G12 - TAS2R19 complex model

GPCR CLASS (FAMILY)

T (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 24.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic H8 R 284 8x48 G.h4s6 K 344 G.h4s6.19
Van-der-waals H8 R 284 8x48 G.h4s6 K 344 G.h4s6.19
Hydrophobic TM3 K 109 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 K 109 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM2 Q 46 2x41 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 I 110 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 110 3x54 G.H5 L 375 G.H5.20
Polar ICL2 N 112 34x44 G.H5 K 367 G.H5.12
Hydrophobic ICL2 N 112 34x44 G.H5 K 367 G.H5.12
Van-der-waals ICL2 N 112 34x44 G.H5 K 367 G.H5.12
Aromatic TM5 H 212 5x75 G.H5 F 361 G.H5.06
Hydrophobic TM5 H 212 5x75 G.H5 F 361 G.H5.06
Van-der-waals TM5 H 212 5x75 G.H5 F 361 G.H5.06
Hydrophobic TM2 S 42 2x37 G.H5 I 378 G.H5.23
Van-der-waals TM2 S 42 2x37 G.H5 I 378 G.H5.23
Hydrophobic TM3 K 109 3x53 G.H5 L 375 G.H5.20
Van-der-waals TM3 K 109 3x53 G.H5 L 375 G.H5.20
Hydrophobic TM6 P 219 6x26 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 P 219 6x26 G.h4s6 P 345 G.h4s6.20
Hydrophobic H8 L 286 8x50 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 K 123 34x55 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 K 123 34x55 G.s2s3 K 220 G.s2s3.02
Hydrophobic H8 L 286 8x50 G.H5 L 380 G.H5.25
Van-der-waals H8 L 286 8x50 G.H5 L 380 G.H5.25
Hydrophobic TM7 L 279 7x53 G.H5 M 379 G.H5.24
Van-der-waals TM7 L 279 7x53 G.H5 M 379 G.H5.24
Hydrophobic TM3 I 110 3x54 G.H5 Q 372 G.H5.17
Hydrophobic TM6 T 230 6x37 G.H5 L 380 G.H5.25
Polar ICL2 N 112 34x44 G.H5 D 368 G.H5.13
Van-der-waals ICL2 N 112 34x44 G.H5 D 368 G.H5.13
Hydrophobic TM4 K 126 4x39 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 K 126 4x39 G.hns1 R 56 G.hns1.03
Polar TM6 H 224 6x31 G.H5 Q 372 G.H5.17
Hydrophobic TM6 H 224 6x31 G.H5 Q 372 G.H5.17
Van-der-waals TM6 H 224 6x31 G.H5 Q 372 G.H5.17
Polar TM2 E 45 2x40 G.H5 Q 381 G.H5.26
Hydrophobic TM2 E 45 2x40 G.H5 Q 381 G.H5.26
Van-der-waals TM2 E 45 2x40 G.H5 Q 381 G.H5.26
Hydrophobic TM7 L 279 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 L 279 7x53 G.H5 L 380 G.H5.25
Polar TM1 R 39 1x65 G.hns1 R 55 G.hns1.02
Van-der-waals TM1 R 39 1x65 G.hns1 R 55 G.hns1.02
Polar ICL2 N 112 34x44 G.H5 H 364 G.H5.09
Hydrophobic ICL2 N 112 34x44 G.H5 H 364 G.H5.09
Van-der-waals ICL2 N 112 34x44 G.H5 H 364 G.H5.09
Hydrophobic ICL1 K 40 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 K 40 - G.hns1 R 55 G.hns1.02
Hydrophobic TM6 S 220 6x27 G.S6 F 347 G.S6.02
Hydrophobic TM3 F 105 3x49 G.H5 I 378 G.H5.23
Hydrophobic TM1 N 31 1x57 G.H5 Q 381 G.H5.26
Van-der-waals TM1 N 31 1x57 G.H5 Q 381 G.H5.26
Hydrophobic TM3 C 106 3x50 G.H5 M 379 G.H5.24
Van-der-waals TM3 C 106 3x50 G.H5 M 379 G.H5.24
Hydrophobic ICL1 K 40 - G.hns1 V 54 G.hns1.01
Van-der-waals ICL1 K 40 - G.hns1 V 54 G.hns1.01
Hydrophobic TM3 C 106 3x50 G.H5 L 375 G.H5.20
Hydrophobic ICL1 K 40 - G.HN R 51 G.HN.51
Polar TM2 S 42 2x37 G.H5 Q 381 G.H5.26
Polar TM6 V 223 6x30 G.H5 K 376 G.H5.21
Hydrophobic TM6 V 223 6x30 G.H5 K 376 G.H5.21
Van-der-waals TM6 V 223 6x30 G.H5 K 376 G.H5.21
Van-der-waals TM1 I 27 1x53 G.H5 Q 381 G.H5.26
Hydrophobic TM6 V 223 6x30 G.S6 F 347 G.S6.02
Van-der-waals TM6 V 223 6x30 G.S6 F 347 G.S6.02
Polar H8 S 283 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 S 283 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 S 283 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM6 A 227 6x34 G.H5 K 376 G.H5.21
Hydrophobic TM5 M 209 5x72 G.H5 F 361 G.H5.06
Hydrophobic H8 K 285 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 285 8x49 G.H5 Q 381 G.H5.26
Ionic TM5 H 205 5x68 G.H5 D 368 G.H5.13
Polar TM5 H 205 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 H 205 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 H 205 5x68 G.H5 D 368 G.H5.13
Hydrophobic ICL2 L 119 34x51 G.s2s3 K 219 G.s2s3.01
Hydrophobic TM7 G 282 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 G 282 7x56 G.H5 L 380 G.H5.25
Polar H8 R 284 8x48 G.h3s5 F 287 G.h3s5.01
Aromatic H8 R 284 8x48 G.h3s5 F 287 G.h3s5.01
Hydrophobic H8 R 284 8x48 G.h3s5 F 287 G.h3s5.01
Van-der-waals H8 R 284 8x48 G.h3s5 F 287 G.h3s5.01
Hydrophobic H8 Q 288 8x52 G.h3s5 F 287 G.h3s5.01
Van-der-waals H8 Q 288 8x52 G.h3s5 F 287 G.h3s5.01
Polar ICL1 I 41 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL1 I 41 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 I 41 - G.hns1 R 55 G.hns1.02
Hydrophobic TM6 V 223 6x30 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM5 M 209 5x72 G.H5 A 365 G.H5.10
Van-der-waals TM5 M 209 5x72 G.H5 A 365 G.H5.10
Hydrophobic TM2 A 44 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 A 44 2x39 G.H5 I 378 G.H5.23
Hydrophobic TM2 L 48 2x43 G.H5 Q 381 G.H5.26
Van-der-waals TM2 L 48 2x43 G.H5 Q 381 G.H5.26