G12 - TRH1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 S 256 6x25 G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL2 F 135 34x55 G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 135 34x55 G.S3 I 221 G.S3.01
Hydrophobic TM2 T 60 2x39 G.H5 I 378 G.H5.23
Polar ICL3 C 253 - G.h4s6 R 342 G.h4s6.11
Hydrophobic ICL3 C 253 - G.h4s6 R 342 G.h4s6.11
Van-der-waals ICL3 C 253 - G.h4s6 R 342 G.h4s6.11
Hydrophobic TM6 V 264 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 V 264 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL2 P 130 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 130 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM3 I 127 3x54 G.H5 L 375 G.H5.20
Ionic TM5 D 226 5x73 G.S6 H 349 G.S6.04
Polar TM5 D 226 5x73 G.S6 H 349 G.S6.04
Ionic TM6 R 261 6x30 G.H5 D 368 G.H5.13
Polar TM6 R 261 6x30 G.H5 D 368 G.H5.13
Polar TM3 A 126 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 126 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 126 3x53 G.H5 N 374 G.H5.19
Polar TM4 S 140 4x40 G.HN R 52 G.HN.52
Hydrophobic TM4 S 140 4x40 G.HN R 52 G.HN.52
Van-der-waals TM4 S 140 4x40 G.HN R 52 G.HN.52
Ionic C-term E 366 - G.s4h3 R 265 G.s4h3.12
Polar C-term E 366 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term E 366 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term E 366 - G.s4h3 R 265 G.s4h3.12
Polar C-term T 373 - G.hfs2 K 206 G.hfs2.03
Polar C-term I 370 - G.hfs2 K 209 G.hfs2.06
Hydrophobic C-term I 370 - G.hfs2 K 209 G.hfs2.06
Van-der-waals C-term I 370 - G.hfs2 K 209 G.hfs2.06
Hydrophobic ICL2 I 131 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 I 131 34x51 G.H5 F 363 G.H5.08
Ionic C-term E 366 - H.HA K 114 H.HA.28
Polar C-term E 366 - H.HA K 114 H.HA.28
Hydrophobic ICL1 M 56 12x50 G.H5 L 380 G.H5.25
Van-der-waals ICL1 M 56 12x50 G.H5 L 380 G.H5.25
Hydrophobic TM5 I 223 5x70 G.H5 D 368 G.H5.13
Van-der-waals TM5 I 223 5x70 G.H5 D 368 G.H5.13
Polar TM2 N 61 2x40 G.H5 D 377 G.H5.22
Hydrophobic TM5 I 223 5x70 G.H5 Q 372 G.H5.17
Van-der-waals TM5 I 223 5x70 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 Q 134 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 Q 134 34x54 G.H5 I 370 G.H5.15
Polar TM6 Q 263 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 Q 263 6x32 G.H5 Q 381 G.H5.26
Polar H8 K 326 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 K 326 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 326 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 K 326 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 K 326 8x49 G.H5 L 380 G.H5.25
Hydrophobic ICL3 W 234 - G.H4 Q 333 G.H4.13
Van-der-waals ICL3 W 234 - G.H4 Q 333 G.H4.13
Hydrophobic TM3 I 127 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 127 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM6 Q 263 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 Q 263 6x32 G.H5 M 379 G.H5.24
Polar C-term T 371 - G.hfs2 K 209 G.hfs2.06
Van-der-waals C-term T 371 - G.hfs2 K 209 G.hfs2.06
Hydrophobic TM6 T 257 6x26 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 F 135 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 F 135 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic C-term I 370 - G.hfs2 A 207 G.hfs2.04
Aromatic ICL3 W 234 - G.H4 R 329 G.H4.09
Hydrophobic ICL3 W 234 - G.H4 R 329 G.H4.09
Van-der-waals ICL3 W 234 - G.H4 R 329 G.H4.09
Van-der-waals ICL2 Q 134 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 P 130 34x50 G.H5 L 371 G.H5.16
Hydrophobic C-term V 372 - G.hfs2 K 209 G.hfs2.06
Van-der-waals C-term V 372 - G.hfs2 K 209 G.hfs2.06
Hydrophobic TM5 P 224 5x71 G.H5 H 364 G.H5.09
