Gt2 - QRFP receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 13.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 M 275 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 143 3x50 G.H5 L 353 G.H5.25
Hydrophobic C-term F 391 - G.H3 S 252 G.H3.11
Van-der-waals C-term F 391 - G.H3 S 252 G.H3.11
Hydrophobic TM6 I 264 6x26 G.H5 K 345 G.H5.17
Polar TM3 R 143 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 143 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 143 3x50 G.H5 C 351 G.H5.23
Aromatic ICL2 W 155 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 W 155 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 W 155 34x55 G.hns1 K 32 G.hns1.03
Polar ICL3 E 260 - G.h4s6 N 311 G.h4s6.02
Hydrophobic ICL2 P 150 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 K 267 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 267 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM5 V 247 5x71 G.H5 K 345 G.H5.17
Van-der-waals TM5 V 247 5x71 G.H5 K 345 G.H5.17
Polar TM5 T 255 5x79 G.S6 H 322 G.S6.04
Hydrophobic TM5 T 255 5x79 G.S6 H 322 G.S6.04
Van-der-waals TM5 T 255 5x79 G.S6 H 322 G.S6.04
Polar H8 N 338 8x49 G.H5 K 349 G.H5.21
Hydrophobic H8 N 338 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 N 338 8x49 G.H5 K 349 G.H5.21
Hydrophobic TM5 V 247 5x71 G.H5 D 341 G.H5.13
Van-der-waals TM5 V 247 5x71 G.H5 D 341 G.H5.13
Polar TM5 T 255 5x79 G.H4 K 304 G.H4.12
Van-der-waals TM5 T 255 5x79 G.H4 K 304 G.H4.12
Hydrophobic C-term I 396 - G.H2 W 211 G.H2.07
Polar ICL2 P 150 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 150 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM5 V 252 5x76 G.S6 Y 320 G.S6.02
Van-der-waals TM5 V 252 5x76 G.S6 Y 320 G.S6.02
Ionic TM4 R 160 4x40 G.HN E 20 G.HN.44
Polar TM4 R 160 4x40 G.HN E 20 G.HN.44
Polar TM5 S 251 5x75 G.H5 D 337 G.H5.09
Hydrophobic TM5 R 246 5x70 G.H5 I 344 G.H5.16
Hydrophobic TM6 A 271 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 271 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL3 E 260 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 M 153 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 M 153 34x53 G.H5 N 347 G.H5.19
Polar TM2 T 80 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 80 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 80 2x39 G.H5 D 350 G.H5.22
Polar TM5 R 254 5x78 G.H4 K 304 G.H4.12
Polar TM5 G 248 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM5 G 248 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 G 248 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM5 L 241 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 150 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 150 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 A 271 6x33 G.H5 F 354 G.H5.26
Polar TM2 T 80 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 80 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 80 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM5 T 255 5x79 G.S6 Y 320 G.S6.02
Hydrophobic C-term I 396 - G.H2 K 209 G.H2.05
Hydrophobic TM6 M 274 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 M 274 6x36 G.H5 G 352 G.H5.24
Ionic ICL3 H 257 - G.H4 D 309 G.H4.17
Hydrophobic TM5 V 247 5x71 G.H5 L 348 G.H5.20
Hydrophobic TM3 L 147 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 M 153 34x53 G.H5 C 351 G.H5.23
Van-der-waals ICL2 M 153 34x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 I 264 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 I 264 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 S 251 5x75 G.H5 F 334 G.H5.06
Hydrophobic ICL2 F 151 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 F 151 34x51 G.H5 T 340 G.H5.12
Hydrophobic C-term L 400 - G.s4h3 V 240 G.s4h3.14
Van-der-waals C-term L 400 - G.s4h3 V 240 G.s4h3.14
Hydrophobic TM3 E 142 3x49 G.H5 C 351 G.H5.23
Hydrophobic C-term F 391 - G.H3 I 253 G.H3.12
Hydrophobic ICL2 F 151 34x51 G.H5 I 343 G.H5.15
Hydrophobic C-term L 400 - G.H2 R 205 G.H2.01
Van-der-waals C-term L 400 - G.H2 R 205 G.H2.01
Hydrophobic TM6 K 268 6x30 G.H5 F 354 G.H5.26
Hydrophobic TM5 V 247 5x71 G.H5 F 354 G.H5.26
Hydrophobic C-term I 396 - G.H2 R 208 G.H2.04
Van-der-waals C-term I 396 - G.H2 R 208 G.H2.04
Hydrophobic TM5 I 256 5x80 G.S6 Y 320 G.S6.02
Van-der-waals TM5 I 256 5x80 G.S6 Y 320 G.S6.02
Ionic ICL2 K 154 34x54 G.H5 E 346 G.H5.18
Polar ICL2 K 154 34x54 G.H5 E 346 G.H5.18
Hydrophobic ICL2 K 154 34x54 G.H5 E 346 G.H5.18
Van-der-waals ICL2 K 154 34x54 G.H5 E 346 G.H5.18
Polar TM3 G 146 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 G 146 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 G 146 3x53 G.H5 N 347 G.H5.19
Aromatic C-term F 391 - G.H3 H 256 G.H3.15
Hydrophobic C-term F 391 - G.H3 H 256 G.H3.15
Van-der-waals C-term F 391 - G.H3 H 256 G.H3.15
Polar ICL3 E 260 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 E 260 - G.S6 I 319 G.S6.01
Hydrophobic TM5 V 252 5x76 G.S6 H 322 G.S6.04
Hydrophobic TM6 M 274 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 274 6x36 G.H5 L 353 G.H5.25
Hydrophobic C-term F 391 - G.h2s4 F 215 G.h2s4.01
Hydrophobic ICL2 K 154 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 K 154 34x54 G.hns1 A 31 G.hns1.02
Polar ICL2 W 155 34x55 G.HN D 28 G.HN.52
Hydrophobic ICL2 W 155 34x55 G.HN D 28 G.HN.52
Van-der-waals ICL2 W 155 34x55 G.HN D 28 G.HN.52
Hydrophobic ICL2 F 151 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 151 34x51 G.S3 L 194 G.S3.01
Hydrophobic C-term A 390 - G.H3 S 252 G.H3.11
Van-der-waals C-term A 390 - G.H3 S 252 G.H3.11
Hydrophobic TM3 L 147 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 L 147 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM5 V 247 5x71 G.H5 I 344 G.H5.16
Van-der-waals TM5 V 247 5x71 G.H5 I 344 G.H5.16
Ionic TM6 K 263 6x25 G.h4s6 D 315 G.h4s6.09
Polar TM6 K 263 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 K 263 6x25 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 K 263 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 F 151 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 F 151 34x51 G.H5 F 336 G.H5.08
Polar TM5 T 255 5x79 G.S6 S 321 G.S6.03
Hydrophobic TM5 T 255 5x79 G.S6 S 321 G.S6.03
Van-der-waals TM5 T 255 5x79 G.S6 S 321 G.S6.03
Hydrophobic TM5 V 252 5x76 G.H5 D 337 G.H5.09
Van-der-waals TM5 V 252 5x76 G.H5 D 337 G.H5.09
Hydrophobic H8 N 336 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 336 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL3 H 257 - G.H4 L 308 G.H4.16