5 R 367 G.H5.12
Van-der-waals TM5 R 246 5x70 G.H5 R 367 G.H5.12
Hydrophobic TM5 V 252 5x76 G.S6 H 349 G.S6.04
Van-der-waals TM5 V 252 5x76 G.S6 H 349 G.S6.04
Polar TM3 G 146 3x53 G.H5 H 374 G.H5.19
Hydrophobic TM3 G 146 3x53 G.H5 H 374 G.H5.19
Van-der-waals TM3 G 146 3x53 G.H5 H 374 G.H5.19
Polar TM5 R 254 5x78 G.hgh4 T 312 G.hgh4.15
Hydrophobic TM5 R 254 5x78 G.hgh4 T 312 G.hgh4.15
Van-der-waals TM5 R 254 5x78 G.hgh4 T 312 G.hgh4.15
Hydrophobic TM6 K 267 6x29 G.H5 L 381 G.H5.26
Van-der-waals TM6 K 267 6x29 G.H5 L 381 G.H5.26
Hydrophobic ICL2 K 154 34x54 G.S1 H 43 G.S1.02
Ionic C-term D 393 - G.H3 R 267 G.H3.16
Polar C-term D 393 - G.H3 R 267 G.H3.16
Van-der-waals C-term D 393 - G.H3 R 267 G.H3.16
Hydrophobic C-term I 396 - G.H2 I 222 G.H2.08
Van-der-waals C-term I 396 - G.H2 I 222 G.H2.08
Hydrophobic ICL2 P 150 34x50 G.H5 R 367 G.H5.12
Van-der-waals ICL2 P 150 34x50 G.H5 R 367 G.H5.12
Hydrophobic ICL1 M 76 12x50 G.H5 E 379 G.H5.24
Van-der-waals ICL1 M 76 12x50 G.H5 E 379 G.H5.24
Polar TM5 S 251 5x75 G.S6 H 349 G.S6.04
Hydrophobic TM5 S 251 5x75 G.S6 H 349 G.S6.04
Van-der-waals TM5 S 251 5x75 G.S6 H 349 G.S6.04
Hydrophobic ICL2 W 155 34x55 G.HN L 37 G.HN.52
Van-der-waals ICL2 W 155 34x55 G.HN L 37 G.HN.52
Hydrophobic TM5 V 247 5x71 G.H5 N 364 G.H5.09
Van-der-waals TM5 V 247 5x71 G.H5 N 364 G.H5.09
Hydrophobic TM3 L 147 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 L 147 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 P 150 34x50 G.H5 Q 371 G.H5.16
Polar ICL2 Y 157 34x57 G.H5 Y 378 G.H5.23
Hydrophobic ICL2 Y 157 34x57 G.H5 Y 378 G.H5.23
Van-der-waals ICL2 Y 157 34x57 G.H5 Y 378 G.H5.23
Polar ICL2 W 155 34x55 G.hns1 K 40 G.hns1.02
Aromatic ICL2 W 155 34x55 G.hns1 K 40 G.hns1.02
Hydrophobic ICL2 W 155 34x55 G.hns1 K 40 G.hns1.02
Van-der-waals ICL2 W 155 34x55 G.hns1 K 40 G.hns1.02
Polar ICL2 K 154 34x54 G.h2s4 T 229 G.h2s4.05