Gt1 - TAS2R19 complex model

GPCR CLASS (FAMILY)

T (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 86.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 T 230 6x37 G.H5 L 349 G.H5.25
Hydrophobic TM6 T 230 6x37 G.H5 L 349 G.H5.25
Van-der-waals TM6 T 230 6x37 G.H5 L 349 G.H5.25
Aromatic TM5 H 212 5x75 G.H5 F 330 G.H5.06
Hydrophobic TM5 H 212 5x75 G.H5 F 330 G.H5.06
Van-der-waals TM5 H 212 5x75 G.H5 F 330 G.H5.06
Hydrophobic TM5 H 205 5x68 G.H5 T 336 G.H5.12
Van-der-waals ICL2 F 113 34x45 G.s2s3 D 189 G.s2s3.02
Hydrophobic TM2 A 44 2x39 G.H5 C 347 G.H5.23
Hydrophobic TM3 K 109 3x53 G.H5 C 347 G.H5.23
Hydrophobic TM5 L 202 5x65 G.H5 I 340 G.H5.16
Ionic TM5 H 212 5x75 G.H5 D 333 G.H5.09
Polar TM5 H 212 5x75 G.H5 D 333 G.H5.09
Hydrophobic TM5 H 212 5x75 G.H5 D 333 G.H5.09
Van-der-waals TM5 H 212 5x75 G.H5 D 333 G.H5.09
Hydrophobic TM2 A 44 2x39 G.H5 D 346 G.H5.22
Van-der-waals TM2 A 44 2x39 G.H5 D 346 G.H5.22
Hydrophobic TM3 I 110 3x54 G.H5 C 347 G.H5.23
Ionic H8 R 284 8x48 G.h4s6 D 311 G.h4s6.09
Polar H8 R 284 8x48 G.h4s6 D 311 G.h4s6.09
Hydrophobic H8 R 284 8x48 G.h4s6 D 311 G.h4s6.09
Van-der-waals H8 R 284 8x48 G.h4s6 D 311 G.h4s6.09
Hydrophobic TM3 I 110 3x54 G.H5 L 344 G.H5.20
Van-der-waals TM3 I 110 3x54 G.H5 L 344 G.H5.20
Ionic TM5 H 205 5x68 G.H5 D 337 G.H5.13
Polar TM5 H 205 5x68 G.H5 D 337 G.H5.13
Hydrophobic TM5 H 205 5x68 G.H5 D 337 G.H5.13
Van-der-waals TM5 H 205 5x68 G.H5 D 337 G.H5.13
Hydrophobic TM6 H 224 6x31 G.H5 L 344 G.H5.20
Hydrophobic TM3 I 110 3x54 G.H5 N 343 G.H5.19
Van-der-waals ICL2 K 123 34x55 G.HN E 24 G.HN.52
Polar TM6 S 220 6x27 G.h4s6 E 314 G.h4s6.12
Van-der-waals TM6 S 220 6x27 G.h4s6 E 314 G.h4s6.12
Ionic TM5 K 208 5x71 G.H5 D 333 G.H5.09
Polar TM5 K 208 5x71 G.H5 D 333 G.H5.09
Hydrophobic TM5 K 208 5x71 G.H5 D 333 G.H5.09
Van-der-waals TM5 K 208 5x71 G.H5 D 333 G.H5.09
Hydrophobic TM5 L 202 5x65 G.H5 L 344 G.H5.20
Hydrophobic TM6 A 227 6x34 G.H5 L 344 G.H5.20
Van-der-waals TM6 A 227 6x34 G.H5 L 344 G.H5.20
Hydrophobic TM3 I 110 3x54 G.H5 L 349 G.H5.25
Hydrophobic TM3 I 110 3x54 G.H5 I 340 G.H5.16
Hydrophobic TM5 M 209 5x72 G.H5 D 337 G.H5.13
Hydrophobic TM6 V 223 6x30 G.H5 K 341 G.H5.17
Van-der-waals TM6 V 223 6x30 G.H5 K 341 G.H5.17
Hydrophobic TM6 H 224 6x31 G.H5 I 340 G.H5.16
Van-der-waals TM6 H 224 6x31 G.H5 I 340 G.H5.16
Polar TM6 P 219 6x26 G.h4s6 E 314 G.h4s6.12
Hydrophobic TM6 P 219 6x26 G.h4s6 E 314 G.h4s6.12
