G12 - TAS2R60 complex model

GPCR CLASS (FAMILY)

T (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 76.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 23.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ECL1 P 84 - G.h4s6 S 343 G.h4s6.12
Hydrophobic ECL2 D 183 - G.H5 Q 372 G.H5.17
Van-der-waals ECL2 D 183 - G.H5 Q 372 G.H5.17
Polar ECL1 M 85 - G.h4s6 S 343 G.h4s6.12
Hydrophobic ECL1 M 85 - G.h4s6 S 343 G.h4s6.12
Van-der-waals ECL1 M 85 - G.h4s6 S 343 G.h4s6.12
Hydrophobic ECL2 T 181 - G.H5 A 365 G.H5.10
Van-der-waals ECL2 T 181 - G.H5 A 365 G.H5.10
Polar ECL2 P 177 - G.H4 Q 328 G.H4.08
Hydrophobic ECL2 P 177 - G.H4 Q 328 G.H4.08
Van-der-waals ECL2 P 177 - G.H4 Q 328 G.H4.08
Van-der-waals ECL2 V 180 - G.S6 F 347 G.S6.02
Van-der-waals ECL2 N 179 - G.S6 H 348 G.S6.03
Hydrophobic TM6 P 272 6x61 G.H5 L 375 G.H5.20
Ionic ECL2 H 174 - G.H4 D 336 G.H4.16
Hydrophobic TM7 D 275 7x31 G.H5 L 380 G.H5.25
Van-der-waals TM7 D 275 7x31 G.H5 L 380 G.H5.25
Polar ECL2 Y 170 - G.h4s6 K 344 G.h4s6.19
Hydrophobic ECL2 P 177 - G.S6 F 350 G.S6.05
Van-der-waals ECL2 P 177 - G.S6 F 350 G.S6.05
Polar ECL2 T 181 - G.S6 H 349 G.S6.04
Hydrophobic ECL2 T 181 - G.S6 H 349 G.S6.04
Van-der-waals ECL2 T 181 - G.S6 H 349 G.S6.04
Hydrophobic ECL2 L 175 - G.H4 Q 333 G.H4.13
Van-der-waals ECL2 L 175 - G.H4 Q 333 G.H4.13
Van-der-waals ECL2 H 174 - G.H4 V 332 G.H4.12
Hydrophobic TM6 P 272 6x61 G.H5 L 380 G.H5.25
Van-der-waals TM6 P 272 6x61 G.H5 L 380 G.H5.25
Polar TM3 P 88 3x20 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM3 P 88 3x20 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM3 P 88 3x20 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM3 F 87 3x19 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM3 F 87 3x19 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM3 F 87 3x19 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM3 F 87 3x19 G.h4s6 P 345 G.h4s6.20
Polar ECL2 N 179 - G.S6 F 350 G.S6.05
Hydrophobic ECL2 N 179 - G.S6 F 350 G.S6.05
Van-der-waals ECL2 N 179 - G.S6 F 350 G.S6.05
Hydrophobic TM3 F 87 3x19 G.h4s6 K 344 G.h4s6.19
Van-der-waals TM3 F 87 3x19 G.h4s6 K 344 G.h4s6.19
Polar ECL2 L 175 - G.H4 R 329 G.H4.09
Hydrophobic ECL2 L 175 - G.H4 R 329 G.H4.09
Van-der-waals ECL2 L 175 - G.H4 R 329 G.H4.09
Polar ECL2 Y 170 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ECL2 Y 170 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ECL2 Y 170 - G.h4s6 P 345 G.h4s6.20
Polar ECL2 W 178 - G.S6 H 348 G.S6.03
Van-der-waals ECL2 W 178 - G.S6 H 348 G.S6.03
Polar TM3 A 86 3x18 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM3 A 86 3x18 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM3 A 86 3x18 G.h4s6 S 343 G.h4s6.12
Polar ECL2 N 179 - G.S6 H 349 G.S6.04
Hydrophobic ECL2 N 179 - G.S6 H 349 G.S6.04
Van-der-waals ECL2 N 179 - G.S6 H 349 G.S6.04
Polar ECL2 D 183 - G.H5 T 369 G.H5.14
Polar TM7 D 275 7x31 G.H5 M 379 G.H5.24
Hydrophobic TM7 D 275 7x31 G.H5 M 379 G.H5.24
Van-der-waals TM7 D 275 7x31 G.H5 M 379 G.H5.24
Polar TM7 F 276 7x32 G.H5 M 379 G.H5.24
Polar ECL2 Y 170 - G.h4s6 R 342 G.h4s6.11
Polar ECL2 H 174 - G.S6 L 346 G.S6.01
Hydrophobic ECL2 H 174 - G.S6 L 346 G.S6.01
Van-der-waals ECL2 H 174 - G.S6 L 346 G.S6.01
Polar ECL2 V 180 - G.S6 H 348 G.S6.03
Hydrophobic ECL2 V 180 - G.S6 H 348 G.S6.03
Van-der-waals ECL2 V 180 - G.S6 H 348 G.S6.03
Hydrophobic ECL2 T 181 - G.S6 F 347 G.S6.02
Hydrophobic TM6 P 272 6x61 G.H5 K 376 G.H5.21
Van-der-waals TM6 P 272 6x61 G.H5 K 376 G.H5.21
Hydrophobic TM6 I 270 6x59 G.H5 M 379 G.H5.24
Van-der-waals TM6 I 270 6x59 G.H5 M 379 G.H5.24
Hydrophobic ECL1 P 84 - G.h3s5 F 287 G.h3s5.01
Van-der-waals ECL1 P 84 - G.h3s5 F 287 G.h3s5.01
Hydrophobic ECL1 M 85 - G.h3s5 F 287 G.h3s5.01
Van-der-waals ECL1 M 85 - G.h3s5 F 287 G.h3s5.01
Hydrophobic TM3 F 87 3x19 G.h4s6 R 342 G.h4s6.11
Van-der-waals TM3 F 87 3x19 G.h4s6 R 342 G.h4s6.11
Hydrophobic ECL1 M 85 - G.h4s6 N 341 G.h4s6.10
Van-der-waals ECL1 M 85 - G.h4s6 N 341 G.h4s6.10
Polar ECL2 V 180 - G.S6 H 349 G.S6.04
Hydrophobic ECL2 V 180 - G.S6 H 349 G.S6.04
Hydrophobic ECL2 G 182 - G.S6 F 347 G.S6.02
Van-der-waals ECL2 G 182 - G.S6 F 347 G.S6.02
Polar ECL2 G 182 - G.H5 T 369 G.H5.14
Hydrophobic ECL2 T 181 - G.H5 V 366 G.H5.11
Polar ECL2 Q 176 - G.S6 H 348 G.S6.03
Van-der-waals ECL2 Q 176 - G.S6 H 348 G.S6.03
Hydrophobic TM6 P 272 6x61 G.H5 M 379 G.H5.24
Van-der-waals TM6 P 272 6x61 G.H5 M 379 G.H5.24
Hydrophobic ECL2 P 177 - G.H4 E 325 G.H4.05
Polar ECL2 H 174 - G.h4s6 R 339 G.h4s6.08
Hydrophobic ECL2 H 174 - G.h4s6 R 339 G.h4s6.08
Van-der-waals ECL2 H 174 - G.h4s6 R 339 G.h4s6.08
Hydrophobic ECL2 H 174 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ECL2 H 174 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ECL3 P 273 - G.H5 L 380 G.H5.25
Hydrophobic ECL3 L 274 - G.H5 L 380 G.H5.25
Van-der-waals ECL3 L 274 - G.H5 L 380 G.H5.25