Van-der-waals TM5 P 224 5x71 G.H5 H 364 G.H5.09
Hydrophobic TM7 Y 320 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 320 7x53 G.H5 L 380 G.H5.25
Hydrophobic ICL2 I 131 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 I 131 34x51 G.S1 V 58 G.S1.02
Polar TM3 R 123 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM6 R 261 6x30 G.H5 L 375 G.H5.20
Hydrophobic ICL2 F 135 34x55 G.S1 L 57 G.S1.01
Van-der-waals ICL2 F 135 34x55 G.S1 L 57 G.S1.01
Hydrophobic TM6 M 267 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 M 267 6x36 G.H5 M 379 G.H5.24
Polar H8 F 327 8x50 G.H5 L 380 G.H5.25
Hydrophobic H8 F 327 8x50 G.H5 L 380 G.H5.25
Van-der-waals H8 F 327 8x50 G.H5 L 380 G.H5.25
Hydrophobic ICL2 F 135 34x55 G.S1 V 58 G.S1.02
Polar H8 S 324 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 S 324 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 S 324 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM5 I 223 5x70 G.S6 F 347 G.S6.02
Van-der-waals TM5 I 223 5x70 G.S6 F 347 G.S6.02
Hydrophobic ICL2 I 131 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM5 L 218 5x65 G.H5 L 375 G.H5.20
Hydrophobic H8 S 324 8x47 G.H5 Q 381 G.H5.26
Hydrophobic TM6 V 264 6x33 G.H5 L 375 G.H5.20
Hydrophobic ICL2 I 131 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM6 R 261 6x30 G.H5 L 371 G.H5.16
Polar ICL3 C 253 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL3 C 253 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 C 253 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 Q 134 34x54 G.h2s4 T 246 G.h2s4.05
Hydrophobic TM2 N 61 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 N 61 2x40 G.H5 L 380 G.H5.25
Hydrophobic C-term L 367 - G.s4h3 M 262 G.s4h3.09
Van-der-waals C-term L 367 - G.s4h3 M 262 G.s4h3.09
Polar H8 S 324 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 S 324 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 S 324 8x47 G.H5 M 379 G.H5.24
Hydrophobic TM3 A 126 3x53 G.H5 I 378 G.H5.23
Hydrophobic C-term F 384 - G.S3 P 222 G.S3.02
Hydrophobic ICL2 I 131 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 I 131 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM3 I 127 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 127 3x54 G.H5 I 378 G.H5.23
Hydrophobic C-term F 384 - G.S2 V 217 G.S2.07
Van-der-waals C-term F 384 - G.S2 V 217 G.S2.07
Hydrophobic TM2 T 58 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 T 58 2x37 G.H5 D 377 G.H5.22
Hydrophobic ICL2 P 130 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 130 34x50 G.H5 K 367 G.H5.12
Polar TM7 M 323 7x56 G.H5 Q 381 G.H5.26
Hydrophobic TM6 T 257 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 T 257 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 M 267 6x36 G.H5 I 378 G.H5.23
Van-der-waals TM6 M 267 6x36 G.H5 I 378 G.H5.23
Hydrophobic TM5 L 218 5x65 G.H5 L 371 G.H5.16
Hydrophobic C-term L 367 - H.hdhe Q 174 H.hdhe.02
Hydrophobic TM2 L 64 2x43 G.H5 L 380 G.H5.25
Hydrophobic ICL2 F 135 34x55 G.S3 P 222 G.S3.02
Hydrophobic ICL2 F 135 34x55 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 F 135 34x55 G.hns1 R 55 G.hns1.02
Polar ICL3 C 253 - G.h4s6 K 344 G.h4s6.19
Hydrophobic ICL3 C 253 - G.h4s6 K 344 G.h4s6.19
Van-der-waals ICL3 C 253 - G.h4s6 K 344 G.h4s6.19
Polar ICL3 C 253 - G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL3 C 253 - G.h4s6 S 343 G.h4s6.12
Van-der-waals ICL3 C 253 - G.h4s6 S 343 G.h4s6.12
Polar C-term Y 376 - H.HA E 92 H.HA.06
Hydrophobic C-term Y 376 - H.HA E 92 H.HA.06
Van-der-waals C-term Y 376 - H.HA E 92 H.HA.06
Hydrophobic TM7 M 323 7x56 G.H5 M 379 G.H5.24