Van-der-waals TM6 P 219 6x26 G.h4s6 E 314 G.h4s6.12
Ionic TM6 H 224 6x31 G.H5 D 337 G.H5.13
Polar TM6 H 224 6x31 G.H5 D 337 G.H5.13
Van-der-waals TM6 H 224 6x31 G.H5 D 337 G.H5.13
Hydrophobic TM6 K 226 6x33 G.H5 F 350 G.H5.26
Hydrophobic TM5 M 209 5x72 G.H5 D 333 G.H5.09
Van-der-waals TM5 M 209 5x72 G.H5 D 333 G.H5.09
Polar TM6 S 220 6x27 G.H5 D 337 G.H5.13
Hydrophobic TM6 S 220 6x27 G.H5 D 337 G.H5.13
Van-der-waals TM6 S 220 6x27 G.H5 D 337 G.H5.13
Hydrophobic ICL2 L 119 34x51 G.s2s3 D 189 G.s2s3.02
Van-der-waals ICL2 L 119 34x51 G.s2s3 D 189 G.s2s3.02
Polar H8 S 283 8x47 G.H5 F 350 G.H5.26
Hydrophobic H8 S 283 8x47 G.H5 F 350 G.H5.26
Van-der-waals H8 S 283 8x47 G.H5 F 350 G.H5.26
Polar H8 R 284 8x48 G.H5 F 350 G.H5.26
Hydrophobic H8 R 284 8x48 G.H5 F 350 G.H5.26
Van-der-waals H8 R 284 8x48 G.H5 F 350 G.H5.26
Hydrophobic ICL2 K 123 34x55 G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 K 123 34x55 G.hns1 R 28 G.hns1.03
Hydrophobic TM6 S 220 6x27 G.S6 Y 316 G.S6.02
Polar TM3 C 106 3x50 G.H5 C 347 G.H5.23
Hydrophobic TM3 C 106 3x50 G.H5 C 347 G.H5.23
Van-der-waals TM3 C 106 3x50 G.H5 C 347 G.H5.23
Hydrophobic H8 R 284 8x48 G.h4s6 V 312 G.h4s6.10
Hydrophobic TM5 H 205 5x68 G.H5 I 340 G.H5.16
Van-der-waals TM5 H 205 5x68 G.H5 I 340 G.H5.16
Ionic TM3 K 109 3x53 G.H5 D 346 G.H5.22
Polar TM3 K 109 3x53 G.H5 D 346 G.H5.22
Hydrophobic TM3 K 109 3x53 G.H5 D 346 G.H5.22
Van-der-waals TM3 K 109 3x53 G.H5 D 346 G.H5.22
Polar ICL2 K 122 34x54 G.hns1 R 28 G.hns1.03
Hydrophobic ICL2 K 122 34x54 G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 K 122 34x54 G.hns1 R 28 G.hns1.03
Hydrophobic TM6 V 231 6x38 G.H5 L 349 G.H5.25
Hydrophobic TM6 V 223 6x30 G.H5 L 344 G.H5.20
Polar TM7 G 282 7x56 G.H5 F 350 G.H5.26
Hydrophobic TM7 G 282 7x56 G.H5 F 350 G.H5.26
Van-der-waals TM7 G 282 7x56 G.H5 F 350 G.H5.26
Polar ICL2 S 114 34x46 G.s2s3 D 189 G.s2s3.02
Hydrophobic ICL2 S 114 34x46 G.s2s3 D 189 G.s2s3.02
Polar ICL2 L 119 34x51 G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 L 119 34x51 G.hns1 R 28 G.hns1.03
Hydrophobic TM3 F 105 3x49 G.H5 C 347 G.H5.23
Polar TM3 K 109 3x53 G.H5 N 343 G.H5.19
Hydrophobic TM3 K 109 3x53 G.H5 N 343 G.H5.19
Van-der-waals TM3 K 109 3x53 G.H5 N 343 G.H5.19
Hydrophobic TM6 V 223 6x30 G.H5 F 350 G.H5.26
Van-der-waals TM6 V 223 6x30 G.H5 F 350 G.H5.26
Hydrophobic TM6 A 227 6x34 G.H5 L 349 G.H5.25
Polar H8 S 283 8x47 G.H5 G 348 G.H5.24
Hydrophobic H8 S 283 8x47 G.H5 G 348 G.H5.24